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Advanced Kidney Carcinoma

MedGen UID:
1742252
•Concept ID:
C5419741
•
Neoplastic Process

Definition

Kidney carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Risks from Deferring Treatment for Genitourinary Cancers: A Collaborative Review to Aid Triage and Management During the COVID-19 Pandemic.
Wallis CJD, Novara G, Marandino L, Bex A, Kamat AM, Karnes RJ, Morgan TM, Mottet N, Gillessen S, Bossi A, Roupret M, Powles T, Necchi A, Catto JWF, Klaassen Z
Eur Urol 2020 Jul;78(1):29-42. Epub 2020 May 3 doi: 10.1016/j.eururo.2020.04.063. PMID: 32414626Free PMC Article

Recent clinical studies

Etiology

Renal cell carcinoma.
Young M, Jackson-Spence F, Beltran L, Day E, Suarez C, Bex A, Powles T, Szabados B
Lancet 2024 Aug 3;404(10451):476-491. Epub 2024 Jul 18 doi: 10.1016/S0140-6736(24)00917-6. PMID: 39033764
Treatment Landscape of Renal Cell Carcinoma.
Chen YW, Wang L, Panian J, Dhanji S, Derweesh I, Rose B, Bagrodia A, McKay RR
Curr Treat Options Oncol 2023 Dec;24(12):1889-1916. Epub 2023 Dec 28 doi: 10.1007/s11864-023-01161-5. PMID: 38153686Free PMC Article
Epidemiology of Renal Cell Carcinoma: 2022 Update.
Bukavina L, Bensalah K, Bray F, Carlo M, Challacombe B, Karam JA, Kassouf W, Mitchell T, Montironi R, O'Brien T, Panebianco V, Scelo G, Shuch B, van Poppel H, Blosser CD, Psutka SP
Eur Urol 2022 Nov;82(5):529-542. Epub 2022 Sep 10 doi: 10.1016/j.eururo.2022.08.019. PMID: 36100483
Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.
Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L
G Ital Nefrol 2022 Jun 20;39(3) PMID: 35819037
Kidney Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.
Motzer RJ, Jonasch E, Agarwal N, Alva A, Baine M, Beckermann K, Carlo MI, Choueiri TK, Costello BA, Derweesh IH, Desai A, Ged Y, George S, Gore JL, Haas N, Hancock SL, Kapur P, Kyriakopoulos C, Lam ET, Lara PN, Lau C, Lewis B, Madoff DC, Manley B, Michaelson MD, Mortazavi A, Nandagopal L, Plimack ER, Ponsky L, Ramalingam S, Shuch B, Smith ZL, Sosman J, Dwyer MA, Gurski LA, Motter A
J Natl Compr Canc Netw 2022 Jan;20(1):71-90. doi: 10.6004/jnccn.2022.0001. PMID: 34991070Free PMC Article

Diagnosis

Renal cell carcinoma.
Young M, Jackson-Spence F, Beltran L, Day E, Suarez C, Bex A, Powles T, Szabados B
Lancet 2024 Aug 3;404(10451):476-491. Epub 2024 Jul 18 doi: 10.1016/S0140-6736(24)00917-6. PMID: 39033764
Treatment Landscape of Renal Cell Carcinoma.
Chen YW, Wang L, Panian J, Dhanji S, Derweesh I, Rose B, Bagrodia A, McKay RR
Curr Treat Options Oncol 2023 Dec;24(12):1889-1916. Epub 2023 Dec 28 doi: 10.1007/s11864-023-01161-5. PMID: 38153686Free PMC Article
Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma.
Rosellini M, Marchetti A, Mollica V, Rizzo A, Santoni M, Massari F
Nat Rev Urol 2023 Mar;20(3):133-157. Epub 2022 Nov 21 doi: 10.1038/s41585-022-00676-0. PMID: 36414800
Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.
Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L
G Ital Nefrol 2022 Jun 20;39(3) PMID: 35819037
Kidney Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.
Motzer RJ, Jonasch E, Agarwal N, Alva A, Baine M, Beckermann K, Carlo MI, Choueiri TK, Costello BA, Derweesh IH, Desai A, Ged Y, George S, Gore JL, Haas N, Hancock SL, Kapur P, Kyriakopoulos C, Lam ET, Lara PN, Lau C, Lewis B, Madoff DC, Manley B, Michaelson MD, Mortazavi A, Nandagopal L, Plimack ER, Ponsky L, Ramalingam S, Shuch B, Smith ZL, Sosman J, Dwyer MA, Gurski LA, Motter A
J Natl Compr Canc Netw 2022 Jan;20(1):71-90. doi: 10.6004/jnccn.2022.0001. PMID: 34991070Free PMC Article

