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Metastatic Malignant Neoplasm in the Larynx

MedGen UID:
146340
•Concept ID:
C0684984
•
Neoplastic Process
Synonyms: Metastatic malignant neoplasm of larynx; Metastatic malignant neoplasm to larynx; Metastatic Malignant Neoplasm to the Larynx; Metastatic Neoplasm to the Larynx; Metastatic Tumor to the Larynx; Secondary malignant neoplasm of larynx
SNOMED CT: Secondary malignant neoplasm of larynx (94370000); Metastatic malignant neoplasm to larynx (94370000); Metastatic malignant neoplasm of larynx (94370000)

Definition

A malignant neoplasm that has spread to the larynx from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Larynx

Professional guidelines

PubMed

Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Primary mucosal melanoma of the larynx: systematic review of the literature and qualitative synthesis.
Fernandez IJ, Spagnolo F, Roncadi L, Molinari G, Marchioni D, Presutti L, Lucidi D
Eur Arch Otorhinolaryngol 2022 Dec;279(12):5535-5545. Epub 2022 Aug 1 doi: 10.1007/s00405-022-07565-7. PMID: 35913632
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, ± Docetaxel for Larynx Preservation.
Janoray G, Pointreau Y, Garaud P, Chapet S, Alfonsi M, Sire C, Jadaud E, Calais G
J Natl Cancer Inst 2016 Apr;108(4) Epub 2015 Dec 16 doi: 10.1093/jnci/djv368. PMID: 26681800
Vocal fold cancer.
Schultz P
Eur Ann Otorhinolaryngol Head Neck Dis 2011 Dec;128(6):301-8. Epub 2011 Sep 29 doi: 10.1016/j.anorl.2011.04.004. PMID: 21959270

Diagnosis

Cancer of unknown primary in the head and neck: Diagnosis and treatment.
Ota I, Kitahara T
Auris Nasus Larynx 2021 Feb;48(1):23-31. Epub 2020 Sep 1 doi: 10.1016/j.anl.2020.08.014. PMID: 32888761
Adenoid Cystic Carcinoma of the Larynx Presenting as a Thyroid Mass and Brief Literature Review.
Shirian S, Maghbool M, Aledavood A, Negahban S, Khademi B, Daneshbod Y
Acta Cytol 2017;61(3):237-241. Epub 2017 May 11 doi: 10.1159/000464271. PMID: 28490006
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
Recurrent differentiated thyroid cancer.
Shaha AR
Endocr Pract 2012 Jul-Aug;18(4):600-3. doi: 10.4158/EP12047.CO. PMID: 22849875
Vocal fold cancer.
Schultz P
Eur Ann Otorhinolaryngol Head Neck Dis 2011 Dec;128(6):301-8. Epub 2011 Sep 29 doi: 10.1016/j.anorl.2011.04.004. PMID: 21959270

Therapy

Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).
Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069
Capecitabine: a review.
Walko CM, Lindley C
Clin Ther 2005 Jan;27(1):23-44. doi: 10.1016/j.clinthera.2005.01.005. PMID: 15763604

Prognosis

Primary mucosal melanoma of the larynx: systematic review of the literature and qualitative synthesis.
Fernandez IJ, Spagnolo F, Roncadi L, Molinari G, Marchioni D, Presutti L, Lucidi D
Eur Arch Otorhinolaryngol 2022 Dec;279(12):5535-5545. Epub 2022 Aug 1 doi: 10.1007/s00405-022-07565-7. PMID: 35913632
PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography-computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer.
Mehanna H, McConkey CC, Rahman JK, Wong WL, Smith AF, Nutting C, Hartley AG, Hall P, Hulme C, Patel DK, Zeidler SV, Robinson M, Sanghera B, Fresco L, Dunn JA
Health Technol Assess 2017 Apr;21(17):1-122. doi: 10.3310/hta21170. PMID: 28409743Free PMC Article
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, ± Docetaxel for Larynx Preservation.
Janoray G, Pointreau Y, Garaud P, Chapet S, Alfonsi M, Sire C, Jadaud E, Calais G
J Natl Cancer Inst 2016 Apr;108(4) Epub 2015 Dec 16 doi: 10.1093/jnci/djv368. PMID: 26681800
Vocal fold cancer.
Schultz P
Eur Ann Otorhinolaryngol Head Neck Dis 2011 Dec;128(6):301-8. Epub 2011 Sep 29 doi: 10.1016/j.anorl.2011.04.004. PMID: 21959270

Clinical prediction guides

Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.
Hajdú SF, Wessel I, Dalton SO, Eskildsen SJ, Johansen C
Dysphagia 2022 Aug;37(4):749-762. Epub 2021 Jun 11 doi: 10.1007/s00455-021-10320-5. PMID: 34117531Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173

Recent systematic reviews

Primary mucosal melanoma of the larynx: systematic review of the literature and qualitative synthesis.
Fernandez IJ, Spagnolo F, Roncadi L, Molinari G, Marchioni D, Presutti L, Lucidi D
Eur Arch Otorhinolaryngol 2022 Dec;279(12):5535-5545. Epub 2022 Aug 1 doi: 10.1007/s00405-022-07565-7. PMID: 35913632
Primary versus secondary tracheoesophageal puncture: systematic review and meta-analysis.
Chakravarty PD, McMurran AEL, Banigo A, Shakeel M, Ah-See KW
J Laryngol Otol 2018 Jan;132(1):14-21. Epub 2017 Nov 27 doi: 10.1017/S0022215117002390. PMID: 29173195
Comparison between Primary and Secondary Tracheoesophageal Puncture Prosthesis: A Systematic Review.
Barauna Neto JC, Dedivitis RA, Aires FT, Pfann RZ, Matos LL, Cernea CR
ORL J Otorhinolaryngol Relat Spec 2017;79(4):222-229. Epub 2017 Jul 29 doi: 10.1159/000477970. PMID: 28768272
Metastatic melanoma to the upper aerodigestive tract: a systematic review of the literature.
Mifsud M, Padhya TA
Laryngoscope 2014 May;124(5):1143-9. Epub 2013 Nov 7 doi: 10.1002/lary.24436. PMID: 24115042
Systematic review of the relation between smokeless tobacco and cancer in Europe and North America.
Lee PN, Hamling J
BMC Med 2009 Jul 29;7:36. doi: 10.1186/1741-7015-7-36. PMID: 19638245Free PMC Article

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