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Microsatellite Stable Colorectal Carcinoma

MedGen UID:
1771326
•Concept ID:
C5420144
•
Neoplastic Process

Definition

Colorectal carcinoma characterized by the absence of microsatellite instability. [from NCI]

Professional guidelines

PubMed

Treatment of Metastatic Colorectal Cancer: ASCO Guideline.
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer.
Wang P, Sun LL, Clark R, Hristopoulos M, Chiu CPC, Dillon M, Lin W, Lo AA, Chalsani S, Das Thakur M, Zimmerman Savill KM, Rougé L, Lupardus P, Piskol R, Husain B, Ellerman D, Shivva V, Leong SR, Ovacik M, Totpal K, Wu Y, Spiess C, Lee G, Leipold DD, Polson AG
Mol Cancer Ther 2022 Jun 1;21(6):974-985. doi: 10.1158/1535-7163.MCT-21-0599. PMID: 35364611Free PMC Article
Pembrolizumab for the treatment of colorectal cancer.
Coupez D, Hulo P, Touchefeu Y, Bossard C, Bennouna J
Expert Opin Biol Ther 2020 Mar;20(3):219-226. Epub 2020 Feb 3 doi: 10.1080/14712598.2020.1718095. PMID: 31952453

Recent clinical studies

Etiology

Newer pathologic assessment techniques for colorectal carcinoma.
Turner RR, Li C, Compton CC
Clin Cancer Res 2007 Nov 15;13(22 Pt 2):6871s-6s. doi: 10.1158/1078-0432.CCR-07-1151. PMID: 18006792

Diagnosis

RNF43 Is an Early and Specific Mutated Gene in the Serrated Pathway, With Increased Frequency in Traditional Serrated Adenoma and Its Associated Malignancy.
Tsai JH, Liau JY, Yuan CT, Lin YL, Tseng LH, Cheng ML, Jeng YM
Am J Surg Pathol 2016 Oct;40(10):1352-9. doi: 10.1097/PAS.0000000000000664. PMID: 27305845
Serrated tubulovillous adenoma of the large intestine.
Bettington M, Walker N, Rosty C, Brown I, Clouston A, McKeone D, Pearson SA, Klein K, Leggett B, Whitehall V
Histopathology 2016 Mar;68(4):578-87. Epub 2015 Sep 17 doi: 10.1111/his.12788. PMID: 26212352
Absence of MGMT promoter methylation in endometrial cancer.
Rimel BJ, Huettner P, Powell MA, Mutch DG, Goodfellow PJ
Gynecol Oncol 2009 Jan;112(1):224-8. Epub 2008 Oct 29 doi: 10.1016/j.ygyno.2008.08.038. PMID: 18973931Free PMC Article
Newer pathologic assessment techniques for colorectal carcinoma.
Turner RR, Li C, Compton CC
Clin Cancer Res 2007 Nov 15;13(22 Pt 2):6871s-6s. doi: 10.1158/1078-0432.CCR-07-1151. PMID: 18006792

Therapy

Neoadjuvant therapy in microsatellite-stable colorectal carcinoma induces concomitant loss of MSH6 and Ki-67 expression.
Kuan SF, Ren B, Brand R, Dudley B, Pai RK
Hum Pathol 2017 May;63:33-39. Epub 2017 Feb 21 doi: 10.1016/j.humpath.2017.02.003. PMID: 28232158
CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma.
Ogino S, Meyerhardt JA, Kawasaki T, Clark JW, Ryan DP, Kulke MH, Enzinger PC, Wolpin BM, Loda M, Fuchs CS
Virchows Arch 2007 May;450(5):529-37. Epub 2007 Mar 20 doi: 10.1007/s00428-007-0398-3. PMID: 17372756

Prognosis

BRAF-mutated microsatellite stable colorectal carcinoma: an aggressive adenocarcinoma with reduced CDX2 and increased cytokeratin 7 immunohistochemical expression.
Landau MS, Kuan SF, Chiosea S, Pai RK
Hum Pathol 2014 Aug;45(8):1704-12. Epub 2014 Apr 24 doi: 10.1016/j.humpath.2014.04.008. PMID: 24908142
Absence of MGMT promoter methylation in endometrial cancer.
Rimel BJ, Huettner P, Powell MA, Mutch DG, Goodfellow PJ
Gynecol Oncol 2009 Jan;112(1):224-8. Epub 2008 Oct 29 doi: 10.1016/j.ygyno.2008.08.038. PMID: 18973931Free PMC Article
Newer pathologic assessment techniques for colorectal carcinoma.
Turner RR, Li C, Compton CC
Clin Cancer Res 2007 Nov 15;13(22 Pt 2):6871s-6s. doi: 10.1158/1078-0432.CCR-07-1151. PMID: 18006792
CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma.
Ogino S, Meyerhardt JA, Kawasaki T, Clark JW, Ryan DP, Kulke MH, Enzinger PC, Wolpin BM, Loda M, Fuchs CS
Virchows Arch 2007 May;450(5):529-37. Epub 2007 Mar 20 doi: 10.1007/s00428-007-0398-3. PMID: 17372756

Clinical prediction guides

BRAF-mutated microsatellite stable colorectal carcinoma: an aggressive adenocarcinoma with reduced CDX2 and increased cytokeratin 7 immunohistochemical expression.
Landau MS, Kuan SF, Chiosea S, Pai RK
Hum Pathol 2014 Aug;45(8):1704-12. Epub 2014 Apr 24 doi: 10.1016/j.humpath.2014.04.008. PMID: 24908142
Newer pathologic assessment techniques for colorectal carcinoma.
Turner RR, Li C, Compton CC
Clin Cancer Res 2007 Nov 15;13(22 Pt 2):6871s-6s. doi: 10.1158/1078-0432.CCR-07-1151. PMID: 18006792
CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma.
Ogino S, Meyerhardt JA, Kawasaki T, Clark JW, Ryan DP, Kulke MH, Enzinger PC, Wolpin BM, Loda M, Fuchs CS
Virchows Arch 2007 May;450(5):529-37. Epub 2007 Mar 20 doi: 10.1007/s00428-007-0398-3. PMID: 17372756

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