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Malignant tumor of ureter

MedGen UID:
102281
•Concept ID:
C0153619
•
Neoplastic Process
Synonyms: Cancer of ureter; Ureter cancer
SNOMED CT: Cancer of ureter (363458004); Ureter Ca (363458004); Malignant tumor of ureter (363458004)
 
Monarch Initiative: MONDO:0008627
OMIM®: 191600

Definition

A primary or metastatic malignant tumor involving the ureter. The majority are carcinomas. [from NCI]

Clinical features

From HPO
Neoplasm of the ureter
MedGen UID:
12011
•Concept ID:
C0041955
•
Neoplastic Process
The presence of a neoplasm of the ureter.
See: Feature record | Search on this feature

Term Hierarchy

Professional guidelines

PubMed

Diagnosis and Management of Non-Metastatic Upper Tract Urothelial Carcinoma: AUA/SUO Guideline.
Coleman JA, Clark PE, Bixler BR, Buckley DI, Chang SS, Chou R, Hoffman-Censits J, Kulkarni GS, Matin SF, Pierorazio PM, Potretzke AM, Psutka SP, Raman JD, Smith AB, Smith L
J Urol 2023 Jun;209(6):1071-1081. Epub 2023 Apr 25 doi: 10.1097/JU.0000000000003480. PMID: 37096584
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Diagnosis and management of upper tract urothelial carcinoma.
Krabbe LM, Bagrodia A, Westerman ME, Margulis V
Minerva Urol Nefrol 2014 Mar;66(1):37-48. PMID: 24721939

Recent clinical studies

Etiology

Diagnosis and Management of Non-Metastatic Upper Tract Urothelial Carcinoma: AUA/SUO Guideline.
Coleman JA, Clark PE, Bixler BR, Buckley DI, Chang SS, Chou R, Hoffman-Censits J, Kulkarni GS, Matin SF, Pierorazio PM, Potretzke AM, Psutka SP, Raman JD, Smith AB, Smith L
J Urol 2023 Jun;209(6):1071-1081. Epub 2023 Apr 25 doi: 10.1097/JU.0000000000003480. PMID: 37096584
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2023 Update.
Rouprêt M, Seisen T, Birtle AJ, Capoun O, Compérat EM, Dominguez-Escrig JL, Gürses Andersson I, Liedberg F, Mariappan P, Hugh Mostafid A, Pradere B, van Rhijn BWG, Shariat SF, Rai BP, Soria F, Soukup V, Wood RG, Xylinas EN, Masson-Lecomte A, Gontero P
Eur Urol 2023 Jul;84(1):49-64. Epub 2023 Mar 24 doi: 10.1016/j.eururo.2023.03.013. PMID: 36967359
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Endoscopic management of upper-tract urothelial carcinoma.
Raman JD, Park R
Expert Rev Anticancer Ther 2017 Jun;17(6):545-554. Epub 2017 May 15 doi: 10.1080/14737140.2017.1326823. PMID: 28480774
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375

Diagnosis

Diagnosis and Management of Non-Metastatic Upper Tract Urothelial Carcinoma: AUA/SUO Guideline.
Coleman JA, Clark PE, Bixler BR, Buckley DI, Chang SS, Chou R, Hoffman-Censits J, Kulkarni GS, Matin SF, Pierorazio PM, Potretzke AM, Psutka SP, Raman JD, Smith AB, Smith L
J Urol 2023 Jun;209(6):1071-1081. Epub 2023 Apr 25 doi: 10.1097/JU.0000000000003480. PMID: 37096584
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2023 Update.
Rouprêt M, Seisen T, Birtle AJ, Capoun O, Compérat EM, Dominguez-Escrig JL, Gürses Andersson I, Liedberg F, Mariappan P, Hugh Mostafid A, Pradere B, van Rhijn BWG, Shariat SF, Rai BP, Soria F, Soukup V, Wood RG, Xylinas EN, Masson-Lecomte A, Gontero P
Eur Urol 2023 Jul;84(1):49-64. Epub 2023 Mar 24 doi: 10.1016/j.eururo.2023.03.013. PMID: 36967359
Malignant Glomus Tumor of the Ureter.
Demir M, Tuncekin A, Yagmur I, Aydogdu A
J Coll Physicians Surg Pak 2022 Dec;32(12):SS206-SS208. doi: 10.29271/jcpsp.2022.Supp0.SS206. PMID: 36597340
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Ureteral neoplasms.
Winalski CS, Lipman JC, Tumeh SS
Radiographics 1990 Mar;10(2):271-83. doi: 10.1148/radiographics.10.2.2183298. PMID: 2183298