Therapy

Immune Checkpoint Inhibitor Therapy Before Nephrectomy for Locally Advanced and Metastatic Renal Cell Carcinoma: A Review.
Ghoreifi A, Vaishampayan U, Yin M, Psutka SP, Djaladat H
JAMA Oncol 2024 Feb 1;10(2):240-248. doi: 10.1001/jamaoncol.2023.5269. PMID: 38095885
LITESPARK-011: belzutifan plus lenvatinib vs cabozantinib in advanced renal cell carcinoma after anti-PD-1/PD-L1 therapy.
Motzer RJ, Schmidinger M, Eto M, Suarez C, Figlin R, Liu Y, Perini R, Zhang Y, Heng DY
Future Oncol 2023 Jan;19(2):113-121. Epub 2023 Feb 8 doi: 10.2217/fon-2022-0802. PMID: 36752726
Resistance to Systemic Therapies in Clear Cell Renal Cell Carcinoma: Mechanisms and Management Strategies.
Makhov P, Joshi S, Ghatalia P, Kutikov A, Uzzo RG, Kolenko VM
Mol Cancer Ther 2018 Jul;17(7):1355-1364. doi: 10.1158/1535-7163.MCT-17-1299. PMID: 29967214Free PMC Article
Treatment of renal cell carcinoma: Current status and future directions.
Barata PC, Rini BI
CA Cancer J Clin 2017 Nov;67(6):507-524. Epub 2017 Sep 29 doi: 10.3322/caac.21411. PMID: 28961310
Renal cell carcinoma.
Jonasch E, Gao J, Rathmell WK
BMJ 2014 Nov 10;349:g4797. doi: 10.1136/bmj.g4797. PMID: 25385470Free PMC Article

Prognosis

Treatment Landscape of Renal Cell Carcinoma.
Chen YW, Wang L, Panian J, Dhanji S, Derweesh I, Rose B, Bagrodia A, McKay RR
Curr Treat Options Oncol 2023 Dec;24(12):1889-1916. Epub 2023 Dec 28 doi: 10.1007/s11864-023-01161-5. PMID: 38153686Free PMC Article
Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma.
Rosellini M, Marchetti A, Mollica V, Rizzo A, Santoni M, Massari F
Nat Rev Urol 2023 Mar;20(3):133-157. Epub 2022 Nov 21 doi: 10.1038/s41585-022-00676-0. PMID: 36414800
Nivolumab plus cabozantinib versus sunitinib in first-line treatment for advanced renal cell carcinoma (CheckMate 9ER): long-term follow-up results from an open-label, randomised, phase 3 trial.
Motzer RJ, Powles T, Burotto M, Escudier B, Bourlon MT, Shah AY, Suárez C, Hamzaj A, Porta C, Hocking CM, Kessler ER, Gurney H, Tomita Y, Bedke J, Zhang J, Simsek B, Scheffold C, Apolo AB, Choueiri TK
Lancet Oncol 2022 Jul;23(7):888-898. Epub 2022 Jun 7 doi: 10.1016/S1470-2045(22)00290-X. PMID: 35688173Free PMC Article
Renal cell carcinoma.
Jonasch E, Gao J, Rathmell WK
BMJ 2014 Nov 10;349:g4797. doi: 10.1136/bmj.g4797. PMID: 25385470Free PMC Article
Renal cell carcinoma.
Rini BI, Campbell SC, Escudier B
Lancet 2009 Mar 28;373(9669):1119-32. Epub 2009 Mar 5 doi: 10.1016/S0140-6736(09)60229-4. PMID: 19269025

