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Recurrent Acute Myeloid Leukemia

MedGen UID:
1661148
•Concept ID:
C1142169
•
Neoplastic Process

Definition

The reemergence of acute myeloid leukemia after a period of remission. [from NCI]

Professional guidelines

PubMed

Successful Management of Decitabine prior to Full-Dose Idarubicin and Cytarabine in the Treatment of Refractory/Recurrent Acute Myeloid Leukemia.
Zhao H, Xu L, Yang Y, Shao J, Chen P, Dong X, Gu L, Li D
Acta Haematol 2017;137(4):195-200. Epub 2017 Apr 27 doi: 10.1159/000464013. PMID: 28445872

Recent clinical studies

Etiology

Successful Management of Decitabine prior to Full-Dose Idarubicin and Cytarabine in the Treatment of Refractory/Recurrent Acute Myeloid Leukemia.
Zhao H, Xu L, Yang Y, Shao J, Chen P, Dong X, Gu L, Li D
Acta Haematol 2017;137(4):195-200. Epub 2017 Apr 27 doi: 10.1159/000464013. PMID: 28445872
AAML0523: a report from the Children's Oncology Group on the efficacy of clofarabine in combination with cytarabine in pediatric patients with recurrent acute myeloid leukemia.
Cooper TM, Alonzo TA, Gerbing RB, Perentesis JP, Whitlock JA, Taub JW, Horton TM, Gamis AS, Meshinchi S, Loken MR, Razzouk BI
Cancer 2014 Aug 15;120(16):2482-9. Epub 2014 Apr 25 doi: 10.1002/cncr.28674. PMID: 24771494Free PMC Article
Analysis of drug resistance-associated proteins expressions of patients with the recurrent of acute leukemia via protein microarray technology.
Zeng DF, Zhang J, Zhu LD, Kong PY, Li JP, Zhang X, Xu W, Wang JL, Pen XG, Wang P, Liu SH
Eur Rev Med Pharmacol Sci 2014;18(4):537-43. PMID: 24615181
ABO-incompatible living-donor lobar lung transplantation.
Shoji T, Bando T, Fujinaga T, Chen F, Yurugi K, Maekawa T, Date H
J Heart Lung Transplant 2011 Apr;30(4):479-80. Epub 2010 Dec 18 doi: 10.1016/j.healun.2010.10.015. PMID: 21168345
Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders.
Cortes J, Giles F, O'Brien S, Thomas D, Albitar M, Rios MB, Talpaz M, Garcia-Manero G, Faderl S, Letvak L, Salvado A, Kantarjian H
Cancer 2003 Jun 1;97(11):2760-6. doi: 10.1002/cncr.11416. PMID: 12767088

Diagnosis

Analysis of drug resistance-associated proteins expressions of patients with the recurrent of acute leukemia via protein microarray technology.
Zeng DF, Zhang J, Zhu LD, Kong PY, Li JP, Zhang X, Xu W, Wang JL, Pen XG, Wang P, Liu SH
Eur Rev Med Pharmacol Sci 2014;18(4):537-43. PMID: 24615181
Teaching NeuroImages: sacral spine chloroma.
Chamberlain MC, Tredway TL, Born D, Fink J
Neurology 2013 Sep 10;81(11):e87. doi: 10.1212/WNL.0b013e3182a43aed. PMID: 24019392Free PMC Article
Posterior reversible encephalopathy syndrome due to immunosuppressant after living-donor lobar lung transplantation: report of a case.
Shoji T, Bando T, Fujinaga T, Chen F, Kohno M, Yabe M, Yabe H, Date H
Gen Thorac Cardiovasc Surg 2012 Aug;60(8):514-7. Epub 2012 Apr 28 doi: 10.1007/s11748-012-0030-6. PMID: 22544427
Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia.
Staber PB, Linkesch W, Zauner D, Beham-Schmid C, Guelly C, Schauer S, Sill H, Hoefler G
Oncogene 2004 Jan 29;23(4):894-904. doi: 10.1038/sj.onc.1207192. PMID: 14749762
Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation.
Hussey DJ, Moore S, Nicola M, Dobrovic A
BMC Genet 2001;2:20. Epub 2001 Nov 23 doi: 10.1186/1471-2156-2-20. PMID: 11737860Free PMC Article