Therapy

Drug instillation in the management of urinary tract urothelial carcinoma.
Kim SH, Lerner SP
Curr Opin Urol 2022 Sep 1;32(5):531-535. Epub 2022 Jul 15 doi: 10.1097/MOU.0000000000001021. PMID: 35849701
Nephron-sparing management of upper tract urothelial carcinoma.
Farrow JM, Kern SQ, Gryzinski GM, Sundaram CP
Investig Clin Urol 2021 Jul;62(4):389-398. doi: 10.4111/icu.20210113. PMID: 34190434Free PMC Article
Open-label, Multicenter, Phase II Study of RC48-ADC, a HER2-Targeting Antibody-Drug Conjugate, in Patients with Locally Advanced or Metastatic Urothelial Carcinoma.
Sheng X, Yan X, Wang L, Shi Y, Yao X, Luo H, Shi B, Liu J, He Z, Yu G, Ying J, Han W, Hu C, Ling Y, Chi Z, Cui C, Si L, Fang J, Zhou A, Guo J
Clin Cancer Res 2021 Jan 1;27(1):43-51. Epub 2020 Oct 27 doi: 10.1158/1078-0432.CCR-20-2488. PMID: 33109737
Neoadjuvant and Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A 2020 Systematic Review and Meta-analysis, and Future Perspectives on Systemic Therapy.
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146
Immune checkpoint inhibitors for urothelial carcinoma.
Kim HS, Seo HK
Investig Clin Urol 2018 Sep;59(5):285-296. Epub 2018 Aug 31 doi: 10.4111/icu.2018.59.5.285. PMID: 30182073Free PMC Article

Prognosis

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Urothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?
Lwin AA, Hsu CH, Chipollini J
Clin Genitourin Cancer 2020 Feb;18(1):45-49.e1. Epub 2019 Nov 6 doi: 10.1016/j.clgc.2019.10.023. PMID: 31786118
A contemporary review of management and prognostic factors of upper tract urothelial carcinoma.
Leow JJ, Orsola A, Chang SL, Bellmunt J
Cancer Treat Rev 2015 Apr;41(4):310-9. Epub 2015 Feb 18 doi: 10.1016/j.ctrv.2015.02.006. PMID: 25736461
Diagnosis and management of upper tract urothelial carcinoma.
Krabbe LM, Bagrodia A, Westerman ME, Margulis V
Minerva Urol Nefrol 2014 Mar;66(1):37-48. PMID: 24721939
Extra-adrenal pheochromocytoma.
Atiyeh BA, Barakat AJ, Abumrad NN
J Nephrol 1997 Jan-Feb;10(1):25-9. PMID: 9241621

Clinical prediction guides

Malignant Glomus Tumor of the Ureter.
Demir M, Tuncekin A, Yagmur I, Aydogdu A
J Coll Physicians Surg Pak 2022 Dec;32(12):SS206-SS208. doi: 10.29271/jcpsp.2022.Supp0.SS206. PMID: 36597340
Discordance Between Clinical and Pathological Staging and Grading in Upper Tract Urothelial Carcinoma.
Mori K, Katayama S, Laukhtina E, Schuettfort VM, Pradere B, Quhal F, Sari Motlagh R, Mostafaei H, Grossmann NC, Rajwa P, Zimmermann K, Karakiewicz PI, Abufaraj M, Fajkovic H, Rouprêt M, Margulis V, Enikeev DV, Egawa S, Shariat SF
Clin Genitourin Cancer 2022 Feb;20(1):95.e1-95.e6. Epub 2021 Oct 10 doi: 10.1016/j.clgc.2021.10.002. PMID: 34764007
Management of distal ureter and bladder cuff at the time of nephroureterectomy: surgical techniques and predictors of outcome.
Attalla K, Patnaik S, Vellos T, Mehrazin R
Future Oncol 2019 Jul;15(20):2385-2393. Epub 2019 Jun 25 doi: 10.2217/fon-2019-0064. PMID: 31237445
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Diagnosis and management of upper tract urothelial carcinoma.
Krabbe LM, Bagrodia A, Westerman ME, Margulis V
Minerva Urol Nefrol 2014 Mar;66(1):37-48. PMID: 24721939

Recent systematic reviews

Diagnosis and management of complicated urogenital schistosomiasis: a systematic review of the literature.
Manciulli T, Marangoni D, Salas-Coronas J, Bocanegra C, Richter J, Gobbi F, Motta L, Minervini A, Bartoloni A, Zammarchi L; TropNet Schisto Task Force
Infection 2023 Oct;51(5):1185-1221. Epub 2023 Jul 19 doi: 10.1007/s15010-023-02060-5. PMID: 37466786Free PMC Article
Neoadjuvant and Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A 2020 Systematic Review and Meta-analysis, and Future Perspectives on Systemic Therapy.
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Urologic complications of genitourinary schistosomiasis.
Khalaf I, Shokeir A, Shalaby M
World J Urol 2012 Feb;30(1):31-8. Epub 2011 Sep 10 doi: 10.1007/s00345-011-0751-7. PMID: 21909645

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