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Metastatic Acral Lentiginous Melanoma

MedGen UID:
1792122
•Concept ID:
C5555681
•
Neoplastic Process

Definition

Acral lentiginous melanoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Acral Lentiginous Melanoma

Professional guidelines

PubMed

PRAME is a useful marker for the differential diagnosis of melanocytic tumours and histological mimics.
Chen YP, Zhang WW, Qiu YT, Ke LF, Chen H, Chen G
Histopathology 2023 Jan;82(2):285-295. Epub 2022 Oct 13 doi: 10.1111/his.14814. PMID: 36200756
Diagnosis and treatment of malignant melanoma of the foot.
Gray RJ, Pockaj BA, Vega ML, Connolly SM, DiCaudo DJ, Kile TA, Buchel EW
Foot Ankle Int 2006 Sep;27(9):696-705. doi: 10.1177/107110070602700908. PMID: 17038281
Current concepts in the management of patients with melanoma.
Lang PG
Am J Clin Dermatol 2002;3(6):401-26. doi: 10.2165/00128071-200203060-00004. PMID: 12113649

Recent clinical studies

Etiology

Metastatic acral lentiginous melanoma in a tertiary referral center in Switzerland: a systematic analysis.
Häfliger EM, Ramelyte E, Mangana J, Kunz M, Kazakov DV, Dummer R, Cheng PF
Melanoma Res 2018 Oct;28(5):442-450. doi: 10.1097/CMR.0000000000000465. PMID: 29847461

Diagnosis

Metastatic Acral lentiginous melanoma: A case report and review.
Ahuja G, Kim JH, Tran JF, Nnorom S, Ali A, Ibrahim M, Okoye GA, Shokrani B, Dunmore-Griffith J, Geter K, Frederick WAI, Wilson L
J Natl Med Assoc 2022 Jun;114(3):290-294. Epub 2022 Feb 25 doi: 10.1016/j.jnma.2022.01.011. PMID: 35221075
Metastatic acral lentiginous melanoma in a tertiary referral center in Switzerland: a systematic analysis.
Häfliger EM, Ramelyte E, Mangana J, Kunz M, Kazakov DV, Dummer R, Cheng PF
Melanoma Res 2018 Oct;28(5):442-450. doi: 10.1097/CMR.0000000000000465. PMID: 29847461
Marked response to imatinib mesylate in metastatic acral lentiginous melanoma on the thumb.
Yamaguchi M, Harada K, Ando N, Kawamura T, Shibagaki N, Shimada S
Clin Exp Dermatol 2011 Mar;36(2):174-7. doi: 10.1111/j.1365-2230.2010.03885.x. PMID: 20545949

Therapy

ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma.
Jagirdar K, Portuallo ME, Wei M, Wilhide M, Bravo Narula JA, Robertson BM, Alicea GM, Aguh C, Xiao M, Godok T, Fingerman D, Brown GS, Herlyn M, Elad VM, Guo X, Toska E, Zabransky DJ, Wubbenhorst B, Nathanson KL, Kwatra S, Goyal Y, Ji H, Liu Q, Rebecca VW
Oncogene 2024 Feb;43(6):395-405. Epub 2023 Dec 8 doi: 10.1038/s41388-023-02900-6. PMID: 38066089Free PMC Article
Marked response to imatinib mesylate in metastatic acral lentiginous melanoma on the thumb.
Yamaguchi M, Harada K, Ando N, Kawamura T, Shibagaki N, Shimada S
Clin Exp Dermatol 2011 Mar;36(2):174-7. doi: 10.1111/j.1365-2230.2010.03885.x. PMID: 20545949
Phase II trial of imatinib mesylate in patients with metastatic melanoma.
Kim KB, Eton O, Davis DW, Frazier ML, McConkey DJ, Diwan AH, Papadopoulos NE, Bedikian AY, Camacho LH, Ross MI, Cormier JN, Gershenwald JE, Lee JE, Mansfield PF, Billings LA, Ng CS, Charnsangavej C, Bar-Eli M, Johnson MM, Murgo AJ, Prieto VG
Br J Cancer 2008 Sep 2;99(5):734-40. Epub 2008 Aug 19 doi: 10.1038/sj.bjc.6604482. PMID: 18728664Free PMC Article

Prognosis

Metastatic Acral lentiginous melanoma: A case report and review.
Ahuja G, Kim JH, Tran JF, Nnorom S, Ali A, Ibrahim M, Okoye GA, Shokrani B, Dunmore-Griffith J, Geter K, Frederick WAI, Wilson L
J Natl Med Assoc 2022 Jun;114(3):290-294. Epub 2022 Feb 25 doi: 10.1016/j.jnma.2022.01.011. PMID: 35221075
Metastatic acral lentiginous melanoma in a tertiary referral center in Switzerland: a systematic analysis.
Häfliger EM, Ramelyte E, Mangana J, Kunz M, Kazakov DV, Dummer R, Cheng PF
Melanoma Res 2018 Oct;28(5):442-450. doi: 10.1097/CMR.0000000000000465. PMID: 29847461
Differential expression of melanoma associated antigens in acral lentiginous melanoma and in nodular melanoma lesions.
Kageshita T, Nakamura T, Yamada M, Kuriya N, Arao T, Ferrone S
Cancer Res 1991 Mar 15;51(6):1726-32. PMID: 1671829

Recent systematic reviews

Metastatic acral lentiginous melanoma in a tertiary referral center in Switzerland: a systematic analysis.
Häfliger EM, Ramelyte E, Mangana J, Kunz M, Kazakov DV, Dummer R, Cheng PF
Melanoma Res 2018 Oct;28(5):442-450. doi: 10.1097/CMR.0000000000000465. PMID: 29847461

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