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Metastatic malignant neoplasm to vertebral column

MedGen UID:
195773
•Concept ID:
C0684550
•
Neoplastic Process
Synonyms: CA - Secondary cancer of spine; Metastases to Spine; Metastases to the Spine; Metastasis to spine; Metastasis to Spine; Metastasis to the Spine; Metastasis to vertebral column; Metastatic Cancer to the Spine; Metastatic Cancer to the Vertebral Column; Metastatic Malignant Neoplasm in the Spine; Metastatic malignant neoplasm of vertebral column; Metastatic malignant neoplasm to spine; Metastatic Malignant Neoplasm to the Spine; Metastatic Neoplasm to the Spine; Metastatic Neoplasm to the Vertebral Column; Metastatic Tumor to the Spine; Metastatic Tumor to the Vertebral Column; Secondary cancer of spine; Secondary malignant neoplasm of spine; Secondary malignant neoplasm of vertebral column; Secondary tumor of spine; Spinal metastases
SNOMED CT: Secondary malignant neoplasm of vertebral column (94602001); Secondary malignant neoplasm of spine (94602001); Metastatic malignant neoplasm to spine (94602001); Metastatic malignant neoplasm to vertebral column (94602001); Metastatic malignant neoplasm of vertebral column (94602001); Secondary tumor of spine (94602001); Metastasis to vertebral column (94602001); Metastasis to spine (94602001); Secondary cancer of spine (94602001); CA - Secondary cancer of spine (94602001); Spinal metastases (94602001)

Definition

The spread of a malignant neoplasm to the spine. This may be from a primary spinal malignant neoplasm, or from a malignant neoplasm at a distant site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic malignant neoplasm to vertebral column

Professional guidelines

PubMed

Current Overview of Treatment for Metastatic Bone Disease.
Tsukamoto S, Kido A, Tanaka Y, Facchini G, Peta G, Rossi G, Mavrogenis AF
Curr Oncol 2021 Aug 29;28(5):3347-3372. doi: 10.3390/curroncol28050290. PMID: 34590591Free PMC Article
Assessment and Management of Patients With Metastatic Spinal Cord Compression: A Multidisciplinary Review.
Lawton AJ, Lee KA, Cheville AL, Ferrone ML, Rades D, Balboni TA, Abrahm JL
J Clin Oncol 2019 Jan 1;37(1):61-71. Epub 2018 Nov 5 doi: 10.1200/JCO.2018.78.1211. PMID: 30395488
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954

Curated

UK NICE Guideline (NG234), Spinal metastases and metastatic spinal cord compression, 2023

Recent clinical studies

Etiology

Congenital spinal cord anomalies: a pictorial review.
Gupta P, Kumar A, Kumar A, Goel S
Curr Probl Diagn Radiol 2013 Mar-Apr;42(2):57-66. doi: 10.1067/j.cpradiol.2012.06.002. PMID: 23332138
Epidemiology and demographics for primary vertebral tumors.
Chi JH, Bydon A, Hsieh P, Witham T, Wolinsky JP, Gokaslan ZL
Neurosurg Clin N Am 2008 Jan;19(1):1-4. doi: 10.1016/j.nec.2007.10.005. PMID: 18156042
Surgical management of metastatic spine tumors.
Khan SN, Donthineni R
Orthop Clin North Am 2006 Jan;37(1):99-104. doi: 10.1016/j.ocl.2005.09.002. PMID: 16311115
Biomechanics of metastatic spine cancer.
Krishnaney AA, Steinmetz MP, Benzel EC
Neurosurg Clin N Am 2004 Oct;15(4):375-80. doi: 10.1016/j.nec.2004.04.001. PMID: 15450872
Primary bone tumors and pseudotumors of the lumbosacral spine.
Leone A, Costantini A, Guglielmi G, Settecasi C, Priolo F
Rays 2000 Jan-Mar;25(1):89-103. PMID: 10967637

