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Advanced Malignant Small Intestinal Neoplasm

MedGen UID:
1780677
•Concept ID:
C5447368
•
Neoplastic Process

Definition

A malignant small intestinal neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Updates in the diagnosis and management of small-bowel tumors.
Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845

Recent clinical studies

Etiology

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Circulating vitamin C and digestive system cancers: Mendelian randomization study.
Larsson SC, Mason AM, Vithayathil M, Carter P, Kar S, Zheng JS, Burgess S
Clin Nutr 2022 Sep;41(9):2031-2035. Epub 2022 Aug 7 doi: 10.1016/j.clnu.2022.07.040. PMID: 35986965Free PMC Article
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Radiation enteritis.
Bismar MM, Sinicrope FA
Curr Gastroenterol Rep 2002 Oct;4(5):361-5. doi: 10.1007/s11894-002-0005-3. PMID: 12228037
Continent reservoirs.
Colberg JW, Schiff SF, Lytton B
Conn Med 1989 Oct;53(10):573-6. PMID: 2582760

Diagnosis

Peutz-Jeghers syndrome.
Tacheci I, Kopacova M, Bures J
Curr Opin Gastroenterol 2021 May 1;37(3):245-254. doi: 10.1097/MOG.0000000000000718. PMID: 33591027
Insights and updates on endoscopic papillectomy.
Yamamoto K, Iwasaki E, Itoi T
Expert Rev Gastroenterol Hepatol 2020 Jun;14(6):435-444. Epub 2020 May 22 doi: 10.1080/17474124.2020.1766965. PMID: 32380873
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Duodenal-Type Follicular Lymphoma: A Clinicopathologic Review.
Marks E, Shi Y
Arch Pathol Lab Med 2018 Apr;142(4):542-547. doi: 10.5858/arpa.2016-0519-RS. PMID: 29565210
Gastrointestinal lymphoma.
Thomas CR Jr, Share R
Med Pediatr Oncol 1991;19(1):48-60. doi: 10.1002/mpo.2950190109. PMID: 1990257

Therapy

The Evolving Landscape of Neuroendocrine Tumors.
Russo A, Gangi A
Surg Oncol Clin N Am 2023 Jan;32(1):185-198. Epub 2022 Nov 3 doi: 10.1016/j.soc.2022.08.003. PMID: 36410917
Circulating vitamin C and digestive system cancers: Mendelian randomization study.
Larsson SC, Mason AM, Vithayathil M, Carter P, Kar S, Zheng JS, Burgess S
Clin Nutr 2022 Sep;41(9):2031-2035. Epub 2022 Aug 7 doi: 10.1016/j.clnu.2022.07.040. PMID: 35986965Free PMC Article
Targeted Cancer Therapy: The Next Generation of Cancer Treatment.
Baudino TA
Curr Drug Discov Technol 2015;12(1):3-20. doi: 10.2174/1570163812666150602144310. PMID: 26033233
Radiation enteritis.
Bismar MM, Sinicrope FA
Curr Gastroenterol Rep 2002 Oct;4(5):361-5. doi: 10.1007/s11894-002-0005-3. PMID: 12228037
Gastrointestinal lymphoma.
Thomas CR Jr, Share R
Med Pediatr Oncol 1991;19(1):48-60. doi: 10.1002/mpo.2950190109. PMID: 1990257

Prognosis

Update on medical treatment of small intestinal neuroendocrine tumors.
Pusceddu S, Femia D, Lo Russo G, Ortolani S, Milione M, Maccauro M, Vernieri C, Prinzi N, Concas L, Leuzzi L, De Braud F, Buzzoni R
Expert Rev Anticancer Ther 2016 Sep;16(9):969-76. Epub 2016 Jul 13 doi: 10.1080/14737140.2016.1207534. PMID: 27353232
Pharyngo-cervical esophageal reconstruction.
Archibald S, Young JE, Thoma A
Clin Plast Surg 2005 Jul;32(3):339-46, vi. doi: 10.1016/j.cps.2005.01.002. PMID: 15979473
Radiation enteritis.
Bismar MM, Sinicrope FA
Curr Gastroenterol Rep 2002 Oct;4(5):361-5. doi: 10.1007/s11894-002-0005-3. PMID: 12228037
Gastrointestinal lymphoma.
Thomas CR Jr, Share R
Med Pediatr Oncol 1991;19(1):48-60. doi: 10.1002/mpo.2950190109. PMID: 1990257
Continent reservoirs.
Colberg JW, Schiff SF, Lytton B
Conn Med 1989 Oct;53(10):573-6. PMID: 2582760

