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Locally Advanced Microsatellite Stable Colon Carcinoma

MedGen UID:
1791351
•Concept ID:
C5554910
•
Neoplastic Process

Definition

Microsatellite stable colon carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Microsatellite Stable Colon Carcinoma

Recent clinical studies

Etiology

NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions.
Kim JH, Hong JH, Choi YL, Lee JA, Seo MK, Lee MS, An SB, Sung MJ, Cho NY, Kim SS, Shin YK, Kim S, Kang GH
J Pathol 2021 Dec;255(4):399-411. Epub 2021 Sep 23 doi: 10.1002/path.5779. PMID: 34402529
Rectal Cancer in Adolescent and Young Adult Patients: Pattern of Clinical Presentation and Case-Matched Comparison of Outcomes.
Foppa C, Francesca Bertuzzi A, Cianchi F, Carvello M, Maroli A, Wolthuis AM, Rimassa L, Laghi L, Montorsi M, D'Hoore AJL, Spinelli A
Dis Colon Rectum 2021 Sep 1;64(9):1064-1073. doi: 10.1097/DCR.0000000000002022. PMID: 34397557
TRIM72 Immunohistochemical Expression Can Predict Relapse in Colorectal Carcinoma.
Fernández-Aceñero MJ, Cruz M, Sastre-Varela J, Casal JI, Nieto MAC, Del Puerto-Nevado L, García-Foncillas J, Cebrián A
Pathol Oncol Res 2020 Apr;26(2):861-865. Epub 2019 Mar 9 doi: 10.1007/s12253-019-00629-w. PMID: 30852740

Diagnosis

Rectal Cancer in Adolescent and Young Adult Patients: Pattern of Clinical Presentation and Case-Matched Comparison of Outcomes.
Foppa C, Francesca Bertuzzi A, Cianchi F, Carvello M, Maroli A, Wolthuis AM, Rimassa L, Laghi L, Montorsi M, D'Hoore AJL, Spinelli A
Dis Colon Rectum 2021 Sep 1;64(9):1064-1073. doi: 10.1097/DCR.0000000000002022. PMID: 34397557
Distinct genetic and epigenetic signatures of colorectal cancers according to ethnic origin.
Nieminen TT, Shoman S, Eissa S, Peltomäki P, Abdel-Rahman WM
Cancer Epidemiol Biomarkers Prev 2012 Jan;21(1):202-11. Epub 2011 Oct 25 doi: 10.1158/1055-9965.EPI-11-0662. PMID: 22028395

Prognosis

Rectal Cancer in Adolescent and Young Adult Patients: Pattern of Clinical Presentation and Case-Matched Comparison of Outcomes.
Foppa C, Francesca Bertuzzi A, Cianchi F, Carvello M, Maroli A, Wolthuis AM, Rimassa L, Laghi L, Montorsi M, D'Hoore AJL, Spinelli A
Dis Colon Rectum 2021 Sep 1;64(9):1064-1073. doi: 10.1097/DCR.0000000000002022. PMID: 34397557
TRIM72 Immunohistochemical Expression Can Predict Relapse in Colorectal Carcinoma.
Fernández-Aceñero MJ, Cruz M, Sastre-Varela J, Casal JI, Nieto MAC, Del Puerto-Nevado L, García-Foncillas J, Cebrián A
Pathol Oncol Res 2020 Apr;26(2):861-865. Epub 2019 Mar 9 doi: 10.1007/s12253-019-00629-w. PMID: 30852740
Distinct genetic and epigenetic signatures of colorectal cancers according to ethnic origin.
Nieminen TT, Shoman S, Eissa S, Peltomäki P, Abdel-Rahman WM
Cancer Epidemiol Biomarkers Prev 2012 Jan;21(1):202-11. Epub 2011 Oct 25 doi: 10.1158/1055-9965.EPI-11-0662. PMID: 22028395

Clinical prediction guides

NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions.
Kim JH, Hong JH, Choi YL, Lee JA, Seo MK, Lee MS, An SB, Sung MJ, Cho NY, Kim SS, Shin YK, Kim S, Kang GH
J Pathol 2021 Dec;255(4):399-411. Epub 2021 Sep 23 doi: 10.1002/path.5779. PMID: 34402529
Rectal Cancer in Adolescent and Young Adult Patients: Pattern of Clinical Presentation and Case-Matched Comparison of Outcomes.
Foppa C, Francesca Bertuzzi A, Cianchi F, Carvello M, Maroli A, Wolthuis AM, Rimassa L, Laghi L, Montorsi M, D'Hoore AJL, Spinelli A
Dis Colon Rectum 2021 Sep 1;64(9):1064-1073. doi: 10.1097/DCR.0000000000002022. PMID: 34397557
TRIM72 Immunohistochemical Expression Can Predict Relapse in Colorectal Carcinoma.
Fernández-Aceñero MJ, Cruz M, Sastre-Varela J, Casal JI, Nieto MAC, Del Puerto-Nevado L, García-Foncillas J, Cebrián A
Pathol Oncol Res 2020 Apr;26(2):861-865. Epub 2019 Mar 9 doi: 10.1007/s12253-019-00629-w. PMID: 30852740

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