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Testicular Leydig cell tumor

MedGen UID:
163584
Concept ID:
C0863027
Neoplastic Process
Synonyms: Leydig Cell Neoplasm of Testis; Leydig cell neoplasm of testis; Leydig Cell Neoplasm of the Testis; Leydig cell neoplasm of the testis; Leydig Cell Tumor of Testis; Leydig cell tumor of testis; Leydig Cell Tumor of the Testis; Leydig cell tumor of the testis; Leydig cell tumour of testis; Leydig cell tumour of the testis; Testicular Leydig Cell Neoplasm; testicular Leydig cell neoplasm; Testicular Leydig Cell Tumor; testicular Leydig cell tumor; testis Leydig cell tumor; testis Leydig cell tumour
 
Monarch Initiative: MONDO:0003124

Definition

A sex cord-stromal tumor that arises from the testis and is characterized by the presence of cells that resemble the successive stages of development of Leydig cells. It usually presents as a painless testicular mass. Gynecomastia is present in approximately thirty percent of the cases. Libido may be decreased. In children, precocious puberty may be present. A minority of cases exhibit malignant characteristics. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Leydig cell tumor

Professional guidelines

PubMed

Eyer de Jesus L, Paz de Oliveira AP, Porto LC, Dekermacher S
J Pediatr Urol 2024 Feb;20(1):77-87. Epub 2023 Oct 7 doi: 10.1016/j.jpurol.2023.10.005. PMID: 37845103
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Narula HS, Carlson HE
Nat Rev Endocrinol 2014 Nov;10(11):684-98. Epub 2014 Aug 12 doi: 10.1038/nrendo.2014.139. PMID: 25112235

Recent clinical studies

Etiology

Tavolini IM, Rossato M, Milani C, Dal Moro F
Arch Ital Urol Androl 2007 Sep;79(3):141-2. PMID: 18041368
Carmignani L, Salvioni R, Gadda F, Colecchia M, Gazzano G, Torelli T, Rocco F, Colpi GM, Pizzocaro G
J Urol 2006 Nov;176(5):2040-3; discussion 2043. doi: 10.1016/j.juro.2006.07.005. PMID: 17070249
Mineur P, De Cooman S, Hustin J, Verhoeven G, De Hertogh R
J Clin Endocrinol Metab 1987 Apr;64(4):686-91. doi: 10.1210/jcem-64-4-686. PMID: 3818898
Sohval AR, Churg J, Gabrilove JL, Freiberg EK, Katz N
Ultrastruct Pathol 1982 Oct-Dec;3(4):335-45. doi: 10.3109/01913128209018556. PMID: 7157496

Diagnosis

Yang X, Quan LJ
J Clin Ultrasound 2024 Jun;52(5):643-648. Epub 2024 Mar 7 doi: 10.1002/jcu.23665. PMID: 38450802
Yamamoto Y, Taiji R, Takewa M, Kitatsuji W, Okura A, Saito N, Ohyama N, Tachiiri T, Nishiofuku H, Itoh T, Marugami N, Tanaka T
Abdom Radiol (NY) 2023 Aug;48(8):2477-2482. Epub 2023 May 10 doi: 10.1007/s00261-023-03932-y. PMID: 37165207
Kong Q, Yu Y, Tian T, Zhang H, Sun M, Liu R, Liu Y
Medicine (Baltimore) 2020 Sep 4;99(36):e22085. doi: 10.1097/MD.0000000000022085. PMID: 32899084Free PMC Article
Zhu J, Luan Y, Li H
Medicine (Baltimore) 2018 Jun;97(25):e11158. doi: 10.1097/MD.0000000000011158. PMID: 29924022Free PMC Article
Carmignani L, Salvioni R, Gadda F, Colecchia M, Gazzano G, Torelli T, Rocco F, Colpi GM, Pizzocaro G
J Urol 2006 Nov;176(5):2040-3; discussion 2043. doi: 10.1016/j.juro.2006.07.005. PMID: 17070249

Therapy

Chortis V, Johal NJ, Bancos I, Evans M, Skordilis K, Guest P, Cullen MH, Porfiri E, Arlt W
Eur J Endocrinol 2018 Mar;178(3):K21-K27. Epub 2018 Jan 12 doi: 10.1530/EJE-17-0542. PMID: 29330226Free PMC Article

Prognosis

Yang X, Quan LJ
J Clin Ultrasound 2024 Jun;52(5):643-648. Epub 2024 Mar 7 doi: 10.1002/jcu.23665. PMID: 38450802
Tavolini IM, Rossato M, Milani C, Dal Moro F
Arch Ital Urol Androl 2007 Sep;79(3):141-2. PMID: 18041368
Carmignani L, Salvioni R, Gadda F, Colecchia M, Gazzano G, Torelli T, Rocco F, Colpi GM, Pizzocaro G
J Urol 2006 Nov;176(5):2040-3; discussion 2043. doi: 10.1016/j.juro.2006.07.005. PMID: 17070249
Mineur P, De Cooman S, Hustin J, Verhoeven G, De Hertogh R
J Clin Endocrinol Metab 1987 Apr;64(4):686-91. doi: 10.1210/jcem-64-4-686. PMID: 3818898

Clinical prediction guides

Yang X, Quan LJ
J Clin Ultrasound 2024 Jun;52(5):643-648. Epub 2024 Mar 7 doi: 10.1002/jcu.23665. PMID: 38450802
Yamamoto Y, Taiji R, Takewa M, Kitatsuji W, Okura A, Saito N, Ohyama N, Tachiiri T, Nishiofuku H, Itoh T, Marugami N, Tanaka T
Abdom Radiol (NY) 2023 Aug;48(8):2477-2482. Epub 2023 May 10 doi: 10.1007/s00261-023-03932-y. PMID: 37165207
Tavolini IM, Rossato M, Milani C, Dal Moro F
Arch Ital Urol Androl 2007 Sep;79(3):141-2. PMID: 18041368
Sohval AR, Churg J, Gabrilove JL, Freiberg EK, Katz N
Ultrastruct Pathol 1982 Oct-Dec;3(4):335-45. doi: 10.3109/01913128209018556. PMID: 7157496

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