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Recurrent Endometrial Mixed Cell Adenocarcinoma

MedGen UID:
1663352
•Concept ID:
C4744400
•
Neoplastic Process
Synonym: Recurrent Endometrial Mixed Epithelial Carcinoma

Definition

The reemergence of endometrial mixed cell adenocarcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Endometrial Mixed Cell Adenocarcinoma

Professional guidelines

PubMed

Clinicopathologic features and treatment in patients with early stage uterine clear cell carcinoma: A 16-year experience.
Armbruster SD, Previs R, Soliman PT, Westin SN, Fellman B, Jhingran A, Fleming ND
Gynecol Oncol 2019 Aug;154(2):328-332. Epub 2019 Jun 18 doi: 10.1016/j.ygyno.2019.06.001. PMID: 31221496Free PMC Article
The role of vaginal brachytherapy in the treatment of surgical stage I papillary serous or clear cell endometrial cancer.
Barney BM, Petersen IA, Mariani A, Dowdy SC, Bakkum-Gamez JN, Haddock MG
Int J Radiat Oncol Biol Phys 2013 Jan 1;85(1):109-15. Epub 2012 Apr 28 doi: 10.1016/j.ijrobp.2012.03.011. PMID: 22543202
Management of aggressive histologic variants of endometrial carcinoma at the Tom Baker Cancer Centre between 1984 and 1994.
Craighead PS, Sait K, Stuart GC, Arthur K, Nation J, Duggan M, Guo D
Gynecol Oncol 2000 May;77(2):248-53. doi: 10.1006/gyno.2000.5746. PMID: 10785473

Recent clinical studies

Etiology

How do different histologic components of mixed endometrial carcinomas affect prognosis? Does it really matter?
Thomakos N, Dimopoulou S, Sotiropoulou M, Machairiotis N, Pandraklakis A, Haidopoulos D, Liontos M, Bamias A, Rodolakis A
Horm Mol Biol Clin Investig 2020 Dec 18;42(1):105-111. doi: 10.1515/hmbci-2020-0042. PMID: 33781006
Early-stage Uterine Pure and Mixed Clear Cell Carcinoma: Outcomes and Recurrence With and Without Adjuvant Therapy.
Chang-Halpenny CN, Natarajan S, Hwang-Graziano JM
Am J Clin Oncol 2018 Apr;41(4):371-378. doi: 10.1097/COC.0000000000000277. PMID: 26950465
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038
Outcome and patterns of failure in pathologic stages I-IV clear-cell carcinoma of the endometrium: implications for adjuvant radiation therapy.
Murphy KT, Rotmensch J, Yamada SD, Mundt AJ
Int J Radiat Oncol Biol Phys 2003 Apr 1;55(5):1272-6. doi: 10.1016/s0360-3016(02)04404-8. PMID: 12654437
Malignant mullerian mixed tumors of the uterine cervix: a report of nine cases of a neoplasm with morphology often different from its counterpart in the corpus.
Clement PB, Zubovits JT, Young RH, Scully RE
Int J Gynecol Pathol 1998 Jul;17(3):211-22. PMID: 9656116

Diagnosis

Primary mixed large cell neuroendocrine and high grade serous carcinoma of the endometrium.
Hardy LE, Chaudry Z, Wan K, Ayres C
BMJ Case Rep 2020 Sep 2;13(9) doi: 10.1136/bcr-2020-234977. PMID: 32878852Free PMC Article
Comparison of pure and mixed-type clear cell carcinoma of the ovary: a clinicopathological analysis of 341 Chinese patients.
Ye S, You Y, Yang J, Cao D, Bai H, Huang H, Wu M, Chen J, Lang J, Shen K
Int J Gynecol Cancer 2014 Nov;24(9):1590-6. doi: 10.1097/IGC.0000000000000275. PMID: 25254564
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038
Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma.
Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA
Am J Surg Pathol 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a. PMID: 23154767
Malignant mullerian mixed tumors of the uterine cervix: a report of nine cases of a neoplasm with morphology often different from its counterpart in the corpus.
Clement PB, Zubovits JT, Young RH, Scully RE
Int J Gynecol Pathol 1998 Jul;17(3):211-22. PMID: 9656116

