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Acral lentiginous melanoma

MedGen UID:
87530
Concept ID:
C0346037
Neoplastic Process
Synonyms: Acral lentiginous melanoma (disease); Palmar/plantar melanoma; Subungual melanoma
SNOMED CT: Acral lentiginous melanoma, malignant (16974005); Acral lentiginous malignant melanoma of skin (254732008); Acral lentiginous melanoma of skin (254732008); ALM - Acral lentiginous melanoma of skin (254732008); ALMM - Acral lentiginous malignant melanoma of skin (254732008)
 
HPO: HP:0012060
Monarch Initiative: MONDO:0003865

Definition

A type of cutaneous melanoma localized to the palm, sole, or beneath the nail (subungual melanoma). Acral lentiginous melanoma starts as a slowly-enlarging flat patch of discolored skin and usually displays a size above 6 mm and often several centimeters or more in diameter upon diagnosis and variable pigmentation with a mixutre of colors including brown, and blue-grey, black and red. The surface of the lesion is initially smooth but later in the course may become thicker and irregular, and may ulcerate or bleed. [from HPO]

Professional guidelines

PubMed

Ingrassia JP, Stein JA, Levine A, Liebman TN
Dermatol Surg 2023 Oct 1;49(10):926-931. Epub 2023 Aug 8 doi: 10.1097/DSS.0000000000003891. PMID: 37556446
Nakamura Y, Fujisawa Y
Curr Treat Options Oncol 2018 Jun 27;19(8):42. doi: 10.1007/s11864-018-0560-y. PMID: 29951919
Lans J, van Leeuwen W, Jupiter JB, Eberlin KR
Plast Reconstr Surg 2018 Aug;142(2):439-445. doi: 10.1097/PRS.0000000000004579. PMID: 29933293

Recent clinical studies

Etiology

Usatine RP, Heath CR
J Fam Pract 2022 May;71(4):178-179. doi: 10.12788/jfp.0410. PMID: 35730705
Cheraghlou S, Ugwu N, Girardi M
JAMA Dermatol 2022 Jan 1;158(1):51-58. doi: 10.1001/jamadermatol.2021.4812. PMID: 34878492Free PMC Article
Mejbel HA, Torres-Cabala CA, Milton DR, Ivan D, Feldmeyer L, Namikawa K, Nagarajan P, Tetzlaff MT, Curry JL, Ross MI, Hwu WJ, Prieto VG, Aung PP
Mod Pathol 2021 Mar;34(3):572-583. Epub 2020 Aug 5 doi: 10.1038/s41379-020-0641-x. PMID: 32759976
Csányi I, Houshmand N, Szűcs M, Ócsai H, Kemény L, Oláh J, Baltás E
J Eur Acad Dermatol Venereol 2020 Sep;34(9):2004-2010. Epub 2020 Mar 20 doi: 10.1111/jdv.16227. PMID: 31989672
Runkle GP, Zaloznik AJ
Am Fam Physician 1994 Jan;49(1):91-8, 102-4. PMID: 8273727

Diagnosis

Usatine RP, Heath CR
J Fam Pract 2022 May;71(4):178-179. doi: 10.12788/jfp.0410. PMID: 35730705
Lallas A, Paschou E, Manoli SM, Papageorgiou C, Spyridis I, Liopyris K, Bobos M, Moutsoudis A, Lazaridou E, Apalla Z
Ital J Dermatol Venerol 2021 Jun;156(3):274-288. Epub 2020 Dec 14 doi: 10.23736/S2784-8671.20.06784-X. PMID: 33314891
Darmawan CC, Jo G, Montenegro SE, Kwak Y, Cheol L, Cho KH, Mun JH
J Am Acad Dermatol 2019 Sep;81(3):805-812. Epub 2019 Feb 5 doi: 10.1016/j.jaad.2019.01.081. PMID: 30731177
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Situm M, Buljan M, Kolić M, Vučić M
Acta Dermatovenerol Croat 2014;22(1):1-12. PMID: 24813835

