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Clear cell papillary renal cell carcinoma

MedGen UID:
1388623
Concept ID:
C4518333
Neoplastic Process
Synonyms: clear cell papillary renal cell carcinoma; Clear Cell Papillary Renal Neoplasm; Clear Cell Papillary Renal Tumor
SNOMED CT: Clear cell papillary renal cell carcinoma (734014001); Clear cell papillary renal cell carcinoma (734015000)
 
Monarch Initiative: MONDO:0018448
Orphanet: ORPHA404511

Definition

A rare indolent subtype of clear cell renal carcinoma arising from epithelial cells in the renal cortex. It most frequently manifests with a well-circumscribed, well-encapsulated, unicentric, unilateral, small tumour that typically does not metastasize. Clinically it can present with flank or abdominal pain or haematuria, although most patients are usually asymptomatic at the time of diagnosis. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear cell papillary renal cell carcinoma

Professional guidelines

PubMed

Gupta S, Pitel BA, Knight SM, Halling KC, Jimenez RE, Cheville JC
Eur Urol 2021 Aug;80(2):e62-e63. Epub 2021 May 19 doi: 10.1016/j.eururo.2021.05.011. PMID: 34020826
Weng S, DiNatale RG, Silagy A, Mano R, Attalla K, Kashani M, Weiss K, Benfante NE, Winer AG, Coleman JA, Reuter VE, Russo P, Reznik E, Tickoo SK, Hakimi AA
Eur Urol 2021 Apr;79(4):468-477. Epub 2020 Oct 10 doi: 10.1016/j.eururo.2020.09.027. PMID: 33046271Free PMC Article
Williamson SR, Eble JN, Cheng L, Grignon DJ
Mod Pathol 2013 May;26(5):697-708. Epub 2012 Dec 14 doi: 10.1038/modpathol.2012.204. PMID: 23238627

Recent clinical studies

Etiology

Clingan MJ, Zhang Z, Caserta MP, Cox KL, Gupta V, Baumgarten DA, Zhai QJ, Alexander LF
Radiographics 2023 May;43(5):e220116. doi: 10.1148/rg.220116. PMID: 37053100
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Rysz J, Franczyk B, Ławiński J, Gluba-Brzózka A
Int J Mol Sci 2021 Dec 23;23(1) doi: 10.3390/ijms23010151. PMID: 35008576Free PMC Article
Griffin BB, Lin X
Cancer Cytopathol 2021 Mar;129(3):192-203. Epub 2020 Oct 9 doi: 10.1002/cncy.22355. PMID: 33036062
Morlote DM, Harada S, Batista D, Gordetsky J, Rais-Bahrami S
Hum Pathol 2019 Sep;91:52-60. Epub 2019 Jun 6 doi: 10.1016/j.humpath.2019.05.011. PMID: 31175917

Diagnosis

Rysz J, Franczyk B, Ławiński J, Gluba-Brzózka A
Int J Mol Sci 2021 Dec 23;23(1) doi: 10.3390/ijms23010151. PMID: 35008576Free PMC Article
Zhao J, Eyzaguirre E
Arch Pathol Lab Med 2019 Sep;143(9):1154-1158. Epub 2019 Jan 23 doi: 10.5858/arpa.2018-0121-RS. PMID: 30672334
Lin X
Cancer Cytopathol 2017 Jan;125(1):48-54. Epub 2016 Sep 16 doi: 10.1002/cncy.21779. PMID: 27636377
Mehra R, Smith SC, Divatia M, Amin MB
Surg Pathol Clin 2015 Dec;8(4):623-56. doi: 10.1016/j.path.2015.08.004. PMID: 26612218
Williamson SR, Eble JN, Cheng L, Grignon DJ
Mod Pathol 2013 May;26(5):697-708. Epub 2012 Dec 14 doi: 10.1038/modpathol.2012.204. PMID: 23238627

Therapy

Abdeltawab H, Khalifa F, Ghazal M, Cheng L, Gondim D, El-Baz A
Sci Rep 2021 Oct 12;11(1):20189. doi: 10.1038/s41598-021-99735-6. PMID: 34642404Free PMC Article
Zhou Y, Murugan P, Li F, Bu L
Diagn Pathol 2021 May 16;16(1):43. doi: 10.1186/s13000-021-01106-2. PMID: 33993889Free PMC Article
Harriman D, Mikhailov A, Rogers J, Stratta R, Farney A
Can J Urol 2019 Jun;26(3):9794-9798. PMID: 31180312
Wang K, Zarzour J, Rais-Bahrami S, Gordetsky J
Urology 2017 May;103:136-141. Epub 2017 Jan 24 doi: 10.1016/j.urology.2016.12.002. PMID: 28130179

Prognosis

Rysz J, Franczyk B, Ławiński J, Gluba-Brzózka A
Int J Mol Sci 2021 Dec 23;23(1) doi: 10.3390/ijms23010151. PMID: 35008576Free PMC Article
Morlote DM, Harada S, Batista D, Gordetsky J, Rais-Bahrami S
Hum Pathol 2019 Sep;91:52-60. Epub 2019 Jun 6 doi: 10.1016/j.humpath.2019.05.011. PMID: 31175917
Zhao J, Eyzaguirre E
Arch Pathol Lab Med 2019 Sep;143(9):1154-1158. Epub 2019 Jan 23 doi: 10.5858/arpa.2018-0121-RS. PMID: 30672334
Mehra R, Smith SC, Divatia M, Amin MB
Surg Pathol Clin 2015 Dec;8(4):623-56. doi: 10.1016/j.path.2015.08.004. PMID: 26612218
Kuroda N, Ohe C, Kawakami F, Mikami S, Furuya M, Matsuura K, Moriyama M, Nagashima Y, Zhou M, Petersson F, López JI, Hes O, Michal M, Amin MB
Int J Clin Exp Pathol 2014;7(11):7312-8. Epub 2014 Oct 15 PMID: 25550767Free PMC Article

Clinical prediction guides

Canete-Portillo S, Rodriguez Pena MDC, Wang D, Sanchez DF, Netto GJ, Magi-Galluzzi C
Virchows Arch 2021 Dec;479(6):1187-1196. Epub 2021 Oct 5 doi: 10.1007/s00428-021-03214-2. PMID: 34611731
Morlote DM, Harada S, Batista D, Gordetsky J, Rais-Bahrami S
Hum Pathol 2019 Sep;91:52-60. Epub 2019 Jun 6 doi: 10.1016/j.humpath.2019.05.011. PMID: 31175917
Wang K, Zarzour J, Rais-Bahrami S, Gordetsky J
Urology 2017 May;103:136-141. Epub 2017 Jan 24 doi: 10.1016/j.urology.2016.12.002. PMID: 28130179
Mehra R, Smith SC, Divatia M, Amin MB
Surg Pathol Clin 2015 Dec;8(4):623-56. doi: 10.1016/j.path.2015.08.004. PMID: 26612218
Yan WX, Cao WR, Zhao J, Zhang W, Wang XL, Yuan Q, Dang SQ
Int J Clin Exp Pathol 2015;8(5):4595-9. Epub 2015 May 1 PMID: 26191150Free PMC Article

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