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Regional ureteric cancer

MedGen UID:
167733
•Concept ID:
C0854921
•
Neoplastic Process
Synonyms: Local Malignant Ureter Neoplasm; Local Malignant Ureter Tumor; Local Malignant Ureteral Neoplasm; Local Malignant Ureteral Tumor; Regional Malignant Ureter Neoplasm; Regional Malignant Ureter Tumor; Regional Malignant Ureteral Neoplasm; Regional Malignant Ureteral Tumor; regional malignant ureteral tumor; regional malignant ureteral tumour; Regional Ureter Carcinoma; regional ureter carcinoma; regional ureteric cancer; Regional Ureteric Carcinoma; regional ureteric carcinoma
 
Monarch Initiative: MONDO:0001978

Definition

A carcinoma of the ureter that has not spread to other regions. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRegional ureteric cancer

Professional guidelines

PubMed

Diagnosis and Management of Non-Metastatic Upper Tract Urothelial Carcinoma: AUA/SUO Guideline.
Coleman JA, Clark PE, Bixler BR, Buckley DI, Chang SS, Chou R, Hoffman-Censits J, Kulkarni GS, Matin SF, Pierorazio PM, Potretzke AM, Psutka SP, Raman JD, Smith AB, Smith L
J Urol 2023 Jun;209(6):1071-1081. Epub 2023 Apr 25 doi: 10.1097/JU.0000000000003480. PMID: 37096584
ACR Appropriateness Criteria® Renal Failure.
Expert Panel on Urologic Imaging, Wong-You-Cheong JJ, Nikolaidis P, Khatri G, Dogra VS, Ganeshan D, Goldfarb S, Gore JL, Gupta RT, Heilbrun ME, Lyshchik A, Metter DF, Purysko AS, Savage SJ, Smith AD, Wang ZJ, Wolfman DJ, Lockhart ME
J Am Coll Radiol 2021 May;18(5S):S174-S188. doi: 10.1016/j.jacr.2021.02.019. PMID: 33958111
Contemporary Evaluation and Management of Upper Tract Urothelial Cancer.
Mandalapu RS, Matin SF
Urology 2016 Aug;94:17-23. Epub 2016 Feb 2 doi: 10.1016/j.urology.2015.12.035. PMID: 26850816

Recent clinical studies

Etiology

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Primary chemoablation of low-grade upper tract urothelial carcinoma using UGN-101, a mitomycin-containing reverse thermal gel (OLYMPUS): an open-label, single-arm, phase 3 trial.
Kleinmann N, Matin SF, Pierorazio PM, Gore JL, Shabsigh A, Hu B, Chamie K, Godoy G, Hubosky S, Rivera M, O'Donnell M, Quek M, Raman JD, Knoedler JJ, Scherr D, Stern J, Weight C, Weizer A, Woods M, Kaimakliotis H, Smith AB, Linehan J, Coleman J, Humphreys MR, Pak R, Lifshitz D, Verni M, Adibi M, Amin MB, Seltzer E, Klein I, Konorty M, Strauss-Ayali D, Hakim G, Schoenberg M, Lerner SP
Lancet Oncol 2020 Jun;21(6):776-785. Epub 2020 Apr 29 doi: 10.1016/S1470-2045(20)30147-9. PMID: 32631491
Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers.
Paner GP, Stadler WM, Hansel DE, Montironi R, Lin DW, Amin MB
Eur Urol 2018 Apr;73(4):560-569. Epub 2018 Jan 9 doi: 10.1016/j.eururo.2017.12.018. PMID: 29325693
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Idiopathic hemihypertrophy.
Mohanna MA, Sallam AK
Saudi Med J 2014 Apr;35(4):403-5. PMID: 24749139

Diagnosis

Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers.
Paner GP, Stadler WM, Hansel DE, Montironi R, Lin DW, Amin MB
Eur Urol 2018 Apr;73(4):560-569. Epub 2018 Jan 9 doi: 10.1016/j.eururo.2017.12.018. PMID: 29325693
Fetal surgery: a critical review.
Kitagawa H, Pringle KC
Pediatr Surg Int 2017 Apr;33(4):421-433. Epub 2017 Jan 5 doi: 10.1007/s00383-016-4044-5. PMID: 28058487
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Idiopathic hemihypertrophy.
Mohanna MA, Sallam AK
Saudi Med J 2014 Apr;35(4):403-5. PMID: 24749139
Obstructive uropathy.
Tseng TY, Stoller ML
Clin Geriatr Med 2009 Aug;25(3):437-43. doi: 10.1016/j.cger.2009.06.003. PMID: 19765491

Therapy

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Primary chemoablation of low-grade upper tract urothelial carcinoma using UGN-101, a mitomycin-containing reverse thermal gel (OLYMPUS): an open-label, single-arm, phase 3 trial.
Kleinmann N, Matin SF, Pierorazio PM, Gore JL, Shabsigh A, Hu B, Chamie K, Godoy G, Hubosky S, Rivera M, O'Donnell M, Quek M, Raman JD, Knoedler JJ, Scherr D, Stern J, Weight C, Weizer A, Woods M, Kaimakliotis H, Smith AB, Linehan J, Coleman J, Humphreys MR, Pak R, Lifshitz D, Verni M, Adibi M, Amin MB, Seltzer E, Klein I, Konorty M, Strauss-Ayali D, Hakim G, Schoenberg M, Lerner SP
Lancet Oncol 2020 Jun;21(6):776-785. Epub 2020 Apr 29 doi: 10.1016/S1470-2045(20)30147-9. PMID: 32631491
Consultation on UTUC, Stockholm 2018: aspects of treatment.
Jung H, Giusti G, Fajkovic H, Herrmann T, Jones R, Straub M, Baard J, Osther PJS, Brehmer M
World J Urol 2019 Nov;37(11):2279-2287. Epub 2019 May 23 doi: 10.1007/s00345-019-02811-w. PMID: 31123852Free PMC Article
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791
Contemporary Evaluation and Management of Upper Tract Urothelial Cancer.
Mandalapu RS, Matin SF
Urology 2016 Aug;94:17-23. Epub 2016 Feb 2 doi: 10.1016/j.urology.2015.12.035. PMID: 26850816

