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Benign neoplasm of major salivary gland

MedGen UID:
96923
•Concept ID:
C0496858
•
Neoplastic Process
Synonyms: Benign Major Salivary Gland Neoplasm; benign Major salivary gland neoplasm; Benign Major Salivary Gland Tumor; benign Major salivary gland tumor; benign Major salivary gland tumour; Benign Neoplasm of Major Salivary Gland; benign neoplasm of major salivary gland; Benign neoplasm of major salivary glands; Benign Neoplasm of the Major Salivary Gland; benign neoplasm of the Major salivary gland; Benign tumor major salivary gland; Benign Tumor of Major Salivary Gland; benign tumor of Major salivary gland; Benign Tumor of the Major Salivary Gland; benign tumor of the Major salivary gland; benign tumour of Major salivary gland; benign tumour of the Major salivary gland; major salivary gland benign neoplasm
SNOMED CT: Benign tumor major salivary gland (92205005); Benign neoplasm of major salivary glands (92205005); Benign neoplasm of major salivary gland (92205005)
 
Monarch Initiative: MONDO:0021492

Definition

A neoplasm that arises from the major salivary glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include Warthin tumor, monomorphic adenoma, and pleomorphic adenoma. [from NCI]

Professional guidelines

PubMed

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Management of Malignant Salivary Gland Conditions.
Pang J, Houlton JJ
Surg Clin North Am 2022 Apr;102(2):325-333. doi: 10.1016/j.suc.2021.12.008. PMID: 35344700
Guidelines for Clinical Target Volume Definition for Perineural Spread of Major Salivary Gland Cancers.
Armstrong K, Ward J, Hughes NM, Mihai A, Blayney A, Mascott C, Kileen R, Armstrong J
Clin Oncol (R Coll Radiol) 2018 Dec;30(12):773-779. Epub 2018 Sep 14 doi: 10.1016/j.clon.2018.08.018. PMID: 30224202

Recent clinical studies

Etiology

Major and minor salivary gland cancers: A multicenter retrospective study.
Hacioglu MB, Erdogan B, Bardakcı M, Algın E, Gulbagcı B, Hacibekiroglu I, Hamdard J, Olmez OF, Akkus H, Oksuzoglu B, Goksu SS, Dae SA, Sumbul AT, Ugraklı M, Karaagac M, Sahin E, Cabuk D, Ozer O, Yavuzsen T, Arıkan R, Köstek O, Atcı MM, Sakin A, Deligonul A, Bayır D, Dincer M, Unsal O, Yazıcı O, Zeynelgil E, Gulmez A, Harputluoglu H, Erol C, Sendur MAN, Aytekin A, Akagunduz B, Oner I, Er O, Oztosun B, Gumus M, Selçukbiricik F, Aykan MB, Karadurmus N, Degerli E, Demirci NS, Turkmen E, Şakalar T, Secmeler S, Tanrıverdi O, Alkan A, Kemal Y, Cil I, Unal C, Iriagaç Y, Alan O, Balli S, Urun Y, Ozcan E, Turhal NS, Cicin I
Head Neck 2023 Jul;45(7):1643-1653. Epub 2023 Apr 21 doi: 10.1002/hed.27376. PMID: 37084179
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Guidelines for Clinical Target Volume Definition for Perineural Spread of Major Salivary Gland Cancers.
Armstrong K, Ward J, Hughes NM, Mihai A, Blayney A, Mascott C, Kileen R, Armstrong J
Clin Oncol (R Coll Radiol) 2018 Dec;30(12):773-779. Epub 2018 Sep 14 doi: 10.1016/j.clon.2018.08.018. PMID: 30224202

Diagnosis

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
Salivary Gland Malignancies.
Carlson ER, Schlieve T
Oral Maxillofac Surg Clin North Am 2019 Feb;31(1):125-144. doi: 10.1016/j.coms.2018.08.007. PMID: 30449524
CT and MR imaging findings of palatal tumors.
Kato H, Kanematsu M, Makita H, Kato K, Hatakeyama D, Shibata T, Mizuta K, Aoki M
Eur J Radiol 2014 Mar;83(3):e137-46. Epub 2013 Dec 12 doi: 10.1016/j.ejrad.2013.11.028. PMID: 24377674
Salivary glands.
Silvers AR, Som PM
Radiol Clin North Am 1998 Sep;36(5):941-66, vi. doi: 10.1016/s0033-8389(05)70070-1. PMID: 9747195

