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Myelodysplastic/myeloproliferative neoplasm

MedGen UID:
226981
•Concept ID:
C1301355
•
Neoplastic Process
Synonyms: Disease, Myelodysplastic-Myeloproliferative; Disease, Myeloproliferative-Myelodisplastic; Diseases, Myelodysplastic-Myeloproliferative; Diseases, Myeloproliferative-Myelodisplastic; Myelodysplastic Myeloproliferative Diseases; Myelodysplastic-Myeloproliferative Disease; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Myelodisplastic Diseases; Myeloproliferative-Myelodisplastic Disease; Myeloproliferative-Myelodisplastic Diseases
SNOMED CT: Myelodysplastic/myeloproliferative disease (397336008); Myelodysplastic/myeloproliferative disease (445738007); Myelodysplastic-myeloproliferative neoplasm (397336008)
 
Monarch Initiative: MONDO:0006311

Definition

A category of clonal hematopoietic disorders that have both myelodysplastic and myeloproliferative features at the time of initial presentation. [from NCI]

Professional guidelines

PubMed

Atypical chronic myeloid leukemia and myelodysplastic/myeloproliferative neoplasm, not otherwise specified: 2023 update on diagnosis, risk stratification, and management.
Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management.
Parikh SA, Tefferi A
Am J Hematol 2013 Nov;88(11):967-74. doi: 10.1002/ajh.23574. PMID: 23963888
Chronic myelomonocytic leukemia: 2012 update on diagnosis, risk stratification, and management.
Parikh SA, Tefferi A
Am J Hematol 2012 Jun;87(6):610-9. doi: 10.1002/ajh.23203. PMID: 22615103

Recent clinical studies

Etiology

Clinical characteristics of Japanese patients with myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis.
Edahiro Y, Ochiai T, Hashimoto Y, Morishita S, Shirane S, Inano T, Furuya C, Koike M, Noguchi M, Usuki K, Shiratsuchi M, Nakajima K, Ohtsuka E, Tanaka H, Kawata E, Nakamae M, Ueda Y, Aota Y, Sugita Y, Ohara S, Yamasaki S, Asagoe K, Yoshida S, Yamanouchi J, Suzuki S, Kondo T, Kanisawa Y, Toyama K, Omura H, Mizuchi D, Sakamaki S, Ando M, Komatsu N
Int J Hematol 2023 Jul;118(1):47-53. Epub 2023 Apr 14 doi: 10.1007/s12185-023-03592-0. PMID: 37058247
Atypical chronic myeloid leukemia and myelodysplastic/myeloproliferative neoplasm, not otherwise specified: 2023 update on diagnosis, risk stratification, and management.
Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Advances in myelodysplastic/myeloproliferative neoplasms.
Prakash S, Arber DA, Bueso-Ramos C, Hasserjian RP, Orazi A
Virchows Arch 2023 Jan;482(1):69-83. Epub 2022 Dec 5 doi: 10.1007/s00428-022-03465-7. PMID: 36469102
Molecular genetics of MDS/MPN overlap syndromes.
Hunter AM, Padron E
Best Pract Res Clin Haematol 2020 Sep;33(3):101195. Epub 2020 Jul 5 doi: 10.1016/j.beha.2020.101195. PMID: 33038984
Myelodysplastic/myeloproliferative neoplasms: are morphology and immunophenotyping still relevant?
Sangiorgio VFI, Orazi A, Arber DA
Best Pract Res Clin Haematol 2020 Jun;33(2):101139. Epub 2019 Dec 26 doi: 10.1016/j.beha.2019.101139. PMID: 32460987

Diagnosis

Genomics of myelodysplastic/myeloproliferative neoplasm.
Patwardhan PP, Aarabi M, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):195-201. Epub 2023 Apr 12 doi: 10.1053/j.semdp.2023.04.005. PMID: 37105794
Atypical chronic myeloid leukemia and myelodysplastic/myeloproliferative neoplasm, not otherwise specified: 2023 update on diagnosis, risk stratification, and management.
Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Advances in myelodysplastic/myeloproliferative neoplasms.
Prakash S, Arber DA, Bueso-Ramos C, Hasserjian RP, Orazi A
Virchows Arch 2023 Jan;482(1):69-83. Epub 2022 Dec 5 doi: 10.1007/s00428-022-03465-7. PMID: 36469102
Myelodysplastic/myeloproliferative neoplasms: are morphology and immunophenotyping still relevant?
Sangiorgio VFI, Orazi A, Arber DA
Best Pract Res Clin Haematol 2020 Jun;33(2):101139. Epub 2019 Dec 26 doi: 10.1016/j.beha.2019.101139. PMID: 32460987
Myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U): More than just a "catch-all" term?
Shallis RM, Zeidan AM
Best Pract Res Clin Haematol 2020 Jun;33(2):101132. Epub 2019 Dec 6 doi: 10.1016/j.beha.2019.101132. PMID: 32460977

