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Mucosal Melanoma of the Genitourinary System

MedGen UID:
1791478
•Concept ID:
C5555037
•
Neoplastic Process

Definition

A malignant melanocytic neoplasm that arises from a mucosal site of the genitourinary system. [from NCI]

Professional guidelines

PubMed

Multimodality Imaging and Genetics of Primary Mucosal Melanomas and Response to Treatment.
Saleh M, Javadi S, Elsherif S, Patnana M, Sagebiel TL, Torres-Cabala C, Mattei J, Bhosale P, Faria SC
Radiographics 2021 Nov-Dec;41(7):1954-1972. Epub 2021 Oct 22 doi: 10.1148/rg.2021210063. PMID: 34678102
Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Management of primary melanoma of the female urogenital tract.
Piura B
Lancet Oncol 2008 Oct;9(10):973-81. doi: 10.1016/S1470-2045(08)70254-7. PMID: 19071254

Recent clinical studies

Etiology

Clinical and Dermoscopic Features of Vulvar Melanosis Over the Last 20 Years.
De Giorgi V, Gori A, Salvati L, Scarfì F, Maida P, Trane L, Silvestri F, Portelli F, Venturi F, Covarelli P, Massi D
JAMA Dermatol 2020 Nov 1;156(11):1185-1191. doi: 10.1001/jamadermatol.2020.2528. PMID: 32785609Free PMC Article
Mucosal melanomas in the racially diverse population of California.
Altieri L, Wong MK, Peng DH, Cockburn M
J Am Acad Dermatol 2017 Feb;76(2):250-257. Epub 2016 Oct 11 doi: 10.1016/j.jaad.2016.08.007. PMID: 27742175Free PMC Article
Immunoglobulin A nephropathy: current progress and future directions.
Zhang C, Zeng X, Li Z, Wang Z, Li S
Transl Res 2015 Aug;166(2):134-44. Epub 2015 Mar 4 doi: 10.1016/j.trsl.2015.02.007. PMID: 25797891
Primary malignant melanoma of the urethra: a clinicopathologic analysis of 15 cases.
Oliva E, Quinn TR, Amin MB, Eble JN, Epstein JI, Srigley JR, Young RH
Am J Surg Pathol 2000 Jun;24(6):785-96. doi: 10.1097/00000478-200006000-00003. PMID: 10843280
Malignant melanoma of the vulva in a nationwide, 25-year study of 219 Swedish females: clinical observations and histopathologic features.
Ragnarsson-Olding BK, Kanter-Lewensohn LR, Lagerlöf B, Nilsson BR, Ringborg UK
Cancer 1999 Oct 1;86(7):1273-84. PMID: 10506714

Diagnosis

Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Immunoglobulin A nephropathy: current progress and future directions.
Zhang C, Zeng X, Li Z, Wang Z, Li S
Transl Res 2015 Aug;166(2):134-44. Epub 2015 Mar 4 doi: 10.1016/j.trsl.2015.02.007. PMID: 25797891
Significance of dermatoscopy in genital dermatoses.
Paštar Z, Lipozenčić J
Clin Dermatol 2014 Mar-Apr;32(2):315-8. doi: 10.1016/j.clindermatol.2013.08.016. PMID: 24559569
Management of primary melanoma of the female urogenital tract.
Piura B
Lancet Oncol 2008 Oct;9(10):973-81. doi: 10.1016/S1470-2045(08)70254-7. PMID: 19071254
Extracutaneous malignant melanomas.
Hussein MR
Cancer Invest 2008 Jun;26(5):516-34. doi: 10.1080/07357900701781762. PMID: 18568775

Therapy

Clinical and Dermoscopic Features of Vulvar Melanosis Over the Last 20 Years.
De Giorgi V, Gori A, Salvati L, Scarfì F, Maida P, Trane L, Silvestri F, Portelli F, Venturi F, Covarelli P, Massi D
JAMA Dermatol 2020 Nov 1;156(11):1185-1191. doi: 10.1001/jamadermatol.2020.2528. PMID: 32785609Free PMC Article
Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice.
Domingos-Pereira S, Decrausaz L, Derré L, Bobst M, Romero P, Schiller JT, Jichlinski P, Nardelli-Haefliger D
Mucosal Immunol 2013 Mar;6(2):393-404. Epub 2012 Sep 12 doi: 10.1038/mi.2012.83. PMID: 22968420Free PMC Article