Therapy

Weekly Adaptive Radiotherapy vs Standard Intensity-Modulated Radiotherapy for Improving Salivary Function in Patients With Head and Neck Cancer: A Phase 3 Randomized Clinical Trial.
Castelli J, Thariat J, Benezery K, Hasbini A, Gery B, Berger A, Liem X, Guihard S, Chapet S, Thureau S, Auberdiac P, Pommier P, Ruffier A, Perrier L, Devillers A, Campillo-Gimenez B, de Crevoisier R
JAMA Oncol 2023 Aug 1;9(8):1056-1064. doi: 10.1001/jamaoncol.2023.1352. PMID: 37261806Free PMC Article
Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline.
Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, Coppes RP, Jessen N, Malhotra NK, Murphy B, Rosenthal DI, Vissink A, Wu J, Saunders DP, Peterson DE
J Clin Oncol 2021 Sep 1;39(25):2825-2843. Epub 2021 Jul 20 doi: 10.1200/JCO.21.01208. PMID: 34283635
Extensive preclinical evaluation of lutetium-177-labeled PSMA-specific tracers for prostate cancer radionuclide therapy.
Ruigrok EAM, van Vliet N, Dalm SU, de Blois E, van Gent DC, Haeck J, de Ridder C, Stuurman D, Konijnenberg MW, van Weerden WM, de Jong M, Nonnekens J
Eur J Nucl Med Mol Imaging 2021 May;48(5):1339-1350. Epub 2020 Oct 23 doi: 10.1007/s00259-020-05057-6. PMID: 33094433Free PMC Article
Current State of Knowledge on Salivary Gland Cancers.
Lin HH, Limesand KH, Ann DK
Crit Rev Oncog 2018;23(3-4):139-151. doi: 10.1615/CritRevOncog.2018027598. PMID: 30311570Free PMC Article
Radiotherapy-induced taste impairment.
Ruo Redda MG, Allis S
Cancer Treat Rev 2006 Nov;32(7):541-7. Epub 2006 Aug 2 doi: 10.1016/j.ctrv.2006.06.003. PMID: 16887272

Prognosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Guidelines for Clinical Target Volume Definition for Perineural Spread of Major Salivary Gland Cancers.
Armstrong K, Ward J, Hughes NM, Mihai A, Blayney A, Mascott C, Kileen R, Armstrong J
Clin Oncol (R Coll Radiol) 2018 Dec;30(12):773-779. Epub 2018 Sep 14 doi: 10.1016/j.clon.2018.08.018. PMID: 30224202
Primary Salivary Gland Type Tumors of the Thymus.
Kalhor N, Weissferdt A, Moran CA
Adv Anat Pathol 2017 Jan;24(1):15-23. doi: 10.1097/PAP.0000000000000132. PMID: 27941539
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Clinical prediction guides

A retrospective study of nonneoplastic and neoplastic disorders of the salivary glands.
Vamesu S, Ursica OA, Gurita AM, Voda RI, Deacu M, Aschie M, Bosoteanu M, Cozaru GC, Mitroi AF, Orasanu CI
Medicine (Baltimore) 2023 Oct 20;102(42):e35751. doi: 10.1097/MD.0000000000035751. PMID: 37861511Free PMC Article
Microsecretory Adenocarcinoma of Salivary Glands.
Bishop JA, Sajed DP
Adv Anat Pathol 2023 Mar 1;30(2):130-135. Epub 2022 Dec 19 doi: 10.1097/PAP.0000000000000385. PMID: 36729381
Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Margins for Benign Salivary Gland Neoplasms of the Head and Neck.
Carlson ER, McCoy JM
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):325-340. doi: 10.1016/j.coms.2017.03.009. PMID: 28709532
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Recent systematic reviews

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review.
Cruz VMS, Pérez-de-Oliveira ME, Dos Santos Leite ÉG, Louredo BVR, Bezerra HKF, Lopes MA, Vargas PA, Santos-Silva AR, Kowalski LP, da Cruz Perez DE
Head Neck 2023 Aug;45(8):2136-2148. Epub 2023 Jun 26 doi: 10.1002/hed.27440. PMID: 37357912
Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Impact of tumor site on the prognosis of salivary gland neoplasms: A systematic review and meta-analysis.
Dos Santos ES, Rodrigues-Fernandes CI, Speight PM, Khurram SA, Alsanie I, Costa Normando AG, Prado-Ribeiro AC, Brandão TB, Kowalski LP, Silva Guerra EN, Lopes MA, Vargas PA, Santos-Silva AR, Leme AFP
Crit Rev Oncol Hematol 2021 Jun;162:103352. Epub 2021 May 12 doi: 10.1016/j.critrevonc.2021.103352. PMID: 33991662
Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review.
Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041

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