U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

High Grade Intraepithelial Neoplasia

MedGen UID:
234349
Concept ID:
C1334015
Neoplastic Process

Definition

A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as grade II (moderate dysplasia) or grade III (severe dysplasia). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Intraepithelial Neoplasia

Professional guidelines

PubMed

Porschen R, Fischbach W, Gockel I, Hollerbach S, Hölscher A, Jansen PL, Miehlke S, Pech O, Stahl M, Vanhoefer U, Ebert MPA
United European Gastroenterol J 2024 Apr;12(3):399-411. Epub 2024 Jan 29 doi: 10.1002/ueg2.12523. PMID: 38284661Free PMC Article
Messmann H, Bisschops R, Antonelli G, Libânio D, Sinonquel P, Abdelrahim M, Ahmad OF, Areia M, Bergman JJGHM, Bhandari P, Boskoski I, Dekker E, Domagk D, Ebigbo A, Eelbode T, Eliakim R, Häfner M, Haidry RJ, Jover R, Kaminski MF, Kuvaev R, Mori Y, Palazzo M, Repici A, Rondonotti E, Rutter MD, Saito Y, Sharma P, Spada C, Spadaccini M, Veitch A, Gralnek IM, Hassan C, Dinis-Ribeiro M
Endoscopy 2022 Dec;54(12):1211-1231. Epub 2022 Oct 21 doi: 10.1055/a-1950-5694. PMID: 36270318
Morote J, Schwartzmann I, Celma A, Roche S, de Torres IM, Mast R, Semidey ME, Regis L, Santamaria A, Planas J, Trilla E
BJU Int 2022 May;129(5):627-633. Epub 2021 Aug 25 doi: 10.1111/bju.15568. PMID: 34375498

Recent clinical studies

Etiology

Chen Y, He L, Zheng X
Medicine (Baltimore) 2023 Dec 8;102(49):e36439. doi: 10.1097/MD.0000000000036439. PMID: 38065868Free PMC Article
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
Krajciova J, Vackova Z, Spicak J, Martinek J
Minerva Chir 2018 Aug;73(4):366-377. Epub 2018 May 25 doi: 10.23736/S0026-4733.18.07783-0. PMID: 29806757

Diagnosis

Chen Y, He L, Zheng X
Medicine (Baltimore) 2023 Dec 8;102(49):e36439. doi: 10.1097/MD.0000000000036439. PMID: 38065868Free PMC Article
Liu X, Wang X, Mao T, Yin X, Wei Z, Fu J, Wu J, Li X
Ann Med 2023 Dec;55(1):2231852. doi: 10.1080/07853890.2023.2231852. PMID: 37450336Free PMC Article
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Messmann H, Bisschops R, Antonelli G, Libânio D, Sinonquel P, Abdelrahim M, Ahmad OF, Areia M, Bergman JJGHM, Bhandari P, Boskoski I, Dekker E, Domagk D, Ebigbo A, Eelbode T, Eliakim R, Häfner M, Haidry RJ, Jover R, Kaminski MF, Kuvaev R, Mori Y, Palazzo M, Repici A, Rondonotti E, Rutter MD, Saito Y, Sharma P, Spada C, Spadaccini M, Veitch A, Gralnek IM, Hassan C, Dinis-Ribeiro M
Endoscopy 2022 Dec;54(12):1211-1231. Epub 2022 Oct 21 doi: 10.1055/a-1950-5694. PMID: 36270318
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article

Therapy

Liu X, Wang X, Mao T, Yin X, Wei Z, Fu J, Wu J, Li X
Ann Med 2023 Dec;55(1):2231852. doi: 10.1080/07853890.2023.2231852. PMID: 37450336Free PMC Article
Zhao K, Feng LN, Xia SH, Zhou WD, Zhang MY, Zhang Y, Dong RN, Tian DA, Liu M, Liao JZ
Curr Med Sci 2023 Apr;43(2):268-273. Epub 2023 Mar 2 doi: 10.1007/s11596-023-2705-x. PMID: 36864248
Zhang HH, Soyfoo MD, Cao JL, Sang HM, Xu SF, Jiang JX
J Laparoendosc Adv Surg Tech A 2022 Apr;32(4):413-421. Epub 2021 Dec 28 doi: 10.1089/lap.2020.0035. PMID: 34962142
Prigge ES, von Knebel Doeberitz M, Reuschenbach M
Mutat Res Rev Mutat Res 2017 Apr-Jun;772:51-66. Epub 2016 Jun 22 doi: 10.1016/j.mrrev.2016.06.005. PMID: 28528690
Bergman JJ
Best Pract Res Clin Gastroenterol 2005 Dec;19(6):889-907. doi: 10.1016/j.bpg.2005.03.002. PMID: 16338648

Prognosis

Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Morote J, Schwartzmann I, Celma A, Roche S, de Torres IM, Mast R, Semidey ME, Regis L, Santamaria A, Planas J, Trilla E
BJU Int 2022 May;129(5):627-633. Epub 2021 Aug 25 doi: 10.1111/bju.15568. PMID: 34375498
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
Gautier M, Brochard C, Lion A, Henno S, Mallet AL, Bodere A, Bouguen G, Lièvre A, Siproudhis L
Dig Liver Dis 2016 Jul;48(7):806-11. Epub 2016 Mar 28 doi: 10.1016/j.dld.2016.03.011. PMID: 27103359

Clinical prediction guides

Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Liu X, Wang X, Mao T, Yin X, Wei Z, Fu J, Wu J, Li X
Ann Med 2023 Dec;55(1):2231852. doi: 10.1080/07853890.2023.2231852. PMID: 37450336Free PMC Article
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
Gautier M, Brochard C, Lion A, Henno S, Mallet AL, Bodere A, Bouguen G, Lièvre A, Siproudhis L
Dig Liver Dis 2016 Jul;48(7):806-11. Epub 2016 Mar 28 doi: 10.1016/j.dld.2016.03.011. PMID: 27103359

Recent systematic reviews

Kang CB, Li XB, Hou S, Zhang J, Chi XQ, Shan HF, Zhang QJ, Liu TJ
Adv Ther 2021 May;38(5):2662-2672. Epub 2021 Apr 17 doi: 10.1007/s12325-021-01635-8. PMID: 33864202
Xu Y, Zhong S, Liang W, Lin XL
Expert Rev Gastroenterol Hepatol 2020 Nov;14(11):1083-1092. Epub 2020 Aug 12 doi: 10.1080/17474124.2020.1801416. PMID: 32721191
Verdoodt F, Jiang X, Williams M, Schnatz PF, Arbyn M
Int J Cancer 2016 Jan 15;138(2):303-10. Epub 2015 Feb 5 doi: 10.1002/ijc.29424. PMID: 25583258
De Souza TF, Artifon EL, Mestieri LH, Reimão SM, Aires FT, Bernardo WM, Otoch JP, De Moura EG
Rev Gastroenterol Peru 2014 Jul;34(3):217-24. PMID: 25293990

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...