Prognosis

Multimodality Imaging and Genetics of Primary Mucosal Melanomas and Response to Treatment.
Saleh M, Javadi S, Elsherif S, Patnana M, Sagebiel TL, Torres-Cabala C, Mattei J, Bhosale P, Faria SC
Radiographics 2021 Nov-Dec;41(7):1954-1972. Epub 2021 Oct 22 doi: 10.1148/rg.2021210063. PMID: 34678102
Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Clinical and Dermoscopic Features of Vulvar Melanosis Over the Last 20 Years.
De Giorgi V, Gori A, Salvati L, Scarfì F, Maida P, Trane L, Silvestri F, Portelli F, Venturi F, Covarelli P, Massi D
JAMA Dermatol 2020 Nov 1;156(11):1185-1191. doi: 10.1001/jamadermatol.2020.2528. PMID: 32785609Free PMC Article
Immunoglobulin A nephropathy: current progress and future directions.
Zhang C, Zeng X, Li Z, Wang Z, Li S
Transl Res 2015 Aug;166(2):134-44. Epub 2015 Mar 4 doi: 10.1016/j.trsl.2015.02.007. PMID: 25797891
Extracutaneous malignant melanomas.
Hussein MR
Cancer Invest 2008 Jun;26(5):516-34. doi: 10.1080/07357900701781762. PMID: 18568775

Clinical prediction guides

Management of Clitoral Melanoma Presenting as an Exophytic Clitoral Mass: A Case Report and Review of the Literature.
Szlachta-McGinn A, Chmielowski B, Kang Y, Raman S, Memarzadeh S
Curr Oncol 2021 Oct 21;28(6):4264-4272. doi: 10.3390/curroncol28060362. PMID: 34898540Free PMC Article
Vaginal Mucosal Melanoma: a Complete Remission after Immunotherapy and '0-7-21' Radiotherapy Regimen (24 Gy/3 fractions/21 days).
Parisi S, Lillo S, Cacciola A, Santacaterina A, Palazzolo C, Platania A, Settineri N, Franchina T, Tamburella C, Pergolizzi S
Folia Med (Plovdiv) 2020 Sep 30;62(3):605-609. doi: 10.3897/folmed.62.e49926. PMID: 33009750
KIT pathway alterations in mucosal melanomas of the vulva and other sites.
Omholt K, Grafström E, Kanter-Lewensohn L, Hansson J, Ragnarsson-Olding BK
Clin Cancer Res 2011 Jun 15;17(12):3933-42. doi: 10.1158/1078-0432.CCR-10-2917. PMID: 21680547
Vulvar melanoma: a report of 10 cases and review of the literature.
De Simone P, Silipo V, Buccini P, Mariani G, Marenda S, Eibenschutz L, Ferrari A, Catricalà C
Melanoma Res 2008 Apr;18(2):127-33. doi: 10.1097/CMR.0b013e3282f94636. PMID: 18337649
Primary malignant melanoma of the urethra: a clinicopathologic analysis of 15 cases.
Oliva E, Quinn TR, Amin MB, Eble JN, Epstein JI, Srigley JR, Young RH
Am J Surg Pathol 2000 Jun;24(6):785-96. doi: 10.1097/00000478-200006000-00003. PMID: 10843280

Recent systematic reviews

Melanoma of glans penis and urethra: A case report and systematic review of the literature of a rare and complex neoplasm.
Franceschelli A, Palmisano F, Gentile G, Vagnoni V, Zannetti G, Cipriani R, Colombo F
Urologia 2023 Nov;90(4):766-774. Epub 2021 Sep 16 doi: 10.1177/03915603211046471. PMID: 34528492

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