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Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

MedGen UID:
208746
Concept ID:
C0796549
Neoplastic Process
Synonyms: Recurrent Askin Tumor; Recurrent Askin's Tumor; Recurrent Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Tumors of Ewing's Family; Recurrent Tumors of the Ewing's Family

Definition

The reemergence of a malignant small round cell tumor with or without neural differentiation after a period of remission. [from NCI]

Professional guidelines

PubMed

Slotkin EK, Meyers PA
Pediatr Blood Cancer 2023 Jan;70(1):e30005. Epub 2022 Oct 2 doi: 10.1002/pbc.30005. PMID: 36184748Free PMC Article
Büyükkapu Bay S, Kebudi R, Görgün O, Zülfikar B, Darendeliler E, Çakır FB
J Oncol Pharm Pract 2019 Sep;25(6):1343-1348. Epub 2018 Aug 6 doi: 10.1177/1078155218790798. PMID: 30080131
Massimo L, Fossati-Guglielmoni A, Fortuna E
Helv Paediatr Acta 1968 Aug;23(4):315-33. PMID: 4300437

Recent clinical studies

Etiology

Reed DR, Grohar P, Rubin E, Binitie O, Krailo M, Davis J, DuBois SG, Janeway KA
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30583. Epub 2023 Jul 27 doi: 10.1002/pbc.30583. PMID: 37501549Free PMC Article
Rokita JL, Rathi KS, Cardenas MF, Upton KA, Jayaseelan J, Cross KL, Pfeil J, Egolf LE, Way GP, Farrel A, Kendsersky NM, Patel K, Gaonkar KS, Modi A, Berko ER, Lopez G, Vaksman Z, Mayoh C, Nance J, McCoy K, Haber M, Evans K, McCalmont H, Bendak K, Böhm JW, Marshall GM, Tyrrell V, Kalletla K, Braun FK, Qi L, Du Y, Zhang H, Lindsay HB, Zhao S, Shu J, Baxter P, Morton C, Kurmashev D, Zheng S, Chen Y, Bowen J, Bryan AC, Leraas KM, Coppens SE, Doddapaneni H, Momin Z, Zhang W, Sacks GI, Hart LS, Krytska K, Mosse YP, Gatto GJ, Sanchez Y, Greene CS, Diskin SJ, Vaske OM, Haussler D, Gastier-Foster JM, Kolb EA, Gorlick R, Li XN, Reynolds CP, Kurmasheva RT, Houghton PJ, Smith MA, Lock RB, Raman P, Wheeler DA, Maris JM
Cell Rep 2019 Nov 5;29(6):1675-1689.e9. doi: 10.1016/j.celrep.2019.09.071. PMID: 31693904Free PMC Article
Quddus MR, Rashid L, Sung CJ, Steinhoff MM, Cunxian Zhang, Lawrence WD
Reprod Sci 2009 Jun;16(6):591-5. Epub 2009 Mar 24 doi: 10.1177/1933719109332824. PMID: 19318687
Geyer JR, Balis FM, Krailo MD, Heideman R, Broxson E, Sato JK, Poplack D, Bleyer WA
Invest New Drugs 1996;13(4):337-42. doi: 10.1007/BF00873141. PMID: 8824353
Castellino RA, Bellani FF, Gasparini M, Terno G, Musumeci R
Lymphology 1975 Sep;8(3):74-83. PMID: 172742

Diagnosis

Lahiri R, Rawat SS, Srikant K, Rao S
BMJ Case Rep 2024 Jan 31;17(1) doi: 10.1136/bcr-2023-256631. PMID: 38296504Free PMC Article
Reed DR, Grohar P, Rubin E, Binitie O, Krailo M, Davis J, DuBois SG, Janeway KA
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30583. Epub 2023 Jul 27 doi: 10.1002/pbc.30583. PMID: 37501549Free PMC Article
Sánchez ML, Rodríguez FD, Coveñas R
Int J Mol Sci 2023 Jun 9;24(12) doi: 10.3390/ijms24129962. PMID: 37373115Free PMC Article
Kim HJ, McLawhorn AS, Goldstein MJ, Boland PJ
J Am Acad Orthop Surg 2012 Oct;20(10):646-56. doi: 10.5435/JAAOS-20-10-646. PMID: 23027694
Castellino RA, Bellani FF, Gasparini M, Terno G, Musumeci R
Lymphology 1975 Sep;8(3):74-83. PMID: 172742

