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Myelodysplastic/myeloproliferative neoplasm

MedGen UID:
226981
•Concept ID:
C1301355
•
Neoplastic Process
Synonyms: Disease, Myelodysplastic-Myeloproliferative; Disease, Myeloproliferative-Myelodisplastic; Diseases, Myelodysplastic-Myeloproliferative; Diseases, Myeloproliferative-Myelodisplastic; Myelodysplastic Myeloproliferative Diseases; Myelodysplastic-Myeloproliferative Disease; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Myelodisplastic Diseases; Myeloproliferative-Myelodisplastic Disease; Myeloproliferative-Myelodisplastic Diseases
SNOMED CT: Myelodysplastic/myeloproliferative disease (397336008); Myelodysplastic/myeloproliferative disease (445738007); Myelodysplastic-myeloproliferative neoplasm (397336008)
 
Monarch Initiative: MONDO:0006311

Definition

A category of clonal hematopoietic disorders that have both myelodysplastic and myeloproliferative features at the time of initial presentation. [from NCI]

Professional guidelines

PubMed

Atypical chronic myeloid leukemia and myelodysplastic/myeloproliferative neoplasm, not otherwise specified: 2023 update on diagnosis, risk stratification, and management.
Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia.
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article
Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management.
Parikh SA, Tefferi A
Am J Hematol 2013 Nov;88(11):967-74. doi: 10.1002/ajh.23574. PMID: 23963888

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myeloproliferative Neoplasms, 2023

Recent clinical studies

Therapy

Allogeneic Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia with a Busulfan, Fludarabine, and Melphalan Regimen: JPLSG JMML-11.
Sakashita K, Yoshida N, Muramatsu H, Ohtsuka Y, Watanabe K, Yabe M, Kakuda H, Honda Y, Watanabe T, Haba M, Ohmori S, Matsuda K, Yuza Y, Saito A, Horibe K, Adachi S, Manabe A
Transplant Cell Ther 2024 Jan;30(1):105.e1-105.e10. Epub 2023 Oct 7 doi: 10.1016/j.jtct.2023.10.002. PMID: 37806448
A novel subclonal rearrangement of the STRN3::PDGFRB gene in de novo acute myeloid leukemia with NPM1 mutation and its leukemogenic effects.
Wang Z, Liu T, Liu W, Gao X, Wan L, Qiu S, Song Y, Gu R, Tian Z, Wang M, Wang J, Mi Y, Wei S
Cancer Gene Ther 2023 Nov;30(11):1471-1484. Epub 2023 Aug 7 doi: 10.1038/s41417-023-00651-w. PMID: 37550570
A focused review of hematopoietic neoplasms occurring in the therapy-related setting.
Zhang L, Wang SA
Int J Clin Exp Pathol 2014;7(7):3512-23. Epub 2014 Jun 15 PMID: 25120730Free PMC Article
Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management.
Parikh SA, Tefferi A
Am J Hematol 2013 Nov;88(11):967-74. doi: 10.1002/ajh.23574. PMID: 23963888
Chronic myelomonocytic leukemia: 2012 update on diagnosis, risk stratification, and management.
Parikh SA, Tefferi A
Am J Hematol 2012 Jun;87(6):610-9. doi: 10.1002/ajh.23203. PMID: 22615103

Prognosis

Co-occurring mutations in ASXL1, SRSF2, and SETBP1 define a subset of myelodysplastic/ myeloproliferative neoplasm with neutrophilia.
Jain T, Ware AD, Dalton WB, Pasca S, Tsai HL, Gocke CD, Gondek LP, Xian RR, Borowitz MJ, Levis MJ
Leuk Res 2023 Aug;131:107345. Epub 2023 Jun 21 doi: 10.1016/j.leukres.2023.107345. PMID: 37354804
Molecular genetics of MDS/MPN overlap syndromes.
Hunter AM, Padron E
Best Pract Res Clin Haematol 2020 Sep;33(3):101195. Epub 2020 Jul 5 doi: 10.1016/j.beha.2020.101195. PMID: 33038984
Update on CML-Like Disorders.
Cross NCP
Clin Lymphoma Myeloma Leuk 2020 Sep;20 Suppl 1:S101-S102. doi: 10.1016/S2152-2650(20)30477-8. PMID: 32862848
Myelodysplastic/myeloproliferative neoplasms: are morphology and immunophenotyping still relevant?
Sangiorgio VFI, Orazi A, Arber DA
Best Pract Res Clin Haematol 2020 Jun;33(2):101139. Epub 2019 Dec 26 doi: 10.1016/j.beha.2019.101139. PMID: 32460987
Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia.
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article

Clinical prediction guides

Clinical Application for Diagnosis of Myelodysplatic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis.
Lee MY, Jang S, Park CJ, Cho YU
Clin Lab 2022 Apr 1;68(4) doi: 10.7754/Clin.Lab.2021.210738. PMID: 35443589
Genomic landscape of myelodysplastic/myeloproliferative neoplasm can predict response to hypomethylating agent therapy.
Karantanos T, Tsai HL, Gondek LP, DeZern AE, Ghiaur G, Dalton WB, Gojo I, Prince GT, Webster J, Ambinder A, Smith BD, Levis MJ, Varadhan R, Jones RJ, Jain T
Leuk Lymphoma 2022 Aug;63(8):1942-1948. Epub 2022 Apr 4 doi: 10.1080/10428194.2022.2057488. PMID: 35379077Free PMC Article
Myelodysplastic/myeloproliferative neoplasms: are morphology and immunophenotyping still relevant?
Sangiorgio VFI, Orazi A, Arber DA
Best Pract Res Clin Haematol 2020 Jun;33(2):101139. Epub 2019 Dec 26 doi: 10.1016/j.beha.2019.101139. PMID: 32460987
Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia.
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article
Acute Myeloid Leukemia With Myelodysplasia-Related Changes.
Vardiman J, Reichard K
Am J Clin Pathol 2015 Jul;144(1):29-43. doi: 10.1309/AJCP58RSMFRHLHHH. PMID: 26071460

Supplemental Content

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myeloproliferative Neoplasms, 2023

    Consumer resources

    Reviews

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