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Ovarian Smooth Muscle Neoplasm

MedGen UID:
1792082
•Concept ID:
C5555641
•
Neoplastic Process
Synonym: Ovarian Smooth Muscle Tumor

Definition

A benign, intermediate, or malignant neoplasm that arises from the ovary and is composed of neoplastic cells with smooth muscle differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Smooth Muscle Neoplasm

Professional guidelines

PubMed

Uterine Tumors Resembling Ovarian Sex Cord Tumors: A Clinicopathologic Study of 75 Cases Emphasizing Features Predicting Adverse Outcome and Differential Diagnosis.
Boyraz B, Watkins JC, Young RH, Oliva E
Am J Surg Pathol 2023 Feb 1;47(2):234-247. Epub 2022 Oct 27 doi: 10.1097/PAS.0000000000001981. PMID: 36306239
Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430
Malignant transformation of ovarian endometriosis. Nature, treatment and report of two cases.
Stevenson CS
Obstet Gynecol 1970 Sep;36(3):443-57. PMID: 5451141

Recent clinical studies

Etiology

Dedifferentiated leiomyosarcoma of the uterus: a clinicopathologic and immunohistochemical analysis of 23 cases.
Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
Gynecological lesions in hereditary cancer predisposition syndromes.
Dundr P, Cibula D, Foretová L, Macek M Jr, Kopečková K, Petruželka L, Němejcová K, Bártů M, Hojný J, Hájková N, Jakša R, Janega P, Stružinská I
Cesk Patol 2021 Summer;57(2):96-104. PMID: 34275319
Protective Effects of Incretin Against Age-Related Diseases.
Zhang D, Ma M, Liu Y
Curr Drug Deliv 2019;16(9):793-806. doi: 10.2174/1567201816666191010145029. PMID: 31622202
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397

Diagnosis

Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling.
Lin SC, Liao YC, Chen PM, Yang YY, Wang YH, Tung SL, Chuang CM, Sung YW, Jang TH, Chuang SE, Wang LH
J Biomed Sci 2022 Dec 22;29(1):109. doi: 10.1186/s12929-022-00888-x. PMID: 36550569Free PMC Article
The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439
Ovarian Lipoleiomyoma: A Rare Entity.
Vishwajeet V, Banerjee N, Dey P
Int J Gynecol Pathol 2019 Mar;38(2):171-174. doi: 10.1097/PGP.0000000000000487. PMID: 29995653
Uterine Mesenchymal Tumors: Hereditary Aspects.
Joehlin-Price AS, Garg K
Adv Anat Pathol 2018 Mar;25(2):96-105. doi: 10.1097/PAP.0000000000000175. PMID: 28945610

Therapy

Increased expression of neurogenic factors in uterine fibroids.
Luddi A, Marrocco C, Governini L, Semplici B, Pavone V, Capaldo A, Tosti C, Greco S, Luisi S, Ciarmela P, Petraglia F, Piomboni P
Hum Reprod 2019 Nov 1;34(11):2153-2162. doi: 10.1093/humrep/dez182. PMID: 31732726
Protective Effects of Incretin Against Age-Related Diseases.
Zhang D, Ma M, Liu Y
Curr Drug Deliv 2019;16(9):793-806. doi: 10.2174/1567201816666191010145029. PMID: 31622202
Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications.
Moravek MB, Yin P, Ono M, Coon JS 5th, Dyson MT, Navarro A, Marsh EE, Chakravarti D, Kim JJ, Wei JJ, Bulun SE
Hum Reprod Update 2015 Jan-Feb;21(1):1-12. Epub 2014 Sep 8 doi: 10.1093/humupd/dmu048. PMID: 25205766Free PMC Article
Pericyte-coverage of human tumor vasculature and nanoparticle permeability.
Zhang L, Nishihara H, Kano MR
Biol Pharm Bull 2012;35(5):761-6. doi: 10.1248/bpb.35.761. PMID: 22687413
Clear cell tumors of the female genital tract.
Matias-Guiu X, Lerma E, Prat J
Semin Diagn Pathol 1997 Nov;14(4):233-9. PMID: 9383823

Prognosis

Dedifferentiated leiomyosarcoma of the uterus: a clinicopathologic and immunohistochemical analysis of 23 cases.
Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling.
Lin SC, Liao YC, Chen PM, Yang YY, Wang YH, Tung SL, Chuang CM, Sung YW, Jang TH, Chuang SE, Wang LH
J Biomed Sci 2022 Dec 22;29(1):109. doi: 10.1186/s12929-022-00888-x. PMID: 36550569Free PMC Article
The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis.
Mei D, Zhu Y, Zhang L, Wei W
Mediators Inflamm 2020;2020:9578701. Epub 2020 Aug 12 doi: 10.1155/2020/9578701. PMID: 32848510Free PMC Article
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439
Primary Ovarian Malignant PEComa: A Case Report.
Westaby JD, Magdy N, Fisher C, El-Bahrawy M
Int J Gynecol Pathol 2017 Jul;36(4):400-404. doi: 10.1097/PGP.0000000000000331. PMID: 27684885

Clinical prediction guides

"Evolution" of intravascular leiomyomatosis.
Chen L, Yang Y, Zhao C
BMC Womens Health 2023 Sep 11;23(1):483. doi: 10.1186/s12905-023-02618-3. PMID: 37697329Free PMC Article
Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling.
Lin SC, Liao YC, Chen PM, Yang YY, Wang YH, Tung SL, Chuang CM, Sung YW, Jang TH, Chuang SE, Wang LH
J Biomed Sci 2022 Dec 22;29(1):109. doi: 10.1186/s12929-022-00888-x. PMID: 36550569Free PMC Article
The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis.
Mei D, Zhu Y, Zhang L, Wei W
Mediators Inflamm 2020;2020:9578701. Epub 2020 Aug 12 doi: 10.1155/2020/9578701. PMID: 32848510Free PMC Article
Protective Effects of Incretin Against Age-Related Diseases.
Zhang D, Ma M, Liu Y
Curr Drug Deliv 2019;16(9):793-806. doi: 10.2174/1567201816666191010145029. PMID: 31622202
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397

Recent systematic reviews

The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343

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