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Distal Esophagus Adenocarcinoma

MedGen UID:
1650160
•Concept ID:
C4726620
•
Neoplastic Process
Synonym: Adenocarcinoma of the Lower Third of the Esophagus

Definition

An adenocarcinoma arising from the lower third of the esophagus. The vast majority of esophageal adenocarcinomas involve the lower third of the esophagus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDistal Esophagus Adenocarcinoma

Professional guidelines

PubMed

Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Surgical management of esophagogastric junction tumors.
von Rahden BH, Stein HJ, Siewert JR
World J Gastroenterol 2006 Nov 7;12(41):6608-13. doi: 10.3748/wjg.v12.i41.6608. PMID: 17075972Free PMC Article

Recent clinical studies

Etiology

Barrett's Esophagus Risk Factors in Patients Without Gastroesophageal Reflux: A Large Population-Based Study.
Saha B, Verma A, Dierkhising R, Canning R, Kisiel JB, Iyer PG
Clin Gastroenterol Hepatol 2024 Oct;22(10):2150-2152.e2. Epub 2024 Apr 24 doi: 10.1016/j.cgh.2024.03.034. PMID: 38670476Free PMC Article
Epidemiology and prevention of oesophageal adenocarcinoma.
Ness-Jensen E
Scand J Gastroenterol 2022 Aug;57(8):891-895. Epub 2022 Mar 2 doi: 10.1080/00365521.2022.2042594. PMID: 35234549
The metaplastic mosaic of Barrett's oesophagus.
Biswas S, Quante M, Leedham S, Jansen M
Virchows Arch 2018 Jan;472(1):43-54. Epub 2018 Mar 3 doi: 10.1007/s00428-018-2317-1. PMID: 29500519Free PMC Article
Esophageal cancer: diagnosis and management.
Lin SH, Chang JY
Chin J Cancer 2010 Oct;29(10):843-54. doi: 10.5732/cjc.010.10151. PMID: 20868553
Advanced esophageal carcinoma.
Lerut TE, de Leyn P, Coosemans W, Van Raemdonck D, Cuypers P, Van Cleynenbreughel B
World J Surg 1994 May-Jun;18(3):379-87. doi: 10.1007/BF00316818. PMID: 8091779

Diagnosis

Barrett's Esophagus Risk Factors in Patients Without Gastroesophageal Reflux: A Large Population-Based Study.
Saha B, Verma A, Dierkhising R, Canning R, Kisiel JB, Iyer PG
Clin Gastroenterol Hepatol 2024 Oct;22(10):2150-2152.e2. Epub 2024 Apr 24 doi: 10.1016/j.cgh.2024.03.034. PMID: 38670476Free PMC Article
Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
The metaplastic mosaic of Barrett's oesophagus.
Biswas S, Quante M, Leedham S, Jansen M
Virchows Arch 2018 Jan;472(1):43-54. Epub 2018 Mar 3 doi: 10.1007/s00428-018-2317-1. PMID: 29500519Free PMC Article
Esophageal cancer: diagnosis and management.
Lin SH, Chang JY
Chin J Cancer 2010 Oct;29(10):843-54. doi: 10.5732/cjc.010.10151. PMID: 20868553
Confocal laser endomicroscopy.
Kiesslich R, Goetz M, Vieth M, Galle PR, Neurath MF
Gastrointest Endosc Clin N Am 2005 Oct;15(4):715-31. doi: 10.1016/j.giec.2005.08.010. PMID: 16278135

Therapy

Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
Claudin-18.
Wong MT, Singhi AD, Larson BK, Huynh CAT, Balzer BL, Burch M, Dhall D, Gangi A, Gong J, Guindi M, Hendifar AE, Kim SA, de Peralta-Venturina M, Waters KM
Arch Pathol Lab Med 2022 May 1;147(5):559-567. doi: 10.5858/arpa.2021-0428-OA. PMID: 35976638
Epidemiology and prevention of oesophageal adenocarcinoma.
Ness-Jensen E
Scand J Gastroenterol 2022 Aug;57(8):891-895. Epub 2022 Mar 2 doi: 10.1080/00365521.2022.2042594. PMID: 35234549
Radiotherapy for Esophageal Adenocarcinoma.
Kwong DLW, Lam KO
Methods Mol Biol 2018;1756:7-17. doi: 10.1007/978-1-4939-7734-5_2. PMID: 29600356
Chemoprevention in Barrett's oesophagus.
Gordon V, Jankowski J
Best Pract Res Clin Gastroenterol 2011 Aug;25(4-5):569-79. doi: 10.1016/j.bpg.2011.10.010. PMID: 22122772