Therapy

Caini S, Gandini S, Botta F, Tagliabue E, Raimondi S, Nagore E, Zanna I, Maisonneuve P, Newton-Bishop J, Polsky D, Lazovich D, Kumar R, Kanetsky PA, Hoiom V, Ghiorzo P, Landi MT, Ribas G, Menin C, Stratigos AJ, Palmieri G, Guida G, García-Borrón JC, Nan H, Little J, Sera F, Puig S, Fargnoli MC; M-SKIP study group
Melanoma Res 2020 Oct;30(5):500-510. doi: 10.1097/CMR.0000000000000668. PMID: 32898390Free PMC Article
Castaneda CA, Torres-Cabala C, Castillo M, Villegas V, Casavilca S, Cano L, Sanchez J, Dunstan J, Calderon G, De La Cruz M, Cotrina JM, Gomez HL, Galvez R, Abugattas J
Clin Transl Oncol 2017 Dec;19(12):1478-1488. Epub 2017 Jun 2 doi: 10.1007/s12094-017-1685-3. PMID: 28577153
Stubblefield J, Kelly B
Surg Clin North Am 2014 Oct;94(5):1115-26, ix. Epub 2014 Aug 19 doi: 10.1016/j.suc.2014.07.008. PMID: 25245971
Nagaoka T, Nakamura A, Okutani H, Kiyohara Y, Koga H, Saida T, Sota T
Skin Res Technol 2013 Feb;19(1):e290-6. Epub 2012 Jun 14 doi: 10.1111/j.1600-0846.2012.00642.x. PMID: 22698068
Phan A, Touzet S, Dalle S, Ronger-Savlé S, Balme B, Thomas L
Br J Dermatol 2006 Sep;155(3):561-9. doi: 10.1111/j.1365-2133.2006.07368.x. PMID: 16911282

Prognosis

Fan KS, Fan KH, Tse PL, Ding H, Su R, Kwok HT
Acta Dermatovenerol Alp Pannonica Adriat 2022 Dec;31(4):127-133. PMID: 36541394
Darmawan CC, Jo G, Montenegro SE, Kwak Y, Cheol L, Cho KH, Mun JH
J Am Acad Dermatol 2019 Sep;81(3):805-812. Epub 2019 Feb 5 doi: 10.1016/j.jaad.2019.01.081. PMID: 30731177
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Goydos JS, Shoen SL
Cancer Treat Res 2016;167:321-9. doi: 10.1007/978-3-319-22539-5_14. PMID: 26601870
Runkle GP, Zaloznik AJ
Am Fam Physician 1994 Jan;49(1):91-8, 102-4. PMID: 8273727

Clinical prediction guides

Tas F, Erturk K
J Cosmet Dermatol 2022 May;21(5):2120-2129. Epub 2021 Aug 1 doi: 10.1111/jocd.14348. PMID: 34333837
Lee TL, Liao YH, Liau JY, Sheen YS
Sci Rep 2021 Oct 25;11(1):21012. doi: 10.1038/s41598-021-00386-4. PMID: 34697327Free PMC Article
Mejbel HA, Torres-Cabala CA, Milton DR, Ivan D, Feldmeyer L, Namikawa K, Nagarajan P, Tetzlaff MT, Curry JL, Ross MI, Hwu WJ, Prieto VG, Aung PP
Mod Pathol 2021 Mar;34(3):572-583. Epub 2020 Aug 5 doi: 10.1038/s41379-020-0641-x. PMID: 32759976
Oyama S, Funasaka Y, Watanabe A, Takizawa T, Kawana S, Saeki H
J Dermatol 2015 May;42(5):477-84. Epub 2015 Mar 13 doi: 10.1111/1346-8138.12822. PMID: 25766129
Revuz J, Clerici T
J Am Acad Dermatol 1989 Apr;20(4):567-70. doi: 10.1016/s0190-9622(89)70064-5. PMID: 2715403

Recent systematic reviews

Tsai SY, Hamilton CE, Mologousis MA, Hawryluk EB
Pediatr Dermatol 2024 Jul-Aug;41(4):613-620. Epub 2024 Mar 18 doi: 10.1111/pde.15597. PMID: 38500311
Steeb T, Wessely A, Petzold A, Kohl C, Erdmann M, Berking C, Heppt MV
Eur J Cancer 2021 Nov;157:348-357. Epub 2021 Sep 22 doi: 10.1016/j.ejca.2021.08.015. PMID: 34562816
Häfliger EM, Ramelyte E, Mangana J, Kunz M, Kazakov DV, Dummer R, Cheng PF
Melanoma Res 2018 Oct;28(5):442-450. doi: 10.1097/CMR.0000000000000465. PMID: 29847461
Durbec F, Martin L, Derancourt C, Grange F
Br J Dermatol 2012 Apr;166(4):727-39. doi: 10.1111/j.1365-2133.2011.10772.x. PMID: 22175696

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