Diagnosis

Metastatic saccrococcygeal chordoma.
Fatehi Hassanabad M, Mansouri A, Alotaibi NM, Hazrati LN, Bernstein M
J Clin Neurosci 2016 Jan;23:149-152. Epub 2015 Nov 18 doi: 10.1016/j.jocn.2015.05.036. PMID: 26602601
Congenital spinal cord anomalies: a pictorial review.
Gupta P, Kumar A, Kumar A, Goel S
Curr Probl Diagn Radiol 2013 Mar-Apr;42(2):57-66. doi: 10.1067/j.cpradiol.2012.06.002. PMID: 23332138
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954
Epidemiology and demographics for primary vertebral tumors.
Chi JH, Bydon A, Hsieh P, Witham T, Wolinsky JP, Gokaslan ZL
Neurosurg Clin N Am 2008 Jan;19(1):1-4. doi: 10.1016/j.nec.2007.10.005. PMID: 18156042
Metastatic disease of the spine.
White AP, Kwon BK, Lindskog DM, Friedlaender GE, Grauer JN
J Am Acad Orthop Surg 2006 Oct;14(11):587-98. doi: 10.5435/00124635-200610000-00001. PMID: 17030592

Therapy

Spinal metastasis.
Ahmad Z, Malik S, Mehmood F, Saifuddin A, Briggs T, Casey A
Br J Hosp Med (Lond) 2012 Jan;73(1):C10-3. doi: 10.12968/hmed.2012.73.sup1.c10. PMID: 22241403
Complication avoidance in vertebral column spine tumors.
Bilsky MH, Fraser JF
Neurosurg Clin N Am 2006 Jul;17(3):317-29, vii. doi: 10.1016/j.nec.2006.04.007. PMID: 16876031
Radiation dose in vertebroplasty.
Mehdizade A, Lovblad KO, Wilhelm KE, Somon T, Wetzel SG, Kelekis AD, Yilmaz H, Abdo G, Martin JB, Viera JM, Rüfenacht DA
Neuroradiology 2004 Mar;46(3):243-5. Epub 2004 Feb 14 doi: 10.1007/s00234-003-1156-0. PMID: 14968269
Spinal surgery.
Johnston R
J Neurol Neurosurg Psychiatry 1990 Dec;53(12):1021-3. doi: 10.1136/jnnp.53.12.1021. PMID: 2292690Free PMC Article
Back pain and epidural spinal cord compression.
Posner JB
Med Clin North Am 1987 Mar;71(2):185-205. doi: 10.1016/s0025-7125(16)30865-3. PMID: 2950289

Prognosis

Treatment of Metastatic Spinal Disease; what the Radiologist needs to know.
Supple S, Ahmad S, Gaddikeri S, Jhaveri MD
Br J Radiol 2022 Jul 1;95(1135):20211300. Epub 2022 Jun 7 doi: 10.1259/bjr.20211300. PMID: 35604660Free PMC Article
Metastatic saccrococcygeal chordoma.
Fatehi Hassanabad M, Mansouri A, Alotaibi NM, Hazrati LN, Bernstein M
J Clin Neurosci 2016 Jan;23:149-152. Epub 2015 Nov 18 doi: 10.1016/j.jocn.2015.05.036. PMID: 26602601
Surgical management of metastatic spine tumors.
Khan SN, Donthineni R
Orthop Clin North Am 2006 Jan;37(1):99-104. doi: 10.1016/j.ocl.2005.09.002. PMID: 16311115
Chordoma cutis.
Rubin AI, Bagel J, Niedt G
J Am Acad Dermatol 2005 May;52(5 Suppl 1):S105-8. doi: 10.1016/j.jaad.2004.07.055. PMID: 15858504
Spinal epidural rhabdomyosarcoma.
Rumboldt Z, Jednacak H, Talan-Hranilović J, Kalousek V
Acta Neurochir (Wien) 2004 Feb;146(2):195-7. Epub 2003 Dec 9 doi: 10.1007/s00701-003-0166-3. PMID: 14963757

