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Locally Advanced Carcinoma

MedGen UID:
1665275
•Concept ID:
C4724834
•
Neoplastic Process

Definition

A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Carcinoma

Professional guidelines

PubMed

Management of Locally Advanced Carcinoma Oesophagus with Radiation/Chemoradiation: Single Institute Experience.
Kumaran D, John S, Isiah R, Das S
J Gastrointest Cancer 2016 Sep;47(3):313-7. doi: 10.1007/s12029-016-9825-5. PMID: 27146042
The epidemiology, diagnosis, and treatment of Barrett's carcinoma.
Labenz J, Koop H, Tannapfel A, Kiesslich R, Hölscher AH
Dtsch Arztebl Int 2015 Mar 27;112(13):224-33; quiz 234. doi: 10.3238/arztebl.2015.0224. PMID: 25869347Free PMC Article
American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: high-dose-rate brachytherapy.
Viswanathan AN, Beriwal S, De Los Santos JF, Demanes DJ, Gaffney D, Hansen J, Jones E, Kirisits C, Thomadsen B, Erickson B; American Brachytherapy Society
Brachytherapy 2012 Jan-Feb;11(1):47-52. doi: 10.1016/j.brachy.2011.07.002. PMID: 22265437Free PMC Article

Recent clinical studies

Etiology

Predictors of tumor response in carcinoma of uterine cervix: data from tertiary cancer centre in India.
Pathy S, Muwonge R, Chander S, Dadhwal V, Pandjatcharam J
Bull Cancer 2014 Feb;101(2):E13-8. doi: 10.1684/bdc.2014.1895. PMID: 24590357
Management of locally advanced rectal cancer.
Sasson AR, Sigurdson ER
Surg Oncol 2000 Dec;9(4):193-204. doi: 10.1016/s0960-7404(01)00012-3. PMID: 11476990
Carcinoma of the cervix treated with chemotherapy and radiation therapy. Cooperative studies in the Gynecologic Oncology Group.
Stehman FB, Bundy BN
Cancer 1993 Feb 15;71(4 Suppl):1697-701. doi: 10.1002/cncr.2820710439. PMID: 8431908
Comparison of helium-ion radiation therapy and split-course megavoltage irradiation for unresectable adenocarcinoma of the pancreas. Final report of a Northern California Oncology Group randomized prospective clinical trial.
Linstadt D, Quivey JM, Castro JR, Andejeski Y, Phillips TL, Hannigan J, Gribble M
Radiology 1988 Jul;168(1):261-4. doi: 10.1148/radiology.168.1.3132732. PMID: 3132732
Radiation myelopathy in patients treated for carcinoma of bronchus using a six fraction regime of radiotherapy.
Dische S, Martin WM, Anderson P
Br J Radiol 1981 Jan;54(637):29-35. doi: 10.1259/0007-1285-54-637-29. PMID: 7448497

Diagnosis

Achalasia leading to diagnosis of adenocarcinoma of the oesophagus.
Segal J, Lagundoye A, Carter M
BMJ Case Rep 2017 Jun 20;2017 doi: 10.1136/bcr-2017-219386. PMID: 28637650Free PMC Article
Management of Locally Advanced Carcinoma Oesophagus with Radiation/Chemoradiation: Single Institute Experience.
Kumaran D, John S, Isiah R, Das S
J Gastrointest Cancer 2016 Sep;47(3):313-7. doi: 10.1007/s12029-016-9825-5. PMID: 27146042
The epidemiology, diagnosis, and treatment of Barrett's carcinoma.
Labenz J, Koop H, Tannapfel A, Kiesslich R, Hölscher AH
Dtsch Arztebl Int 2015 Mar 27;112(13):224-33; quiz 234. doi: 10.3238/arztebl.2015.0224. PMID: 25869347Free PMC Article
Predictors of tumor response in carcinoma of uterine cervix: data from tertiary cancer centre in India.
Pathy S, Muwonge R, Chander S, Dadhwal V, Pandjatcharam J
Bull Cancer 2014 Feb;101(2):E13-8. doi: 10.1684/bdc.2014.1895. PMID: 24590357
Is MRI helpful in evaluating the response of cervical cancer to neoadjuvant chemotherapy?
Vives A, Castelo-Branco C, Iglesias X, Tomás X, Palombo H, Pahisa J, Lejárcegui JA, Salvador A, Puig-Tintoré L
Acta Obstet Gynecol Scand 1995 Jul;74(6):467-71. doi: 10.3109/00016349509024411. PMID: 7541596

