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Brainstem glioma

MedGen UID:
195650
•Concept ID:
C0677865
•
Neoplastic Process
Synonyms: Brain Stem Glioma; brain stem glioma; Brain Stem Neuroglial Neoplasm; brain stem neuroglial neoplasm; Brain Stem Neuroglial Tumor; brain stem neuroglial tumor; brain stem neuroglial tumour; Brainstem Glioma; brainstem glioma; brainstem malignant glioma; Brainstem Neuroglial Neoplasm; brainstem neuroglial neoplasm; Brainstem Neuroglial Tumor; brainstem neuroglial tumor; brainstem neuroglial tumour; diffuse brainstem glioma; Glioma of Brain Stem; glioma of brain stem; Glioma of brainstem; Glioma of Brainstem; glioma of brainstem; Glioma of the Brain Stem; glioma of the brain stem; Glioma of the Brainstem; glioma of the brainstem; malignant glioma of brainstem
SNOMED CT: Glioma of brainstem (444545003)
 
HPO: HP:0010796
Monarch Initiative: MONDO:0002911

Definition

A glioma affecting the brainstem. [from HPO]

Professional guidelines

PubMed

Rapid tumor DNA analysis of cerebrospinal fluid accelerates treatment of central nervous system lymphoma.
Gupta M, Bradley JD, Massaad E, Burns EJ, Georgantas NZ, Maron GE, Batten JM, Gallagher A, Thierauf J, Nayyar N, Gordon A, Jones SS, Pisapia M, Sun Y, Jones PS, Barker FG 2nd, Curry WT, Gupta R, Romero JM, Wang N, Brastianos PK, Martinez-Lage M, Tateishi K, Forst DA, Nahed BV, Batchelor TT, Ritterhouse LL, Iser F, Kessler T, Jordan JT, Dietrich J, Meyerson M, Cahill DP, Lennerz JK, Carter BS, Shankar GM
Blood 2024 Sep 5;144(10):1093-1100. doi: 10.1182/blood.2024023832. PMID: 38776489Free PMC Article
Surgical Management of Adult Brainstem Gliomas: A Systematic Review and Meta-Analysis.
Ius T, Lombardi G, Baiano C, Berardinelli J, Romano A, Montemurro N, Cavallo LM, Pasqualetti F, Feletti A
Curr Oncol 2023 Nov 7;30(11):9772-9785. doi: 10.3390/curroncol30110709. PMID: 37999129Free PMC Article
Oncolytic virotherapy for the treatment of pediatric brainstem gliomas.
Gállego Pérez-Larraya J, García-Moure M, Alonso MM
Rev Neurol (Paris) 2023 Jun;179(5):475-480. Epub 2023 Apr 13 doi: 10.1016/j.neurol.2023.03.016. PMID: 37061388

Curated

UK NICE Guideline NG99, Brain tumours (primary) and brain metastases in over 16s, 2021

Recent clinical studies

Etiology

Rapid tumor DNA analysis of cerebrospinal fluid accelerates treatment of central nervous system lymphoma.
Gupta M, Bradley JD, Massaad E, Burns EJ, Georgantas NZ, Maron GE, Batten JM, Gallagher A, Thierauf J, Nayyar N, Gordon A, Jones SS, Pisapia M, Sun Y, Jones PS, Barker FG 2nd, Curry WT, Gupta R, Romero JM, Wang N, Brastianos PK, Martinez-Lage M, Tateishi K, Forst DA, Nahed BV, Batchelor TT, Ritterhouse LL, Iser F, Kessler T, Jordan JT, Dietrich J, Meyerson M, Cahill DP, Lennerz JK, Carter BS, Shankar GM
Blood 2024 Sep 5;144(10):1093-1100. doi: 10.1182/blood.2024023832. PMID: 38776489Free PMC Article
Surgical Management of Adult Brainstem Gliomas: A Systematic Review and Meta-Analysis.
Ius T, Lombardi G, Baiano C, Berardinelli J, Romano A, Montemurro N, Cavallo LM, Pasqualetti F, Feletti A
Curr Oncol 2023 Nov 7;30(11):9772-9785. doi: 10.3390/curroncol30110709. PMID: 37999129Free PMC Article
Experimental murine models of brainstem gliomas.
Ni S, Chen R, Hu K
Drug Discov Today 2022 May;27(5):1218-1235. Epub 2021 Dec 23 doi: 10.1016/j.drudis.2021.12.016. PMID: 34954326
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Brainstem glioma: a review.
Grimm SA, Chamberlain MC
Curr Neurol Neurosci Rep 2013 May;13(5):346. doi: 10.1007/s11910-013-0346-3. PMID: 23512689

