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Metastatic Bone Sarcoma

MedGen UID:
1656313
•Concept ID:
C4727007
•
Neoplastic Process

Definition

Bone sarcoma that has spread from the original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Longer duration of symptoms at the time of presentation is not associated with worse survival in primary bone sarcoma.
Lawrenz JM, Styron JF, Parry M, Grimer RJ, Mesko NW
Bone Joint J 2018 May 1;100-B(5):652-661. doi: 10.1302/0301-620X.100B5.BJJ-2017-1235.R1. PMID: 29701086

Recent clinical studies

Etiology

Does Primary Tumor Resection in Patients with Metastatic Primary Mobile Vertebral Column Sarcoma Improve Survival?
Matsuoka M, Onodera T, Yokota I, Iwasaki K, Hishimura R, Suzuki Y, Iwata A, Kondo E, Iwasaki N
World Neurosurg 2022 Jul;163:e647-e654. Epub 2022 Apr 18 doi: 10.1016/j.wneu.2022.04.047. PMID: 35439623
Efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma: A retrospective multiple institution study.
Liu Z, Gao S, Zhu L, Wang J, Zhang P, Li P, Zhang F, Yao W
Cancer Med 2021 Nov;10(21):7593-7600. Epub 2021 Sep 26 doi: 10.1002/cam4.4286. PMID: 34564939Free PMC Article
Longer duration of symptoms at the time of presentation is not associated with worse survival in primary bone sarcoma.
Lawrenz JM, Styron JF, Parry M, Grimer RJ, Mesko NW
Bone Joint J 2018 May 1;100-B(5):652-661. doi: 10.1302/0301-620X.100B5.BJJ-2017-1235.R1. PMID: 29701086
Animal models of osteosarcoma.
Fan TM
Expert Rev Anticancer Ther 2010 Aug;10(8):1327-38. doi: 10.1586/era.10.107. PMID: 20735317
Induction chemotherapy for bone sarcoma in adults: correlation of results with erbB-4 expression.
Merimsky O, Kollender Y, Issakov J, Inbar M, Flusser G, Benayahu D, Meller I, Bickels J
Oncol Rep 2003 Sep-Oct;10(5):1593-9. PMID: 12883746

Diagnosis

Longer duration of symptoms at the time of presentation is not associated with worse survival in primary bone sarcoma.
Lawrenz JM, Styron JF, Parry M, Grimer RJ, Mesko NW
Bone Joint J 2018 May 1;100-B(5):652-661. doi: 10.1302/0301-620X.100B5.BJJ-2017-1235.R1. PMID: 29701086
Animal models of osteosarcoma.
Fan TM
Expert Rev Anticancer Ther 2010 Aug;10(8):1327-38. doi: 10.1586/era.10.107. PMID: 20735317
Murine and canine models of appendicular osteosarcoma.
Fan TM
Curr Protoc Pharmacol 2007 Jun;Chapter 14:Unit 14.1. doi: 10.1002/0471141755.ph1401s37. PMID: 21948160

Therapy

Efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma: A retrospective multiple institution study.
Liu Z, Gao S, Zhu L, Wang J, Zhang P, Li P, Zhang F, Yao W
Cancer Med 2021 Nov;10(21):7593-7600. Epub 2021 Sep 26 doi: 10.1002/cam4.4286. PMID: 34564939Free PMC Article
Isolated limb perfusion with tumour necrosis factor-alpha and melphalan for unresectable bone sarcomas of the lower extremity.
Bickels J, Manusama ER, Gutman M, Eggermont AM, Kollender Y, Abu-Abid S, Van Geel AN, Lev-Shlush D, Klausner JM, Meller I
Eur J Surg Oncol 1999 Oct;25(5):509-14. doi: 10.1053/ejso.1999.0687. PMID: 10527599
Hyperthermic isolated limb perfusion with cisplatin in four patients with sarcomas of soft tissue and bone.
van Ginkel RJ, Schraffordt Koops H, de Vries EG, Molenaar WM, Uges DR, Hoekstra HJ
Eur J Surg Oncol 1996 Oct;22(5):528-31. doi: 10.1016/s0748-7983(96)93114-5. PMID: 8903498

Prognosis

Longer duration of symptoms at the time of presentation is not associated with worse survival in primary bone sarcoma.
Lawrenz JM, Styron JF, Parry M, Grimer RJ, Mesko NW
Bone Joint J 2018 May 1;100-B(5):652-661. doi: 10.1302/0301-620X.100B5.BJJ-2017-1235.R1. PMID: 29701086
Induction chemotherapy for bone sarcoma in adults: correlation of results with erbB-4 expression.
Merimsky O, Kollender Y, Issakov J, Inbar M, Flusser G, Benayahu D, Meller I, Bickels J
Oncol Rep 2003 Sep-Oct;10(5):1593-9. PMID: 12883746

Clinical prediction guides

Does Primary Tumor Resection in Patients with Metastatic Primary Mobile Vertebral Column Sarcoma Improve Survival?
Matsuoka M, Onodera T, Yokota I, Iwasaki K, Hishimura R, Suzuki Y, Iwata A, Kondo E, Iwasaki N
World Neurosurg 2022 Jul;163:e647-e654. Epub 2022 Apr 18 doi: 10.1016/j.wneu.2022.04.047. PMID: 35439623
Longer duration of symptoms at the time of presentation is not associated with worse survival in primary bone sarcoma.
Lawrenz JM, Styron JF, Parry M, Grimer RJ, Mesko NW
Bone Joint J 2018 May 1;100-B(5):652-661. doi: 10.1302/0301-620X.100B5.BJJ-2017-1235.R1. PMID: 29701086
Hyperthermic isolated limb perfusion with cisplatin in four patients with sarcomas of soft tissue and bone.
van Ginkel RJ, Schraffordt Koops H, de Vries EG, Molenaar WM, Uges DR, Hoekstra HJ
Eur J Surg Oncol 1996 Oct;22(5):528-31. doi: 10.1016/s0748-7983(96)93114-5. PMID: 8903498

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