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Leydig cell tumor

MedGen UID:
9747
Concept ID:
C0023601
Neoplastic Process
Synonyms: Interstitial Cell Tumor; Interstitial Cell Tumors; Leydig Cell Tumor; Tumor, Interstitial Cell; Tumor, Leydig Cell; Tumors, Interstitial Cell
 
Monarch Initiative: MONDO:0006266

Definition

A sex cord-stromal tumor occurring in the testis and rarely in the ovary. It is predominantly or completely composed of Leydig cells which may contain crystals of Reinke. In males it usually presents as a painless testicular enlargement and it may be associated with gynecomastia and decreased libido. The majority of the cases have a benign clinical course. Approximately 10% of the cases have a malignant clinical course and metastasize. In females it may be associated with androgenic manifestations and it follows a benign clinical course. [from NCI]

Professional guidelines

PubMed

Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841

Recent clinical studies

Etiology

Dupeux M, Maxwell F, Rocher L, Izard V, Guettier C, Ferlicot S
Am J Clin Pathol 2022 Jun 7;157(6):936-941. doi: 10.1093/ajcp/aqab214. PMID: 34935941
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Durmuş Y, Kılıç Ç, Çakır C, Yüksel D, Boran N, Karalök A, Boyraz G, Turan AT
J Obstet Gynaecol Res 2019 Jul;45(7):1311-1318. Epub 2019 May 20 doi: 10.1111/jog.13977. PMID: 31106943
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Stewart CJ, Charles A, Foulkes WD
Surg Pathol Clin 2016 Jun;9(2):227-41. Epub 2016 Apr 9 doi: 10.1016/j.path.2016.01.002. PMID: 27241106

Diagnosis

Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Durmuş Y, Kılıç Ç, Çakır C, Yüksel D, Boran N, Karalök A, Boyraz G, Turan AT
J Obstet Gynaecol Res 2019 Jul;45(7):1311-1318. Epub 2019 May 20 doi: 10.1111/jog.13977. PMID: 31106943
Pommert L, Bradley W
Curr Oncol Rep 2017 Jul;19(7):44. doi: 10.1007/s11912-017-0604-7. PMID: 28501984
Mennie N, King SK, Marulaiah M, Ferguson P, Heloury Y, Kimber C
J Pediatr Urol 2017 Apr;13(2):158-163. Epub 2017 Feb 10 doi: 10.1016/j.jpurol.2016.12.028. PMID: 28238607
Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

Therapy

Lakis NS, Lombardo KA, Mangray S, Netto GJ, Salles D, Matoso A
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):203-209. doi: 10.1097/PAI.0000000000000567. PMID: 29084059
Gressel GM, Buza N, Pal L
Eur J Gynaecol Oncol 2017;38(2):214-220. PMID: 29953783
Naouar S, Braiek S, El Kamel R
Presse Med 2017 Jun;46(6 Pt 1):572-578. Epub 2017 May 23 doi: 10.1016/j.lpm.2017.05.006. PMID: 28549629
Narula HS, Carlson HE
Nat Rev Endocrinol 2014 Nov;10(11):684-98. Epub 2014 Aug 12 doi: 10.1038/nrendo.2014.139. PMID: 25112235
Cook JC, Klinefelter GR, Hardisty JF, Sharpe RM, Foster PM
Crit Rev Toxicol 1999 Mar;29(2):169-261. doi: 10.1080/10408449991349203. PMID: 10213111

Prognosis

Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Mennie N, King SK, Marulaiah M, Ferguson P, Heloury Y, Kimber C
J Pediatr Urol 2017 Apr;13(2):158-163. Epub 2017 Feb 10 doi: 10.1016/j.jpurol.2016.12.028. PMID: 28238607

Clinical prediction guides

Planinić A, Marić T, Bojanac AK, Ježek D
Andrology 2022 Sep;10(6):1107-1120. Epub 2022 Jun 15 doi: 10.1111/andr.13201. PMID: 35661438
Chen J, Liu Y, Zhang Y, Wang Y, Chen X, Wang Z
Sci Prog 2021 Apr-Jun;104(2):368504211009668. doi: 10.1177/00368504211009668. PMID: 33848213Free PMC Article
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Guillerman RP, Foulkes WD, Priest JR
Pediatr Radiol 2019 Oct;49(11):1488-1505. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04429-x. PMID: 31620849
Kennedy GL Jr, Butenhoff JL, Olsen GW, O'Connor JC, Seacat AM, Perkins RG, Biegel LB, Murphy SR, Farrar DG
Crit Rev Toxicol 2004 Jul-Aug;34(4):351-84. doi: 10.1080/10408440490464705. PMID: 15328768

Recent systematic reviews

Nef J, Huber DE
Eur J Obstet Gynecol Reprod Biol 2021 Aug;263:261-274. Epub 2021 Jun 28 doi: 10.1016/j.ejogrb.2021.06.036. PMID: 34245994
Miao X, Li Y, Zhou T, Lv M
Asian J Surg 2021 Dec;44(12):1503-1509. Epub 2021 Apr 21 doi: 10.1016/j.asjsur.2021.03.016. PMID: 33893031
Cai S, Zhao W, Nie X, Abbas A, Fu L, Bihi S, Feng G, Liu T, Lv Y, Ma X, Peng X
J Pediatr Hematol Oncol 2017 Jul;39(5):355-361. doi: 10.1097/MPH.0000000000000715. PMID: 27906793
Bozzini G, Ratti D, Carmignani L; en representación de Young Academic Urologists (YAU) Men's Health Group
Actas Urol Esp 2017 Apr;41(3):146-154. Epub 2016 Nov 25 doi: 10.1016/j.acuro.2016.04.014. PMID: 27890492
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718

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