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Locally Advanced Malignant Peripheral Nerve Sheath Tumor

MedGen UID:
1717356
•Concept ID:
C5235947
•
Neoplastic Process

Definition

A malignant peripheral nerve sheath tumor that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Malignant Peripheral Nerve Sheath Tumor

Professional guidelines

PubMed

Chemotherapy for the treatment of malignant peripheral nerve sheath tumors in neurofibromatosis 1: a 10-year institutional review.
Zehou O, Fabre E, Zelek L, Sbidian E, Ortonne N, Banu E, Wolkenstein P, Valeyrie-Allanore L
Orphanet J Rare Dis 2013 Aug 23;8:127. doi: 10.1186/1750-1172-8-127. PMID: 23972085Free PMC Article
Malignant Peripheral Nerve Sheath Tumor: molecular pathogenesis and current management considerations.
Grobmyer SR, Reith JD, Shahlaee A, Bush CH, Hochwald SN
J Surg Oncol 2008 Mar 15;97(4):340-9. doi: 10.1002/jso.20971. PMID: 18286466
Malignant peripheral nerve sheath tumors of the head and neck: management of 10 cases and literature review.
Minovi A, Basten O, Hunter B, Draf W, Bockmühl U
Head Neck 2007 May;29(5):439-45. doi: 10.1002/hed.20537. PMID: 17163467

Recent clinical studies

Etiology

Predictors of lung recurrence and disease-specific mortality after pulmonary metastasectomy for soft tissue sarcoma.
Tetta C, Rocca M, Salone M, Longhi A, Ferrari C, Londero F, Parise G, Parise O, Giugliano A, Maessen JG, La Meir M, Gelsomino S
Surg Oncol 2021 Jun;37:101532. Epub 2021 Feb 20 doi: 10.1016/j.suronc.2021.101532. PMID: 33639455
Diagnostic Accuracy of PET/CT-Guided Percutaneous Biopsies for Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1 Patients.
Brahmi M, Thiesse P, Ranchere D, Mognetti T, Pinson S, Renard C, Decouvelaere AV, Blay JY, Combemale P
PLoS One 2015;10(10):e0138386. Epub 2015 Oct 7 doi: 10.1371/journal.pone.0138386. PMID: 26445379Free PMC Article
Chemotherapy for the treatment of malignant peripheral nerve sheath tumors in neurofibromatosis 1: a 10-year institutional review.
Zehou O, Fabre E, Zelek L, Sbidian E, Ortonne N, Banu E, Wolkenstein P, Valeyrie-Allanore L
Orphanet J Rare Dis 2013 Aug 23;8:127. doi: 10.1186/1750-1172-8-127. PMID: 23972085Free PMC Article
Peripheral tumor and tumor-like neurogenic lesions.
Abreu E, Aubert S, Wavreille G, Gheno R, Canella C, Cotten A
Eur J Radiol 2013 Jan;82(1):38-50. Epub 2011 May 10 doi: 10.1016/j.ejrad.2011.04.036. PMID: 21561733
Malignant peripheral nerve sheath tumors of the head and neck: management of 10 cases and literature review.
Minovi A, Basten O, Hunter B, Draf W, Bockmühl U
Head Neck 2007 May;29(5):439-45. doi: 10.1002/hed.20537. PMID: 17163467

Diagnosis

Malignant Peripheral Nerve Sheath Tumor, a Heterogeneous, Aggressive Cancer with Diverse Biomarkers and No Targeted Standard of Care: Review of the Literature and Ongoing Investigational Agents.
Somaiah N, Paudyal B, Winkler RE, Van Tine BA, Hirbe AC
Target Oncol 2024 Sep;19(5):665-678. Epub 2024 Jul 2 doi: 10.1007/s11523-024-01078-5. PMID: 38954182Free PMC Article
Ultrasound and MR imaging of peripheral nerve tumors: the state of the art.
Lefebvre G, Le Corroller T
Skeletal Radiol 2023 Mar;52(3):405-419. Epub 2022 Jun 17 doi: 10.1007/s00256-022-04087-5. PMID: 35713690
Systemic Options for Malignant Peripheral Nerve Sheath Tumors.
Hassan A, Pestana RC, Parkes A
Curr Treat Options Oncol 2021 Feb 27;22(4):33. doi: 10.1007/s11864-021-00830-7. PMID: 33641042
Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Peripheral tumor and tumor-like neurogenic lesions.
Abreu E, Aubert S, Wavreille G, Gheno R, Canella C, Cotten A
Eur J Radiol 2013 Jan;82(1):38-50. Epub 2011 May 10 doi: 10.1016/j.ejrad.2011.04.036. PMID: 21561733

