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Locally Advanced Small Intestinal Adenocarcinoma

MedGen UID:
1786491
•Concept ID:
C5446588
•
Neoplastic Process

Definition

Small intestinal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Small Intestinal Adenocarcinoma

Professional guidelines

PubMed

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Small Bowel Adenocarcinoma: From Molecular Insights to Clinical Management.
Gelsomino F, Balsano R, De Lorenzo S, Garajová I
Curr Oncol 2022 Feb 17;29(2):1223-1236. doi: 10.3390/curroncol29020104. PMID: 35200603Free PMC Article
The evolving management of small bowel adenocarcinoma.
de Bree E, Rovers KP, Stamatiou D, Souglakos J, Michelakis D, de Hingh IH
Acta Oncol 2018 Jun;57(6):712-722. Epub 2018 Jan 30 doi: 10.1080/0284186X.2018.1433321. PMID: 29381126

Recent clinical studies

Etiology

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Radical Resection Combined With Intestinal Autotransplantation for Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy: A Report of 36 Consecutive Cases.
Liang T, Zhang Q, Wu G, Liu C, Bai X, Gao S, Ma T, Sun K, Yan S, Xiao W, Jiang T, Lu F, Zhang Y, Shen Y, Zhang M, Zhang X, Shan J
Ann Surg 2023 Nov 1;278(5):e1055-e1062. Epub 2023 Jan 24 doi: 10.1097/SLA.0000000000005797. PMID: 36727746
Natural history and prognostic factors for localised small bowel adenocarcinoma.
Colina A, Hwang H, Wang H, Katz MHG, Sun R, Lee JE, Thomas J, Tzeng CW, Wolff RA, Raghav K, Overman MJ
ESMO Open 2020 Nov;5(6):e000960. doi: 10.1136/esmoopen-2020-000960. PMID: 33188051Free PMC Article
Laparoscopic Pelvic Exenteration for Locally Advanced Rectal Cancer, Technique and Short-Term Outcomes.
Pokharkar A, Kammar P, D'souza A, Bhamre R, Sugoor P, Saklani A
J Laparoendosc Adv Surg Tech A 2018 Dec;28(12):1489-1494. Epub 2018 May 9 doi: 10.1089/lap.2018.0147. PMID: 29741977
Rectal carcinoids: a systematic review.
McDermott FD, Heeney A, Courtney D, Mohan H, Winter D
Surg Endosc 2014 Jul;28(7):2020-6. Epub 2014 Mar 1 doi: 10.1007/s00464-014-3430-0. PMID: 24584484

Diagnosis

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Progress in the Treatment of Small Intestine Cancer.
Symons R, Daly D, Gandy R, Goldstein D, Aghmesheh M
Curr Treat Options Oncol 2023 Apr;24(4):241-261. Epub 2023 Feb 24 doi: 10.1007/s11864-023-01058-3. PMID: 36826686
The evolving management of small bowel adenocarcinoma.
de Bree E, Rovers KP, Stamatiou D, Souglakos J, Michelakis D, de Hingh IH
Acta Oncol 2018 Jun;57(6):712-722. Epub 2018 Jan 30 doi: 10.1080/0284186X.2018.1433321. PMID: 29381126
Rectal carcinoids: a systematic review.
McDermott FD, Heeney A, Courtney D, Mohan H, Winter D
Surg Endosc 2014 Jul;28(7):2020-6. Epub 2014 Mar 1 doi: 10.1007/s00464-014-3430-0. PMID: 24584484
Tumors of the ampulla of Vater.
Jean M, Dua K
Curr Gastroenterol Rep 2003 Apr;5(2):171-5. doi: 10.1007/s11894-003-0088-5. PMID: 12631460

Therapy

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
FDA Approval Summary: Selpercatinib for the Treatment of Advanced RET Fusion-Positive Solid Tumors.
Duke ES, Bradford D, Marcovitz M, Amatya AK, Mishra-Kalyani PS, Nguyen E, Price LSL, Fourie Zirkelbach J, Li Y, Bi Y, Kraft J, Dorff SE, Scepura B, Stephenson M, Ojofeitimi I, Nair A, Han Y, Tezak Z, Lemery SJ, Pazdur R, Larkins E, Singh H
Clin Cancer Res 2023 Sep 15;29(18):3573-3578. doi: 10.1158/1078-0432.CCR-23-0459. PMID: 37265412Free PMC Article
Progress in the Treatment of Small Intestine Cancer.
Symons R, Daly D, Gandy R, Goldstein D, Aghmesheh M
Curr Treat Options Oncol 2023 Apr;24(4):241-261. Epub 2023 Feb 24 doi: 10.1007/s11864-023-01058-3. PMID: 36826686
Radical Resection Combined With Intestinal Autotransplantation for Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy: A Report of 36 Consecutive Cases.
Liang T, Zhang Q, Wu G, Liu C, Bai X, Gao S, Ma T, Sun K, Yan S, Xiao W, Jiang T, Lu F, Zhang Y, Shen Y, Zhang M, Zhang X, Shan J
Ann Surg 2023 Nov 1;278(5):e1055-e1062. Epub 2023 Jan 24 doi: 10.1097/SLA.0000000000005797. PMID: 36727746
ALK inhibitors in the treatment of advanced NSCLC.
Gridelli C, Peters S, Sgambato A, Casaluce F, Adjei AA, Ciardiello F
Cancer Treat Rev 2014 Mar;40(2):300-6. Epub 2013 Aug 7 doi: 10.1016/j.ctrv.2013.07.002. PMID: 23931927

