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Abnormal circulating thromboxane concentration

MedGen UID:
1684670
•Concept ID:
C5139108
•
Finding
Synonym: Abnormality of thromboxane metabolism
 
HPO: HP:0030389

Definition

Any deviation from the normal concentration in the blood circulation of a thromboxane. Thromboxanes are derived from prostaglandin precursors in platelets, and stimulate aggregation of platelets and constriction of blood vessels. [from HPO]

Recent clinical studies

Etiology

Importance of platelet aggregation in patients with end-stage renal disease.
Martinović Z, Basić-Jukić N, Pavlović DB, Kes P
Acta Clin Croat 2013 Dec;52(4):472-7. PMID: 24696998
Homocysteine, coagulation, platelet function, and thrombosis.
Coppola A, Davi G, De Stefano V, Mancini FP, Cerbone AM, Di Minno G
Semin Thromb Hemost 2000;26(3):243-54. doi: 10.1055/s-2000-8469. PMID: 11011842
Low-dose aspirin in pregnancy.
Sibai BM, Mirro R, Chesney CM, Leffler C
Obstet Gynecol 1989 Oct;74(4):551-7. PMID: 2797631
Effects of cardiopulmonary bypass on eicosanoid metabolism during pediatric cardiovascular surgery.
Greeley WJ, Bushman GA, Kong DL, Oldham HN, Peterson MB
J Thorac Cardiovasc Surg 1988 May;95(5):842-9. PMID: 3283461
Effects of current therapy of Kawasaki disease on eicosanoid metabolism.
Fulton DR, Meissner C, Peterson MB
Am J Cardiol 1988 Jun 1;61(15):1323-7. doi: 10.1016/0002-9149(88)91177-0. PMID: 2454025

Diagnosis

Hepatorenal syndrome: emerging perspectives of pathophysiology and therapy.
Epstein M
J Am Soc Nephrol 1994 Apr;4(10):1735-53. doi: 10.1681/ASN.V4101735. PMID: 8068872
Inhibitory effect of acetylsalicylic acid on platelet function in patients with completed stroke or reversible ischemic neurologic deficit.
Lee TK, Chen YC, Lien IN, Liu MC, Huang ZS
Stroke 1988 May;19(5):566-70. doi: 10.1161/01.str.19.5.566. PMID: 3363589
Comparison of the effect of acetylsalicylic acid on platelet function in male and female patients with ischemic stroke.
Lee TK, Chen YC, Kuo TL
Thromb Res 1987 Aug 1;47(3):295-304. doi: 10.1016/0049-3848(87)90143-5. PMID: 3629557
Iloprost (ZK36374), a stable analogue of prostacyclin, preserves platelets during simulated extracorporeal circulation.
Addonizio VP Jr, Fisher CA, Jenkin BK, Strauss JF 3rd, Musial JF, Edmunds LH Jr
J Thorac Cardiovasc Surg 1985 Jun;89(6):926-33. PMID: 2582210
In vivo platelet activation with in vitro hyperaggregability to arachidonic acid in renal allograft recipients.
Frampton G, Parbtani A, Marchesi D, Duffus P, Livio M, Remuzzi G, Cameron JS
Kidney Int 1983 Mar;23(3):506-13. doi: 10.1038/ki.1983.48. PMID: 6405075

Therapy

Aspirin resistance in adult patients after Fontan surgery.
Tomkiewicz-Pajak L, Wojcik T, Chłopicki S, Olszowska M, Pajak J, Podolec J, Sitek B, Musiałek P, Rubis P, Komar M, Podolec P
Int J Cardiol 2015 Feb 15;181:19-26. Epub 2014 Nov 27 doi: 10.1016/j.ijcard.2014.11.219. PMID: 25479533
Importance of platelet aggregation in patients with end-stage renal disease.
Martinović Z, Basić-Jukić N, Pavlović DB, Kes P
Acta Clin Croat 2013 Dec;52(4):472-7. PMID: 24696998
Homocysteine, coagulation, platelet function, and thrombosis.
Coppola A, Davi G, De Stefano V, Mancini FP, Cerbone AM, Di Minno G
Semin Thromb Hemost 2000;26(3):243-54. doi: 10.1055/s-2000-8469. PMID: 11011842
Hepatorenal syndrome: emerging perspectives of pathophysiology and therapy.
Epstein M
J Am Soc Nephrol 1994 Apr;4(10):1735-53. doi: 10.1681/ASN.V4101735. PMID: 8068872
Low-dose aspirin in pregnancy.
Sibai BM, Mirro R, Chesney CM, Leffler C
Obstet Gynecol 1989 Oct;74(4):551-7. PMID: 2797631

Prognosis

Hepatorenal syndrome: emerging perspectives of pathophysiology and therapy.
Epstein M
J Am Soc Nephrol 1994 Apr;4(10):1735-53. doi: 10.1681/ASN.V4101735. PMID: 8068872
In vivo platelet activation with in vitro hyperaggregability to arachidonic acid in renal allograft recipients.
Frampton G, Parbtani A, Marchesi D, Duffus P, Livio M, Remuzzi G, Cameron JS
Kidney Int 1983 Mar;23(3):506-13. doi: 10.1038/ki.1983.48. PMID: 6405075

Clinical prediction guides

Hypertensive and normal pregnancy: a longitudinal study of blood pressure, distensibility of dorsal hand veins and the ratio of the stable metabolites of thromboxane A2 and prostacyclin in plasma.
Smith AJ, Walters WA, Buckley NA, Gallagher L, Mason A, McPherson J
Br J Obstet Gynaecol 1995 Nov;102(11):900-6. doi: 10.1111/j.1471-0528.1995.tb10879.x. PMID: 8534627
Comparison of the effect of acetylsalicylic acid on platelet function in male and female patients with ischemic stroke.
Lee TK, Chen YC, Kuo TL
Thromb Res 1987 Aug 1;47(3):295-304. doi: 10.1016/0049-3848(87)90143-5. PMID: 3629557
Release of prostanoids into the portal and hepatic vein in patients with chronic liver disease.
Wernze H, Tittor W, Goerig M
Hepatology 1986 Sep-Oct;6(5):911-6. doi: 10.1002/hep.1840060517. PMID: 3530946
In vivo platelet activation with in vitro hyperaggregability to arachidonic acid in renal allograft recipients.
Frampton G, Parbtani A, Marchesi D, Duffus P, Livio M, Remuzzi G, Cameron JS
Kidney Int 1983 Mar;23(3):506-13. doi: 10.1038/ki.1983.48. PMID: 6405075

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