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High Grade Vulvar Squamous Intraepithelial Lesion

MedGen UID:
141672
Concept ID:
C0495107
Neoplastic Process
Synonyms: Grade 2 VIN; Grade 2 Vulvar Intraepithelial Neoplasia; Grade 3 VIN; Grade II VIN; Grade II Vulvar Intraepithelial Neoplasia; Intraepithelial Neoplasia of the Vulva Grade 2; Intraepithelial Neoplasia of Vulva Grade 2; Moderate dysplasia of vulva; VIN - Vulval intraepithelial neoplasia grade 2; VIN 2 of Usual Type; VIN 3 of Usual Type; VIN Grade 2; VIN, Usual Type; Vulva Intraepithelial Neoplasia Grade 2; Vulva Intraepithelial Neoplasia Grade 3; Vulval intraepithelial neoplasia grade 2; Vulvar High Grade Squamous Intraepithelial Lesion; Vulvar High-Grade Squamous Intraepithelial Lesion; Vulvar HSIL; Vulvar Intraepithelial Neoplasia 2 of Usual Type; Vulvar Intraepithelial Neoplasia 3 of Usual Type; Vulvar Intraepithelial Neoplasia Grade 2; Vulvar Intraepithelial Neoplasia Grade 3; Vulvar Intraepithelial Neoplasia, Usual Type
SNOMED CT: Vulval intraepithelial neoplasia grade 2 (276874005); Moderate dysplasia of vulva (276874005); VIN - Vulval intraepithelial neoplasia grade 2 (276874005)

Definition

An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by loss of maturation, nuclear hyperchromasia, high nuclear:cytoplasmic ratios, cytological and architectural atypia, and mitoses. Two morphological patterns have been described: basaloid (undifferentiated) and warty (condylomatous, bowenoid). It carries a significant but relatively low risk of progression to squamous cell carcinoma if untreated. (WHO 2020) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Vulvar Squamous Intraepithelial Lesion

Professional guidelines

PubMed

Lebreton M, Carton I, Brousse S, Lavoué V, Body G, Levêque J, Nyangoh-Timoh K
J Gynecol Obstet Hum Reprod 2020 Nov;49(9):101801. Epub 2020 May 14 doi: 10.1016/j.jogoh.2020.101801. PMID: 32417455
Obstet Gynecol 2016 Oct;128(4):e178-e182. doi: 10.1097/AOG.0000000000001713. PMID: 27661656
Obstet Gynecol 2016 Oct;128(4):937-938. doi: 10.1097/AOG.0000000000001704. PMID: 27661648

Recent clinical studies

Etiology

Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Albuquerque A, Stockdale CK, Heller D, Bornstein J, Roberts JM, Preti M, Poynten IM, Vieira-Baptista P
J Low Genit Tract Dis 2022 Jan 1;26(1):32-37. doi: 10.1097/LGT.0000000000000631. PMID: 34670242
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071
Lebreton M, Carton I, Brousse S, Lavoué V, Body G, Levêque J, Nyangoh-Timoh K
J Gynecol Obstet Hum Reprod 2020 Nov;49(9):101801. Epub 2020 May 14 doi: 10.1016/j.jogoh.2020.101801. PMID: 32417455
Lin A, Day T, Ius Y, Scurry J
J Low Genit Tract Dis 2020 Jul;24(3):311-316. doi: 10.1097/LGT.0000000000000540. PMID: 32324694

Diagnosis

Albuquerque A, Stockdale CK, Heller D, Bornstein J, Roberts JM, Preti M, Poynten IM, Vieira-Baptista P
J Low Genit Tract Dis 2022 Jan 1;26(1):32-37. doi: 10.1097/LGT.0000000000000631. PMID: 34670242
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2020 Jul;136(1):e1-e14. doi: 10.1097/AOG.0000000000003944. PMID: 32590724
Lebreton M, Carton I, Brousse S, Lavoué V, Body G, Levêque J, Nyangoh-Timoh K
J Gynecol Obstet Hum Reprod 2020 Nov;49(9):101801. Epub 2020 May 14 doi: 10.1016/j.jogoh.2020.101801. PMID: 32417455
Preti M, Scurry J, Marchitelli CE, Micheletti L
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):1051-62. Epub 2014 Jul 18 doi: 10.1016/j.bpobgyn.2014.07.010. PMID: 25106700

Therapy

Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
Huisman BW, Pagan L, Naafs RGC, Ten Voorde W, Rissmann R, Piek JMJ, Damman J, Juachon MJ, Osse M, Niemeyer-van der Kolk T, van Hees CLM, van Poelgeest MIE
J Low Genit Tract Dis 2023 Jul 1;27(3):255-261. Epub 2023 Mar 16 doi: 10.1097/LGT.0000000000000731. PMID: 36924426Free PMC Article
Preti M, Joura E, Vieira-Baptista P, Van Beurden M, Bevilacqua F, Bleeker MCG, Bornstein J, Carcopino X, Chargari C, Cruickshank ME, Erzeneoglu BE, Gallio N, Heller D, Kesic V, Reich O, Stockdale CK, Temiz BE, Woelber L, Planchamp F, Zodzika J, Querleu D, Gultekin M
J Low Genit Tract Dis 2022 Jul 1;26(3):229-244. Epub 2022 Jun 21 doi: 10.1097/LGT.0000000000000683. PMID: 35763611Free PMC Article
Abdulrahman Z, de Miranda N, van Esch EMG, de Vos van Steenwijk PJ, Nijman HW, J P Welters M, van Poelgeest MIE, van der Burg SH
J Immunother Cancer 2020 Mar;8(1) doi: 10.1136/jitc-2020-000563. PMID: 32169871Free PMC Article
Lawrie TA, Nordin A, Chakrabarti M, Bryant A, Kaushik S, Pepas L
Cochrane Database Syst Rev 2016 Jan 5;2016(1):CD011837. doi: 10.1002/14651858.CD011837.pub2. PMID: 26728940Free PMC Article

