U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Brainstem glioma

MedGen UID:
195650
•Concept ID:
C0677865
•
Neoplastic Process
Synonyms: Brain Stem Glioma; brain stem glioma; Brain Stem Neuroglial Neoplasm; brain stem neuroglial neoplasm; Brain Stem Neuroglial Tumor; brain stem neuroglial tumor; Brainstem Glioma; brainstem glioma; brainstem malignant glioma; Brainstem Neuroglial Neoplasm; brainstem neuroglial neoplasm; Brainstem Neuroglial Tumor; brainstem neuroglial tumor; diffuse brainstem glioma; Glioma of Brain Stem; glioma of brain stem; Glioma of brainstem; Glioma of Brainstem; glioma of brainstem; Glioma of the Brain Stem; glioma of the brain stem; Glioma of the Brainstem; glioma of the brainstem; malignant glioma of brainstem
SNOMED CT: Glioma of brainstem (444545003)
 
HPO: HP:0010796
Monarch Initiative: MONDO:0002911

Definition

A glioma affecting the brainstem. [from HPO]

Professional guidelines

PubMed

Oncolytic virotherapy for the treatment of pediatric brainstem gliomas.
Gállego Pérez-Larraya J, García-Moure M, Alonso MM
Rev Neurol (Paris) 2023 Jun;179(5):475-480. Epub 2023 Apr 13 doi: 10.1016/j.neurol.2023.03.016. PMID: 37061388
Adult brainstem glioma differential diagnoses: an MRI-based approach in a series of 68 patients.
Duran-Peña A, Ducray F, Ramirez C, Bauchet L, Constans JM, Grand S, Guillamo JS, Larrieu-Ciron D, Frappaz D, Pyatigorskaya N, Savatovsky J, Loiseau H, Duverneuil NM, Laigle-Donadey F
J Neurol 2022 Aug;269(8):4349-4362. Epub 2022 Apr 20 doi: 10.1007/s00415-022-11070-6. PMID: 35441889
Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG.
Ehteda A, Simon S, Franshaw L, Giorgi FM, Liu J, Joshi S, Rouaen JRC, Pang CNI, Pandher R, Mayoh C, Tang Y, Khan A, Ung C, Tolhurst O, Kankean A, Hayden E, Lehmann R, Shen S, Gopalakrishnan A, Trebilcock P, Gurova K, Gudkov AV, Norris MD, Haber M, Vittorio O, Tsoli M, Ziegler DS
Cell Rep 2021 Apr 13;35(2):108994. doi: 10.1016/j.celrep.2021.108994. PMID: 33852836

Curated

UK NICE Guideline NG99, Brain tumours (primary) and brain metastases in over 16s, 2021

Recent clinical studies

Etiology

Experimental murine models of brainstem gliomas.
Ni S, Chen R, Hu K
Drug Discov Today 2022 May;27(5):1218-1235. Epub 2021 Dec 23 doi: 10.1016/j.drudis.2021.12.016. PMID: 34954326
Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG.
Ehteda A, Simon S, Franshaw L, Giorgi FM, Liu J, Joshi S, Rouaen JRC, Pang CNI, Pandher R, Mayoh C, Tang Y, Khan A, Ung C, Tolhurst O, Kankean A, Hayden E, Lehmann R, Shen S, Gopalakrishnan A, Trebilcock P, Gurova K, Gudkov AV, Norris MD, Haber M, Vittorio O, Tsoli M, Ziegler DS
Cell Rep 2021 Apr 13;35(2):108994. doi: 10.1016/j.celrep.2021.108994. PMID: 33852836
The integrated genomic and epigenomic landscape of brainstem glioma.
Chen LH, Pan C, Diplas BH, Xu C, Hansen LJ, Wu Y, Chen X, Geng Y, Sun T, Sun Y, Zhang P, Wu Z, Zhang J, Li D, Zhang Y, Wu W, Wang Y, Li G, Yang J, Wang X, Xu C, Wang S, Waitkus MS, He Y, McLendon RE, Ashley DM, Yan H, Zhang L
Nat Commun 2020 Jun 17;11(1):3077. doi: 10.1038/s41467-020-16682-y. PMID: 32555164Free PMC Article
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Brainstem glioma: a review.
Grimm SA, Chamberlain MC
Curr Neurol Neurosci Rep 2013 May;13(5):346. doi: 10.1007/s11910-013-0346-3. PMID: 23512689

