U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Malignant Small Intestinal Neoplasm

MedGen UID:
1788457
•Concept ID:
C0861816
•
Neoplastic Process

Definition

A malignant small intestinal neoplasm that has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Non-surgical management of small bowel obstruction secondary to Burkitt's lymphoma.
Hitchen T, Chen N, Heng C
ANZ J Surg 2022 Dec;92(12):3335-3337. Epub 2022 Mar 2 doi: 10.1111/ans.17590. PMID: 35233894

Recent clinical studies

Etiology

Antiproliferative Systemic Therapies for Metastatic Small Bowel Neuroendocrine Tumours.
Dawod M, Gordoa TA, Cives M, De Mestier L, Crona J, Spada F, Oberg K, Pavel M, Lamarca A
Curr Treat Options Oncol 2021 Jun 29;22(8):73. doi: 10.1007/s11864-021-00863-y. PMID: 34185197
Molecular pathways and targeted therapy in cholangiocarcinoma.
Dabney RS, Khalife M, Shahid K, Phan AT
Clin Adv Hematol Oncol 2019 Nov;17(11):630-637. PMID: 31851165
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Small Bowel Adenocarcinoma.
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article

Diagnosis

Neuroendocrine Tumors of the Pancreatobiliary and Gastrointestinal Tracts.
Bonds M, Rocha FG
Surg Clin North Am 2020 Jun;100(3):635-648. Epub 2020 Apr 1 doi: 10.1016/j.suc.2020.02.010. PMID: 32402306
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Demystifying the mesenteric root lesions.
Kumar P, Malla S, Singh A, Razik A, Madhusudhan KS
Abdom Radiol (NY) 2019 Aug;44(8):2708-2720. Epub 2019 May 11 doi: 10.1007/s00261-019-02053-9. PMID: 31079195
Update on Surgical Management of Small Bowel Neuroendocrine Tumors.
Moris D, Ntanasis-Stathopoulos I, Tsilimigras DI, Vagios S, Karamitros A, Karaolanis G, Griniatsos J, Papalampros A, Papaconstantinou I, Glantzounis GK, Spartalis E, Blazer DG 3rd, Felekouras E
Anticancer Res 2018 Mar;38(3):1267-1278. doi: 10.21873/anticanres.12349. PMID: 29491050
Small Bowel Adenocarcinoma.
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842

Therapy

The Evolving Landscape of Neuroendocrine Tumors.
Russo A, Gangi A
Surg Oncol Clin N Am 2023 Jan;32(1):185-198. Epub 2022 Nov 3 doi: 10.1016/j.soc.2022.08.003. PMID: 36410917
Small Bowel Adenocarcinoma.
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056
Gastrointestinal lymphoma.
Thomas CR Jr, Share R
Med Pediatr Oncol 1991;19(1):48-60. doi: 10.1002/mpo.2950190109. PMID: 1990257

Prognosis

Immunotherapy in small bowel adenocarcinoma: a potential role?
Vitiello F, Cereda S, Foti S, Liscia N, Mazza E, Ronzoni M, Cascinu S
Immunol Med 2024 Mar;47(1):1-5. Epub 2023 Jun 9 doi: 10.1080/25785826.2023.2220938. PMID: 37293784
Epidemiology of liver metastases.
Horn SR, Stoltzfus KC, Lehrer EJ, Dawson LA, Tchelebi L, Gusani NJ, Sharma NK, Chen H, Trifiletti DM, Zaorsky NG
Cancer Epidemiol 2020 Aug;67:101760. Epub 2020 Jun 17 doi: 10.1016/j.canep.2020.101760. PMID: 32562887
Neuroendocrine Tumors of the Pancreatobiliary and Gastrointestinal Tracts.
Bonds M, Rocha FG
Surg Clin North Am 2020 Jun;100(3):635-648. Epub 2020 Apr 1 doi: 10.1016/j.suc.2020.02.010. PMID: 32402306
Small Bowel Adenocarcinoma.
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842
Malignant fibrous histiocytoma.
Pillay SP, Roberts SJ, Thynne GS, Hardie IR
Aust N Z J Surg 1980 Oct;50(5):532-7. doi: 10.1111/j.1445-2197.1980.tb04188.x. PMID: 6255921