Prognosis

Lebreton M, Carton I, Brousse S, Lavoué V, Body G, Levêque J, Nyangoh-Timoh K
J Gynecol Obstet Hum Reprod 2020 Nov;49(9):101801. Epub 2020 May 14 doi: 10.1016/j.jogoh.2020.101801. PMID: 32417455
Tessier-Cloutier B, Kortekaas KE, Thompson E, Pors J, Chen J, Ho J, Prentice LM, McConechy MK, Chow C, Proctor L, McAlpine JN, Huntsman DG, Gilks CB, Bosse T, Hoang LN
Mod Pathol 2020 Aug;33(8):1595-1605. Epub 2020 Mar 20 doi: 10.1038/s41379-020-0524-1. PMID: 32203095
Abdulrahman Z, de Miranda N, van Esch EMG, de Vos van Steenwijk PJ, Nijman HW, J P Welters M, van Poelgeest MIE, van der Burg SH
J Immunother Cancer 2020 Mar;8(1) doi: 10.1136/jitc-2020-000563. PMID: 32169871Free PMC Article
Cohen PA, Anderson L, Eva L, Scurry J
Int J Gynecol Cancer 2019 May;29(4):821-828. Epub 2019 Feb 7 doi: 10.1136/ijgc-2018-000135. PMID: 30737358
Stier EA, Sebring MC, Mendez AE, Ba FS, Trimble DD, Chiao EY
Am J Obstet Gynecol 2015 Sep;213(3):278-309. Epub 2015 Mar 19 doi: 10.1016/j.ajog.2015.03.034. PMID: 25797230Free PMC Article

Clinical prediction guides

Thuijs NB, van Beurden M, Duin S, Heideman DAM, Berkhof J, Steenbergen RDM, Bleeker MCG
Histopathology 2024 Jan;84(2):301-314. Epub 2023 Sep 19 doi: 10.1111/his.15050. PMID: 37726173
Huisman BW, Pagan L, Naafs RGC, Ten Voorde W, Rissmann R, Piek JMJ, Damman J, Juachon MJ, Osse M, Niemeyer-van der Kolk T, van Hees CLM, van Poelgeest MIE
J Low Genit Tract Dis 2023 Jul 1;27(3):255-261. Epub 2023 Mar 16 doi: 10.1097/LGT.0000000000000731. PMID: 36924426Free PMC Article
Tessier-Cloutier B, Kortekaas KE, Thompson E, Pors J, Chen J, Ho J, Prentice LM, McConechy MK, Chow C, Proctor L, McAlpine JN, Huntsman DG, Gilks CB, Bosse T, Hoang LN
Mod Pathol 2020 Aug;33(8):1595-1605. Epub 2020 Mar 20 doi: 10.1038/s41379-020-0524-1. PMID: 32203095
Abdulrahman Z, de Miranda N, van Esch EMG, de Vos van Steenwijk PJ, Nijman HW, J P Welters M, van Poelgeest MIE, van der Burg SH
J Immunother Cancer 2020 Mar;8(1) doi: 10.1136/jitc-2020-000563. PMID: 32169871Free PMC Article
Lawrie TA, Nordin A, Chakrabarti M, Bryant A, Kaushik S, Pepas L
Cochrane Database Syst Rev 2016 Jan 5;2016(1):CD011837. doi: 10.1002/14651858.CD011837.pub2. PMID: 26728940Free PMC Article

Recent systematic reviews

Vieira-Baptista P, Pérez-López FR, López-Baena MT, Stockdale CK, Preti M, Bornstein J
J Low Genit Tract Dis 2022 Jul 1;26(3):250-257. Epub 2022 Mar 11 doi: 10.1097/LGT.0000000000000673. PMID: 35285455
Dasgupta S, Ewing-Graham PC, Swagemakers SMA, van der Spek PJ, van Doorn HC, Noordhoek Hegt V, Koljenović S, van Kemenade FJ
Crit Rev Oncol Hematol 2020 Mar;147:102866. Epub 2020 Jan 15 doi: 10.1016/j.critrevonc.2020.102866. PMID: 32058913
Lawrie TA, Nordin A, Chakrabarti M, Bryant A, Kaushik S, Pepas L
Cochrane Database Syst Rev 2016 Jan 5;2016(1):CD011837. doi: 10.1002/14651858.CD011837.pub2. PMID: 26728940Free PMC Article
Stier EA, Sebring MC, Mendez AE, Ba FS, Trimble DD, Chiao EY
Am J Obstet Gynecol 2015 Sep;213(3):278-309. Epub 2015 Mar 19 doi: 10.1016/j.ajog.2015.03.034. PMID: 25797230Free PMC Article
Thomas LK, Bermejo JL, Vinokurova S, Jensen K, Bierkens M, Steenbergen R, Bergmann M, von Knebel Doeberitz M, Reuschenbach M
Eur J Cancer 2014 Jan;50(1):85-98. Epub 2013 Sep 17 doi: 10.1016/j.ejca.2013.08.022. PMID: 24054023

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