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Abnormal circulating unsaturated fatty acid concentration

MedGen UID:
1684810
•Concept ID:
C5139059
•
Finding
Synonym: Abnormality of unsaturated fatty acid metabolism
 
HPO: HP:0011022

Definition

A deviation from the normal concentration of an unsaturated fatty acid in the blood circulation. [from HPO]

Professional guidelines

PubMed

Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension.
Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM
Pediatr Pulmonol 2019 Jan;54(1):66-72. Epub 2018 Nov 28 doi: 10.1002/ppul.24190. PMID: 30485728
Diagnostic and therapeutic uses of inhaled nitric oxide in neonatal Ebstein's anomaly.
Atz AM, Munoz RA, Adatia I, Wessel DL
Am J Cardiol 2003 Apr 1;91(7):906-8. doi: 10.1016/s0002-9149(03)00036-5. PMID: 12667588

Recent clinical studies

Etiology

Chia (Salvia hispanica)-supplemented diet ameliorates non-alcoholic fatty liver disease and its metabolic abnormalities in humans.
Medina-Urrutia A, Lopez-Uribe AR, El Hafidi M, González-Salazar MDC, Posadas-Sánchez R, Jorge-Galarza E, Del Valle-Mondragón L, Juárez-Rojas JG
Lipids Health Dis 2020 May 19;19(1):96. doi: 10.1186/s12944-020-01283-x. PMID: 32430018Free PMC Article
Serum fatty acid profile in psoriasis and its comorbidity.
Myśliwiec H, Baran A, Harasim-Symbor E, Myśliwiec P, Milewska AJ, Chabowski A, Flisiak I
Arch Dermatol Res 2017 Jul;309(5):371-380. Epub 2017 Jun 5 doi: 10.1007/s00403-017-1748-x. PMID: 28585093Free PMC Article
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS
Am J Clin Nutr 2010 Dec;92(6):1350-8. Epub 2010 Oct 13 doi: 10.3945/ajcn.110.003970. PMID: 20943795Free PMC Article
Homocysteine, coagulation, platelet function, and thrombosis.
Coppola A, Davi G, De Stefano V, Mancini FP, Cerbone AM, Di Minno G
Semin Thromb Hemost 2000;26(3):243-54. doi: 10.1055/s-2000-8469. PMID: 11011842
Plasma and lipoprotein fatty acid composition in glycogen storage disease type I.
Levy E, Letarte J, Lepage G, Thibault L, Roy CC
Lipids 1987 Jun;22(6):381-5. doi: 10.1007/BF02537265. PMID: 3475522

Diagnosis

Low-fat diet with omega-3 fatty acids increases plasma insulin-like growth factor concentration in healthy postmenopausal women.
Young LR, Kurzer MS, Thomas W, Redmon JB, Raatz SK
Nutr Res 2013 Jul;33(7):565-71. Epub 2013 May 30 doi: 10.1016/j.nutres.2013.04.011. PMID: 23827131Free PMC Article
Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study.
Colter AL, Cutler C, Meckling KA
Nutr J 2008 Feb 14;7:8. doi: 10.1186/1475-2891-7-8. PMID: 18275609Free PMC Article
Hepatorenal syndrome: emerging perspectives of pathophysiology and therapy.
Epstein M
J Am Soc Nephrol 1994 Apr;4(10):1735-53. doi: 10.1681/ASN.V4101735. PMID: 8068872
Inhibitory effect of acetylsalicylic acid on platelet function in patients with completed stroke or reversible ischemic neurologic deficit.
Lee TK, Chen YC, Lien IN, Liu MC, Huang ZS
Stroke 1988 May;19(5):566-70. doi: 10.1161/01.str.19.5.566. PMID: 3363589
In vivo platelet activation with in vitro hyperaggregability to arachidonic acid in renal allograft recipients.
Frampton G, Parbtani A, Marchesi D, Duffus P, Livio M, Remuzzi G, Cameron JS
Kidney Int 1983 Mar;23(3):506-13. doi: 10.1038/ki.1983.48. PMID: 6405075