Diagnosis

Prognostic factors in adult brainstem glioma: a tertiary care center analysis and review of the literature.
Leibetseder A, Leitner J, Mair MJ, Meckel S, Hainfellner JA, Aichholzer M, Widhalm G, Dieckmann K, Weis S, Furtner J, von Oertzen T, Preusser M, Pichler J, Berghoff AS
J Neurol 2022 Mar;269(3):1574-1590. Epub 2021 Aug 3 doi: 10.1007/s00415-021-10725-0. PMID: 34342680Free PMC Article
Posterior Fossa Tumors.
Brandão LA, Young Poussaint T
Neuroimaging Clin N Am 2017 Feb;27(1):1-37. doi: 10.1016/j.nic.2016.08.001. PMID: 27889018
Radiotherapy for brainstem gliomas in children and adults: A single-institution experience and literature review.
Yoshida K, Sulaiman NS, Miyawaki D, Ejima Y, Nishimura H, Ishihara T, Matsuo Y, Nishikawa R, Sasayama T, Hayakawa A, Kohmura E, Sasaki R
Asia Pac J Clin Oncol 2017 Apr;13(2):e153-e160. Epub 2016 Mar 3 doi: 10.1111/ajco.12451. PMID: 26935004
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Brainstem glioma: a review.
Grimm SA, Chamberlain MC
Curr Neurol Neurosci Rep 2013 May;13(5):346. doi: 10.1007/s11910-013-0346-3. PMID: 23512689

Therapy

Oncolytic virotherapy for the treatment of pediatric brainstem gliomas.
Gállego Pérez-Larraya J, García-Moure M, Alonso MM
Rev Neurol (Paris) 2023 Jun;179(5):475-480. Epub 2023 Apr 13 doi: 10.1016/j.neurol.2023.03.016. PMID: 37061388
Prediction of H3K27M-mutant brainstem glioma by amide proton transfer-weighted imaging and its derived radiomics.
Zhuo Z, Qu L, Zhang P, Duan Y, Cheng D, Xu X, Sun T, Ding J, Xie C, Liu X, Haller S, Barkhof F, Zhang L, Liu Y
Eur J Nucl Med Mol Imaging 2021 Dec;48(13):4426-4436. Epub 2021 Jun 16 doi: 10.1007/s00259-021-05455-4. PMID: 34131804
Developing chemotherapy for diffuse pontine intrinsic gliomas (DIPG).
Gwak HS, Park HJ
Crit Rev Oncol Hematol 2017 Dec;120:111-119. Epub 2017 Oct 31 doi: 10.1016/j.critrevonc.2017.10.013. PMID: 29198324
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Brainstem gliomas in children and adults.
Laigle-Donadey F, Doz F, Delattre JY
Curr Opin Oncol 2008 Nov;20(6):662-7. doi: 10.1097/CCO.0b013e32831186e0. PMID: 18841048

