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Carcinosarcoma

MedGen UID:
2876
•Concept ID:
C0007140
•
Neoplastic Process
Synonym: Carcinosarcomas
SNOMED CT: Carcinosarcoma (63264007)
 
Monarch Initiative: MONDO:0002928

Definition

A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. [from NCI]

Professional guidelines

PubMed

Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231

Recent clinical studies

Etiology

Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Systemic therapy for non-serous ovarian carcinoma.
Chávarri-Guerra Y, González-Ochoa E, De-la-Mora-Molina H, Soto-Perez-de-Celis E
Chin Clin Oncol 2020 Aug;9(4):52. Epub 2020 Jul 28 doi: 10.21037/cco-20-36. PMID: 32787339
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA
J Natl Cancer Inst 2019 Jan 1;111(1):60-68. doi: 10.1093/jnci/djy071. PMID: 29718305Free PMC Article
Sinonasal teratocarcinosarcoma.
Su YY, Friedman M, Huang CC, Wilson M, Lin HC
Am J Otolaryngol 2010 Jul-Aug;31(4):300-3. Epub 2009 May 19 doi: 10.1016/j.amjoto.2009.02.022. PMID: 20015764
Uterine sarcoma 2008.
Lin JF, Slomovitz BM
Curr Oncol Rep 2008 Nov;10(6):512-8. doi: 10.1007/s11912-008-0077-9. PMID: 18928666

Diagnosis

Uterine carcinosarcoma: An overview.
Pezzicoli G, Moscaritolo F, Silvestris E, Silvestris F, Cormio G, Porta C, D'Oronzo S
Crit Rev Oncol Hematol 2021 Jul;163:103369. Epub 2021 May 27 doi: 10.1016/j.critrevonc.2021.103369. PMID: 34051304
Gallbladder carcinosarcoma: current perspectives and new development.
Chen X, Zhou Y, Shu X, Wei G, Qiu M
Expert Rev Gastroenterol Hepatol 2021 Oct;15(10):1107-1114. Epub 2021 May 11 doi: 10.1080/17474124.2021.1919509. PMID: 33878994
Uterine carcinosarcoma: a primer for radiologists.
Ravishankar P, Smith DA, Avril S, Kikano E, Ramaiya NH
Abdom Radiol (NY) 2019 Aug;44(8):2874-2885. doi: 10.1007/s00261-019-02038-8. PMID: 31030248
Uterine carcinosarcoma.
Arend R, Doneza JA, Wright JD
Curr Opin Oncol 2011 Sep;23(5):531-6. doi: 10.1097/CCO.0b013e328349a45b. PMID: 21743326
Uterine carcinosarcoma.
El-Nashar SA, Mariani A
Clin Obstet Gynecol 2011 Jun;54(2):292-304. doi: 10.1097/GRF.0b013e31821ac635. PMID: 21508698

Therapy

Endometrial carcinosarcoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Caruso G, Enomoto T, Takehara K, Denys H, Lorusso D, Coleman R, Vaughan MM, Takano M, Provencher DM, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Kim JW, Candido Dos Reis FJ, Ramirez PT, Mariani A, Leitao M, Makker V, Abu-Rustum NR, Vergote I, Zannoni G, Tan D, McCormack M, Paolini B, Bini M, Raspagliesi F, Benedetti Panici P, Di Donato V, Muzii L, Colombo N, Pignata S, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Feb 6;33(2):147-174. doi: 10.1136/ijgc-2022-004073. PMID: 36585027
Randomized Phase III Trial of Paclitaxel and Carboplatin Versus Paclitaxel and Ifosfamide in Patients With Carcinosarcoma of the Uterus or Ovary: An NRG Oncology Trial.
Powell MA, Filiaci VL, Hensley ML, Huang HQ, Moore KN, Tewari KS, Copeland LJ, Secord AA, Mutch DG, Santin A, Warshal DP, Spirtos NM, DiSilvestro PA, Ioffe OB, Miller DS
J Clin Oncol 2022 Mar 20;40(9):968-977. Epub 2022 Jan 10 doi: 10.1200/JCO.21.02050. PMID: 35007153Free PMC Article
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465

