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Benign neoplasm of submandibular gland

MedGen UID:
151936
•Concept ID:
C0685988
•
Neoplastic Process
Synonyms: Benign Neoplasm of Submandibular Gland; benign neoplasm of submandibular gland; Benign neoplasm of submaxillary gland; Benign Neoplasm of the Submandibular Gland; benign neoplasm of the submandibular gland; Benign Submandibular Gland Neoplasm; benign submandibular gland neoplasm; Benign Submandibular Gland Tumor; benign submandibular gland tumor; benign submandibular gland tumour; Benign tumor of submandibular gland; Benign Tumor of Submandibular Gland; benign tumor of submandibular gland; Benign Tumor of the Submandibular Gland; benign tumor of the submandibular gland; benign tumour of submandibular gland; benign tumour of the submandibular gland; submandibular gland benign neoplasm
SNOMED CT: Benign neoplasm of submaxillary gland (92415001); Benign tumor of submandibular gland (92415001); Benign neoplasm of submandibular gland (92415001)
 
Monarch Initiative: MONDO:0021481

Definition

A neoplasm that arises from the submandibular gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of submandibular gland

Professional guidelines

PubMed

Salivary gland cancer: ESMO-European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up.
van Herpen C, Vander Poorten V, Skalova A, Terhaard C, Maroldi R, van Engen A, Baujat B, Locati LD, Jensen AD, Smeele L, Hardillo J, Martineau VC, Trama A, Kinloch E, Even C, Machiels JP; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
ESMO Open 2022 Dec;7(6):100602. Epub 2022 Nov 2 doi: 10.1016/j.esmoop.2022.100602. PMID: 36567082Free PMC Article
Management of Malignant Salivary Gland Conditions.
Pang J, Houlton JJ
Surg Clin North Am 2022 Apr;102(2):325-333. doi: 10.1016/j.suc.2021.12.008. PMID: 35344700
Guidelines for Clinical Target Volume Definition for Perineural Spread of Major Salivary Gland Cancers.
Armstrong K, Ward J, Hughes NM, Mihai A, Blayney A, Mascott C, Kileen R, Armstrong J
Clin Oncol (R Coll Radiol) 2018 Dec;30(12):773-779. Epub 2018 Sep 14 doi: 10.1016/j.clon.2018.08.018. PMID: 30224202

Recent clinical studies

Etiology

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Radiographic-anatomy, natural history and extension pathways of parotid and submandibular gland cancers.
Biau J, Nutting C, Langendijk JA, Frédéric-Moreau T, Thariat J, Piram L, Bellini R, Saroul N, Pham Dang N, O'Sullivan B, Giralt J, Blanchard P, Bourhis J, Lapeyre M
Radiother Oncol 2022 May;170:48-54. Epub 2022 Mar 11 doi: 10.1016/j.radonc.2022.03.005. PMID: 35288225
Functional gland-preserving surgery for submandibular gland pleomorphic adenoma.
Roh JL
J Cancer Res Clin Oncol 2022 Oct;148(10):2623-2629. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03844-8. PMID: 34705103
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Submandibular gland-sparing intensity-modulated radiotherapy.
Mendenhall WM, Mendenhall CM, Mendenhall NP
Am J Clin Oncol 2014 Oct;37(5):514-6. doi: 10.1097/COC.0b013e318261054e. PMID: 22892434

Diagnosis

Leiomyoma of submandibular gland.
Ukwas A, Elshikh M, Umar T, Borumandi F
BMJ Case Rep 2024 Jul 16;17(7) doi: 10.1136/bcr-2023-258871. PMID: 39013622
Controversies in Oral and Maxillofacial Oncology.
Ettinger KS, Yetzer JG
Oral Maxillofac Surg Clin North Am 2017 Nov;29(4):487-501. doi: 10.1016/j.coms.2017.07.004. PMID: 28987229
Salivary glands.
Silvers AR, Som PM
Radiol Clin North Am 1998 Sep;36(5):941-66, vi. doi: 10.1016/s0033-8389(05)70070-1. PMID: 9747195
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940
Submandibular gland tumors.
Hanna DC, Clairmont AA
Plast Reconstr Surg 1978 Feb;61(2):198-203. doi: 10.1097/00006534-197802000-00007. PMID: 202980

