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Metastatic Carcinosarcoma

MedGen UID:
1736034
•Concept ID:
C5418878
•
Neoplastic Process

Definition

Carcinosarcoma that has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Role of chemotherapy and biomolecular therapy in the treatment of uterine sarcomas.
Hensley ML
Best Pract Res Clin Obstet Gynaecol 2011 Dec;25(6):773-82. Epub 2011 Jul 14 doi: 10.1016/j.bpobgyn.2011.06.003. PMID: 21752717

Recent clinical studies

Etiology

Role of chemotherapy and biomolecular therapy in the treatment of uterine sarcomas.
Hensley ML
Best Pract Res Clin Obstet Gynaecol 2011 Dec;25(6):773-82. Epub 2011 Jul 14 doi: 10.1016/j.bpobgyn.2011.06.003. PMID: 21752717
Progression of aggressive metastatic carcinosarcoma after treatment of epithelioid osteosarcoma.
Amanatullah DF, Ngann KK, Borys D, Tamurian RM
Orthopedics 2010 Jun 9;33(6):445. doi: 10.3928/01477447-20100429-26. PMID: 20806764
Cisplatin, doxorubicin and ifosfamide in carcinosarcoma of the female genital tract. A phase II study of the European Organization for Research and Treatment of Cancer Gynaecological Cancer Group (EORTC 55923).
van Rijswijk RE, Vermorken JB, Reed N, Favalli G, Mendiola C, Zanaboni F, Mangili G, Vergote I, Guastalla JP, ten Bokkel Huinink WW, Lacave AJ, Bonnefoi H, Tumulo S, Rietbroek R, Teodorovic I, Coens C, Pecorelli S
Eur J Cancer 2003 Mar;39(4):481-7. doi: 10.1016/s0959-8049(02)00740-2. PMID: 12751379

Diagnosis

Morphological and Immunohistochemical Characterization of an Oral Metastatic Carcinosarcoma in a Cat.
Malatesta D, Defourny SVP, Di Teodoro G, Seca F, Guardiani P, Martino M, D'Alterio N, Petrini A
J Comp Pathol 2022 Nov;199:17-22. Epub 2022 Oct 18 doi: 10.1016/j.jcpa.2022.09.001. PMID: 36265216
Metastatic esophageal carcinosarcoma comprising neuroendocrine carcinoma, squamous cell carcinoma, and sarcoma: A case report.
Tsuchihashi K, Arita S, Fujiwara M, Iwasaki K, Hirano A, Yoshihiro T, Nio K, Koga Y, Esaki M, Ariyama H, Kusaba H, Moriyama T, Ohuchida K, Nagai E, Nakamura M, Oda Y, Akashi K, Baba E
Medicine (Baltimore) 2018 Oct;97(41):e12796. doi: 10.1097/MD.0000000000012796. PMID: 30313107Free PMC Article
Role of chemotherapy and biomolecular therapy in the treatment of uterine sarcomas.
Hensley ML
Best Pract Res Clin Obstet Gynaecol 2011 Dec;25(6):773-82. Epub 2011 Jul 14 doi: 10.1016/j.bpobgyn.2011.06.003. PMID: 21752717
Progression of aggressive metastatic carcinosarcoma after treatment of epithelioid osteosarcoma.
Amanatullah DF, Ngann KK, Borys D, Tamurian RM
Orthopedics 2010 Jun 9;33(6):445. doi: 10.3928/01477447-20100429-26. PMID: 20806764
Clitoromegaly caused by metastatic carcinosarcoma of the urinary bladder.
Langenstroer P, Romanas M, Damjanov I
Arch Pathol Lab Med 2003 Apr;127(4):505. doi: 10.5858/2003-127-0505-CCBMCO. PMID: 12683889

