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Lung carcinoid tumor

MedGen UID:
79070
•Concept ID:
C0280089
•
Neoplastic Process
Synonyms: Carcinoid tumor of lung; Pulmonary carcinoid tumor
SNOMED CT: Carcinoid tumor of lung (254627002)
 
HPO: HP:0030445
Monarch Initiative: MONDO:0006041
OMIM®: 613733

Definition

A malignant neuroendocrine tumor of the lung. According to histopathologic criteria (WHO 2004), carcinoids are divided into four groups i.e. typical and atypical carcinoids, large cell neuroendocrine carcinoma and small cell lung carcinoma. [from HPO]

Professional guidelines

PubMed

Lung carcinoid tumor biology: treatment and survival.
Dahabreh J, Stathopoulos GP, Koutantos J, Rigatos S
Oncol Rep 2009 Mar;21(3):757-60. PMID: 19212636

Recent clinical studies

Etiology

Median 10 years follow-up of patients with covert Cushing's syndrome: a case series.
Najafipour F, Bahrami A, Niafar M, Houshyar J, Halimi M, Sadra V
J Med Case Rep 2021 Oct 11;15(1):514. doi: 10.1186/s13256-021-03046-3. PMID: 34635153Free PMC Article
The Prognostic Significance of the 8th Edition TNM Staging of Pulmonary Carcinoid Tumors: A Single Institution Study With Long-term Follow-up.
Dermawan JK, Farver CF
Am J Surg Pathol 2019 Sep;43(9):1291-1296. doi: 10.1097/PAS.0000000000001268. PMID: 31094922
The clinical value of exhaled nitric oxide in patients with lung cancer.
Liu PF, Zhao DH, Qi Y, Wang JG, Zhao M, Xiao K, Xie LX
Clin Respir J 2018 Jan;12(1):23-30. Epub 2016 Apr 7 doi: 10.1111/crj.12471. PMID: 26934059
Fluorodeoxyglucose positron emission tomography in pulmonary carcinoid tumors.
Gasparri R, Rezende GC, Fazio N, Maisonneuve P, Brambilla D, Travaini LL, Paganelli G, Petrella F, Galetta D, Spaggiari L
Q J Nucl Med Mol Imaging 2015 Dec;59(4):446-54. PMID: 26416036
Surgical management of left-sided carcinoid heart disease.
Connolly HM, Schaff HV, Mullany CJ, Rubin J, Abel MD, Pellikka PA
Circulation 2001 Sep 18;104(12 Suppl 1):I36-40. doi: 10.1161/hc37t1.094898. PMID: 11568027

Diagnosis

Co‑occurrence of granulomatosis with polyangiitis and a lung carcinoid tumor.
Kosko F, Dębska-Ślizień A, Skonieczny P, Wołyniec W, Lizakowski S, Heleniak Z
Pol Arch Intern Med 2023 Nov 29;133(11) Epub 2023 Oct 10 doi: 10.20452/pamw.16582. PMID: 37818987
Heterogeneous tumor-immune microenvironments between primary and metastatic carcinoid tumors differentially respond to anti-PD-L1 antibody therapy.
Sakata S, Imamura K, Tajima Y, Masuda Y, Sato R, Yoshida C, Okamoto S, Saeki S, Tomita Y, Sakagami T
Thorac Cancer 2021 Feb;12(3):397-401. Epub 2020 Dec 9 doi: 10.1111/1759-7714.13772. PMID: 33300302Free PMC Article
Advanced multimodal diagnostic approaches for detection of lung cancer.
Shende P, Augustine S, Prabhakar B, Gaud RS
Expert Rev Mol Diagn 2019 May;19(5):409-417. Epub 2019 Apr 22 doi: 10.1080/14737159.2019.1607299. PMID: 30977684
Fluorodeoxyglucose positron emission tomography in pulmonary carcinoid tumors.
Gasparri R, Rezende GC, Fazio N, Maisonneuve P, Brambilla D, Travaini LL, Paganelli G, Petrella F, Galetta D, Spaggiari L
Q J Nucl Med Mol Imaging 2015 Dec;59(4):446-54. PMID: 26416036
Lung carcinoid tumor biology: treatment and survival.
Dahabreh J, Stathopoulos GP, Koutantos J, Rigatos S
Oncol Rep 2009 Mar;21(3):757-60. PMID: 19212636