Clinical prediction guides

Immunotherapy in small bowel adenocarcinoma: a potential role?
Vitiello F, Cereda S, Foti S, Liscia N, Mazza E, Ronzoni M, Cascinu S
Immunol Med 2024 Mar;47(1):1-5. Epub 2023 Jun 9 doi: 10.1080/25785826.2023.2220938. PMID: 37293784
The impact of surgery and survival prediction in patients with gastroenteropancreatic neuroendocrine tumors: a population-based cohort study.
Wu Z, Wang W, Zhang K, Fan M, Lin R
Int J Surg 2023 Jun 1;109(6):1629-1638. doi: 10.1097/JS9.0000000000000336. PMID: 37133986Free PMC Article
A Predictive Nomogram for Small Intestine Neuroendocrine Tumors.
Kelly S, Aalberg J, Kim MK, Divino CM
Pancreas 2020 Apr;49(4):524-528. doi: 10.1097/MPA.0000000000001526. PMID: 32282765
Surgical management of neuroendocrine tumors.
Tamburrino D, Spoletini G, Partelli S, Muffatti F, Adamenko O, Crippa S, Falconi M
Best Pract Res Clin Endocrinol Metab 2016 Jan;30(1):93-102. Epub 2015 Oct 8 doi: 10.1016/j.beem.2015.10.003. PMID: 26971846
Carcinoid disease.
Wood ER, Wood WG
South Med J 1980 May;73(5):621-6. doi: 10.1097/00007611-198005000-00021. PMID: 7375982

Recent systematic reviews

Risk of extracolonic second primary cancers following a primary colorectal cancer: a systematic review and meta-analysis.
Robertson D, Ng SK, Baade PD, Lam AK
Int J Colorectal Dis 2022 Mar;37(3):541-551. Epub 2022 Feb 12 doi: 10.1007/s00384-022-04105-x. PMID: 35152308Free PMC Article
Management of primary and metastatic malignant small bowel obstruction, operate or palliate. A systematic review.
Banting SP, Waters PS, Peacock O, Narasimhan V, Lynch AC, McCormick JJ, Warrier SK, Heriot AG
ANZ J Surg 2021 Mar;91(3):282-290. Epub 2020 Aug 31 doi: 10.1111/ans.16188. PMID: 32869479
Clival Metastasis of a Duodenal Adenocarcinoma: A Case Report and Literature Review.
Dekker SE, Wasman J, Yoo KK, Alonso F, Tarr RW, Bambakidis NC, Rodriguez K
World Neurosurg 2017 Apr;100:62-68. Epub 2016 Dec 27 doi: 10.1016/j.wneu.2016.12.078. PMID: 28034818
Imaging spectrum of nonneoplastic duodenal diseases.
Srisajjakul S, Prapaisilp P, Bangchokdee S
Clin Imaging 2016 Nov-Dec;40(6):1173-1181. Epub 2016 Aug 6 doi: 10.1016/j.clinimag.2016.08.007. PMID: 27572283
Prognostic value of lymph node metastases detected during surgical exploration for pancreatic or periampullary cancer: a systematic review and meta-analysis.
van Rijssen LB, Narwade P, van Huijgevoort NC, Tseng DS, van Santvoort HC, Molenaar IQ, van Laarhoven HW, van Eijck CH, Busch OR, Besselink MG; Dutch Pancreatic Cancer Group
HPB (Oxford) 2016 Jul;18(7):559-66. Epub 2016 May 27 doi: 10.1016/j.hpb.2016.05.001. PMID: 27346135Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...