U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Lung Carcinoid Tumor

MedGen UID:
1779422
•Concept ID:
C5447646
•
Neoplastic Process

Definition

Lung carcinoid tumor that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Lung Carcinoid Tumor

Professional guidelines

PubMed

Management of pulmonary neuroendocrine tumors.
Ramirez RA, Chauhan A, Gimenez J, Thomas KEH, Kokodis I, Voros BA
Rev Endocr Metab Disord 2017 Dec;18(4):433-442. doi: 10.1007/s11154-017-9429-9. PMID: 28868578
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Diagnosis and treatment of neuroendocrine lung tumors.
Sánchez de Cos Escuín J
Arch Bronconeumol 2014 Sep;50(9):392-6. Epub 2014 Mar 28 doi: 10.1016/j.arbres.2014.02.004. PMID: 24685201

Recent clinical studies

Etiology

Explanted malignancies after lung transplantation: the University of Michigan experience.
Mondoñedo JR, Huang T, Lin J, Wakeam E
Interact Cardiovasc Thorac Surg 2022 Jul 9;35(2) doi: 10.1093/icvts/ivac203. PMID: 35877066Free PMC Article
Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors.
Robelin P, Hadoux J, Forestier J, Planchard D, Hervieu V, Berdelou A, Scoazec JY, Valette PJ, Leboulleux S, Ducreux M, Lombard-Bohas C, Baudin E, Walter T
J Thorac Oncol 2019 Jun;14(6):993-1002. Epub 2019 Feb 13 doi: 10.1016/j.jtho.2019.02.002. PMID: 30771520
T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.
Ott PA, Bang YJ, Piha-Paul SA, Razak ARA, Bennouna J, Soria JC, Rugo HS, Cohen RB, O'Neil BH, Mehnert JM, Lopez J, Doi T, van Brummelen EMJ, Cristescu R, Yang P, Emancipator K, Stein K, Ayers M, Joe AK, Lunceford JK
J Clin Oncol 2019 Feb 1;37(4):318-327. Epub 2018 Dec 13 doi: 10.1200/JCO.2018.78.2276. PMID: 30557521
Advanced typical and atypical carcinoid tumours of the lung: management recommendations.
Melosky B
Curr Oncol 2018 Jun;25(Suppl 1):S86-S93. Epub 2018 Jun 13 doi: 10.3747/co.25.3808. PMID: 29910651Free PMC Article
Cutaneous manifestations of lung cancer.
Owen CE
Semin Oncol 2016 Jun;43(3):366-9. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.025. PMID: 27178690

Diagnosis

Lung Cancer and Radiological Imaging.
Panunzio A, Sartori P
Curr Radiopharm 2020;13(3):238-242. doi: 10.2174/1874471013666200523161849. PMID: 32445458Free PMC Article
Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Isgrò MA, Bottoni P, Scatena R
Adv Exp Med Biol 2015;867:125-43. doi: 10.1007/978-94-017-7215-0_9. PMID: 26530364
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Carcinoid tumors.
Pinchot SN, Holen K, Sippel RS, Chen H
Oncologist 2008 Dec;13(12):1255-69. Epub 2008 Dec 17 doi: 10.1634/theoncologist.2008-0207. PMID: 19091780Free PMC Article
Carcinoid tumors.
Sippel RS, Chen H
Surg Oncol Clin N Am 2006 Jul;15(3):463-78. doi: 10.1016/j.soc.2006.05.002. PMID: 16882492

Therapy

FDA Approval Summary: Selpercatinib for the Treatment of Advanced RET Fusion-Positive Solid Tumors.
Duke ES, Bradford D, Marcovitz M, Amatya AK, Mishra-Kalyani PS, Nguyen E, Price LSL, Fourie Zirkelbach J, Li Y, Bi Y, Kraft J, Dorff SE, Scepura B, Stephenson M, Ojofeitimi I, Nair A, Han Y, Tezak Z, Lemery SJ, Pazdur R, Larkins E, Singh H
Clin Cancer Res 2023 Sep 15;29(18):3573-3578. doi: 10.1158/1078-0432.CCR-23-0459. PMID: 37265412Free PMC Article
Serotonin Pathway in Cancer.
Balakrishna P, George S, Hatoum H, Mukherjee S
Int J Mol Sci 2021 Jan 28;22(3) doi: 10.3390/ijms22031268. PMID: 33525332Free PMC Article
T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.
Ott PA, Bang YJ, Piha-Paul SA, Razak ARA, Bennouna J, Soria JC, Rugo HS, Cohen RB, O'Neil BH, Mehnert JM, Lopez J, Doi T, van Brummelen EMJ, Cristescu R, Yang P, Emancipator K, Stein K, Ayers M, Joe AK, Lunceford JK
J Clin Oncol 2019 Feb 1;37(4):318-327. Epub 2018 Dec 13 doi: 10.1200/JCO.2018.78.2276. PMID: 30557521
Radionuclide Therapy for Neuroendocrine Tumors.
Cives M, Strosberg J
Curr Oncol Rep 2017 Feb;19(2):9. doi: 10.1007/s11912-017-0567-8. PMID: 28220446
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Prognosis