Therapy

Quality-of-Life Outcomes and Toxic Effects Among Patients With Cancers of the Uterus Treated With Stereotactic Pelvic Adjuvant Radiation Therapy: The SPARTACUS Phase 1/2 Nonrandomized Controlled Trial.
Leung E, Gladwish AP, Davidson M, Taggar A, Velker V, Barnes E, Mendez L, Donovan E, Gien LT, Covens A, Vicus D, Kupets R, MacKay H, Han K, Cheung P, Zhang L, Loblaw A, D'Souza DP
JAMA Oncol 2022 Jun 1;8(6):1-9. doi: 10.1001/jamaoncol.2022.0362. PMID: 35420695Free PMC Article
Carboplatin and nonpegylated liposomal doxorubicin in primary advanced or recurrent endometrial cancer: a phase 2 trial conducted by AGO Austria.
Volgger B, Zeimet AG, Reinthaller A, Petru E, Schauer C, Klein M, Sevelda-Schwarzgruber U, Bogner G, Wolfram G, Marth C
Int J Gynecol Cancer 2015 Feb;25(2):257-62. doi: 10.1097/IGC.0000000000000352. PMID: 25611899
Gemcitabine for advanced endometrial cancer: a retrospective study of the Memorial sloan-Kettering Cancer Center experience.
Grisham RN, Adaniel C, Hyman DM, Ma W, Iasonos A, Aghajanian C, Konner J
Int J Gynecol Cancer 2012 Jun;22(5):807-11. doi: 10.1097/IGC.0b013e31824a33a2. PMID: 22635030Free PMC Article
Outcome and patterns of failure in pathologic stages I-IV clear-cell carcinoma of the endometrium: implications for adjuvant radiation therapy.
Murphy KT, Rotmensch J, Yamada SD, Mundt AJ
Int J Radiat Oncol Biol Phys 2003 Apr 1;55(5):1272-6. doi: 10.1016/s0360-3016(02)04404-8. PMID: 12654437
Gynecologic tumors in tamoxifen-treated women with breast cancer.
Seoud MA, Johnson J, Weed JC Jr
Obstet Gynecol 1993 Aug;82(2):165-9. PMID: 8393156

Prognosis

How do different histologic components of mixed endometrial carcinomas affect prognosis? Does it really matter?
Thomakos N, Dimopoulou S, Sotiropoulou M, Machairiotis N, Pandraklakis A, Haidopoulos D, Liontos M, Bamias A, Rodolakis A
Horm Mol Biol Clin Investig 2020 Dec 18;42(1):105-111. doi: 10.1515/hmbci-2020-0042. PMID: 33781006
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038
Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma.
Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA
Am J Surg Pathol 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a. PMID: 23154767
Outcome and patterns of failure in pathologic stages I-IV clear-cell carcinoma of the endometrium: implications for adjuvant radiation therapy.
Murphy KT, Rotmensch J, Yamada SD, Mundt AJ
Int J Radiat Oncol Biol Phys 2003 Apr 1;55(5):1272-6. doi: 10.1016/s0360-3016(02)04404-8. PMID: 12654437
Malignant mullerian mixed tumors of the uterine cervix: a report of nine cases of a neoplasm with morphology often different from its counterpart in the corpus.
Clement PB, Zubovits JT, Young RH, Scully RE
Int J Gynecol Pathol 1998 Jul;17(3):211-22. PMID: 9656116

Clinical prediction guides

Early-stage Uterine Pure and Mixed Clear Cell Carcinoma: Outcomes and Recurrence With and Without Adjuvant Therapy.
Chang-Halpenny CN, Natarajan S, Hwang-Graziano JM
Am J Clin Oncol 2018 Apr;41(4):371-378. doi: 10.1097/COC.0000000000000277. PMID: 26950465
Clinicopathological analysis of mixed endometrial carcinomas: clinical relevance of different neoplastic components.
Rossi ED, Bizzarro T, Monterossi G, Inzani F, Fanfani F, Scambia G, Zannoni GF
Hum Pathol 2017 Apr;62:99-107. Epub 2016 Dec 30 doi: 10.1016/j.humpath.2016.12.015. PMID: 28041971
Comparison of pure and mixed-type clear cell carcinoma of the ovary: a clinicopathological analysis of 341 Chinese patients.
Ye S, You Y, Yang J, Cao D, Bai H, Huang H, Wu M, Chen J, Lang J, Shen K
Int J Gynecol Cancer 2014 Nov;24(9):1590-6. doi: 10.1097/IGC.0000000000000275. PMID: 25254564
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038
Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma.
Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA
Am J Surg Pathol 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a. PMID: 23154767

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