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Unresectable Clear Cell Renal Cell Carcinoma

MedGen UID:
1710342
Concept ID:
C5237190
Neoplastic Process

Definition

A clear cell renal cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Clear Cell Renal Cell Carcinoma

Professional guidelines

PubMed

Suárez C, Vieito M, Valdivia A, González M, Carles J
Med Sci (Basel) 2023 Jun 30;11(3) doi: 10.3390/medsci11030046. PMID: 37489462Free PMC Article
Ball MW
Discov Med 2017 Jun;23(129):379-387. PMID: 28877449
Seront E, Machiels JP
Recent Pat Anticancer Drug Discov 2009 Jun;4(2):146-56. doi: 10.2174/157489209788452803. PMID: 19519537

Recent clinical studies

Etiology

Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Yan XQ, Ye MJ, Zou Q, Chen P, He ZS, Wu B, He DL, He CH, Xue XY, Ji ZG, Chen H, Zhang S, Liu YP, Zhang XD, Fu C, Xu DF, Qiu MX, Lv JJ, Huang J, Ren XB, Cheng Y, Qin WJ, Zhang X, Zhou FJ, Ma LL, Guo JM, Ding DG, Wei SZ, He Y, Guo HQ, Shi BK, Liu L, Liu F, Hu ZQ, Jin XM, Yang L, Zhu SX, Liu JH, Huang YH, Xu T, Liu B, Sun T, Wang ZJ, Jiang HW, Yu DX, Zhou AP, Jiang J, Luan GD, Jin CL, Xu J, Hu JX, Huang YR, Guo J, Zhai W, Sheng XN
Ann Oncol 2024 Feb;35(2):190-199. Epub 2023 Oct 21 doi: 10.1016/j.annonc.2023.09.3108. PMID: 37872020
Roy AM, Briggler A, Tippit D, Dawson K, Verma R
Clin Genitourin Cancer 2020 Dec;18(6):e688-e691. Epub 2020 Apr 21 doi: 10.1016/j.clgc.2020.04.003. PMID: 32660880
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Dengina N, Tsimafeyeu I, Mitin T
Clin Genitourin Cancer 2017 Apr;15(2):183-187. Epub 2016 Sep 19 doi: 10.1016/j.clgc.2016.09.004. PMID: 27789182

Diagnosis

Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Armas-Alvarez AL, Alois Osorio-Manyari A, Donate-Moreno MJ, Vera-Beron R, Salinas-Sánchez AS
Arch Esp Urol 2020 Jan;73(1):71-75. PMID: 31950927
Mavrogenis AF, Mimidis G, Kokkalis ZT, Karampi ES, Karampela I, Papagelopoulos PJ, Armaganidis A
Eur J Orthop Surg Traumatol 2014 Apr;24(3):279-83. Epub 2013 Sep 8 doi: 10.1007/s00590-013-1311-1. PMID: 24013815
Spreafico F, Collini P, Terenziani M, Marchianò A, Piva L
Expert Rev Anticancer Ther 2010 Dec;10(12):1967-78. doi: 10.1586/era.10.188. PMID: 21110762
Sahni VA, Silverman SG
Cancer Imaging 2009 Jul 6;9(1):44-55. doi: 10.1102/1470-7330.2009.0005. PMID: 19602467Free PMC Article

Therapy

Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Yan XQ, Ye MJ, Zou Q, Chen P, He ZS, Wu B, He DL, He CH, Xue XY, Ji ZG, Chen H, Zhang S, Liu YP, Zhang XD, Fu C, Xu DF, Qiu MX, Lv JJ, Huang J, Ren XB, Cheng Y, Qin WJ, Zhang X, Zhou FJ, Ma LL, Guo JM, Ding DG, Wei SZ, He Y, Guo HQ, Shi BK, Liu L, Liu F, Hu ZQ, Jin XM, Yang L, Zhu SX, Liu JH, Huang YH, Xu T, Liu B, Sun T, Wang ZJ, Jiang HW, Yu DX, Zhou AP, Jiang J, Luan GD, Jin CL, Xu J, Hu JX, Huang YR, Guo J, Zhai W, Sheng XN
Ann Oncol 2024 Feb;35(2):190-199. Epub 2023 Oct 21 doi: 10.1016/j.annonc.2023.09.3108. PMID: 37872020
Roy AM, Briggler A, Tippit D, Dawson K, Verma R
Clin Genitourin Cancer 2020 Dec;18(6):e688-e691. Epub 2020 Apr 21 doi: 10.1016/j.clgc.2020.04.003. PMID: 32660880
Heng DY, Kollmannsberger C
Recent Results Cancer Res 2010;184:71-82. doi: 10.1007/978-3-642-01222-8_6. PMID: 20072832
Deeks ED, Keating GM
Drugs 2006;66(17):2255-66; discussion 2267-8. doi: 10.2165/00003495-200666170-00007. PMID: 17137406

