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Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

MedGen UID:: 208746
•Concept ID:: C0796549
•: Neoplastic Process

Synonyms:

Recurrent Askin Tumor; Recurrent Askin's Tumor; Recurrent Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Tumors of Ewing's Family; Recurrent Tumors of the Ewing's Family

Definition

The reemergence of a malignant small round cell tumor with or without neural differentiation after a period of remission. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRecurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Abnormality of the nervous system
- Abnormal nervous system morphology
  - Neoplasm of the nervous system
    - Neoplasm of the peripheral nervous system
      - Peripheral neuroepithelioma
        Askin tumor
        Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
        Recurrent Ewing Sarcoma
        Recurrent Bone Ewing Sarcoma
        Recurrent Extraskeletal Ewing Sarcoma
        Recurrent Peripheral Primitive Neuroectodermal Tumor
        Recurrent Peripheral Primitive Neuroectodermal Tumor of Bone

Professional guidelines

PubMed

Irinotecan dose schedule for the treatment of Ewing sarcoma.

Slotkin EK, Meyers PA
Pediatr Blood Cancer 2023 Jan;70(1):e30005. Epub 2022 Oct 2 doi: 10.1002/pbc.30005. PMID: 36184748 Free PMC Article

Vincristine, irinotecan, and temozolomide treatment for refractory/relapsed pediatric solid tumors: A single center experience.

Büyükkapu Bay S, Kebudi R, Görgün O, Zülfikar B, Darendeliler E, Çakır FB
J Oncol Pharm Pract 2019 Sep;25(6):1343-1348. Epub 2018 Aug 6 doi: 10.1177/1078155218790798. PMID: 30080131

High-dose melphalan therapy for the treatment of children with refractory neuroblastoma and Ewing's sarcoma.

Graham-Pole J, Lazarus HM, Herzig RH, Gross S, Coccia P, Weiner R, Strandjord S
Am J Pediatr Hematol Oncol 1984 Spring;6(1):17-26. PMID: 6370012

See all (10)

Recent clinical studies

Etiology

Children's Oncology Group's 2023 blueprint for research: Bone tumors.

Reed DR, Grohar P, Rubin E, Binitie O, Krailo M, Davis J, DuBois SG, Janeway KA
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30583. Epub 2023 Jul 27 doi: 10.1002/pbc.30583. PMID: 37501549 Free PMC Article

Membrane-type 1 matrix metalloproteinase as predictor of survival and candidate therapeutic target in Ewing sarcoma.

Brookes MJ, Roundhill EA, Jeys L, Parry M, Burchill SA, Rankin KS
Pediatr Blood Cancer 2022 Dec;69(12):e29959. Epub 2022 Sep 15 doi: 10.1002/pbc.29959. PMID: 36106829

Multiple Ewing Sarcoma/Primitive Neuroectodermal Tumors in the Mediastinum: A Case Report and Literature Review.

Bae SH, Hwang JH, Da Nam B, Kim HJ, Kim KU, Kim DW, Choi IH
Medicine (Baltimore) 2016 Feb;95(7):e2725. doi: 10.1097/MD.0000000000002725. PMID: 26886614 Free PMC Article

Ewing sarcoma/primitive neuroectodermal tumor of the kidney: clinicopathologic analysis of 34 cases.

Karpate A, Menon S, Basak R, Yuvaraja TB, Tongaonkar HB, Desai SB
Ann Diagn Pathol 2012 Aug;16(4):267-74. Epub 2012 Apr 23 doi: 10.1016/j.anndiagpath.2011.07.011. PMID: 22534242

Ewing's sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) differentiation in endometrial serous carcinomas.

Quddus MR, Rashid L, Sung CJ, Steinhoff MM, Cunxian Zhang, Lawrence WD
Reprod Sci 2009 Jun;16(6):591-5. Epub 2009 Mar 24 doi: 10.1177/1933719109332824. PMID: 19318687

See all (53)

Diagnosis

Children's Oncology Group's 2023 blueprint for research: Bone tumors.

Neuropeptide Y Peptide Family and Cancer: Antitumor Therapeutic Strategies.

Sánchez ML, Rodríguez FD, Coveñas R
Int J Mol Sci 2023 Jun 9;24(12) doi: 10.3390/ijms24129962. PMID: 37373115 Free PMC Article

Extraosseous Ewing's sarcoma/peripheral primitive neuroectodermal tumour of the kidney: a case report and literature review.

Li J, Nie F, Li Y
BMC Urol 2022 Nov 30;22(1):197. doi: 10.1186/s12894-022-01146-w. PMID: 36451163 Free PMC Article

Primary intracranial Ewing sarcoma/ peripheral primitive neuroectodermal tumor, an entity of unacquaintance: a series of 8 cases.

Deshpande G, Epari S, Gupta C, Shetty O, Gurav M, Chinnaswamy G, Moiyadi A, Gupta T
Childs Nerv Syst 2021 Mar;37(3):839-849. Epub 2020 Aug 6 doi: 10.1007/s00381-020-04850-w. PMID: 32761378

Multiple Ewing Sarcoma/Primitive Neuroectodermal Tumors in the Mediastinum: A Case Report and Literature Review.

Bae SH, Hwang JH, Da Nam B, Kim HJ, Kim KU, Kim DW, Choi IH
Medicine (Baltimore) 2016 Feb;95(7):e2725. doi: 10.1097/MD.0000000000002725. PMID: 26886614 Free PMC Article

See all (70)

Therapy

Children's Oncology Group's 2023 blueprint for research: Bone tumors.