Clinical prediction guides

Immune Checkpoint Inhibitor Therapy Before Nephrectomy for Locally Advanced and Metastatic Renal Cell Carcinoma: A Review.
Ghoreifi A, Vaishampayan U, Yin M, Psutka SP, Djaladat H
JAMA Oncol 2024 Feb 1;10(2):240-248. doi: 10.1001/jamaoncol.2023.5269. PMID: 38095885
Treatment Landscape of Renal Cell Carcinoma.
Chen YW, Wang L, Panian J, Dhanji S, Derweesh I, Rose B, Bagrodia A, McKay RR
Curr Treat Options Oncol 2023 Dec;24(12):1889-1916. Epub 2023 Dec 28 doi: 10.1007/s11864-023-01161-5. PMID: 38153686Free PMC Article
Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma.
Rosellini M, Marchetti A, Mollica V, Rizzo A, Santoni M, Massari F
Nat Rev Urol 2023 Mar;20(3):133-157. Epub 2022 Nov 21 doi: 10.1038/s41585-022-00676-0. PMID: 36414800
Epidemiology of Renal Cell Carcinoma: 2022 Update.
Bukavina L, Bensalah K, Bray F, Carlo M, Challacombe B, Karam JA, Kassouf W, Mitchell T, Montironi R, O'Brien T, Panebianco V, Scelo G, Shuch B, van Poppel H, Blosser CD, Psutka SP
Eur Urol 2022 Nov;82(5):529-542. Epub 2022 Sep 10 doi: 10.1016/j.eururo.2022.08.019. PMID: 36100483
Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients.
Derosa L, Routy B, Fidelle M, Iebba V, Alla L, Pasolli E, Segata N, Desnoyer A, Pietrantonio F, Ferrere G, Fahrner JE, Le Chatellier E, Pons N, Galleron N, Roume H, Duong CPM, Mondragón L, Iribarren K, Bonvalet M, Terrisse S, Rauber C, Goubet AG, Daillère R, Lemaitre F, Reni A, Casu B, Alou MT, Alves Costa Silva C, Raoult D, Fizazi K, Escudier B, Kroemer G, Albiges L, Zitvogel L
Eur Urol 2020 Aug;78(2):195-206. Epub 2020 May 4 doi: 10.1016/j.eururo.2020.04.044. PMID: 32376136

Recent systematic reviews

Stereotactic body radiotherapy for primary renal cell carcinoma: a systematic review and practice guideline from the International Society of Stereotactic Radiosurgery (ISRS).
Siva S, Louie AV, Kotecha R, Barber MN, Ali M, Zhang Z, Guckenberger M, Kim MS, Scorsetti M, Tree AC, Slotman BJ, Sahgal A, Lo SS
Lancet Oncol 2024 Jan;25(1):e18-e28. doi: 10.1016/S1470-2045(23)00513-2. PMID: 38181809
First-line therapy for adults with advanced renal cell carcinoma: a systematic review and network meta-analysis.
Aldin A, Besiroglu B, Adams A, Monsef I, Piechotta V, Tomlinson E, Hornbach C, Dressen N, Goldkuhle M, Maisch P, Dahm P, Heidenreich A, Skoetz N
Cochrane Database Syst Rev 2023 May 4;5(5):CD013798. doi: 10.1002/14651858.CD013798.pub2. PMID: 37146227Free PMC Article
Cardiac Toxicity Associated with Immune Checkpoint Inhibitors: A Systematic Review.
Cozma A, Sporis ND, Lazar AL, Buruiana A, Ganea AM, Malinescu TV, Berechet BM, Fodor A, Sitar-Taut AV, Vlad VC, Negrean V, Orasan OH
Int J Mol Sci 2022 Sep 19;23(18) doi: 10.3390/ijms231810948. PMID: 36142866Free PMC Article
Epidemiology of Renal Cell Carcinoma: 2022 Update.
Bukavina L, Bensalah K, Bray F, Carlo M, Challacombe B, Karam JA, Kassouf W, Mitchell T, Montironi R, O'Brien T, Panebianco V, Scelo G, Shuch B, van Poppel H, Blosser CD, Psutka SP
Eur Urol 2022 Nov;82(5):529-542. Epub 2022 Sep 10 doi: 10.1016/j.eururo.2022.08.019. PMID: 36100483
Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302

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