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Locally Advanced Esophageal Squamous Cell Carcinoma

MedGen UID:
1745399
•Concept ID:
C5419605
•
Neoplastic Process

Definition

Esophageal squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Esophageal Squamous Cell Carcinoma

Professional guidelines

PubMed

Radiomics Nomogram with Added Nodal Features Improves Treatment Response Prediction in Locally Advanced Esophageal Squamous Cell Carcinoma: A Multicenter Study.
Li K, Zhang S, Hu Y, Cai A, Ao Y, Gong J, Liang M, Yang S, Chen X, Li M, Tian J, Shan H
Ann Surg Oncol 2023 Dec;30(13):8231-8243. Epub 2023 Sep 27 doi: 10.1245/s10434-023-14253-1. PMID: 37755566
Real-world treatment patterns and survival for locally advanced esophageal squamous cell carcinoma.
Luo HC, Wu JJ, Zhu LJ, Cai LJ, Feng J, Shen ZY, Wu MJ, Chen FF, Fu ZC, Xie FW
Medicine (Baltimore) 2023 Aug 25;102(34):e34647. doi: 10.1097/MD.0000000000034647. PMID: 37653737Free PMC Article
The current status of multimodality treatment for unresectable locally advanced esophageal squamous cell carcinoma.
Hirano H, Boku N
Asia Pac J Clin Oncol 2018 Aug;14(4):291-299. Epub 2018 Jun 5 doi: 10.1111/ajco.12995. PMID: 29873183

Recent clinical studies

Etiology

Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy for locally advanced esophageal squamous cell carcinoma: a prospective multicenter randomized clinical trial.
Tang H, Wang H, Fang Y, Zhu JY, Yin J, Shen YX, Zeng ZC, Jiang DX, Hou YY, Du M, Lian CH, Zhao Q, Jiang HJ, Gong L, Li ZG, Liu J, Xie DY, Li WF, Chen C, Zheng B, Chen KN, Dai L, Liao YD, Li K, Li HC, Zhao NQ, Tan LJ
Ann Oncol 2023 Feb;34(2):163-172. Epub 2022 Nov 15 doi: 10.1016/j.annonc.2022.10.508. PMID: 36400384
Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: The NEOCRTEC5010 Randomized Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J
JAMA Surg 2021 Aug 1;156(8):721-729. doi: 10.1001/jamasurg.2021.2373. PMID: 34160577Free PMC Article
Morbidity and Mortality of Patients Who Underwent Minimally Invasive Esophagectomy After Neoadjuvant Chemoradiotherapy vs Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial.
Wang H, Tang H, Fang Y, Tan L, Yin J, Shen Y, Zeng Z, Zhu J, Hou Y, Du M, Jiao J, Jiang H, Gong L, Li Z, Liu J, Xie D, Li W, Lian C, Zhao Q, Chen C, Zheng B, Liao Y, Li K, Li H, Wu H, Dai L, Chen KN
JAMA Surg 2021 May 1;156(5):444-451. doi: 10.1001/jamasurg.2021.0133. PMID: 33729467Free PMC Article
Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Lordick F, D'Journo XB, Cerfolio RJ, Korst RJ, Novoa NM, Swanson SJ, Brunelli A, Ismail M, Fernando HC, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J; AME Thoracic Surgery Collaborative Group
J Clin Oncol 2018 Sep 20;36(27):2796-2803. Epub 2018 Aug 8 doi: 10.1200/JCO.2018.79.1483. PMID: 30089078Free PMC Article
A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907).
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261