Irinotecan dose schedule for the treatment of Ewing sarcoma.

Slotkin EK, Meyers PA
Pediatr Blood Cancer 2023 Jan;70(1):e30005. Epub 2022 Oct 2 doi: 10.1002/pbc.30005. PMID: 36184748 Free PMC Article

Membrane-type 1 matrix metalloproteinase as predictor of survival and candidate therapeutic target in Ewing sarcoma.

Brookes MJ, Roundhill EA, Jeys L, Parry M, Burchill SA, Rankin KS
Pediatr Blood Cancer 2022 Dec;69(12):e29959. Epub 2022 Sep 15 doi: 10.1002/pbc.29959. PMID: 36106829

Ewing sarcoma of the adrenal gland: a case report and review of the literature.

Eddaoualline H, Mazouz K, Rafiq B, El Mghari Tabib G, El Ansari N, Belbaraka R, El Omrani A, Khouchani M
J Med Case Rep 2018 Mar 16;12(1):69. doi: 10.1186/s13256-018-1601-7. PMID: 29544549 Free PMC Article

Ewing's sarcoma/primitive neuroectodermal tumor arising from the adrenal gland: a case report and literature review.

Sasaki T, Onishi T, Yabana T, Hoshina A
Tumori 2013 May-Jun;99(3):e104-6. doi: 10.1177/030089161309900326. PMID: 24158076

See all (54)

Prognosis

Membrane-type 1 matrix metalloproteinase as predictor of survival and candidate therapeutic target in Ewing sarcoma.

Brookes MJ, Roundhill EA, Jeys L, Parry M, Burchill SA, Rankin KS
Pediatr Blood Cancer 2022 Dec;69(12):e29959. Epub 2022 Sep 15 doi: 10.1002/pbc.29959. PMID: 36106829

Primary intracranial Ewing sarcoma/ peripheral primitive neuroectodermal tumor, an entity of unacquaintance: a series of 8 cases.

Deshpande G, Epari S, Gupta C, Shetty O, Gurav M, Chinnaswamy G, Moiyadi A, Gupta T
Childs Nerv Syst 2021 Mar;37(3):839-849. Epub 2020 Aug 6 doi: 10.1007/s00381-020-04850-w. PMID: 32761378

Malignant osseous tumors of the pediatric spine.

Kim HJ, McLawhorn AS, Goldstein MJ, Boland PJ
J Am Acad Orthop Surg 2012 Oct;20(10):646-56. doi: 10.5435/JAAOS-20-10-646. PMID: 23027694

Ewing sarcoma/primitive neuroectodermal tumor of the kidney: clinicopathologic analysis of 34 cases.

Karpate A, Menon S, Basak R, Yuvaraja TB, Tongaonkar HB, Desai SB
Ann Diagn Pathol 2012 Aug;16(4):267-74. Epub 2012 Apr 23 doi: 10.1016/j.anndiagpath.2011.07.011. PMID: 22534242

Ewing's sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) differentiation in endometrial serous carcinomas.

Quddus MR, Rashid L, Sung CJ, Steinhoff MM, Cunxian Zhang, Lawrence WD
Reprod Sci 2009 Jun;16(6):591-5. Epub 2009 Mar 24 doi: 10.1177/1933719109332824. PMID: 19318687

See all (58)

Clinical prediction guides

Membrane-type 1 matrix metalloproteinase as predictor of survival and candidate therapeutic target in Ewing sarcoma.

Brookes MJ, Roundhill EA, Jeys L, Parry M, Burchill SA, Rankin KS
Pediatr Blood Cancer 2022 Dec;69(12):e29959. Epub 2022 Sep 15 doi: 10.1002/pbc.29959. PMID: 36106829

Prognostic value of detection of CD99(+) , CD45(-) cells in peripheral blood by flow cytometry in children with Ewing sarcoma.

Zakzok O, Elshanshory M, Zekri W, Elsharkawy N, Zaky I, Salama A, Kamel A, Elantably I, Said S
Pediatr Blood Cancer 2022 Jan;69(1):e29298. Epub 2021 Aug 17 doi: 10.1002/pbc.29298. PMID: 34403190

Ewing sarcoma/primitive neuro-ectodermal tumor of the urogenital system in children: a retrospective observational case series.

He Y, Sun N, Zhang W, Ma X, Ni X, Jin M, Sun J, Song H
J Pediatr Urol 2019 Oct;15(5):556.e1-556.e7. Epub 2019 Jul 5 doi: 10.1016/j.jpurol.2019.06.022. PMID: 31377020

Ewing's sarcoma/primitive neuroectodermal tumor arising from the adrenal gland: a case report and literature review.

Sasaki T, Onishi T, Yabana T, Hoshina A
Tumori 2013 May-Jun;99(3):e104-6. doi: 10.1177/030089161309900326. PMID: 24158076

Adult soft tissue Ewing sarcoma or primitive neuroectodermal tumors: predictors of survival?

Martin RC 2nd, Brennan MF
Arch Surg 2003 Mar;138(3):281-5. doi: 10.1001/archsurg.138.3.281. PMID: 12611575

See all (35)

Recent systematic reviews

(18) F-FDG PET and PET/CT as a diagnostic method for Ewing sarcoma: A systematic review and meta-analysis.

Seth N, Seth I, Bulloch G, Siu AHY, Guo A, Chatterjee R, MacManus M, Donnan L
Pediatr Blood Cancer 2022 Mar;69(3):e29415. Epub 2021 Oct 28 doi: 10.1002/pbc.29415. PMID: 34709700

See all (1)

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Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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