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Metastatic Platinum-Resistant Malignant Germ Cell Tumor

MedGen UID:
1736970
•Concept ID:
C5418902
•
Neoplastic Process

Definition

A platinum-resistant malignant germ cell tumor that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Platinum-Resistant Malignant Germ Cell Tumor

Professional guidelines

PubMed

Management of recurrent and persistent malignant ovarian germ cell tumors: a narrative review.
Nasioudis D, Pashankar FD
Int J Gynecol Cancer 2024 Sep 2;34(9):1454-1460. doi: 10.1136/ijgc-2023-005052. PMID: 38991656
Current Management of Refractory Germ Cell Tumors and Future Directions.
Allen JC, Kirschner A, Scarpato KR, Morgans AK
Curr Oncol Rep 2017 Feb;19(2):8. doi: 10.1007/s11912-017-0572-y. PMID: 28220447

Recent clinical studies

Etiology

Remission of refractory gestational trophoblastic disease in the brain with ifosfamide, carboplatin, and etoposide (ICE): first report and review of literature.
Piamsomboon S, Kudelka AP, Termrungruanglert W, Van Besien K, Edwards CL, Lifshitz S, Schomer DF, Champlin R, Mante RP, Kavanagh JJ, Verschraegen CF
Eur J Gynaecol Oncol 1997;18(6):453-6. PMID: 9443008

Diagnosis

Management of recurrent and persistent malignant ovarian germ cell tumors: a narrative review.
Nasioudis D, Pashankar FD
Int J Gynecol Cancer 2024 Sep 2;34(9):1454-1460. doi: 10.1136/ijgc-2023-005052. PMID: 38991656
Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.
Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, Sakai W, Karlan BY, Taniguchi T, Swisher EM
J Clin Oncol 2011 Aug 1;29(22):3008-15. Epub 2011 Jun 27 doi: 10.1200/JCO.2010.34.2980. PMID: 21709188Free PMC Article
Update on malignant ovarian germ cell tumors.
Gershenson DM
Cancer 1993 Feb 15;71(4 Suppl):1581-90. doi: 10.1002/cncr.2820710425. PMID: 8381708

Therapy

Management of recurrent and persistent malignant ovarian germ cell tumors: a narrative review.
Nasioudis D, Pashankar FD
Int J Gynecol Cancer 2024 Sep 2;34(9):1454-1460. doi: 10.1136/ijgc-2023-005052. PMID: 38991656
Therapeutic approaches for refractory germ cell cancer.
Oing C, Seidel C, Bokemeyer C
Expert Rev Anticancer Ther 2018 Apr;18(4):389-397. Epub 2018 Mar 12 doi: 10.1080/14737140.2018.1450630. PMID: 29516750
Current Management of Refractory Germ Cell Tumors and Future Directions.
Allen JC, Kirschner A, Scarpato KR, Morgans AK
Curr Oncol Rep 2017 Feb;19(2):8. doi: 10.1007/s11912-017-0572-y. PMID: 28220447
Oxaliplatin in tumors other than colorectal cancer.
Lorusso PM
Oncology (Williston Park) 2000 Dec;14(12 Suppl 11):33-7. PMID: 11204661
Update on malignant ovarian germ cell tumors.
Gershenson DM
Cancer 1993 Feb 15;71(4 Suppl):1581-90. doi: 10.1002/cncr.2820710425. PMID: 8381708

Prognosis

Therapeutic approaches for refractory germ cell cancer.
Oing C, Seidel C, Bokemeyer C
Expert Rev Anticancer Ther 2018 Apr;18(4):389-397. Epub 2018 Mar 12 doi: 10.1080/14737140.2018.1450630. PMID: 29516750
Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.
Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, Sakai W, Karlan BY, Taniguchi T, Swisher EM
J Clin Oncol 2011 Aug 1;29(22):3008-15. Epub 2011 Jun 27 doi: 10.1200/JCO.2010.34.2980. PMID: 21709188Free PMC Article
Remission of refractory gestational trophoblastic disease in the brain with ifosfamide, carboplatin, and etoposide (ICE): first report and review of literature.
Piamsomboon S, Kudelka AP, Termrungruanglert W, Van Besien K, Edwards CL, Lifshitz S, Schomer DF, Champlin R, Mante RP, Kavanagh JJ, Verschraegen CF
Eur J Gynaecol Oncol 1997;18(6):453-6. PMID: 9443008

Clinical prediction guides

Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.
Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, Sakai W, Karlan BY, Taniguchi T, Swisher EM
J Clin Oncol 2011 Aug 1;29(22):3008-15. Epub 2011 Jun 27 doi: 10.1200/JCO.2010.34.2980. PMID: 21709188Free PMC Article

Supplemental Content

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