Diagnosis

Tumor-Resident Microbiota-Based Risk Model Predicts Neoadjuvant Therapy Response of Locally Advanced Esophageal Squamous Cell Carcinoma Patients.
Wu H, Liu Q, Li J, Leng X, He Y, Liu Y, Zhang X, Ouyang Y, Liu Y, Liang W, Xu C
Adv Sci (Weinh) 2024 Nov;11(41):e2309742. Epub 2024 Sep 13 doi: 10.1002/advs.202309742. PMID: 39268829Free PMC Article
Radiotherapy for patients with locally advanced esophageal squamous cell carcinoma receiving neoadjuvant immunotherapy combined with chemotherapy.
Kong Y, Su M, Fang J, Chen M, Zheng C, Jiang Y, Tao K, Wang C, Qiu G, Ji Y, Wang Y, Yang Y
Sci Rep 2024 Jul 17;14(1):16495. doi: 10.1038/s41598-024-67419-6. PMID: 39019976Free PMC Article
Comparison of efficacy and safety between neoadjuvant chemotherapy and neoadjuvant immune checkpoint inhibitors combined with chemotherapy for locally advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis.
Xu J, Cai Y, Hong Z, Duan H, Ke S
Int J Surg 2024 Jan 1;110(1):490-506. doi: 10.1097/JS9.0000000000000816. PMID: 37800587Free PMC Article
Real-world treatment patterns and survival for locally advanced esophageal squamous cell carcinoma.
Luo HC, Wu JJ, Zhu LJ, Cai LJ, Feng J, Shen ZY, Wu MJ, Chen FF, Fu ZC, Xie FW
Medicine (Baltimore) 2023 Aug 25;102(34):e34647. doi: 10.1097/MD.0000000000034647. PMID: 37653737Free PMC Article
Safety and Feasibility of Radiotherapy Plus Camrelizumab for Locally Advanced Esophageal Squamous Cell Carcinoma.
Zhang W, Yan C, Gao X, Li X, Cao F, Zhao G, Zhao J, Er P, Zhang T, Chen X, Wang Y, Jiang Y, Wang Q, Zhang B, Qian D, Wang J, Zhou D, Ren X, Yu Z, Zhao L, Yuan Z, Wang P, Pang Q
Oncologist 2021 Jul;26(7):e1110-e1124. Epub 2021 Jun 5 doi: 10.1002/onco.13797. PMID: 33893689Free PMC Article

Therapy

Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy for locally advanced esophageal squamous cell carcinoma: a prospective multicenter randomized clinical trial.
Tang H, Wang H, Fang Y, Zhu JY, Yin J, Shen YX, Zeng ZC, Jiang DX, Hou YY, Du M, Lian CH, Zhao Q, Jiang HJ, Gong L, Li ZG, Liu J, Xie DY, Li WF, Chen C, Zheng B, Chen KN, Dai L, Liao YD, Li K, Li HC, Zhao NQ, Tan LJ
Ann Oncol 2023 Feb;34(2):163-172. Epub 2022 Nov 15 doi: 10.1016/j.annonc.2022.10.508. PMID: 36400384
Multicenter, single-arm, phase II trial of camrelizumab and chemotherapy as neoadjuvant treatment for locally advanced esophageal squamous cell carcinoma.
Liu J, Yang Y, Liu Z, Fu X, Cai X, Li H, Zhu L, Shen Y, Zhang H, Sun Y, Chen H, Yu B, Zhang R, Shao J, Zhang M, Li Z
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-004291. PMID: 35338088Free PMC Article
Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: The NEOCRTEC5010 Randomized Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J
JAMA Surg 2021 Aug 1;156(8):721-729. doi: 10.1001/jamasurg.2021.2373. PMID: 34160577Free PMC Article
Morbidity and Mortality of Patients Who Underwent Minimally Invasive Esophagectomy After Neoadjuvant Chemoradiotherapy vs Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial.
Wang H, Tang H, Fang Y, Tan L, Yin J, Shen Y, Zeng Z, Zhu J, Hou Y, Du M, Jiao J, Jiang H, Gong L, Li Z, Liu J, Xie D, Li W, Lian C, Zhao Q, Chen C, Zheng B, Liao Y, Li K, Li H, Wu H, Dai L, Chen KN
JAMA Surg 2021 May 1;156(5):444-451. doi: 10.1001/jamasurg.2021.0133. PMID: 33729467Free PMC Article
Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Lordick F, D'Journo XB, Cerfolio RJ, Korst RJ, Novoa NM, Swanson SJ, Brunelli A, Ismail M, Fernando HC, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J; AME Thoracic Surgery Collaborative Group
J Clin Oncol 2018 Sep 20;36(27):2796-2803. Epub 2018 Aug 8 doi: 10.1200/JCO.2018.79.1483. PMID: 30089078Free PMC Article