Clinical prediction guides

A vertebral skeletal stem cell lineage driving metastasis.
Sun J, Hu L, Bok S, Yallowitz AR, Cung M, McCormick J, Zheng LJ, Debnath S, Niu Y, Tan AY, Lalani S, Morse KW, Shinn D, Pajak A, Hammad M, Suhardi VJ, Li Z, Li N, Wang L, Zou W, Mittal V, Bostrom MPG, Xu R, Iyer S, Greenblatt MB
Nature 2023 Sep;621(7979):602-609. Epub 2023 Sep 13 doi: 10.1038/s41586-023-06519-1. PMID: 37704733Free PMC Article
Commentary: Does Low-Grade Versus High-Grade Bilsky Scores Influence Local Recurrence and Overall Survival in Metastatic Spine Tumor Surgery?
El-Ghandour NMF
Neurosurgery 2023 Dec 1;93(6):e151-e152. Epub 2023 Aug 23 doi: 10.1227/neu.0000000000002650. PMID: 37610226
Management Algorithm for Osseous Metastatic Disease: What the Treatment Teams Want to Know.
Gibbs WN, Basha MM, Chazen JL
Neuroimaging Clin N Am 2023 Aug;33(3):487-497. Epub 2023 May 22 doi: 10.1016/j.nic.2023.04.003. PMID: 37356864
The evolution of surgical management for vertebral column tumors.
Fridley J, Gokaslan ZL
J Neurosurg Spine 2019 Apr 1;30(4):417-423. doi: 10.3171/2018.12.SPINE18708. PMID: 30933909
Reliability analysis of the epidural spinal cord compression scale.
Bilsky MH, Laufer I, Fourney DR, Groff M, Schmidt MH, Varga PP, Vrionis FD, Yamada Y, Gerszten PC, Kuklo TR
J Neurosurg Spine 2010 Sep;13(3):324-8. doi: 10.3171/2010.3.SPINE09459. PMID: 20809724

Recent systematic reviews

ESTRO clinical practice guideline: Stereotactic body radiotherapy for spine metastases.
Guckenberger M, Andratschke N, Belka C, Bellut D, Cuccia F, Dahele M, Guninski RS, Josipovic M, Mancosu P, Minniti G, Niyazi M, Ricardi U, Munck Af Rosenschold P, Sahgal A, Tsang Y, Verbakel W, Alongi F
Radiother Oncol 2024 Jan;190:109966. Epub 2023 Nov 2 doi: 10.1016/j.radonc.2023.109966. PMID: 37925107
Stereotactic body radiation therapy versus conventional external beam radiation therapy for painful bone metastases: A systematic review and meta-analysis of randomized trials.
Lee CC, Soon YY, Cheo T, Vellayappan B, Tey J
Crit Rev Oncol Hematol 2022 Oct;178:103775. Epub 2022 Jul 30 doi: 10.1016/j.critrevonc.2022.103775. PMID: 35917886
Stereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis.
Gaebe K, Li AY, Park A, Parmar A, Lok BH, Sahgal A, Chan KKW, Erickson AW, Das S
Lancet Oncol 2022 Jul;23(7):931-939. Epub 2022 May 26 doi: 10.1016/S1470-2045(22)00271-6. PMID: 35644163
Systematic review of site distribution of bone metastases in differentiated thyroid cancer.
Osorio M, Moubayed SP, Su H, Urken ML
Head Neck 2017 Apr;39(4):812-818. Epub 2017 Jan 11 doi: 10.1002/hed.24655. PMID: 28079945
Use of intraoperative cell-salvage for autologous blood transfusions in metastatic spine tumour surgery: a systematic review.
Kumar N, Chen Y, Zaw AS, Nayak D, Ahmed Q, Soong R, Wong HK
Lancet Oncol 2014 Jan;15(1):e33-41. doi: 10.1016/S1470-2045(13)70245-6. PMID: 24384492

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline (NG234), Spinal metastases and metastatic spinal cord compression, 2023

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
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      Related literature resources in PubMed

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