Prognosis

Update on Gastroesophageal Adenocarcinoma Targeted Therapies.
Maron SB, Catenacci DVT
Hematol Oncol Clin North Am 2017 Jun;31(3):511-527. doi: 10.1016/j.hoc.2017.01.009. PMID: 28501091Free PMC Article
Novel Targeted Therapies for Esophagogastric Cancer.
Maron SB, Catenacci DV
Surg Oncol Clin N Am 2017 Apr;26(2):293-312. doi: 10.1016/j.soc.2016.10.002. PMID: 28279470Free PMC Article
Barrett's esophagus: Clinical issues.
Spechler SJ
Gastrointest Endosc Clin N Am 2011 Jan;21(1):1-7. doi: 10.1016/j.giec.2010.09.012. PMID: 21112493Free PMC Article
Pattern of lymphatic spread of Barrett's cancer.
Feith M, Stein HJ, Siewert JR
World J Surg 2003 Sep;27(9):1052-7. Epub 2003 Aug 18 doi: 10.1007/s00268-003-7060-2. PMID: 12917758
Advanced esophageal carcinoma.
Lerut TE, de Leyn P, Coosemans W, Van Raemdonck D, Cuypers P, Van Cleynenbreughel B
World J Surg 1994 May-Jun;18(3):379-87. doi: 10.1007/BF00316818. PMID: 8091779

Clinical prediction guides

AGA Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett's Esophagus: Expert Review.
Muthusamy VR, Wani S, Gyawali CP, Komanduri S; CGIT Barrett’s Esophagus Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 Dec;20(12):2696-2706.e1. Epub 2022 Jul 3 doi: 10.1016/j.cgh.2022.06.003. PMID: 35788412Free PMC Article
The molecular changes driving the carcinogenesis in Barrett's esophagus: which came first, the chicken or the egg?
Russo A, Bronte G, Cabibi D, Bazan V, Cicero G, Bertani A, Rizzo S, Fiorentino E
Crit Rev Oncol Hematol 2013 Jun;86(3):278-89. Epub 2013 Jan 4 doi: 10.1016/j.critrevonc.2012.12.001. PMID: 23290822
Stomach cancer.
Bailey C
BMJ Clin Evid 2011 Mar 28;2011 PMID: 21439098Free PMC Article
Stomach cancer.
Bailey C
BMJ Clin Evid 2008 Sep 3;2008 PMID: 19445803Free PMC Article
Pattern of lymphatic spread of Barrett's cancer.
Feith M, Stein HJ, Siewert JR
World J Surg 2003 Sep;27(9):1052-7. Epub 2003 Aug 18 doi: 10.1007/s00268-003-7060-2. PMID: 12917758

Recent systematic reviews

Preferred neoadjuvant therapy for gastric and gastroesophageal junction adenocarcinoma: a systematic review and network meta-analysis.
Grizzi G, Petrelli F, Di Bartolomeo M, Viti M, Texeira Moraes M, Luciani A, Passalacqua R, Ghidini M, Tomasello G, Baiocchi GL, Celotti A
Gastric Cancer 2022 Sep;25(5):982-987. Epub 2022 Jun 15 doi: 10.1007/s10120-022-01314-9. PMID: 35704113
Longitudinal and circumferential resection margin in adenocarcinoma of distal esophagus and cardia.
Migliore M, Rassl D, Criscione A
Future Oncol 2014 Apr;10(5):891-901. doi: 10.2217/fon.13.241. PMID: 24799068
Obesity, metabolic syndrome and esophageal adenocarcinoma: epidemiology, etiology and new targets.
Ryan AM, Duong M, Healy L, Ryan SA, Parekh N, Reynolds JV, Power DG
Cancer Epidemiol 2011 Aug;35(4):309-19. Epub 2011 Apr 5 doi: 10.1016/j.canep.2011.03.001. PMID: 21470937
Stomach cancer.
Bailey C
BMJ Clin Evid 2011 Mar 28;2011 PMID: 21439098Free PMC Article
Stomach cancer.
Bailey C
BMJ Clin Evid 2008 Sep 3;2008 PMID: 19445803Free PMC Article

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