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Unresectable Lung Carcinoid Tumor

MedGen UID:
1781875
•Concept ID:
C5447648
•
Neoplastic Process

Definition

Lung carcinoid tumor that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Lung Carcinoid Tumor

Professional guidelines

PubMed

Recent Advances in the Management of Typical and Atypical Lung Carcinoids.
Prinzi N, Rossi RE, Proto C, Leuzzi G, Raimondi A, Torchio M, Milione M, Corti F, Colombo E, Prisciandaro M, Cascella T, Spreafico C, Beninato T, Coppa J, Lo Russo G, Di Bartolomeo M, de Braud F, Pusceddu S
Clin Lung Cancer 2021 May;22(3):161-169. Epub 2020 Dec 17 doi: 10.1016/j.cllc.2020.12.004. PMID: 33618994
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Primary carcinoid tumors of the lung: a role for radiotherapy.
Mackley HB, Videtic GM
Oncology (Williston Park) 2006 Nov;20(12):1537-43; discussion 1544-5, 1549. PMID: 17153907

Recent clinical studies

Etiology

Prognosis of Unresected vs Resected Small Pulmonary Carcinoid Tumors.
Roat-Shumway S, Tonelli CM, Baker MS, Abdelsattar ZM
Ann Thorac Surg 2023 Sep;116(3):553-561. Epub 2023 Apr 11 doi: 10.1016/j.athoracsur.2023.04.008. PMID: 37054928
Efficacy and Safety of Lanreotide Autogel and Temozolomide Combination Therapy in Progressive Thoracic Neuroendocrine Tumors (Carcinoid): Results from the Phase 2 ATLANT Study.
Ferolla P, Berruti A, Spada F, Brizzi MP, Ibrahim T, Marconcini R, Giuffrida D, Amoroso V, La Salvia A, Vaccaro V, Faggiano A, Colao A, Volante M, Ghizzoni S, Mazzanti P, Houchard A, Fazio N
Neuroendocrinology 2023;113(3):332-342. Epub 2022 Aug 31 doi: 10.1159/000526811. PMID: 36044870
Hepatic intra-arterial therapies in metastatic neuroendocrine tumors: lessons from clinical practice.
Grozinsky-Glasberg S, Kaltsas G, Kaltsatou M, Lev-Cohain N, Klimov A, Vergadis V, Uri I, Bloom AI, Gross DJ
Endocrine 2018 Jun;60(3):499-509. Epub 2018 Jan 30 doi: 10.1007/s12020-018-1537-0. PMID: 29383678
Advances in the Diagnosis and Management of Well-Differentiated and Intermediate-Differentiated Neuroendocrine Tumors of the Lung.
Wolin EM
Chest 2017 May;151(5):1141-1146. Epub 2016 Jun 29 doi: 10.1016/j.chest.2016.06.018. PMID: 27373769
Primary carcinoid tumors of the lung: a role for radiotherapy.
Mackley HB, Videtic GM
Oncology (Williston Park) 2006 Nov;20(12):1537-43; discussion 1544-5, 1549. PMID: 17153907

Diagnosis

Recent Advances in the Management of Typical and Atypical Lung Carcinoids.
Prinzi N, Rossi RE, Proto C, Leuzzi G, Raimondi A, Torchio M, Milione M, Corti F, Colombo E, Prisciandaro M, Cascella T, Spreafico C, Beninato T, Coppa J, Lo Russo G, Di Bartolomeo M, de Braud F, Pusceddu S
Clin Lung Cancer 2021 May;22(3):161-169. Epub 2020 Dec 17 doi: 10.1016/j.cllc.2020.12.004. PMID: 33618994
Advances in the Diagnosis and Management of Well-Differentiated and Intermediate-Differentiated Neuroendocrine Tumors of the Lung.
Wolin EM
Chest 2017 May;151(5):1141-1146. Epub 2016 Jun 29 doi: 10.1016/j.chest.2016.06.018. PMID: 27373769
Challenges in the Diagnosis and Management of Well-Differentiated Neuroendocrine Tumors of the Lung (Typical and Atypical Carcinoid): Current Status and Future Considerations.
Wolin EM
Oncologist 2015 Oct;20(10):1123-31. Epub 2015 Aug 25 doi: 10.1634/theoncologist.2015-0198. PMID: 26306904Free PMC Article
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Primary carcinoid tumors of the lung: a role for radiotherapy.
Mackley HB, Videtic GM
Oncology (Williston Park) 2006 Nov;20(12):1537-43; discussion 1544-5, 1549. PMID: 17153907