Therapy

Reed DR, Grohar P, Rubin E, Binitie O, Krailo M, Davis J, DuBois SG, Janeway KA
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30583. Epub 2023 Jul 27 doi: 10.1002/pbc.30583. PMID: 37501549Free PMC Article
Rokita JL, Rathi KS, Cardenas MF, Upton KA, Jayaseelan J, Cross KL, Pfeil J, Egolf LE, Way GP, Farrel A, Kendsersky NM, Patel K, Gaonkar KS, Modi A, Berko ER, Lopez G, Vaksman Z, Mayoh C, Nance J, McCoy K, Haber M, Evans K, McCalmont H, Bendak K, Böhm JW, Marshall GM, Tyrrell V, Kalletla K, Braun FK, Qi L, Du Y, Zhang H, Lindsay HB, Zhao S, Shu J, Baxter P, Morton C, Kurmashev D, Zheng S, Chen Y, Bowen J, Bryan AC, Leraas KM, Coppens SE, Doddapaneni H, Momin Z, Zhang W, Sacks GI, Hart LS, Krytska K, Mosse YP, Gatto GJ, Sanchez Y, Greene CS, Diskin SJ, Vaske OM, Haussler D, Gastier-Foster JM, Kolb EA, Gorlick R, Li XN, Reynolds CP, Kurmasheva RT, Houghton PJ, Smith MA, Lock RB, Raman P, Wheeler DA, Maris JM
Cell Rep 2019 Nov 5;29(6):1675-1689.e9. doi: 10.1016/j.celrep.2019.09.071. PMID: 31693904Free PMC Article
de Pasquale MD, Castellano A, de Sio L, de Laurentis C, Mastronuzzi A, Serra A, Cozza R, Jenkner A, de Ioris MA
Anticancer Res 2011 Nov;31(11):3953-7. PMID: 22110225
Cowie FJ, Pinkerton CR, Phillips M, Dick G, Judson I, McCarthy PT, Flanagan RJ
Br J Cancer 1995 Apr;71(4):877-81. doi: 10.1038/bjc.1995.169. PMID: 7710958Free PMC Article
Bonadonna G, Tancini G, Rossi A, Gasparini M
Annu Rev Med 1978;29:149-75. doi: 10.1146/annurev.me.29.020178.001053. PMID: 206184

Prognosis

Deshpande G, Epari S, Gupta C, Shetty O, Gurav M, Chinnaswamy G, Moiyadi A, Gupta T
Childs Nerv Syst 2021 Mar;37(3):839-849. Epub 2020 Aug 6 doi: 10.1007/s00381-020-04850-w. PMID: 32761378
Lučić MA, Kozić D, Bjelan M, Marić S
Acta Neurol Belg 2015 Sep;115(3):423-4. Epub 2014 Aug 5 doi: 10.1007/s13760-014-0348-1. PMID: 25092552
de Pasquale MD, Castellano A, de Sio L, de Laurentis C, Mastronuzzi A, Serra A, Cozza R, Jenkner A, de Ioris MA
Anticancer Res 2011 Nov;31(11):3953-7. PMID: 22110225
Cowie FJ, Pinkerton CR, Phillips M, Dick G, Judson I, McCarthy PT, Flanagan RJ
Br J Cancer 1995 Apr;71(4):877-81. doi: 10.1038/bjc.1995.169. PMID: 7710958Free PMC Article
Spitzer G
Blood Rev 1991 Jun;5(2):105-11. doi: 10.1016/0268-960x(91)90042-b. PMID: 1912755

Clinical prediction guides

Liu L, Li L, Ding Y, Kong F, Mo W, Ye H, Shen D
Diagn Pathol 2024 Jan 22;19(1):19. doi: 10.1186/s13000-024-01443-y. PMID: 38254207Free PMC Article
Brookes MJ, Roundhill EA, Jeys L, Parry M, Burchill SA, Rankin KS
Pediatr Blood Cancer 2022 Dec;69(12):e29959. Epub 2022 Sep 15 doi: 10.1002/pbc.29959. PMID: 36106829
Sasaki T, Onishi T, Yabana T, Hoshina A
Tumori 2013 May-Jun;99(3):e104-6. doi: 10.1177/030089161309900326. PMID: 24158076
de Pasquale MD, Castellano A, de Sio L, de Laurentis C, Mastronuzzi A, Serra A, Cozza R, Jenkner A, de Ioris MA
Anticancer Res 2011 Nov;31(11):3953-7. PMID: 22110225
Martin RC 2nd, Brennan MF
Arch Surg 2003 Mar;138(3):281-5. doi: 10.1001/archsurg.138.3.281. PMID: 12611575

Recent systematic reviews

Seth N, Seth I, Bulloch G, Siu AHY, Guo A, Chatterjee R, MacManus M, Donnan L
Pediatr Blood Cancer 2022 Mar;69(3):e29415. Epub 2021 Oct 28 doi: 10.1002/pbc.29415. PMID: 34709700

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