Therapy

Heterogeneous tumor-immune microenvironments between primary and metastatic carcinoid tumors differentially respond to anti-PD-L1 antibody therapy.
Sakata S, Imamura K, Tajima Y, Masuda Y, Sato R, Yoshida C, Okamoto S, Saeki S, Tomita Y, Sakagami T
Thorac Cancer 2021 Feb;12(3):397-401. Epub 2020 Dec 9 doi: 10.1111/1759-7714.13772. PMID: 33300302Free PMC Article
Long-term management with octreotide or cabergoline in ectopic corticotropin hypersecretion: case report and literature review.
Bruno OD, Danilowicz K, Manavela M, Mana D, Rossi MA
Endocr Pract 2010 Sep-Oct;16(5):829-34. doi: 10.4158/EP09286.CR. PMID: 20497940
Lung carcinoid tumor biology: treatment and survival.
Dahabreh J, Stathopoulos GP, Koutantos J, Rigatos S
Oncol Rep 2009 Mar;21(3):757-60. PMID: 19212636
An atypical lung carcinoid tumor resected after induction therapy with involvement of the superior sulcus region: report of a case.
Ohta Y, Toda A, Ohta N, Oda M, Minato H, Nonomura A, Watanabe G
Surg Today 2002;32(7):632-4. doi: 10.1007/s005950200114. PMID: 12111522
Surgical management of left-sided carcinoid heart disease.
Connolly HM, Schaff HV, Mullany CJ, Rubin J, Abel MD, Pellikka PA
Circulation 2001 Sep 18;104(12 Suppl 1):I36-40. doi: 10.1161/hc37t1.094898. PMID: 11568027

Prognosis

The single-cell transcriptional landscape of lung carcinoid tumors.
Bischoff P, Trinks A, Wiederspahn J, Obermayer B, Pett JP, Jurmeister P, Elsner A, Dziodzio T, Rückert JC, Neudecker J, Falk C, Beule D, Sers C, Morkel M, Horst D, Klauschen F, Blüthgen N
Int J Cancer 2022 Jun 15;150(12):2058-2071. Epub 2022 Mar 16 doi: 10.1002/ijc.33995. PMID: 35262195
Median 10 years follow-up of patients with covert Cushing's syndrome: a case series.
Najafipour F, Bahrami A, Niafar M, Houshyar J, Halimi M, Sadra V
J Med Case Rep 2021 Oct 11;15(1):514. doi: 10.1186/s13256-021-03046-3. PMID: 34635153Free PMC Article
Posterior fossa metastasis of lung carcinoid tumor: case report.
Reinas R, Santos RB, Kitumba D, Furtado A, Alves ÓL, Resende M
Br J Neurosurg 2021 Jun;35(3):364-366. Epub 2018 Apr 2 doi: 10.1080/02688697.2018.1457774. PMID: 29607688
The clinical value of exhaled nitric oxide in patients with lung cancer.
Liu PF, Zhao DH, Qi Y, Wang JG, Zhao M, Xiao K, Xie LX
Clin Respir J 2018 Jan;12(1):23-30. Epub 2016 Apr 7 doi: 10.1111/crj.12471. PMID: 26934059
Fluorodeoxyglucose positron emission tomography in pulmonary carcinoid tumors.
Gasparri R, Rezende GC, Fazio N, Maisonneuve P, Brambilla D, Travaini LL, Paganelli G, Petrella F, Galetta D, Spaggiari L
Q J Nucl Med Mol Imaging 2015 Dec;59(4):446-54. PMID: 26416036

Clinical prediction guides

The Prognostic Significance of the 8th Edition TNM Staging of Pulmonary Carcinoid Tumors: A Single Institution Study With Long-term Follow-up.
Dermawan JK, Farver CF
Am J Surg Pathol 2019 Sep;43(9):1291-1296. doi: 10.1097/PAS.0000000000001268. PMID: 31094922
The clinical value of exhaled nitric oxide in patients with lung cancer.
Liu PF, Zhao DH, Qi Y, Wang JG, Zhao M, Xiao K, Xie LX
Clin Respir J 2018 Jan;12(1):23-30. Epub 2016 Apr 7 doi: 10.1111/crj.12471. PMID: 26934059
MEN1 c.825‑1G>A mutation in a family with multiple endocrine neoplasia type 1: A case report.
Ning Z, Wang O, Meng X, Xing X, Xia W, Jiang Y, Li M, Xu Y
Mol Med Rep 2015 Oct;12(4):6152-6. Epub 2015 Jul 29 doi: 10.3892/mmr.2015.4138. PMID: 26239674
Long-term management with octreotide or cabergoline in ectopic corticotropin hypersecretion: case report and literature review.
Bruno OD, Danilowicz K, Manavela M, Mana D, Rossi MA
Endocr Pract 2010 Sep-Oct;16(5):829-34. doi: 10.4158/EP09286.CR. PMID: 20497940
Secondary cancers after a lung carcinoid primary: a population-based analysis.
Cote ML, Wenzlaff AS, Philip PA, Schwartz AG
Lung Cancer 2006 Jun;52(3):273-9. Epub 2006 Mar 29 doi: 10.1016/j.lungcan.2006.02.004. PMID: 16567020

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