Prognosis

Ambalavanan M, Geller JI
Pediatr Blood Cancer 2019 Aug;66(8):e27766. Epub 2019 Apr 23 doi: 10.1002/pbc.27766. PMID: 31012542
Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485
Tomita Y
Int J Urol 2016 Jan;23(1):13-21. Epub 2015 Sep 7 doi: 10.1111/iju.12899. PMID: 26347163
Mavrogenis AF, Mimidis G, Kokkalis ZT, Karampi ES, Karampela I, Papagelopoulos PJ, Armaganidis A
Eur J Orthop Surg Traumatol 2014 Apr;24(3):279-83. Epub 2013 Sep 8 doi: 10.1007/s00590-013-1311-1. PMID: 24013815
Martel CL, Lara PN
Crit Rev Oncol Hematol 2003 Feb;45(2):177-90. doi: 10.1016/s1040-8428(02)00076-8. PMID: 12604128

Clinical prediction guides

Yan XQ, Ye MJ, Zou Q, Chen P, He ZS, Wu B, He DL, He CH, Xue XY, Ji ZG, Chen H, Zhang S, Liu YP, Zhang XD, Fu C, Xu DF, Qiu MX, Lv JJ, Huang J, Ren XB, Cheng Y, Qin WJ, Zhang X, Zhou FJ, Ma LL, Guo JM, Ding DG, Wei SZ, He Y, Guo HQ, Shi BK, Liu L, Liu F, Hu ZQ, Jin XM, Yang L, Zhu SX, Liu JH, Huang YH, Xu T, Liu B, Sun T, Wang ZJ, Jiang HW, Yu DX, Zhou AP, Jiang J, Luan GD, Jin CL, Xu J, Hu JX, Huang YR, Guo J, Zhai W, Sheng XN
Ann Oncol 2024 Feb;35(2):190-199. Epub 2023 Oct 21 doi: 10.1016/j.annonc.2023.09.3108. PMID: 37872020
Roy AM, Briggler A, Tippit D, Dawson K, Verma R
Clin Genitourin Cancer 2020 Dec;18(6):e688-e691. Epub 2020 Apr 21 doi: 10.1016/j.clgc.2020.04.003. PMID: 32660880
Suzuki K, Terakawa T, Furukawa J, Harada K, Hinata N, Nakano Y, Fujisawa M
J Immunother 2020 Jan;43(1):38-42. doi: 10.1097/CJI.0000000000000299. PMID: 31567704
Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485
Karakiewicz PI, Hutterer GC
Curr Opin Urol 2007 Sep;17(5):295-302. doi: 10.1097/MOU.0b013e3282a4a6b7. PMID: 17762620

Recent systematic reviews

Tsuboi I, Matsukawa A, Kardoust Parizi M, Miszczyk M, Fazekas T, Schulz RJ, Mancon S, Litterio G, Laukhtina E, Kawada T, Katayama S, Iwata T, Bekku K, Rajwa P, Wada K, Karakiewicz PI, Araki M, Shariat SF
Clin Genitourin Cancer 2024 Dec;22(6):102237. Epub 2024 Oct 17 doi: 10.1016/j.clgc.2024.102237. PMID: 39546952
Chen J, Ren JJ, Cai J, Wang X
Medicine (Baltimore) 2021 Aug 6;100(31):e26788. doi: 10.1097/MD.0000000000026788. PMID: 34397830Free PMC Article
Tanis PJ, van der Gaag NA, Busch OR, van Gulik TM, Gouma DJ
Br J Surg 2009 Jun;96(6):579-92. doi: 10.1002/bjs.6606. PMID: 19434703

Supplemental Content

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