Clinical prediction guides

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Circulating vitamin C and digestive system cancers: Mendelian randomization study.
Larsson SC, Mason AM, Vithayathil M, Carter P, Kar S, Zheng JS, Burgess S
Clin Nutr 2022 Sep;41(9):2031-2035. Epub 2022 Aug 7 doi: 10.1016/j.clnu.2022.07.040. PMID: 35986965Free PMC Article
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer.
Derosa L, Routy B, Thomas AM, Iebba V, Zalcman G, Friard S, Mazieres J, Audigier-Valette C, Moro-Sibilot D, Goldwasser F, Silva CAC, Terrisse S, Bonvalet M, Scherpereel A, Pegliasco H, Richard C, Ghiringhelli F, Elkrief A, Desilets A, Blanc-Durand F, Cumbo F, Blanco A, Boidot R, Chevrier S, Daillère R, Kroemer G, Alla L, Pons N, Le Chatelier E, Galleron N, Roume H, Dubuisson A, Bouchard N, Messaoudene M, Drubay D, Deutsch E, Barlesi F, Planchard D, Segata N, Martinez S, Zitvogel L, Soria JC, Besse B
Nat Med 2022 Feb;28(2):315-324. Epub 2022 Feb 3 doi: 10.1038/s41591-021-01655-5. PMID: 35115705Free PMC Article
Neuroendocrine Neoplasms of the Small Bowel and Pancreas.
Clift AK, Kidd M, Bodei L, Toumpanakis C, Baum RP, Oberg K, Modlin IM, Frilling A
Neuroendocrinology 2020;110(6):444-476. Epub 2019 Sep 27 doi: 10.1159/000503721. PMID: 31557758Free PMC Article
Surgical management of neuroendocrine tumors.
Tamburrino D, Spoletini G, Partelli S, Muffatti F, Adamenko O, Crippa S, Falconi M
Best Pract Res Clin Endocrinol Metab 2016 Jan;30(1):93-102. Epub 2015 Oct 8 doi: 10.1016/j.beem.2015.10.003. PMID: 26971846

Recent systematic reviews

Endoscopic Management of Ampullary Adenomas in Familial Adenomatous Polyposis Syndrome: A Systematic Review with Pooled Analysis.
Ramai D, Facciorusso A, Singh J, Brooks OW, Mirtorabi H, Barakat M, Ofosu A, Mcdonough S, Adler DG
Dig Dis Sci 2022 Jul;67(7):3220-3227. Epub 2021 Jul 12 doi: 10.1007/s10620-021-07132-w. PMID: 34251561
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845
Natural history of diminutive and small colorectal polyps: a systematic literature review.
Vleugels JLA, Hazewinkel Y, Fockens P, Dekker E
Gastrointest Endosc 2017 Jun;85(6):1169-1176.e1. Epub 2016 Dec 23 doi: 10.1016/j.gie.2016.12.014. PMID: 28024986
Survival Benefit of Adjuvant Chemoradiotherapy in Patients With Ampulla of Vater Cancer: A Systematic Review and Meta-analysis.
Kwon J, Kim BH, Kim K, Chie EK, Ha SW
Ann Surg 2015 Jul;262(1):47-52. doi: 10.1097/SLA.0000000000001182. PMID: 25775067
Surgical management of the duodenal manifestations of familial adenomatous polyposis.
Parc Y, Mabrut JY, Shields C; Mallorca Group
Br J Surg 2011 Apr;98(4):480-4. Epub 2011 Jan 6 doi: 10.1002/bjs.7374. PMID: 21656714

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