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Metastatic Platinum-Resistant Malignant Germ Cell Tumor

MedGen UID:
1736970
•Concept ID:
C5418902
•
Neoplastic Process

Definition

A platinum-resistant malignant germ cell tumor that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Platinum-Resistant Malignant Germ Cell Tumor

Professional guidelines

PubMed

Current Management of Refractory Germ Cell Tumors and Future Directions.
Allen JC, Kirschner A, Scarpato KR, Morgans AK
Curr Oncol Rep 2017 Feb;19(2):8. doi: 10.1007/s11912-017-0572-y. PMID: 28220447

Recent clinical studies

Etiology

Remission of refractory gestational trophoblastic disease in the brain with ifosfamide, carboplatin, and etoposide (ICE): first report and review of literature.
Piamsomboon S, Kudelka AP, Termrungruanglert W, Van Besien K, Edwards CL, Lifshitz S, Schomer DF, Champlin R, Mante RP, Kavanagh JJ, Verschraegen CF
Eur J Gynaecol Oncol 1997;18(6):453-6. PMID: 9443008

Diagnosis

Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.
Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, Sakai W, Karlan BY, Taniguchi T, Swisher EM
J Clin Oncol 2011 Aug 1;29(22):3008-15. Epub 2011 Jun 27 doi: 10.1200/JCO.2010.34.2980. PMID: 21709188Free PMC Article
Update on malignant ovarian germ cell tumors.
Gershenson DM
Cancer 1993 Feb 15;71(4 Suppl):1581-90. doi: 10.1002/cncr.2820710425. PMID: 8381708

Therapy

Therapeutic approaches for refractory germ cell cancer.
Oing C, Seidel C, Bokemeyer C
Expert Rev Anticancer Ther 2018 Apr;18(4):389-397. Epub 2018 Mar 12 doi: 10.1080/14737140.2018.1450630. PMID: 29516750
Current Management of Refractory Germ Cell Tumors and Future Directions.
Allen JC, Kirschner A, Scarpato KR, Morgans AK
Curr Oncol Rep 2017 Feb;19(2):8. doi: 10.1007/s11912-017-0572-y. PMID: 28220447
Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.
Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, Sakai W, Karlan BY, Taniguchi T, Swisher EM
J Clin Oncol 2011 Aug 1;29(22):3008-15. Epub 2011 Jun 27 doi: 10.1200/JCO.2010.34.2980. PMID: 21709188Free PMC Article
Oxaliplatin in tumors other than colorectal cancer.
Lorusso PM
Oncology (Williston Park) 2000 Dec;14(12 Suppl 11):33-7. PMID: 11204661
Update on malignant ovarian germ cell tumors.
Gershenson DM
Cancer 1993 Feb 15;71(4 Suppl):1581-90. doi: 10.1002/cncr.2820710425. PMID: 8381708

Prognosis

Therapeutic approaches for refractory germ cell cancer.
Oing C, Seidel C, Bokemeyer C
Expert Rev Anticancer Ther 2018 Apr;18(4):389-397. Epub 2018 Mar 12 doi: 10.1080/14737140.2018.1450630. PMID: 29516750
Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.
Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, Sakai W, Karlan BY, Taniguchi T, Swisher EM
J Clin Oncol 2011 Aug 1;29(22):3008-15. Epub 2011 Jun 27 doi: 10.1200/JCO.2010.34.2980. PMID: 21709188Free PMC Article
Remission of refractory gestational trophoblastic disease in the brain with ifosfamide, carboplatin, and etoposide (ICE): first report and review of literature.
Piamsomboon S, Kudelka AP, Termrungruanglert W, Van Besien K, Edwards CL, Lifshitz S, Schomer DF, Champlin R, Mante RP, Kavanagh JJ, Verschraegen CF
Eur J Gynaecol Oncol 1997;18(6):453-6. PMID: 9443008

Clinical prediction guides

Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.
Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, Sakai W, Karlan BY, Taniguchi T, Swisher EM
J Clin Oncol 2011 Aug 1;29(22):3008-15. Epub 2011 Jun 27 doi: 10.1200/JCO.2010.34.2980. PMID: 21709188Free PMC Article

Supplemental Content

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