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Recurrent Endometrial Mixed Cell Adenocarcinoma

MedGen UID:
1663352
•Concept ID:
C4744400
•
Neoplastic Process
Synonym: Recurrent Endometrial Mixed Epithelial Carcinoma

Definition

The reemergence of endometrial mixed cell adenocarcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Endometrial Mixed Cell Adenocarcinoma

Professional guidelines

PubMed

The role of adjuvant treatment for early-stage uterine clear cell carcinomas.
Orellana TJ, Garrett AA, Soong TR, Rives T, Courtney-Brooks M, Taylor SE, Lesnock J, Berger J, Boisen M, Coffman L, Buckanovich R, Mahdi H, Comerci JC, Beriwal S, Sukumvanich P, Edwards RP, Bhargava R, Olawaiye AB
Gynecol Oncol 2023 Mar;170:77-83. Epub 2023 Jan 13 doi: 10.1016/j.ygyno.2022.12.024. PMID: 36641903
Clinicopathologic features and treatment in patients with early stage uterine clear cell carcinoma: A 16-year experience.
Armbruster SD, Previs R, Soliman PT, Westin SN, Fellman B, Jhingran A, Fleming ND
Gynecol Oncol 2019 Aug;154(2):328-332. Epub 2019 Jun 18 doi: 10.1016/j.ygyno.2019.06.001. PMID: 31221496Free PMC Article
The role of vaginal brachytherapy in the treatment of surgical stage I papillary serous or clear cell endometrial cancer.
Barney BM, Petersen IA, Mariani A, Dowdy SC, Bakkum-Gamez JN, Haddock MG
Int J Radiat Oncol Biol Phys 2013 Jan 1;85(1):109-15. Epub 2012 Apr 28 doi: 10.1016/j.ijrobp.2012.03.011. PMID: 22543202

Recent clinical studies

Etiology

Clinical Characteristics and Outcomes of a High-grade Endometrial Cancer Cohort Treated at Instituto Nacional de Câncer, Brazil.
Paulino E, Melo AC
Rev Bras Ginecol Obstet 2023 Jul;45(7):e401-e408. Epub 2023 Aug 18 doi: 10.1055/s-0043-1772177. PMID: 37595597Free PMC Article
Survival outcomes and the prognostic significance of clinicopathological features in patients with endometrial clear cell carcinoma: a 35-year single-center retrospective study.
Ma X, Cao D, Zhou H, Wang T, Wang J, Zhang Y, Yu M, Cheng N, Peng P, Yang J, Huang H, Shen K
World J Surg Oncol 2023 Mar 27;21(1):106. doi: 10.1186/s12957-023-02992-0. PMID: 36973753Free PMC Article
The role of adjuvant treatment for early-stage uterine clear cell carcinomas.
Orellana TJ, Garrett AA, Soong TR, Rives T, Courtney-Brooks M, Taylor SE, Lesnock J, Berger J, Boisen M, Coffman L, Buckanovich R, Mahdi H, Comerci JC, Beriwal S, Sukumvanich P, Edwards RP, Bhargava R, Olawaiye AB
Gynecol Oncol 2023 Mar;170:77-83. Epub 2023 Jan 13 doi: 10.1016/j.ygyno.2022.12.024. PMID: 36641903
How do different histologic components of mixed endometrial carcinomas affect prognosis? Does it really matter?
Thomakos N, Dimopoulou S, Sotiropoulou M, Machairiotis N, Pandraklakis A, Haidopoulos D, Liontos M, Bamias A, Rodolakis A
Horm Mol Biol Clin Investig 2020 Dec 18;42(1):105-111. doi: 10.1515/hmbci-2020-0042. PMID: 33781006
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038

Diagnosis

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Clinicopathological analysis of mixed endometrial carcinomas: clinical relevance of different neoplastic components.
Rossi ED, Bizzarro T, Monterossi G, Inzani F, Fanfani F, Scambia G, Zannoni GF
Hum Pathol 2017 Apr;62:99-107. Epub 2016 Dec 30 doi: 10.1016/j.humpath.2016.12.015. PMID: 28041971
Comparison of pure and mixed-type clear cell carcinoma of the ovary: a clinicopathological analysis of 341 Chinese patients.
Ye S, You Y, Yang J, Cao D, Bai H, Huang H, Wu M, Chen J, Lang J, Shen K
Int J Gynecol Cancer 2014 Nov;24(9):1590-6. doi: 10.1097/IGC.0000000000000275. PMID: 25254564
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038
Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma.
Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA
Am J Surg Pathol 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a. PMID: 23154767