Therapy

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands.
Talwar A, Patel E, Tam M, Zhou F, Hu K, Persky M, Vaezi A, Jacobson A, Givi B
Otolaryngol Head Neck Surg 2023 Apr;168(4):775-781. Epub 2023 Jan 29 doi: 10.1177/01945998221120646. PMID: 35998038
Radiographic-anatomy, natural history and extension pathways of parotid and submandibular gland cancers.
Biau J, Nutting C, Langendijk JA, Frédéric-Moreau T, Thariat J, Piram L, Bellini R, Saroul N, Pham Dang N, O'Sullivan B, Giralt J, Blanchard P, Bourhis J, Lapeyre M
Radiother Oncol 2022 May;170:48-54. Epub 2022 Mar 11 doi: 10.1016/j.radonc.2022.03.005. PMID: 35288225
Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients.
Jensen SB, Vissink A, Limesand KH, Reyland ME
J Natl Cancer Inst Monogr 2019 Aug 1;2019(53) doi: 10.1093/jncimonographs/lgz016. PMID: 31425600
Ultrasound-guided core needle biopsy in salivary glands: A meta-analysis.
Kim HJ, Kim JS
Laryngoscope 2018 Jan;128(1):118-125. Epub 2017 Jul 12 doi: 10.1002/lary.26764. PMID: 28699165
Submandibular gland-sparing intensity-modulated radiotherapy.
Mendenhall WM, Mendenhall CM, Mendenhall NP
Am J Clin Oncol 2014 Oct;37(5):514-6. doi: 10.1097/COC.0b013e318261054e. PMID: 22892434

Prognosis

Salivary gland cancer: ESMO-European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up.
van Herpen C, Vander Poorten V, Skalova A, Terhaard C, Maroldi R, van Engen A, Baujat B, Locati LD, Jensen AD, Smeele L, Hardillo J, Martineau VC, Trama A, Kinloch E, Even C, Machiels JP; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
ESMO Open 2022 Dec;7(6):100602. Epub 2022 Nov 2 doi: 10.1016/j.esmoop.2022.100602. PMID: 36567082Free PMC Article
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Surgery for Malignant Submandibular Gland Neoplasms.
Silver NL, Chinn SB, Bradley PJ, Weber RS
Adv Otorhinolaryngol 2016;78:104-12. Epub 2016 Apr 12 doi: 10.1159/000442130. PMID: 27092787
Sialoblastoma.
Vidyadhar M, Amanda C, Thuan Q, Prabhakaran K
J Pediatr Surg 2008 Oct;43(10):e11-3. doi: 10.1016/j.jpedsurg.2008.04.035. PMID: 18926196
Submandibular gland tumors.
Hanna DC, Clairmont AA
Plast Reconstr Surg 1978 Feb;61(2):198-203. doi: 10.1097/00006534-197802000-00007. PMID: 202980

Clinical prediction guides

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
FDG-PET/CT discriminates between patients with and without lymphomas in primary Sjögren's syndrome.
van Ginkel MS, Arends S, van der Vegt B, Nijland M, Spijkervet FKL, Vissink A, Kroese FGM, Glaudemans AWJM, Bootsma H
Rheumatology (Oxford) 2023 Oct 3;62(10):3323-3331. doi: 10.1093/rheumatology/kead071. PMID: 36759907Free PMC Article
Molecular chaperones in tumors of salivary glands.
Basset CA, Cappello F, Rappa F, Lentini VL, Jurjus AR, Conway de Macario E, Macario AJL, Leone A
J Mol Histol 2020 Apr;51(2):109-115. Epub 2020 Apr 16 doi: 10.1007/s10735-020-09871-y. PMID: 32300923
Submandibular gland cancers: prognostic factors and survival analysis.
Şahin MM, Demircan V, Göcek M, Uzunoğlu E, Akmansu M, Sayar E, Kızıl Y, Aydil U
Eur Arch Otorhinolaryngol 2020 Aug;277(8):2307-2313. Epub 2020 Mar 24 doi: 10.1007/s00405-020-05924-w. PMID: 32211936
Margins for Benign Salivary Gland Neoplasms of the Head and Neck.
Carlson ER, McCoy JM
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):325-340. doi: 10.1016/j.coms.2017.03.009. PMID: 28709532

Recent systematic reviews

Deep learning algorithm performance in contouring head and neck organs at risk: a systematic review and single-arm meta-analysis.
Liu P, Sun Y, Zhao X, Yan Y
Biomed Eng Online 2023 Nov 1;22(1):104. doi: 10.1186/s12938-023-01159-y. PMID: 37915046Free PMC Article
Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
Submandibular Gland Invasion by Oral Cavity Cancers: A Systematic Review.
Dundar Y, Mandle Q, Raza SN, Lin HS, Cramer J, Hotaling JM
Otolaryngol Head Neck Surg 2019 Aug;161(2):227-234. Epub 2019 Mar 26 doi: 10.1177/0194599819838475. PMID: 30912983
Ultrasound-guided core needle biopsy in salivary glands: A meta-analysis.
Kim HJ, Kim JS
Laryngoscope 2018 Jan;128(1):118-125. Epub 2017 Jul 12 doi: 10.1002/lary.26764. PMID: 28699165
Sialendoscopy in the Management of Radioiodine Induced Sialadenitis: A Systematic Review.
Cung TD, Lai W, Svider PF, Hanba C, Samantray J, Folbe AJ, Shkoukani M, Raza SN
Ann Otol Rhinol Laryngol 2017 Nov;126(11):768-773. Epub 2017 Sep 26 doi: 10.1177/0003489417732795. PMID: 28949251

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