Diagnosis

Rapid tumor DNA analysis of cerebrospinal fluid accelerates treatment of central nervous system lymphoma.
Gupta M, Bradley JD, Massaad E, Burns EJ, Georgantas NZ, Maron GE, Batten JM, Gallagher A, Thierauf J, Nayyar N, Gordon A, Jones SS, Pisapia M, Sun Y, Jones PS, Barker FG 2nd, Curry WT, Gupta R, Romero JM, Wang N, Brastianos PK, Martinez-Lage M, Tateishi K, Forst DA, Nahed BV, Batchelor TT, Ritterhouse LL, Iser F, Kessler T, Jordan JT, Dietrich J, Meyerson M, Cahill DP, Lennerz JK, Carter BS, Shankar GM
Blood 2024 Sep 5;144(10):1093-1100. doi: 10.1182/blood.2024023832. PMID: 38776489Free PMC Article
Posterior Fossa Tumors.
Brandão LA, Young Poussaint T
Neuroimaging Clin N Am 2017 Feb;27(1):1-37. doi: 10.1016/j.nic.2016.08.001. PMID: 27889018
Radiotherapy for brainstem gliomas in children and adults: A single-institution experience and literature review.
Yoshida K, Sulaiman NS, Miyawaki D, Ejima Y, Nishimura H, Ishihara T, Matsuo Y, Nishikawa R, Sasayama T, Hayakawa A, Kohmura E, Sasaki R
Asia Pac J Clin Oncol 2017 Apr;13(2):e153-e160. Epub 2016 Mar 3 doi: 10.1111/ajco.12451. PMID: 26935004
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Brainstem glioma: a review.
Grimm SA, Chamberlain MC
Curr Neurol Neurosci Rep 2013 May;13(5):346. doi: 10.1007/s11910-013-0346-3. PMID: 23512689

Therapy

Phase I trial of panobinostat in children with diffuse intrinsic pontine glioma: A report from the Pediatric Brain Tumor Consortium (PBTC-047).
Monje M, Cooney T, Glod J, Huang J, Peer CJ, Faury D, Baxter P, Kramer K, Lenzen A, Robison NJ, Kilburn L, Vinitsky A, Figg WD, Jabado N, Fouladi M, Fangusaro J, Onar-Thomas A, Dunkel IJ, Warren KE
Neuro Oncol 2023 Dec 8;25(12):2262-2272. doi: 10.1093/neuonc/noad141. PMID: 37526549Free PMC Article
Oncolytic virotherapy for the treatment of pediatric brainstem gliomas.
Gállego Pérez-Larraya J, García-Moure M, Alonso MM
Rev Neurol (Paris) 2023 Jun;179(5):475-480. Epub 2023 Apr 13 doi: 10.1016/j.neurol.2023.03.016. PMID: 37061388
Developing chemotherapy for diffuse pontine intrinsic gliomas (DIPG).
Gwak HS, Park HJ
Crit Rev Oncol Hematol 2017 Dec;120:111-119. Epub 2017 Oct 31 doi: 10.1016/j.critrevonc.2017.10.013. PMID: 29198324
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Improving outcomes for neurofibromatosis 1-associated brain tumors.
Brossier NM, Gutmann DH
Expert Rev Anticancer Ther 2015 Apr;15(4):415-23. Epub 2015 Feb 5 doi: 10.1586/14737140.2015.1009043. PMID: 25652347

