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Recurrent Myelodysplastic/Myeloproliferative Neoplasm

MedGen UID:
1716734
Concept ID:
C5237729
Neoplastic Process

Definition

The reemergence of a myelodysplastic/myeloproliferative neoplasm after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Myelodysplastic/Myeloproliferative Neoplasm

Recent clinical studies

Etiology

Li P, Brown S, Williams M, White T, Xie W, Cui W, Peker D, Lei L, Kunder CA, Wang HY, Murray SS, Vagher J, Kovacsovics T, Patel JL
Blood 2022 Aug 18;140(7):716-755. doi: 10.1182/blood.2021015135. PMID: 35671390Free PMC Article
Binder M, Carr RM, Lasho TL, Finke CM, Mangaonkar AA, Pin CL, Berger KR, Mazzone A, Potluri S, Ordog T, Robertson KD, Marks DL, Fernandez-Zapico ME, Gaspar-Maia A, Patnaik MM
Nat Commun 2022 Mar 17;13(1):1434. doi: 10.1038/s41467-022-29142-6. PMID: 35301312Free PMC Article
Molony P, Smith AC, Selvarajah S, Sakhdari A
Cytogenet Genome Res 2021;161(12):564-568. Epub 2022 Jan 17 doi: 10.1159/000521509. PMID: 35038703Free PMC Article
Fluhr S, Boerries M, Busch H, Symeonidi A, Witte T, Lipka DB, Mücke O, Nöllke P, Krombholz CF, Niemeyer CM, Plass C, Flotho C
Clin Epigenetics 2016;8:50. Epub 2016 May 5 doi: 10.1186/s13148-016-0216-3. PMID: 27158276Free PMC Article
Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen S, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH Jr, Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber T, Golub T, Stegmaier K, Loh ML
Nat Genet 2015 Nov;47(11):1326-1333. Epub 2015 Oct 12 doi: 10.1038/ng.3400. PMID: 26457647Free PMC Article

Diagnosis

Solary E, Wagner-Ballon O, Selimoglu-Buet D
Best Pract Res Clin Haematol 2020 Jun;33(2):101134. Epub 2019 Dec 7 doi: 10.1016/j.beha.2019.101134. PMID: 32460985
Wall M
Methods Mol Biol 2017;1541:209-222. doi: 10.1007/978-1-4939-6703-2_18. PMID: 27910026
Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen S, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH Jr, Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber T, Golub T, Stegmaier K, Loh ML
Nat Genet 2015 Nov;47(11):1326-1333. Epub 2015 Oct 12 doi: 10.1038/ng.3400. PMID: 26457647Free PMC Article
Falchi L, Verstovsek S
Immunol Allergy Clin North Am 2015 Aug;35(3):439-52. doi: 10.1016/j.iac.2015.04.004. PMID: 26209894Free PMC Article
Itzykson R, Fenaux P, Solary E
Best Pract Res Clin Haematol 2013 Dec;26(4):387-400. Epub 2013 Oct 1 doi: 10.1016/j.beha.2013.09.006. PMID: 24507815

Therapy

Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Falchi L, Verstovsek S
Immunol Allergy Clin North Am 2015 Aug;35(3):439-52. doi: 10.1016/j.iac.2015.04.004. PMID: 26209894Free PMC Article
Locatelli F, Niemeyer CM
Blood 2015 Feb 12;125(7):1083-90. Epub 2015 Jan 6 doi: 10.1182/blood-2014-08-550483. PMID: 25564399
Stieglitz E, Troup CB, Gelston LC, Haliburton J, Chow ED, Yu KB, Akutagawa J, Taylor-Weiner AN, Liu YL, Wang YD, Beckman K, Emanuel PD, Braun BS, Abate A, Gerbing RB, Alonzo TA, Loh ML
Blood 2015 Jan 15;125(3):516-24. Epub 2014 Nov 13 doi: 10.1182/blood-2014-09-601690. PMID: 25395418Free PMC Article
Itzykson R, Fenaux P, Solary E
Best Pract Res Clin Haematol 2013 Dec;26(4):387-400. Epub 2013 Oct 1 doi: 10.1016/j.beha.2013.09.006. PMID: 24507815

Prognosis

Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Palomo L, Meggendorfer M, Hutter S, Twardziok S, Ademà V, Fuhrmann I, Fuster-Tormo F, Xicoy B, Zamora L, Acha P, Kerr CM, Kern W, Maciejewski JP, Solé F, Haferlach C, Haferlach T
Blood 2020 Oct 15;136(16):1851-1862. doi: 10.1182/blood.2019004229. PMID: 32573691Free PMC Article
Wall M
Methods Mol Biol 2017;1541:209-222. doi: 10.1007/978-1-4939-6703-2_18. PMID: 27910026
Itzykson R, Fenaux P, Solary E
Best Pract Res Clin Haematol 2013 Dec;26(4):387-400. Epub 2013 Oct 1 doi: 10.1016/j.beha.2013.09.006. PMID: 24507815
Huret JL
Hum Genet 1990 Oct;85(6):565-8. doi: 10.1007/BF00193575. PMID: 2227945

Clinical prediction guides

Falantes JF, Márquez-Malaver FJ, Carrillo E, Culebras MG, Morales R, Prats C, Vargas MT, Caballero T, Rodríguez-Arbolí E, Espigado I, Pérez-Simón JA
Clin Lymphoma Myeloma Leuk 2022 Dec;22(12):e1059-e1066. Epub 2022 Aug 27 doi: 10.1016/j.clml.2022.08.012. PMID: 36117041
Palomo L, Meggendorfer M, Hutter S, Twardziok S, Ademà V, Fuhrmann I, Fuster-Tormo F, Xicoy B, Zamora L, Acha P, Kerr CM, Kern W, Maciejewski JP, Solé F, Haferlach C, Haferlach T
Blood 2020 Oct 15;136(16):1851-1862. doi: 10.1182/blood.2019004229. PMID: 32573691Free PMC Article
Fluhr S, Boerries M, Busch H, Symeonidi A, Witte T, Lipka DB, Mücke O, Nöllke P, Krombholz CF, Niemeyer CM, Plass C, Flotho C
Clin Epigenetics 2016;8:50. Epub 2016 May 5 doi: 10.1186/s13148-016-0216-3. PMID: 27158276Free PMC Article
Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen S, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH Jr, Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber T, Golub T, Stegmaier K, Loh ML
Nat Genet 2015 Nov;47(11):1326-1333. Epub 2015 Oct 12 doi: 10.1038/ng.3400. PMID: 26457647Free PMC Article
Itzykson R, Fenaux P, Solary E
Best Pract Res Clin Haematol 2013 Dec;26(4):387-400. Epub 2013 Oct 1 doi: 10.1016/j.beha.2013.09.006. PMID: 24507815

Recent systematic reviews

Shao H, Cen J, Chen S, Qiu H, Pan J
Ann Hematol 2018 Mar;97(3):417-424. Epub 2017 Dec 22 doi: 10.1007/s00277-017-3208-2. PMID: 29273914

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