Therapy

Venetoclax in combination with hypomethylating agent for the treatment of advanced myeloproliferative neoplasms and acute myeloid leukemia with extramedullary disease.
Sanber K, Ye K, Tsai HL, Newman M, Webster JA, Gojo I, Ghiaur G, Prince GT, Gondek LP, Smith BD, Levis MJ, DeZern AE, Ambinder AJ, Dalton WB, Jain T
Leuk Lymphoma 2023 Apr;64(4):846-855. Epub 2023 Feb 6 doi: 10.1080/10428194.2023.2173523. PMID: 36744656
A focused review of hematopoietic neoplasms occurring in the therapy-related setting.
Zhang L, Wang SA
Int J Clin Exp Pathol 2014;7(7):3512-23. Epub 2014 Jun 15 PMID: 25120730Free PMC Article
Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management.
Parikh SA, Tefferi A
Am J Hematol 2013 Nov;88(11):967-74. doi: 10.1002/ajh.23574. PMID: 23963888
Chronic myelomonocytic leukemia: 2012 update on diagnosis, risk stratification, and management.
Parikh SA, Tefferi A
Am J Hematol 2012 Jun;87(6):610-9. doi: 10.1002/ajh.23203. PMID: 22615103
Therapy-related myeloid neoplasms following treatment with radioiodine.
Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article

Prognosis

Co-occurring mutations in ASXL1, SRSF2, and SETBP1 define a subset of myelodysplastic/ myeloproliferative neoplasm with neutrophilia.
Jain T, Ware AD, Dalton WB, Pasca S, Tsai HL, Gocke CD, Gondek LP, Xian RR, Borowitz MJ, Levis MJ
Leuk Res 2023 Aug;131:107345. Epub 2023 Jun 21 doi: 10.1016/j.leukres.2023.107345. PMID: 37354804
Molecular genetics of MDS/MPN overlap syndromes.
Hunter AM, Padron E
Best Pract Res Clin Haematol 2020 Sep;33(3):101195. Epub 2020 Jul 5 doi: 10.1016/j.beha.2020.101195. PMID: 33038984
Myelodysplastic/myeloproliferative neoplasms: are morphology and immunophenotyping still relevant?
Sangiorgio VFI, Orazi A, Arber DA
Best Pract Res Clin Haematol 2020 Jun;33(2):101139. Epub 2019 Dec 26 doi: 10.1016/j.beha.2019.101139. PMID: 32460987
Chronic Neutrophilic Leukemia: Current and Future Perspectives.
Venugopal S, Mascarenhas J
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):129-134. Epub 2018 Nov 29 doi: 10.1016/j.clml.2018.11.012. PMID: 30581159
I walk the other line: myelodysplastic/myeloproliferative neoplasm overlap syndromes.
Gerds AT
Curr Hematol Malig Rep 2014 Dec;9(4):400-6. doi: 10.1007/s11899-014-0233-2. PMID: 25195196

Clinical prediction guides

Clinical Application for Diagnosis of Myelodysplatic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis.
Lee MY, Jang S, Park CJ, Cho YU
Clin Lab 2022 Apr 1;68(4) doi: 10.7754/Clin.Lab.2021.210738. PMID: 35443589
Genomic landscape of myelodysplastic/myeloproliferative neoplasm can predict response to hypomethylating agent therapy.
Karantanos T, Tsai HL, Gondek LP, DeZern AE, Ghiaur G, Dalton WB, Gojo I, Prince GT, Webster J, Ambinder A, Smith BD, Levis MJ, Varadhan R, Jones RJ, Jain T
Leuk Lymphoma 2022 Aug;63(8):1942-1948. Epub 2022 Apr 4 doi: 10.1080/10428194.2022.2057488. PMID: 35379077Free PMC Article
The utility of a myeloid mutation panel for the diagnosis of myelodysplastic syndrome and myelodysplastic/myeloproliferative neoplasm.
Ibrar W, Zhang W, Cox JL, Cushman-Vokoun A, Fu K, Greiner TC, Yuan J
Int J Lab Hematol 2021 Dec;43(6):1501-1509. Epub 2021 Jul 16 doi: 10.1111/ijlh.13659. PMID: 34270867
Myelodysplastic/myeloproliferative neoplasms: are morphology and immunophenotyping still relevant?
Sangiorgio VFI, Orazi A, Arber DA
Best Pract Res Clin Haematol 2020 Jun;33(2):101139. Epub 2019 Dec 26 doi: 10.1016/j.beha.2019.101139. PMID: 32460987
Acute Myeloid Leukemia With Myelodysplasia-Related Changes.
Vardiman J, Reichard K
Am J Clin Pathol 2015 Jul;144(1):29-43. doi: 10.1309/AJCP58RSMFRHLHHH. PMID: 26071460

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