Therapy

Successful Management of Decitabine prior to Full-Dose Idarubicin and Cytarabine in the Treatment of Refractory/Recurrent Acute Myeloid Leukemia.
Zhao H, Xu L, Yang Y, Shao J, Chen P, Dong X, Gu L, Li D
Acta Haematol 2017;137(4):195-200. Epub 2017 Apr 27 doi: 10.1159/000464013. PMID: 28445872
AAML0523: a report from the Children's Oncology Group on the efficacy of clofarabine in combination with cytarabine in pediatric patients with recurrent acute myeloid leukemia.
Cooper TM, Alonzo TA, Gerbing RB, Perentesis JP, Whitlock JA, Taub JW, Horton TM, Gamis AS, Meshinchi S, Loken MR, Razzouk BI
Cancer 2014 Aug 15;120(16):2482-9. Epub 2014 Apr 25 doi: 10.1002/cncr.28674. PMID: 24771494Free PMC Article
Analysis of drug resistance-associated proteins expressions of patients with the recurrent of acute leukemia via protein microarray technology.
Zeng DF, Zhang J, Zhu LD, Kong PY, Li JP, Zhang X, Xu W, Wang JL, Pen XG, Wang P, Liu SH
Eur Rev Med Pharmacol Sci 2014;18(4):537-43. PMID: 24615181
Posterior reversible encephalopathy syndrome due to immunosuppressant after living-donor lobar lung transplantation: report of a case.
Shoji T, Bando T, Fujinaga T, Chen F, Kohno M, Yabe M, Yabe H, Date H
Gen Thorac Cardiovasc Surg 2012 Aug;60(8):514-7. Epub 2012 Apr 28 doi: 10.1007/s11748-012-0030-6. PMID: 22544427
Successful treatment with pulse cyclophosphamide of a steroid-refractory hepatitic variant of liver acute graft-vs.-host disease in a child.
Kawahara Y, Morimoto A, Masuzawa A, Ikeda T, Hayase T, Kashii Y, Nozaki Y, Kanai N, Momoi MY
Pediatr Transplant 2012 Nov;16(7):E315-9. Epub 2012 Feb 26 doi: 10.1111/j.1399-3046.2012.01664.x. PMID: 22364121

Prognosis

A randomized trial of three novel regimens for recurrent acute myeloid leukemia demonstrates the continuing challenge of treating this difficult disease.
Litzow MR, Wang XV, Carroll MP, Karp JE, Ketterling RP, Zhang Y, Kaufmann SH, Lazarus HM, Luger SM, Paietta EM, Pratz KW, Tun HW, Altman JK, Broun ER, Rybka WB, Rowe JM, Tallman MS
Am J Hematol 2019 Jan;94(1):111-117. Epub 2018 Nov 15 doi: 10.1002/ajh.25333. PMID: 30370956Free PMC Article
Analysis of drug resistance-associated proteins expressions of patients with the recurrent of acute leukemia via protein microarray technology.
Zeng DF, Zhang J, Zhu LD, Kong PY, Li JP, Zhang X, Xu W, Wang JL, Pen XG, Wang P, Liu SH
Eur Rev Med Pharmacol Sci 2014;18(4):537-43. PMID: 24615181
Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia.
Staber PB, Linkesch W, Zauner D, Beham-Schmid C, Guelly C, Schauer S, Sill H, Hoefler G
Oncogene 2004 Jan 29;23(4):894-904. doi: 10.1038/sj.onc.1207192. PMID: 14749762
Survival after second hematopoietic stem cell transplantation for recurrent pediatric acute myeloid leukemia.
Meshinchi S, Leisenring WM, Carpenter PA, Woolfrey AE, Sievers EL, Radich JP, Sanders JE
Biol Blood Marrow Transplant 2003 Nov;9(11):706-13. doi: 10.1016/j.bbmt.2003.08.003. PMID: 14652854
Combination chemotherapy utilizing continuous infusion of intermediate-dose cytarabine for refractory or recurrent acute myeloid leukemia.
Bahng H, Lee JH, Ahn JH, Lee JH, Lee JS, Kim SH, Kim WK, Lee KH
Leuk Res 2001 Mar;25(3):213-6. doi: 10.1016/s0145-2126(00)00135-1. PMID: 11226516

Clinical prediction guides

AAML0523: a report from the Children's Oncology Group on the efficacy of clofarabine in combination with cytarabine in pediatric patients with recurrent acute myeloid leukemia.
Cooper TM, Alonzo TA, Gerbing RB, Perentesis JP, Whitlock JA, Taub JW, Horton TM, Gamis AS, Meshinchi S, Loken MR, Razzouk BI
Cancer 2014 Aug 15;120(16):2482-9. Epub 2014 Apr 25 doi: 10.1002/cncr.28674. PMID: 24771494Free PMC Article
Analysis of drug resistance-associated proteins expressions of patients with the recurrent of acute leukemia via protein microarray technology.
Zeng DF, Zhang J, Zhu LD, Kong PY, Li JP, Zhang X, Xu W, Wang JL, Pen XG, Wang P, Liu SH
Eur Rev Med Pharmacol Sci 2014;18(4):537-43. PMID: 24615181
Successful treatment with pulse cyclophosphamide of a steroid-refractory hepatitic variant of liver acute graft-vs.-host disease in a child.
Kawahara Y, Morimoto A, Masuzawa A, Ikeda T, Hayase T, Kashii Y, Nozaki Y, Kanai N, Momoi MY
Pediatr Transplant 2012 Nov;16(7):E315-9. Epub 2012 Feb 26 doi: 10.1111/j.1399-3046.2012.01664.x. PMID: 22364121
Survival after second hematopoietic stem cell transplantation for recurrent pediatric acute myeloid leukemia.
Meshinchi S, Leisenring WM, Carpenter PA, Woolfrey AE, Sievers EL, Radich JP, Sanders JE
Biol Blood Marrow Transplant 2003 Nov;9(11):706-13. doi: 10.1016/j.bbmt.2003.08.003. PMID: 14652854
Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders.
Cortes J, Giles F, O'Brien S, Thomas D, Albitar M, Rios MB, Talpaz M, Garcia-Manero G, Faderl S, Letvak L, Salvado A, Kantarjian H
Cancer 2003 Jun 1;97(11):2760-6. doi: 10.1002/cncr.11416. PMID: 12767088

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