Prognosis

Prognostic factors in adult brainstem glioma: a tertiary care center analysis and review of the literature.
Leibetseder A, Leitner J, Mair MJ, Meckel S, Hainfellner JA, Aichholzer M, Widhalm G, Dieckmann K, Weis S, Furtner J, von Oertzen T, Preusser M, Pichler J, Berghoff AS
J Neurol 2022 Mar;269(3):1574-1590. Epub 2021 Aug 3 doi: 10.1007/s00415-021-10725-0. PMID: 34342680Free PMC Article
Adult brainstem glioma presenting with isolated persistent hemifacial spasm or facial nerve palsy.
Dudoit T, Balossier A, Reyes-Botero G, Laigle-Donadey F, Emery E, Blond S, Carluer L, Lechapt-Zalcman E, Delattre JY, Guillamo JS
Rev Neurol (Paris) 2021 Dec;177(10):1276-1282. Epub 2021 Jul 14 doi: 10.1016/j.neurol.2021.03.006. PMID: 34272066
The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors.
Faulkner H, Arnaout O, Hoshide R, Young IM, Yeung JT, Sughrue ME, Teo C
World Neurosurg 2021 Feb;146:e639-e650. Epub 2020 Nov 2 doi: 10.1016/j.wneu.2020.10.147. PMID: 33152495
Radiotherapy for brainstem gliomas in children and adults: A single-institution experience and literature review.
Yoshida K, Sulaiman NS, Miyawaki D, Ejima Y, Nishimura H, Ishihara T, Matsuo Y, Nishikawa R, Sasayama T, Hayakawa A, Kohmura E, Sasaki R
Asia Pac J Clin Oncol 2017 Apr;13(2):e153-e160. Epub 2016 Mar 3 doi: 10.1111/ajco.12451. PMID: 26935004
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article

Clinical prediction guides

Diagnostic performance of MRI perfusion and spectroscopy for brainstem glioma grading.
Tran D, Nguyen DH, Nguyen HK, Nguyen-Thanh VA, Dong-Van H, Nguyen MD
Eur Rev Med Pharmacol Sci 2022 Nov;26(21):7938-7948. doi: 10.26355/eurrev_202211_30145. PMID: 36394742
Prediction of H3K27M-mutant brainstem glioma by amide proton transfer-weighted imaging and its derived radiomics.
Zhuo Z, Qu L, Zhang P, Duan Y, Cheng D, Xu X, Sun T, Ding J, Xie C, Liu X, Haller S, Barkhof F, Zhang L, Liu Y
Eur J Nucl Med Mol Imaging 2021 Dec;48(13):4426-4436. Epub 2021 Jun 16 doi: 10.1007/s00259-021-05455-4. PMID: 34131804
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Paediatric high and low grade glioma: the impact of tumour biology on current and future therapy.
Hargrave D
Br J Neurosurg 2009 Aug;23(4):351-63. doi: 10.1080/02688690903158809. PMID: 19637006
Adult brainstem gliomas.
Landolfi JC, Thaler HT, DeAngelis LM
Neurology 1998 Oct;51(4):1136-9. doi: 10.1212/wnl.51.4.1136. PMID: 9781543

Recent systematic reviews

Artificial Intelligence Applications in Pediatric Brain Tumor Imaging: A Systematic Review.
Huang J, Shlobin NA, Lam SK, DeCuypere M
World Neurosurg 2022 Jan;157:99-105. Epub 2021 Oct 11 doi: 10.1016/j.wneu.2021.10.068. PMID: 34648981
The Prognostic Impact of Radiotherapy in Conjunction with Temozolomide in Diffuse Intrinsic Pontine Glioma: A Systematic Review and Meta-Analysis.
Shi S, Lu S, Jing X, Liao J, Li Q
World Neurosurg 2021 Apr;148:e565-e571. Epub 2021 Jan 19 doi: 10.1016/j.wneu.2021.01.024. PMID: 33476781
Brainstem gliomas in pregnancy: a systematic review†.
Rosen A, Anderson V, Bercovici E, Laperriere N, D'Souza R
J Matern Fetal Neonatal Med 2020 Aug;33(16):2841-2851. Epub 2019 Jan 7 doi: 10.1080/14767058.2018.1560410. PMID: 30563399
Robot-assisted stereotactic brain biopsy: systematic review and bibliometric analysis.
Marcus HJ, Vakharia VN, Ourselin S, Duncan J, Tisdall M, Aquilina K
Childs Nerv Syst 2018 Jul;34(7):1299-1309. Epub 2018 May 10 doi: 10.1007/s00381-018-3821-y. PMID: 29744625Free PMC Article
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG99, Brain tumours (primary) and brain metastases in over 16s, 2021

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...