Therapy

Predictors of lung recurrence and disease-specific mortality after pulmonary metastasectomy for soft tissue sarcoma.
Tetta C, Rocca M, Salone M, Longhi A, Ferrari C, Londero F, Parise G, Parise O, Giugliano A, Maessen JG, La Meir M, Gelsomino S
Surg Oncol 2021 Jun;37:101532. Epub 2021 Feb 20 doi: 10.1016/j.suronc.2021.101532. PMID: 33639455
A novel TJP1-ROS1 fusion in malignant peripheral nerve sheath tumor responding to crizotinib: A case report.
Li J, Liu L, Zhang Q, Huang Y, Zhang Y, Gan X, Liu S, Yue Z, Wei Y
Medicine (Baltimore) 2020 Jun 26;99(26):e20725. doi: 10.1097/MD.0000000000020725. PMID: 32590748Free PMC Article
Diagnostic Accuracy of PET/CT-Guided Percutaneous Biopsies for Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1 Patients.
Brahmi M, Thiesse P, Ranchere D, Mognetti T, Pinson S, Renard C, Decouvelaere AV, Blay JY, Combemale P
PLoS One 2015;10(10):e0138386. Epub 2015 Oct 7 doi: 10.1371/journal.pone.0138386. PMID: 26445379Free PMC Article
Salvage surgical resection after high-dose ifosfamide (HDIF) based regimens in advanced soft tissue sarcoma (ASTS): a potential positive selection bias--a study of the Spanish group for research on sarcomas (GEIS).
Maurel J, Buesa J, López-Pousa A, del Muro XG, Quintana MJ, Martín J, Casado A, Martínez-Trufero J, de Las Peñas R, Balañá C
J Surg Oncol 2004 Oct 1;88(1):44-9. doi: 10.1002/jso.20131. PMID: 15384088
Intraoperative electron irradiation in the management of pediatric malignancies.
Schomberg PJ, Gunderson LL, Moir CR, Gilchrist GS, Smithson WA
Cancer 1997 Jun 1;79(11):2251-6. PMID: 9179074

Prognosis

Systemic Options for Malignant Peripheral Nerve Sheath Tumors.
Hassan A, Pestana RC, Parkes A
Curr Treat Options Oncol 2021 Feb 27;22(4):33. doi: 10.1007/s11864-021-00830-7. PMID: 33641042
Predictors of lung recurrence and disease-specific mortality after pulmonary metastasectomy for soft tissue sarcoma.
Tetta C, Rocca M, Salone M, Longhi A, Ferrari C, Londero F, Parise G, Parise O, Giugliano A, Maessen JG, La Meir M, Gelsomino S
Surg Oncol 2021 Jun;37:101532. Epub 2021 Feb 20 doi: 10.1016/j.suronc.2021.101532. PMID: 33639455
Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Malignant Peripheral Nerve Sheath Tumor: molecular pathogenesis and current management considerations.
Grobmyer SR, Reith JD, Shahlaee A, Bush CH, Hochwald SN
J Surg Oncol 2008 Mar 15;97(4):340-9. doi: 10.1002/jso.20971. PMID: 18286466
Malignant peripheral nerve sheath tumors of the head and neck: management of 10 cases and literature review.
Minovi A, Basten O, Hunter B, Draf W, Bockmühl U
Head Neck 2007 May;29(5):439-45. doi: 10.1002/hed.20537. PMID: 17163467

Clinical prediction guides

Malignant Peripheral Nerve Sheath Tumor, a Heterogeneous, Aggressive Cancer with Diverse Biomarkers and No Targeted Standard of Care: Review of the Literature and Ongoing Investigational Agents.
Somaiah N, Paudyal B, Winkler RE, Van Tine BA, Hirbe AC
Target Oncol 2024 Sep;19(5):665-678. Epub 2024 Jul 2 doi: 10.1007/s11523-024-01078-5. PMID: 38954182Free PMC Article
Predictors of lung recurrence and disease-specific mortality after pulmonary metastasectomy for soft tissue sarcoma.
Tetta C, Rocca M, Salone M, Longhi A, Ferrari C, Londero F, Parise G, Parise O, Giugliano A, Maessen JG, La Meir M, Gelsomino S
Surg Oncol 2021 Jun;37:101532. Epub 2021 Feb 20 doi: 10.1016/j.suronc.2021.101532. PMID: 33639455
Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Diagnostic Accuracy of PET/CT-Guided Percutaneous Biopsies for Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1 Patients.
Brahmi M, Thiesse P, Ranchere D, Mognetti T, Pinson S, Renard C, Decouvelaere AV, Blay JY, Combemale P
PLoS One 2015;10(10):e0138386. Epub 2015 Oct 7 doi: 10.1371/journal.pone.0138386. PMID: 26445379Free PMC Article
Peripheral tumor and tumor-like neurogenic lesions.
Abreu E, Aubert S, Wavreille G, Gheno R, Canella C, Cotten A
Eur J Radiol 2013 Jan;82(1):38-50. Epub 2011 May 10 doi: 10.1016/j.ejrad.2011.04.036. PMID: 21561733

Recent systematic reviews

Impact of CT and MRI in the diagnostic workup of malignant triton tumour-a monocentric analysis and review of the literature.
Drews MA, Milosevic A, Hamacher R, Grüneisen JS, Haubold J, Opitz MK, Bauer S, Umutlu L, Forsting M, Schaarschmidt BM
Br J Radiol 2024 Feb 2;97(1154):430-438. doi: 10.1093/bjr/tqad035. PMID: 38308031

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