Prognosis

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Radical Resection Combined With Intestinal Autotransplantation for Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy: A Report of 36 Consecutive Cases.
Liang T, Zhang Q, Wu G, Liu C, Bai X, Gao S, Ma T, Sun K, Yan S, Xiao W, Jiang T, Lu F, Zhang Y, Shen Y, Zhang M, Zhang X, Shan J
Ann Surg 2023 Nov 1;278(5):e1055-e1062. Epub 2023 Jan 24 doi: 10.1097/SLA.0000000000005797. PMID: 36727746
Small Bowel Adenocarcinoma: From Molecular Insights to Clinical Management.
Gelsomino F, Balsano R, De Lorenzo S, Garajová I
Curr Oncol 2022 Feb 17;29(2):1223-1236. doi: 10.3390/curroncol29020104. PMID: 35200603Free PMC Article
Natural history and prognostic factors for localised small bowel adenocarcinoma.
Colina A, Hwang H, Wang H, Katz MHG, Sun R, Lee JE, Thomas J, Tzeng CW, Wolff RA, Raghav K, Overman MJ
ESMO Open 2020 Nov;5(6):e000960. doi: 10.1136/esmoopen-2020-000960. PMID: 33188051Free PMC Article
The evolving management of small bowel adenocarcinoma.
de Bree E, Rovers KP, Stamatiou D, Souglakos J, Michelakis D, de Hingh IH
Acta Oncol 2018 Jun;57(6):712-722. Epub 2018 Jan 30 doi: 10.1080/0284186X.2018.1433321. PMID: 29381126

Clinical prediction guides

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Radical Resection Combined With Intestinal Autotransplantation for Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy: A Report of 36 Consecutive Cases.
Liang T, Zhang Q, Wu G, Liu C, Bai X, Gao S, Ma T, Sun K, Yan S, Xiao W, Jiang T, Lu F, Zhang Y, Shen Y, Zhang M, Zhang X, Shan J
Ann Surg 2023 Nov 1;278(5):e1055-e1062. Epub 2023 Jan 24 doi: 10.1097/SLA.0000000000005797. PMID: 36727746
Natural history and prognostic factors for localised small bowel adenocarcinoma.
Colina A, Hwang H, Wang H, Katz MHG, Sun R, Lee JE, Thomas J, Tzeng CW, Wolff RA, Raghav K, Overman MJ
ESMO Open 2020 Nov;5(6):e000960. doi: 10.1136/esmoopen-2020-000960. PMID: 33188051Free PMC Article
The characteristics and outcomes of small bowel adenocarcinoma: a multicentre retrospective observational study.
Sakae H, Kanzaki H, Nasu J, Akimoto Y, Matsueda K, Yoshioka M, Nakagawa M, Hori S, Inoue M, Inaba T, Imagawa A, Takatani M, Takenaka R, Suzuki S, Fujiwara T, Okada H
Br J Cancer 2017 Nov 21;117(11):1607-1613. Epub 2017 Oct 5 doi: 10.1038/bjc.2017.338. PMID: 28982111Free PMC Article
Characteristics and Treatment Strategies for Small Bowel Adenocarcinoma in Advanced-stage Cases.
Nakanoko T, Koga T, Taketani K, Hirayama Y, Yoshiya S, Minagawa R, Kai M, Kajiyama K, Maehara Y
Anticancer Res 2015 Jul;35(7):4135-8. PMID: 26124367

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Adjuvant therapy for true ampullary cancer: a systematic review.
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720
Gemcitabine-based chemotherapy for advanced biliary tract carcinomas.
Abdel-Rahman O, Elsayed Z, Elhalawani H
Cochrane Database Syst Rev 2018 Apr 6;4(4):CD011746. doi: 10.1002/14651858.CD011746.pub2. PMID: 29624208Free PMC Article
Rectal carcinoids: a systematic review.
McDermott FD, Heeney A, Courtney D, Mohan H, Winter D
Surg Endosc 2014 Jul;28(7):2020-6. Epub 2014 Mar 1 doi: 10.1007/s00464-014-3430-0. PMID: 24584484

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