Therapy

Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Heterogeneous tumor-immune microenvironments between primary and metastatic carcinoid tumors differentially respond to anti-PD-L1 antibody therapy.
Sakata S, Imamura K, Tajima Y, Masuda Y, Sato R, Yoshida C, Okamoto S, Saeki S, Tomita Y, Sakagami T
Thorac Cancer 2021 Feb;12(3):397-401. Epub 2020 Dec 9 doi: 10.1111/1759-7714.13772. PMID: 33300302Free PMC Article
Advances in the Diagnosis and Management of Well-Differentiated and Intermediate-Differentiated Neuroendocrine Tumors of the Lung.
Wolin EM
Chest 2017 May;151(5):1141-1146. Epub 2016 Jun 29 doi: 10.1016/j.chest.2016.06.018. PMID: 27373769
Challenges in the Diagnosis and Management of Well-Differentiated Neuroendocrine Tumors of the Lung (Typical and Atypical Carcinoid): Current Status and Future Considerations.
Wolin EM
Oncologist 2015 Oct;20(10):1123-31. Epub 2015 Aug 25 doi: 10.1634/theoncologist.2015-0198. PMID: 26306904Free PMC Article
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Prognosis

Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Recent Advances in the Management of Typical and Atypical Lung Carcinoids.
Prinzi N, Rossi RE, Proto C, Leuzzi G, Raimondi A, Torchio M, Milione M, Corti F, Colombo E, Prisciandaro M, Cascella T, Spreafico C, Beninato T, Coppa J, Lo Russo G, Di Bartolomeo M, de Braud F, Pusceddu S
Clin Lung Cancer 2021 May;22(3):161-169. Epub 2020 Dec 17 doi: 10.1016/j.cllc.2020.12.004. PMID: 33618994
Advances in the Diagnosis and Management of Well-Differentiated and Intermediate-Differentiated Neuroendocrine Tumors of the Lung.
Wolin EM
Chest 2017 May;151(5):1141-1146. Epub 2016 Jun 29 doi: 10.1016/j.chest.2016.06.018. PMID: 27373769
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Primary carcinoid tumors of the lung: a role for radiotherapy.
Mackley HB, Videtic GM
Oncology (Williston Park) 2006 Nov;20(12):1537-43; discussion 1544-5, 1549. PMID: 17153907

Clinical prediction guides

Prognosis of Unresected vs Resected Small Pulmonary Carcinoid Tumors.
Roat-Shumway S, Tonelli CM, Baker MS, Abdelsattar ZM
Ann Thorac Surg 2023 Sep;116(3):553-561. Epub 2023 Apr 11 doi: 10.1016/j.athoracsur.2023.04.008. PMID: 37054928
Efficacy and Safety of Lanreotide Autogel and Temozolomide Combination Therapy in Progressive Thoracic Neuroendocrine Tumors (Carcinoid): Results from the Phase 2 ATLANT Study.
Ferolla P, Berruti A, Spada F, Brizzi MP, Ibrahim T, Marconcini R, Giuffrida D, Amoroso V, La Salvia A, Vaccaro V, Faggiano A, Colao A, Volante M, Ghizzoni S, Mazzanti P, Houchard A, Fazio N
Neuroendocrinology 2023;113(3):332-342. Epub 2022 Aug 31 doi: 10.1159/000526811. PMID: 36044870
Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Hepatic intra-arterial therapies in metastatic neuroendocrine tumors: lessons from clinical practice.
Grozinsky-Glasberg S, Kaltsas G, Kaltsatou M, Lev-Cohain N, Klimov A, Vergadis V, Uri I, Bloom AI, Gross DJ
Endocrine 2018 Jun;60(3):499-509. Epub 2018 Jan 30 doi: 10.1007/s12020-018-1537-0. PMID: 29383678
Combination chemotherapy trials in metastatic carcinoid tumor and the malignant carcinoid syndrome.
Moertel CG, Hanley JA
Cancer Clin Trials 1979 Winter;2(4):327-34. PMID: 93982

Recent systematic reviews

Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

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