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Myelodysplastic/myeloproliferative neoplasm

MedGen UID:
226981
Concept ID:
C1301355
Neoplastic Process
Synonyms: Disease, Myelodysplastic-Myeloproliferative; Disease, Myeloproliferative-Myelodisplastic; Diseases, Myelodysplastic-Myeloproliferative; Diseases, Myeloproliferative-Myelodisplastic; Myelodysplastic Myeloproliferative Diseases; Myelodysplastic-Myeloproliferative Disease; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Myelodisplastic Diseases; Myeloproliferative-Myelodisplastic Disease; Myeloproliferative-Myelodisplastic Diseases
SNOMED CT: Myelodysplastic/myeloproliferative disease (397336008); Myelodysplastic/myeloproliferative disease (445738007); Myelodysplastic-myeloproliferative neoplasm (397336008)
 
Monarch Initiative: MONDO:0006311

Definition

A category of clonal hematopoietic disorders that have both myelodysplastic and myeloproliferative features at the time of initial presentation. [from NCI]

Professional guidelines

PubMed

Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article
Parikh SA, Tefferi A
Am J Hematol 2013 Nov;88(11):967-74. doi: 10.1002/ajh.23574. PMID: 23963888

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myeloproliferative Neoplasms, 2023

Recent clinical studies

Etiology

Sanber K, Ye K, Tsai HL, Newman M, Webster JA, Gojo I, Ghiaur G, Prince GT, Gondek LP, Smith BD, Levis MJ, DeZern AE, Ambinder AJ, Dalton WB, Jain T
Leuk Lymphoma 2023 Apr;64(4):846-855. Epub 2023 Feb 6 doi: 10.1080/10428194.2023.2173523. PMID: 36744656
Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Prakash S, Arber DA, Bueso-Ramos C, Hasserjian RP, Orazi A
Virchows Arch 2023 Jan;482(1):69-83. Epub 2022 Dec 5 doi: 10.1007/s00428-022-03465-7. PMID: 36469102
Molony P, Smith AC, Selvarajah S, Sakhdari A
Cytogenet Genome Res 2021;161(12):564-568. Epub 2022 Jan 17 doi: 10.1159/000521509. PMID: 35038703Free PMC Article
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article

Diagnosis

Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Prakash S, Arber DA, Bueso-Ramos C, Hasserjian RP, Orazi A
Virchows Arch 2023 Jan;482(1):69-83. Epub 2022 Dec 5 doi: 10.1007/s00428-022-03465-7. PMID: 36469102
Forghieri F, Nasillo V, Paolini A, Bettelli F, Pioli V, Giusti D, Gilioli A, Colasante C, Acquaviva G, Riva G, Barozzi P, Maffei R, Potenza L, Marasca R, Fozza C, Tagliafico E, Trenti T, Comoli P, Longo G, Luppi M
Int J Mol Sci 2020 Nov 26;21(23) doi: 10.3390/ijms21238975. PMID: 33255988Free PMC Article
Cross NCP
Clin Lymphoma Myeloma Leuk 2020 Sep;20 Suppl 1:S101-S102. doi: 10.1016/S2152-2650(20)30477-8. PMID: 32862848
Venugopal S, Mascarenhas J
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):129-134. Epub 2018 Nov 29 doi: 10.1016/j.clml.2018.11.012. PMID: 30581159

Therapy

Sanber K, Ye K, Tsai HL, Newman M, Webster JA, Gojo I, Ghiaur G, Prince GT, Gondek LP, Smith BD, Levis MJ, DeZern AE, Ambinder AJ, Dalton WB, Jain T
Leuk Lymphoma 2023 Apr;64(4):846-855. Epub 2023 Feb 6 doi: 10.1080/10428194.2023.2173523. PMID: 36744656
Liu H, Bai H, Zhang S, Zhao X, Mao D, Xi R
Int J Hematol 2023 Jun;117(6):929-932. Epub 2023 Jan 24 doi: 10.1007/s12185-023-03531-z. PMID: 36694063
Andrade DC, Fatakhova M, Fatteh S, Rubio-Gomez H
J Oncol Pharm Pract 2021 Jun;27(4):1033-1036. Epub 2020 Sep 21 doi: 10.1177/1078155220959408. PMID: 32955996
Sahin I, Reagan JL, Niroula R, Sweeney JD
Transfusion 2018 Nov;58(11):2513-2516. Epub 2018 Sep 27 doi: 10.1111/trf.14876. PMID: 30260482
Bandyopadhyay D, Manna S, Hajra A, Bhattacharya TD
BMJ Case Rep 2015 Nov 12;2015 doi: 10.1136/bcr-2015-212821. PMID: 26564117Free PMC Article

Prognosis

Forghieri F, Nasillo V, Paolini A, Bettelli F, Pioli V, Giusti D, Gilioli A, Colasante C, Acquaviva G, Riva G, Barozzi P, Maffei R, Potenza L, Marasca R, Fozza C, Tagliafico E, Trenti T, Comoli P, Longo G, Luppi M
Int J Mol Sci 2020 Nov 26;21(23) doi: 10.3390/ijms21238975. PMID: 33255988Free PMC Article
Cross NCP
Clin Lymphoma Myeloma Leuk 2020 Sep;20 Suppl 1:S101-S102. doi: 10.1016/S2152-2650(20)30477-8. PMID: 32862848
Venugopal S, Mascarenhas J
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):129-134. Epub 2018 Nov 29 doi: 10.1016/j.clml.2018.11.012. PMID: 30581159
Sahin I, Reagan JL, Niroula R, Sweeney JD
Transfusion 2018 Nov;58(11):2513-2516. Epub 2018 Sep 27 doi: 10.1111/trf.14876. PMID: 30260482
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article

Clinical prediction guides

Lee MY, Jang S, Park CJ, Cho YU
Clin Lab 2022 Apr 1;68(4) doi: 10.7754/Clin.Lab.2021.210738. PMID: 35443589
Sangiorgio VFI, Orazi A, Arber DA
Best Pract Res Clin Haematol 2020 Jun;33(2):101139. Epub 2019 Dec 26 doi: 10.1016/j.beha.2019.101139. PMID: 32460987
Fang H, He R, Chiu A, Viswanatha DS, Ketterling RP, Patnaik MS, Reichard KK
Am J Clin Pathol 2020 Apr 15;153(5):656-663. doi: 10.1093/ajcp/aqz206. PMID: 31977035
Sahin I, Reagan JL, Niroula R, Sweeney JD
Transfusion 2018 Nov;58(11):2513-2516. Epub 2018 Sep 27 doi: 10.1111/trf.14876. PMID: 30260482
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article

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    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myeloproliferative Neoplasms, 2023

    Consumer resources

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