Therapy

Chia (Salvia hispanica)-supplemented diet ameliorates non-alcoholic fatty liver disease and its metabolic abnormalities in humans.
Medina-Urrutia A, Lopez-Uribe AR, El Hafidi M, González-Salazar MDC, Posadas-Sánchez R, Jorge-Galarza E, Del Valle-Mondragón L, Juárez-Rojas JG
Lipids Health Dis 2020 May 19;19(1):96. doi: 10.1186/s12944-020-01283-x. PMID: 32430018Free PMC Article
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS
Am J Clin Nutr 2010 Dec;92(6):1350-8. Epub 2010 Oct 13 doi: 10.3945/ajcn.110.003970. PMID: 20943795Free PMC Article
Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study.
Colter AL, Cutler C, Meckling KA
Nutr J 2008 Feb 14;7:8. doi: 10.1186/1475-2891-7-8. PMID: 18275609Free PMC Article
Hepatorenal syndrome: emerging perspectives of pathophysiology and therapy.
Epstein M
J Am Soc Nephrol 1994 Apr;4(10):1735-53. doi: 10.1681/ASN.V4101735. PMID: 8068872
Plasma and lipoprotein fatty acid composition in glycogen storage disease type I.
Levy E, Letarte J, Lepage G, Thibault L, Roy CC
Lipids 1987 Jun;22(6):381-5. doi: 10.1007/BF02537265. PMID: 3475522

Prognosis

Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension.
Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM
Pediatr Pulmonol 2019 Jan;54(1):66-72. Epub 2018 Nov 28 doi: 10.1002/ppul.24190. PMID: 30485728
Chemical mediators of the muscle ergoreflex in chronic heart failure: a putative role for prostaglandins in reflex ventilatory control.
Scott AC, Wensel R, Davos CH, Kemp M, Kaczmarek A, Hooper J, Coats AJ, Piepoli MF
Circulation 2002 Jul 9;106(2):214-20. doi: 10.1161/01.cir.0000021603.36744.5e. PMID: 12105161
Hepatorenal syndrome: emerging perspectives of pathophysiology and therapy.
Epstein M
J Am Soc Nephrol 1994 Apr;4(10):1735-53. doi: 10.1681/ASN.V4101735. PMID: 8068872
In vivo platelet activation with in vitro hyperaggregability to arachidonic acid in renal allograft recipients.
Frampton G, Parbtani A, Marchesi D, Duffus P, Livio M, Remuzzi G, Cameron JS
Kidney Int 1983 Mar;23(3):506-13. doi: 10.1038/ki.1983.48. PMID: 6405075
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

Clinical prediction guides

Serum fatty acid profile in psoriasis and its comorbidity.
Myśliwiec H, Baran A, Harasim-Symbor E, Myśliwiec P, Milewska AJ, Chabowski A, Flisiak I
Arch Dermatol Res 2017 Jul;309(5):371-380. Epub 2017 Jun 5 doi: 10.1007/s00403-017-1748-x. PMID: 28585093Free PMC Article
Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study.
Colter AL, Cutler C, Meckling KA
Nutr J 2008 Feb 14;7:8. doi: 10.1186/1475-2891-7-8. PMID: 18275609Free PMC Article
Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells.
Mu YM, Yanase T, Nishi Y, Tanaka A, Saito M, Jin CH, Mukasa C, Okabe T, Nomura M, Goto K, Nawata H
Endocrinology 2001 Aug;142(8):3590-7. doi: 10.1210/endo.142.8.8293. PMID: 11459807
Altered lipid profile, lipoprotein composition, and oxidant and antioxidant status in pediatric Crohn disease.
Levy E, Rizwan Y, Thibault L, Lepage G, Brunet S, Bouthillier L, Seidman E
Am J Clin Nutr 2000 Mar;71(3):807-15. doi: 10.1093/ajcn/71.3.807. PMID: 10702177
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

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