Prognosis

The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors.
Faulkner H, Arnaout O, Hoshide R, Young IM, Yeung JT, Sughrue ME, Teo C
World Neurosurg 2021 Feb;146:e639-e650. Epub 2020 Nov 2 doi: 10.1016/j.wneu.2020.10.147. PMID: 33152495
Developing chemotherapy for diffuse pontine intrinsic gliomas (DIPG).
Gwak HS, Park HJ
Crit Rev Oncol Hematol 2017 Dec;120:111-119. Epub 2017 Oct 31 doi: 10.1016/j.critrevonc.2017.10.013. PMID: 29198324
Radiotherapy for brainstem gliomas in children and adults: A single-institution experience and literature review.
Yoshida K, Sulaiman NS, Miyawaki D, Ejima Y, Nishimura H, Ishihara T, Matsuo Y, Nishikawa R, Sasayama T, Hayakawa A, Kohmura E, Sasaki R
Asia Pac J Clin Oncol 2017 Apr;13(2):e153-e160. Epub 2016 Mar 3 doi: 10.1111/ajco.12451. PMID: 26935004
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Adult brainstem gliomas.
Landolfi JC, Thaler HT, DeAngelis LM
Neurology 1998 Oct;51(4):1136-9. doi: 10.1212/wnl.51.4.1136. PMID: 9781543

Clinical prediction guides

Editorial for "Prediction of H3K27M Alteration Status in Brainstem Glioma Using Multi-Shell Diffusion MRI Metrics".
Choi KS
J Magn Reson Imaging 2024 Aug;60(2):586-587. Epub 2023 Oct 31 doi: 10.1002/jmri.29102. PMID: 37905976
Prediction of H3K27M Alteration Status in Brainstem Glioma Using Multi-Shell Diffusion MRI Metrics.
Xu X, Zhang P, Zhuo Z, Duan Y, Qu L, Cheng D, Sun T, Ding J, Xie C, Liu X, Haller S, Barkhof F, Ye C, Zhang L, Liu Y
J Magn Reson Imaging 2024 Aug;60(2):576-585. Epub 2023 Oct 27 doi: 10.1002/jmri.29104. PMID: 37889147
Prediction of H3K27M-mutant brainstem glioma by amide proton transfer-weighted imaging and its derived radiomics.
Zhuo Z, Qu L, Zhang P, Duan Y, Cheng D, Xu X, Sun T, Ding J, Xie C, Liu X, Haller S, Barkhof F, Zhang L, Liu Y
Eur J Nucl Med Mol Imaging 2021 Dec;48(13):4426-4436. Epub 2021 Jun 16 doi: 10.1007/s00259-021-05455-4. PMID: 34131804
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Adult brainstem gliomas.
Landolfi JC, Thaler HT, DeAngelis LM
Neurology 1998 Oct;51(4):1136-9. doi: 10.1212/wnl.51.4.1136. PMID: 9781543

Recent systematic reviews

Decoding the puzzle: A multidisciplinary systematic review of adult brainstem glioma.
Ius T, Montemurro N, Lombardi G, Berardinelli J, Romano A, Barresi V, Cerretti G, Guarnera A, Tel A, Cavallo LM, Pasqualetti F, Feletti A
Crit Rev Oncol Hematol 2024 Apr;196:104261. Epub 2024 Feb 22 doi: 10.1016/j.critrevonc.2024.104261. PMID: 38395241
Surgical Management of Adult Brainstem Gliomas: A Systematic Review and Meta-Analysis.
Ius T, Lombardi G, Baiano C, Berardinelli J, Romano A, Montemurro N, Cavallo LM, Pasqualetti F, Feletti A
Curr Oncol 2023 Nov 7;30(11):9772-9785. doi: 10.3390/curroncol30110709. PMID: 37999129Free PMC Article
Artificial Intelligence Applications in Pediatric Brain Tumor Imaging: A Systematic Review.
Huang J, Shlobin NA, Lam SK, DeCuypere M
World Neurosurg 2022 Jan;157:99-105. Epub 2021 Oct 11 doi: 10.1016/j.wneu.2021.10.068. PMID: 34648981
Robot-assisted stereotactic brain biopsy: systematic review and bibliometric analysis.
Marcus HJ, Vakharia VN, Ourselin S, Duncan J, Tisdall M, Aquilina K
Childs Nerv Syst 2018 Jul;34(7):1299-1309. Epub 2018 May 10 doi: 10.1007/s00381-018-3821-y. PMID: 29744625Free PMC Article
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG99, Brain tumours (primary) and brain metastases in over 16s, 2021

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
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      Related literature resources in PubMed

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