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Abnormal circulating eicosanoid concentration

MedGen UID:
892588
Concept ID:
C4072901
Finding
Synonym: Abnormality of eicosanoid metabolism
 
HPO: HP:0030361

Definition

Any deviation from the normal concentration in the blood circulation of an icosanoid (also known as eicosanoids). These are signaling molecules derived from oxidation of 20-carbon fatty acids. Most are produced from arachidonic acid, a 20-carbon polyunsaturated fatty acid (5,8,11,14-eicosatetraenoic acid). [from HPO]

Conditions with this feature

Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder
MedGen UID:
1799074
Concept ID:
C5567651
Disease or Syndrome
Recurrent gastrointestinal ulceration with dysfunctional platelets (GURDP) is an autosomal recessive disorder characterized by onset of severe gastrointestinal mucosal ulceration in early childhood. Affected individuals may have secondary iron deficiency anemia or malnourishment. Studies of platelet aggregation show a functional defect associated with decreased thromboxane-A2 production and decreased eicosanoid biosynthesis. The gastrointestinal disease is believed to result from decreased or absent production of prostaglandins that protect the gut mucosa (summary by Adler et al., 2008 and Faioni et al., 2014).

Professional guidelines

PubMed

Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM
Pediatr Pulmonol 2019 Jan;54(1):66-72. Epub 2018 Nov 28 doi: 10.1002/ppul.24190. PMID: 30485728
Atz AM, Munoz RA, Adatia I, Wessel DL
Am J Cardiol 2003 Apr 1;91(7):906-8. doi: 10.1016/s0002-9149(03)00036-5. PMID: 12667588

Recent clinical studies

Etiology

Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM
Pediatr Pulmonol 2019 Jan;54(1):66-72. Epub 2018 Nov 28 doi: 10.1002/ppul.24190. PMID: 30485728
Martinović Z, Basić-Jukić N, Pavlović DB, Kes P
Acta Clin Croat 2013 Dec;52(4):472-7. PMID: 24696998
Otsuki M, Goya K, Kasayama S
Vasc Health Risk Manag 2005;1(3):209-15. PMID: 17319106Free PMC Article
Coppola A, Davi G, De Stefano V, Mancini FP, Cerbone AM, Di Minno G
Semin Thromb Hemost 2000;26(3):243-54. doi: 10.1055/s-2000-8469. PMID: 11011842
Sibai BM, Mirro R, Chesney CM, Leffler C
Obstet Gynecol 1989 Oct;74(4):551-7. PMID: 2797631

Diagnosis

Condorelli RA, Calogero AE, Vicari E, di Pino L, Giacone F, Mongioì L, la Vignera S
J Androl 2012 Nov-Dec;33(6):1268-75. Epub 2012 Feb 23 doi: 10.2164/jandrol.111.015933. PMID: 22362078
Martin JS, Beck DT, Aranda JM Jr, Braith RW
J Appl Physiol (1985) 2012 Mar;112(5):868-76. Epub 2011 Dec 22 doi: 10.1152/japplphysiol.01336.2011. PMID: 22194326
Epstein M
J Am Soc Nephrol 1994 Apr;4(10):1735-53. doi: 10.1681/ASN.V4101735. PMID: 8068872
Lee TK, Chen YC, Lien IN, Liu MC, Huang ZS
Stroke 1988 May;19(5):566-70. doi: 10.1161/01.str.19.5.566. PMID: 3363589
Frampton G, Parbtani A, Marchesi D, Duffus P, Livio M, Remuzzi G, Cameron JS
Kidney Int 1983 Mar;23(3):506-13. doi: 10.1038/ki.1983.48. PMID: 6405075

Therapy

Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM
Pediatr Pulmonol 2019 Jan;54(1):66-72. Epub 2018 Nov 28 doi: 10.1002/ppul.24190. PMID: 30485728
Martinović Z, Basić-Jukić N, Pavlović DB, Kes P
Acta Clin Croat 2013 Dec;52(4):472-7. PMID: 24696998
Coppola A, Davi G, De Stefano V, Mancini FP, Cerbone AM, Di Minno G
Semin Thromb Hemost 2000;26(3):243-54. doi: 10.1055/s-2000-8469. PMID: 11011842
Sibai BM, Mirro R, Chesney CM, Leffler C
Obstet Gynecol 1989 Oct;74(4):551-7. PMID: 2797631
Holub BJ
Annu Rev Nutr 1986;6:563-97. doi: 10.1146/annurev.nu.06.070186.003023. PMID: 2425833

Prognosis

Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM
Pediatr Pulmonol 2019 Jan;54(1):66-72. Epub 2018 Nov 28 doi: 10.1002/ppul.24190. PMID: 30485728
Scott AC, Wensel R, Davos CH, Kemp M, Kaczmarek A, Hooper J, Coats AJ, Piepoli MF
Circulation 2002 Jul 9;106(2):214-20. doi: 10.1161/01.cir.0000021603.36744.5e. PMID: 12105161
Epstein M
J Am Soc Nephrol 1994 Apr;4(10):1735-53. doi: 10.1681/ASN.V4101735. PMID: 8068872
Frampton G, Parbtani A, Marchesi D, Duffus P, Livio M, Remuzzi G, Cameron JS
Kidney Int 1983 Mar;23(3):506-13. doi: 10.1038/ki.1983.48. PMID: 6405075
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

Clinical prediction guides

Hamed SA, Hermann BP, Moussa EM, Youssef AH, Rageh TA, Elserogy YE, NasrEldin E
Seizure 2015 Feb;25:40-8. Epub 2014 Dec 12 doi: 10.1016/j.seizure.2014.12.002. PMID: 25645635
Mu YM, Yanase T, Nishi Y, Tanaka A, Saito M, Jin CH, Mukasa C, Okabe T, Nomura M, Goto K, Nawata H
Endocrinology 2001 Aug;142(8):3590-7. doi: 10.1210/endo.142.8.8293. PMID: 11459807
Smith AJ, Walters WA, Buckley NA, Gallagher L, Mason A, McPherson J
Br J Obstet Gynaecol 1995 Nov;102(11):900-6. doi: 10.1111/j.1471-0528.1995.tb10879.x. PMID: 8534627
Frampton G, Parbtani A, Marchesi D, Duffus P, Livio M, Remuzzi G, Cameron JS
Kidney Int 1983 Mar;23(3):506-13. doi: 10.1038/ki.1983.48. PMID: 6405075
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

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