Therapy

Metastatic esophageal carcinosarcoma comprising neuroendocrine carcinoma, squamous cell carcinoma, and sarcoma: A case report.
Tsuchihashi K, Arita S, Fujiwara M, Iwasaki K, Hirano A, Yoshihiro T, Nio K, Koga Y, Esaki M, Ariyama H, Kusaba H, Moriyama T, Ohuchida K, Nagai E, Nakamura M, Oda Y, Akashi K, Baba E
Medicine (Baltimore) 2018 Oct;97(41):e12796. doi: 10.1097/MD.0000000000012796. PMID: 30313107Free PMC Article
An uncommon response to metronomic therapy in a heavily pretreated patient with metastatic carcinosarcoma: a case report.
Gagliato Dde M, Linck RD, Bezerra RO, Souto M, Lopes GL, Baiocchi G, Mano MS
J Med Case Rep 2016 Mar 14;10:60. doi: 10.1186/s13256-016-0837-3. PMID: 26971567Free PMC Article
Role of chemotherapy and biomolecular therapy in the treatment of uterine sarcomas.
Hensley ML
Best Pract Res Clin Obstet Gynaecol 2011 Dec;25(6):773-82. Epub 2011 Jul 14 doi: 10.1016/j.bpobgyn.2011.06.003. PMID: 21752717
Diagnosis of carcinosarcoma metastatic to the umbilicus by fine needle aspiration biopsy: a case report.
Barboza-Quintana O, Alvarado-Bernal YL, Flores-Gutiérrez JP, Ancer-Rodríguez J, Garza-Guajardo R
Acta Cytol 2010 Sep-Oct;54(5 Suppl):819-22. PMID: 21053548
Progression of aggressive metastatic carcinosarcoma after treatment of epithelioid osteosarcoma.
Amanatullah DF, Ngann KK, Borys D, Tamurian RM
Orthopedics 2010 Jun 9;33(6):445. doi: 10.3928/01477447-20100429-26. PMID: 20806764

Prognosis

Morphological and Immunohistochemical Characterization of an Oral Metastatic Carcinosarcoma in a Cat.
Malatesta D, Defourny SVP, Di Teodoro G, Seca F, Guardiani P, Martino M, D'Alterio N, Petrini A
J Comp Pathol 2022 Nov;199:17-22. Epub 2022 Oct 18 doi: 10.1016/j.jcpa.2022.09.001. PMID: 36265216
Pulmonary carcinosarcoma with an aggressive heterologous angiosarcoma component: A case report.
Keow JY, Inculet RI, Hammond R, Zeman-Pocrnich C
Indian J Pathol Microbiol 2022 Jan-Mar;65(1):145-148. doi: 10.4103/IJPM.IJPM_1451_20. PMID: 35074981
Metastatic esophageal carcinosarcoma comprising neuroendocrine carcinoma, squamous cell carcinoma, and sarcoma: A case report.
Tsuchihashi K, Arita S, Fujiwara M, Iwasaki K, Hirano A, Yoshihiro T, Nio K, Koga Y, Esaki M, Ariyama H, Kusaba H, Moriyama T, Ohuchida K, Nagai E, Nakamura M, Oda Y, Akashi K, Baba E
Medicine (Baltimore) 2018 Oct;97(41):e12796. doi: 10.1097/MD.0000000000012796. PMID: 30313107Free PMC Article
Diagnosis of carcinosarcoma metastatic to the umbilicus by fine needle aspiration biopsy: a case report.
Barboza-Quintana O, Alvarado-Bernal YL, Flores-Gutiérrez JP, Ancer-Rodríguez J, Garza-Guajardo R
Acta Cytol 2010 Sep-Oct;54(5 Suppl):819-22. PMID: 21053548
Metastatic cutaneous carcinosarcoma to the tongue.
Tanaka N, Hidaka S, Yamamura M, Ohyama H, Urade M
Int J Oral Maxillofac Surg 2010 Oct;39(10):1033-6. Epub 2010 Jun 1 doi: 10.1016/j.ijom.2010.04.041. PMID: 20570108

Clinical prediction guides

Metastatic esophageal carcinosarcoma comprising neuroendocrine carcinoma, squamous cell carcinoma, and sarcoma: A case report.
Tsuchihashi K, Arita S, Fujiwara M, Iwasaki K, Hirano A, Yoshihiro T, Nio K, Koga Y, Esaki M, Ariyama H, Kusaba H, Moriyama T, Ohuchida K, Nagai E, Nakamura M, Oda Y, Akashi K, Baba E
Medicine (Baltimore) 2018 Oct;97(41):e12796. doi: 10.1097/MD.0000000000012796. PMID: 30313107Free PMC Article
Cisplatin, doxorubicin and ifosfamide in carcinosarcoma of the female genital tract. A phase II study of the European Organization for Research and Treatment of Cancer Gynaecological Cancer Group (EORTC 55923).
van Rijswijk RE, Vermorken JB, Reed N, Favalli G, Mendiola C, Zanaboni F, Mangili G, Vergote I, Guastalla JP, ten Bokkel Huinink WW, Lacave AJ, Bonnefoi H, Tumulo S, Rietbroek R, Teodorovic I, Coens C, Pecorelli S
Eur J Cancer 2003 Mar;39(4):481-7. doi: 10.1016/s0959-8049(02)00740-2. PMID: 12751379

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