Prognosis

Predictive role of ctDNA in esophageal squamous cell carcinoma receiving definitive chemoradiotherapy combined with toripalimab.
Chen B, Liu S, Zhu Y, Wang R, Cheng X, Chen B, Dragomir MP, Zhang Y, Hu Y, Liu M, Li Q, Yang H, Xi M
Nat Commun 2024 Mar 1;15(1):1919. doi: 10.1038/s41467-024-46307-7. PMID: 38429311Free PMC Article
Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: The NEOCRTEC5010 Randomized Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J
JAMA Surg 2021 Aug 1;156(8):721-729. doi: 10.1001/jamasurg.2021.2373. PMID: 34160577Free PMC Article
Morbidity and Mortality of Patients Who Underwent Minimally Invasive Esophagectomy After Neoadjuvant Chemoradiotherapy vs Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial.
Wang H, Tang H, Fang Y, Tan L, Yin J, Shen Y, Zeng Z, Zhu J, Hou Y, Du M, Jiao J, Jiang H, Gong L, Li Z, Liu J, Xie D, Li W, Lian C, Zhao Q, Chen C, Zheng B, Liao Y, Li K, Li H, Wu H, Dai L, Chen KN
JAMA Surg 2021 May 1;156(5):444-451. doi: 10.1001/jamasurg.2021.0133. PMID: 33729467Free PMC Article
Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Lordick F, D'Journo XB, Cerfolio RJ, Korst RJ, Novoa NM, Swanson SJ, Brunelli A, Ismail M, Fernando HC, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J; AME Thoracic Surgery Collaborative Group
J Clin Oncol 2018 Sep 20;36(27):2796-2803. Epub 2018 Aug 8 doi: 10.1200/JCO.2018.79.1483. PMID: 30089078Free PMC Article
A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907).
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261

Clinical prediction guides

Predictive role of ctDNA in esophageal squamous cell carcinoma receiving definitive chemoradiotherapy combined with toripalimab.
Chen B, Liu S, Zhu Y, Wang R, Cheng X, Chen B, Dragomir MP, Zhang Y, Hu Y, Liu M, Li Q, Yang H, Xi M
Nat Commun 2024 Mar 1;15(1):1919. doi: 10.1038/s41467-024-46307-7. PMID: 38429311Free PMC Article
Short-course neoadjuvant radiotherapy combined with chemotherapy and toripalimab for locally advanced esophageal squamous cell carcinoma (SCALE-1): a single-arm phase Ib clinical trial.
Jiang N, Zhang J, Guo Z, Wu Y, Zhao L, Kong C, Song X, Gu L, Zhao Y, Li S, He X, Ren B, Zhu X, Jiang M
J Immunother Cancer 2024 Jan 9;12(1) doi: 10.1136/jitc-2023-008229. PMID: 38199609Free PMC Article
(18)F-FAPI-04 PET/CT parameters predict PD-L1 expression in esophageal squamous cell carcinoma.
Zhao Y, Ren J
Front Immunol 2023;14:1266843. Epub 2023 Nov 15 doi: 10.3389/fimmu.2023.1266843. PMID: 38035081Free PMC Article
Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy for locally advanced esophageal squamous cell carcinoma: a prospective multicenter randomized clinical trial.
Tang H, Wang H, Fang Y, Zhu JY, Yin J, Shen YX, Zeng ZC, Jiang DX, Hou YY, Du M, Lian CH, Zhao Q, Jiang HJ, Gong L, Li ZG, Liu J, Xie DY, Li WF, Chen C, Zheng B, Chen KN, Dai L, Liao YD, Li K, Li HC, Zhao NQ, Tan LJ
Ann Oncol 2023 Feb;34(2):163-172. Epub 2022 Nov 15 doi: 10.1016/j.annonc.2022.10.508. PMID: 36400384
Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Tsuchiya N, Kunisaki C, Sato S, Tanaka Y, Sato K, Watanabe J, Takeda K, Kosaka T, Akiyama H, Endo I
Langenbecks Arch Surg 2022 Aug;407(5):1911-1921. Epub 2022 Mar 1 doi: 10.1007/s00423-022-02445-4. PMID: 35230525

Recent systematic reviews

A commentary on 'Comparison of efficacy and safety between neoadjuvant chemotherapy and neoadjuvant immune checkpoint inhibitors combined with chemotherapy for locally advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis'.
Qiao L, Liu Y, Ge D, Jiang S
Int J Surg 2024 May 1;110(5):3118-3119. doi: 10.1097/JS9.0000000000001211. PMID: 38363989Free PMC Article
Comparison of efficacy and safety between neoadjuvant chemotherapy and neoadjuvant immune checkpoint inhibitors combined with chemotherapy for locally advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis.
Xu J, Cai Y, Hong Z, Duan H, Ke S
Int J Surg 2024 Jan 1;110(1):490-506. doi: 10.1097/JS9.0000000000000816. PMID: 37800587Free PMC Article
The efficacy and safety of neoadjuvant immunotherapy in resectable locally advanced esophageal squamous cell carcinoma: A systematic review and meta-analysis.
He W, Wang C, Li C, Nie X, Li H, Li J, Zhao N, Chen H, Miao X, Han Y, Peng L, Leng X
Front Immunol 2023;14:1118902. Epub 2023 Feb 17 doi: 10.3389/fimmu.2023.1118902. PMID: 36875107Free PMC Article
Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer.
Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2. PMID: 28829911Free PMC Article

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