Prognosis

Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers.
Paner GP, Stadler WM, Hansel DE, Montironi R, Lin DW, Amin MB
Eur Urol 2018 Apr;73(4):560-569. Epub 2018 Jan 9 doi: 10.1016/j.eururo.2017.12.018. PMID: 29325693
Fetal surgery: a critical review.
Kitagawa H, Pringle KC
Pediatr Surg Int 2017 Apr;33(4):421-433. Epub 2017 Jan 5 doi: 10.1007/s00383-016-4044-5. PMID: 28058487
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Obstructive uropathy.
Tseng TY, Stoller ML
Clin Geriatr Med 2009 Aug;25(3):437-43. doi: 10.1016/j.cger.2009.06.003. PMID: 19765491
Urinary system.
Lynch CF, Cohen MB
Cancer 1995 Jan 1;75(1 Suppl):316-29. doi: 10.1002/1097-0142(19950101)75:1+<316::aid-cncr2820751314>3.0.co;2-t. PMID: 8001003

Clinical prediction guides

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Macroscopic somatic clonal expansion in morphologically normal human urothelium.
Li R, Du Y, Chen Z, Xu D, Lin T, Jin S, Wang G, Liu Z, Lu M, Chen X, Xu T, Bai F
Science 2020 Oct 2;370(6512):82-89. doi: 10.1126/science.aba7300. PMID: 33004515
Primary chemoablation of low-grade upper tract urothelial carcinoma using UGN-101, a mitomycin-containing reverse thermal gel (OLYMPUS): an open-label, single-arm, phase 3 trial.
Kleinmann N, Matin SF, Pierorazio PM, Gore JL, Shabsigh A, Hu B, Chamie K, Godoy G, Hubosky S, Rivera M, O'Donnell M, Quek M, Raman JD, Knoedler JJ, Scherr D, Stern J, Weight C, Weizer A, Woods M, Kaimakliotis H, Smith AB, Linehan J, Coleman J, Humphreys MR, Pak R, Lifshitz D, Verni M, Adibi M, Amin MB, Seltzer E, Klein I, Konorty M, Strauss-Ayali D, Hakim G, Schoenberg M, Lerner SP
Lancet Oncol 2020 Jun;21(6):776-785. Epub 2020 Apr 29 doi: 10.1016/S1470-2045(20)30147-9. PMID: 32631491
Fetal surgery: a critical review.
Kitagawa H, Pringle KC
Pediatr Surg Int 2017 Apr;33(4):421-433. Epub 2017 Jan 5 doi: 10.1007/s00383-016-4044-5. PMID: 28058487
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375

Recent systematic reviews

The impact of lymphovascular invasion in patients treated with radical nephroureterectomy for upper tract urothelial carcinoma: An extensive updated systematic review and meta-analysis.
Stangl-Kremser J, Muto G, Grosso AA, Briganti A, Comperat E, Di Maida F, Montironi R, Remzi M, Pradere B, Soria F, Albisinni S, Roupret M, Shariat SF, Minervini A, Teoh JY, Moschini M, Cimadamore A, Mari A; European Association of Urology-Young Academic Urologists (EAU-YAU): Urothelial carcinoma working group
Urol Oncol 2022 Jun;40(6):243-261. Epub 2022 Feb 28 doi: 10.1016/j.urolonc.2022.01.014. PMID: 35241364
Imaging modalities and treatment of paediatric upper tract urolithiasis: A systematic review and update on behalf of the EAU urolithiasis guidelines panel.
Grivas N, Thomas K, Drake T, Donaldson J, Neisius A, Petřík A, Ruhayel Y, Seitz C, Türk C, Skolarikos A
J Pediatr Urol 2020 Oct;16(5):612-624. Epub 2020 Jul 4 doi: 10.1016/j.jpurol.2020.07.003. PMID: 32739360
Granulocyte colony-stimulating factor-producing upper urinary tract carcinoma: systematic review of 46 cases reported in Japan.
Matsumoto K, Hayakawa N, Nakamura S
Clin Oncol (R Coll Radiol) 2014 Dec;26(12):781-8. Epub 2014 Aug 30 doi: 10.1016/j.clon.2014.08.006. PMID: 25179323
Results and outcomes after endoscopic treatment of upper urinary tract carcinoma: the Austrian experience.
Fajkovic H, Klatte T, Nagele U, Dunzinger M, Zigeuner R, Hübner W, Remzi M
World J Urol 2013 Feb;31(1):37-44. Epub 2012 Sep 27 doi: 10.1007/s00345-012-0948-4. PMID: 23014836
Surgical management for upper urinary tract transitional cell carcinoma.
Rai BP, Shelley M, Coles B, Biyani CS, El-Mokadem I, Nabi G
Cochrane Database Syst Rev 2011 Apr 13;(4):CD007349. doi: 10.1002/14651858.CD007349.pub2. PMID: 21491399

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