Therapy

Cerebral venous thrombosis: an unanticipated consequence of unilateral internal jugular vein ligation.
Moideen A, Panda S, Parihar J, Meena SK
BMJ Case Rep 2024 Oct 14;17(10) doi: 10.1136/bcr-2024-261523. PMID: 39406452
Is MRI helpful in evaluating the response of cervical cancer to neoadjuvant chemotherapy?
Vives A, Castelo-Branco C, Iglesias X, Tomás X, Palombo H, Pahisa J, Lejárcegui JA, Salvador A, Puig-Tintoré L
Acta Obstet Gynecol Scand 1995 Jul;74(6):467-71. doi: 10.3109/00016349509024411. PMID: 7541596
Comparison of helium-ion radiation therapy and split-course megavoltage irradiation for unresectable adenocarcinoma of the pancreas. Final report of a Northern California Oncology Group randomized prospective clinical trial.
Linstadt D, Quivey JM, Castro JR, Andejeski Y, Phillips TL, Hannigan J, Gribble M
Radiology 1988 Jul;168(1):261-4. doi: 10.1148/radiology.168.1.3132732. PMID: 3132732
Simple mastectomy under local anaesthesia.
Dennison AR, Watkins RM, Ward ME, Lee EC
Ann R Coll Surg Engl 1985 Jul;67(4):243-4. PMID: 4037637Free PMC Article
Tracheal sleeve pneumonectomy for carcinomas of the proximal left main bronchus.
Gilbert A, Deslauriers J, McClish A, Piraux M
Can J Surg 1984 Nov;27(6):583-5. PMID: 6498651

Prognosis

Predictors of tumor response in carcinoma of uterine cervix: data from tertiary cancer centre in India.
Pathy S, Muwonge R, Chander S, Dadhwal V, Pandjatcharam J
Bull Cancer 2014 Feb;101(2):E13-8. doi: 10.1684/bdc.2014.1895. PMID: 24590357
Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix.
Donaldson SB, Buckley DL, O'Connor JP, Davidson SE, Carrington BM, Jones AP, West CM
Br J Cancer 2010 Jan 5;102(1):23-6. Epub 2009 Nov 17 doi: 10.1038/sj.bjc.6605415. PMID: 19920831Free PMC Article
Catch me if you can--the use of image guidance in the radiotherapy of an unusual case of esophageal cancer.
Jensen AD, Grehn C, Nikoghosyan A, Thieke C, Krempien R, Huber PE, Debus J, Münter MW
Strahlenther Onkol 2009 Jul;185(7):469-73. Epub 2009 Aug 28 doi: 10.1007/s00066-009-1935-6. PMID: 19714309
Management of locally advanced rectal cancer.
Sasson AR, Sigurdson ER
Surg Oncol 2000 Dec;9(4):193-204. doi: 10.1016/s0960-7404(01)00012-3. PMID: 11476990
Comparison of helium-ion radiation therapy and split-course megavoltage irradiation for unresectable adenocarcinoma of the pancreas. Final report of a Northern California Oncology Group randomized prospective clinical trial.
Linstadt D, Quivey JM, Castro JR, Andejeski Y, Phillips TL, Hannigan J, Gribble M
Radiology 1988 Jul;168(1):261-4. doi: 10.1148/radiology.168.1.3132732. PMID: 3132732

Clinical prediction guides

Prediction of response to radiotherapy in locally advanced carcinoma cervix using multiparametric MRI: A prospective, single-center, longitudinal study.
Verma A, Kumar I, Patel DS, Ranjan R, Singh M, Pradhan S, Shukla RC
Asia Pac J Clin Oncol 2023 Feb;19(1):79-86. Epub 2022 Apr 18 doi: 10.1111/ajco.13761. PMID: 35437940
Predictors of tumor response in carcinoma of uterine cervix: data from tertiary cancer centre in India.
Pathy S, Muwonge R, Chander S, Dadhwal V, Pandjatcharam J
Bull Cancer 2014 Feb;101(2):E13-8. doi: 10.1684/bdc.2014.1895. PMID: 24590357
Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix.
Donaldson SB, Buckley DL, O'Connor JP, Davidson SE, Carrington BM, Jones AP, West CM
Br J Cancer 2010 Jan 5;102(1):23-6. Epub 2009 Nov 17 doi: 10.1038/sj.bjc.6605415. PMID: 19920831Free PMC Article
Detection of occult liver metastases by measurement of biliary carcinoembryonic antigen concentrations.
Paul MA, Visser JJ, Mulder C, Blomjous JG, van Kamp GJ, Cuesta MA, Meijer S
Eur J Surg 1996 Jun;162(6):483-8. PMID: 8817226
A possible new trend in the management of the carcinoma of the cervix uteri.
Sardi JE, di Paola GR, Cachau A, Ortiz OC, Sananes C, Giaroli A, Martins D, Peluffo M
Gynecol Oncol 1986 Oct;25(2):139-49. doi: 10.1016/0090-8258(86)90095-8. PMID: 2428700

Recent systematic reviews

Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma.
Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, Kwong DL, Al-Sarraf M, Chi KH, Hareyama M, Leung SF, Thephamongkhol K, Pignon JP; MAC-NPC Collaborative Group
Cochrane Database Syst Rev 2006 Oct 18;2006(4):CD004329. doi: 10.1002/14651858.CD004329.pub2. PMID: 17054200Free PMC Article

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