The single-cell transcriptional landscape of lung carcinoid tumors.
Bischoff P, Trinks A, Wiederspahn J, Obermayer B, Pett JP, Jurmeister P, Elsner A, Dziodzio T, Rückert JC, Neudecker J, Falk C, Beule D, Sers C, Morkel M, Horst D, Klauschen F, Blüthgen N
Int J Cancer 2022 Jun 15;150(12):2058-2071. Epub 2022 Mar 16 doi: 10.1002/ijc.33995. PMID: 35262195
T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.
Ott PA, Bang YJ, Piha-Paul SA, Razak ARA, Bennouna J, Soria JC, Rugo HS, Cohen RB, O'Neil BH, Mehnert JM, Lopez J, Doi T, van Brummelen EMJ, Cristescu R, Yang P, Emancipator K, Stein K, Ayers M, Joe AK, Lunceford JK
J Clin Oncol 2019 Feb 1;37(4):318-327. Epub 2018 Dec 13 doi: 10.1200/JCO.2018.78.2276. PMID: 30557521
Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Isgrò MA, Bottoni P, Scatena R
Adv Exp Med Biol 2015;867:125-43. doi: 10.1007/978-94-017-7215-0_9. PMID: 26530364
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Carcinoid tumors.
Pinchot SN, Holen K, Sippel RS, Chen H
Oncologist 2008 Dec;13(12):1255-69. Epub 2008 Dec 17 doi: 10.1634/theoncologist.2008-0207. PMID: 19091780Free PMC Article

Clinical prediction guides

Clinical efficacy of thermal ablation for the treatment of pulmonary carcinoid tumor: a propensity-matched analysis.
Yang H, Li M, Liu T, Luo L
Int J Hyperthermia 2023;40(1):2225817. doi: 10.1080/02656736.2023.2225817. PMID: 37364893
Durvalumab plus tremelimumab for the treatment of advanced neuroendocrine neoplasms of gastroenteropancreatic and lung origin.
Capdevila J, Hernando J, Teule A, Lopez C, Garcia-Carbonero R, Benavent M, Custodio A, Garcia-Alvarez A, Cubillo A, Alonso V, Carmona-Bayonas A, Alonso-Gordoa T, Crespo G, Jimenez-Fonseca P, Blanco M, Viudez A, La Casta A, Sevilla I, Segura A, Llanos M, Landolfi S, Nuciforo P, Manzano JL
Nat Commun 2023 May 23;14(1):2973. doi: 10.1038/s41467-023-38611-5. PMID: 37221181Free PMC Article
Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors.
Robelin P, Hadoux J, Forestier J, Planchard D, Hervieu V, Berdelou A, Scoazec JY, Valette PJ, Leboulleux S, Ducreux M, Lombard-Bohas C, Baudin E, Walter T
J Thorac Oncol 2019 Jun;14(6):993-1002. Epub 2019 Feb 13 doi: 10.1016/j.jtho.2019.02.002. PMID: 30771520
T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.
Ott PA, Bang YJ, Piha-Paul SA, Razak ARA, Bennouna J, Soria JC, Rugo HS, Cohen RB, O'Neil BH, Mehnert JM, Lopez J, Doi T, van Brummelen EMJ, Cristescu R, Yang P, Emancipator K, Stein K, Ayers M, Joe AK, Lunceford JK
J Clin Oncol 2019 Feb 1;37(4):318-327. Epub 2018 Dec 13 doi: 10.1200/JCO.2018.78.2276. PMID: 30557521
Atypical carcinoid tumor of the lung: a surveillance, epidemiology, and end results database analysis.
Steuer CE, Behera M, Kim S, Chen Z, Saba NF, Pillai RN, Owonikoko TK, Khuri FR, Ramalingam SS
J Thorac Oncol 2015 Mar;10(3):479-85. doi: 10.1097/JTO.0000000000000419. PMID: 25371080

Recent systematic reviews

Diagnostic accuracy of sentinel lymph node biopsy using indocyanine green in lung cancer: a systematic review and meta-analysis.
Sun WYL, Dang JT, Modasi A, Nasralla A, Switzer NJ, Birch D, Turner SR, Karmali S
Gen Thorac Cardiovasc Surg 2020 Sep;68(9):905-913. Epub 2020 Jun 16 doi: 10.1007/s11748-020-01400-8. PMID: 32557077
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354
Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence.
Wirtschafter E, Walts AE, Liu ST, Marchevsky AM
Lung 2015 Oct;193(5):659-67. Epub 2015 Jun 24 doi: 10.1007/s00408-015-9755-1. PMID: 26104490
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...