Therapy

Quality-of-Life Outcomes and Toxic Effects Among Patients With Cancers of the Uterus Treated With Stereotactic Pelvic Adjuvant Radiation Therapy: The SPARTACUS Phase 1/2 Nonrandomized Controlled Trial.
Leung E, Gladwish AP, Davidson M, Taggar A, Velker V, Barnes E, Mendez L, Donovan E, Gien LT, Covens A, Vicus D, Kupets R, MacKay H, Han K, Cheung P, Zhang L, Loblaw A, D'Souza DP
JAMA Oncol 2022 Jun 1;8(6):1-9. doi: 10.1001/jamaoncol.2022.0362. PMID: 35420695Free PMC Article
Carboplatin and nonpegylated liposomal doxorubicin in primary advanced or recurrent endometrial cancer: a phase 2 trial conducted by AGO Austria.
Volgger B, Zeimet AG, Reinthaller A, Petru E, Schauer C, Klein M, Sevelda-Schwarzgruber U, Bogner G, Wolfram G, Marth C
Int J Gynecol Cancer 2015 Feb;25(2):257-62. doi: 10.1097/IGC.0000000000000352. PMID: 25611899
Gemcitabine for advanced endometrial cancer: a retrospective study of the Memorial sloan-Kettering Cancer Center experience.
Grisham RN, Adaniel C, Hyman DM, Ma W, Iasonos A, Aghajanian C, Konner J
Int J Gynecol Cancer 2012 Jun;22(5):807-11. doi: 10.1097/IGC.0b013e31824a33a2. PMID: 22635030Free PMC Article
Outcome and patterns of failure in pathologic stages I-IV clear-cell carcinoma of the endometrium: implications for adjuvant radiation therapy.
Murphy KT, Rotmensch J, Yamada SD, Mundt AJ
Int J Radiat Oncol Biol Phys 2003 Apr 1;55(5):1272-6. doi: 10.1016/s0360-3016(02)04404-8. PMID: 12654437
Gynecologic tumors in tamoxifen-treated women with breast cancer.
Seoud MA, Johnson J, Weed JC Jr
Obstet Gynecol 1993 Aug;82(2):165-9. PMID: 8393156

Prognosis

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Survival outcomes and the prognostic significance of clinicopathological features in patients with endometrial clear cell carcinoma: a 35-year single-center retrospective study.
Ma X, Cao D, Zhou H, Wang T, Wang J, Zhang Y, Yu M, Cheng N, Peng P, Yang J, Huang H, Shen K
World J Surg Oncol 2023 Mar 27;21(1):106. doi: 10.1186/s12957-023-02992-0. PMID: 36973753Free PMC Article
How do different histologic components of mixed endometrial carcinomas affect prognosis? Does it really matter?
Thomakos N, Dimopoulou S, Sotiropoulou M, Machairiotis N, Pandraklakis A, Haidopoulos D, Liontos M, Bamias A, Rodolakis A
Horm Mol Biol Clin Investig 2020 Dec 18;42(1):105-111. doi: 10.1515/hmbci-2020-0042. PMID: 33781006
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038
Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma.
Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA
Am J Surg Pathol 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a. PMID: 23154767

Clinical prediction guides

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Survival outcomes and the prognostic significance of clinicopathological features in patients with endometrial clear cell carcinoma: a 35-year single-center retrospective study.
Ma X, Cao D, Zhou H, Wang T, Wang J, Zhang Y, Yu M, Cheng N, Peng P, Yang J, Huang H, Shen K
World J Surg Oncol 2023 Mar 27;21(1):106. doi: 10.1186/s12957-023-02992-0. PMID: 36973753Free PMC Article
Clinicopathological analysis of mixed endometrial carcinomas: clinical relevance of different neoplastic components.
Rossi ED, Bizzarro T, Monterossi G, Inzani F, Fanfani F, Scambia G, Zannoni GF
Hum Pathol 2017 Apr;62:99-107. Epub 2016 Dec 30 doi: 10.1016/j.humpath.2016.12.015. PMID: 28041971
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038
Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma.
Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA
Am J Surg Pathol 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a. PMID: 23154767

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