Prognosis

Esophageal Carcinosarcoma: Analysis of Clinical Features and Prognosis of 24 Cases and a Literature Review.
Chen S, Shi Y, Lu Z, Wang M, Cong L, Yang B, Chen X, Cai J, Yang X
Cancer Control 2021 Jan-Dec;28:10732748211004886. doi: 10.1177/10732748211004886. PMID: 33998308Free PMC Article
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA
J Natl Cancer Inst 2019 Jan 1;111(1):60-68. doi: 10.1093/jnci/djy071. PMID: 29718305Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Lung carcinosarcoma.
Vidal Losada MJ, Bernal Monterde V, Amores Arriaga B, Ferrer Pérez AI, Serrano Solares S, Tobeña Puyal M
Clin Transl Oncol 2010 Apr;12(4):303-5. doi: 10.1007/s12094-010-0508-6. PMID: 20462841

Clinical prediction guides

Trastuzumab Deruxtecan for Human Epidermal Growth Factor Receptor 2-Expressing Advanced or Recurrent Uterine Carcinosarcoma (NCCH1615): The STATICE Trial.
Nishikawa T, Hasegawa K, Matsumoto K, Mori M, Hirashima Y, Takehara K, Ariyoshi K, Kato T, Yagishita S, Hamada A, Kawasaki M, Kawashima S, Tomatsuri S, Nagasaka Y, Yoshida H, Machida R, Hirakawa A, Nakamura K, Yonemori K
J Clin Oncol 2023 May 20;41(15):2789-2799. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02558. PMID: 36977309Free PMC Article
Epidemiology and prediction model of patients with carcinosarcoma in the United States.
Chen M, He X, Yang Q, Zhang J, Peng J, Wang D, Tong K, Huang W
Front Public Health 2022;10:1038211. Epub 2022 Nov 28 doi: 10.3389/fpubh.2022.1038211. PMID: 36518582Free PMC Article
High-grade endometrial carcinomas: Morphologic spectrum and molecular classification.
Zhang C, Zheng W
Semin Diagn Pathol 2022 May;39(3):176-186. Epub 2021 Nov 20 doi: 10.1053/j.semdp.2021.11.002. PMID: 34852949
Esophageal Carcinosarcoma: Analysis of Clinical Features and Prognosis of 24 Cases and a Literature Review.
Chen S, Shi Y, Lu Z, Wang M, Cong L, Yang B, Chen X, Cai J, Yang X
Cancer Control 2021 Jan-Dec;28:10732748211004886. doi: 10.1177/10732748211004886. PMID: 33998308Free PMC Article
Sarcomatoid Carcinoma of the Urinary Bladder.
Malla M, Wang JF, Trepeta R, Feng A, Wang J
Clin Genitourin Cancer 2016 Oct;14(5):366-372. Epub 2016 Mar 10 doi: 10.1016/j.clgc.2016.03.004. PMID: 27050715

Recent systematic reviews

Pancreatic carcinosarcoma: An orthogonal analysis.
Fleming AM, Hendrick LE, Glazer ES, Murphy AJ, Dickson PV, Shibata D, Yakoub D, Deneve JL
Surgery 2023 Oct;174(4):907-915. Epub 2023 Jul 29 doi: 10.1016/j.surg.2023.06.039. PMID: 37524640
Basal cell carcinosarcoma: a systematic review and reappraisal of its challenges and the role of Mohs surgery.
Born LJ, Khachemoune A
Arch Dermatol Res 2023 Oct;315(8):2195-2205. Epub 2023 Feb 15 doi: 10.1007/s00403-023-02551-3. PMID: 36790451
Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
Carcinosarcomas of the larynx: systematic review of the literature of a rare nosologic entity.
Colizza A, Gilardi A, Greco A, Cialente F, Zoccali F, Ralli M, Minni A, de Vincentiis M
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1167-1173. Epub 2021 Aug 5 doi: 10.1007/s00405-021-07027-6. PMID: 34351467Free PMC Article
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma.
Galaal K, van der Heijden E, Godfrey K, Naik R, Kucukmetin A, Bryant A, Das N, Lopes AD
Cochrane Database Syst Rev 2013 Feb 28;2013(2):CD006812. doi: 10.1002/14651858.CD006812.pub3. PMID: 23450572Free PMC Article

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