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Hypersomnia

MedGen UID:
214588
•Concept ID:
C0917799
•
Disease or Syndrome; Sign or Symptom
Synonym: Hypersomnias
SNOMED CT: Excessive sleep (77692006); Sleeps too much (77692006); Excessive sleepiness (77692006); Hypersomnia (77692006); Hypersomnia (excessive sleeping) (77692006)
 
HPO: HP:0100786
Monarch Initiative: MONDO:0005466

Definition

Excessive sleepiness or feeling of sleepiness, or difficulty staying awake despite having had adequate sleep, which persists over several days. [from HPO]

Conditions with this feature

Bamforth-Lazarus syndrome
MedGen UID:
343420
•Concept ID:
C1855794
•
Disease or Syndrome
Bamforth-Lazarus syndrome (BAMLAZ) is a rare autosomal recessive disorder characterized by congenital hypothyroidism due to thyroid agenesis or thyroid hypoplasia, cleft palate, and spiky hair, with or without choanal atresia or bifid epiglottis (summary by Sarma et al., 2022).
See: Condition Record
Spinocerebellar ataxia, autosomal recessive 23
MedGen UID:
1667331
•Concept ID:
C4750914
•
Disease or Syndrome
Autosomal recessive spinocerebellar ataxia-23 is a neurologic disorder characterized by epilepsy, intellectual disability, and gait ataxia (summary by Gomez-Herreros et al., 2014).
See: Condition Record
Neuroocular syndrome 1
MedGen UID:
1053724
•Concept ID:
CN377731
•
Disease or Syndrome
Neuroocular syndrome-1 (NOC1) encompasses a broad spectrum of overlapping anomalies, with developmental delay or impaired intellectual development as a consistent finding. Eye abnormalities show marked variability in the type and severity of defects, and include anophthalmia, microphthalmia, and coloboma. Other common systemic features include congenital heart and kidney defects, hypotonia, failure to thrive, and microcephaly (summary by Chowdhury et al., 2021). Genetic Heterogeneity of Neuroocular Syndrome See also NOC2 (168885), caused by mutation in the DAGLA gene (614015) on chromosome 11q12.
See: Condition Record
Bamforth-Lazarus syndrome
Neuroocular syndrome 1
Spinocerebellar ataxia, autosomal recessive 23

Professional guidelines

PubMed

Update on the treatment of idiopathic hypersomnia: Progress, challenges, and expert opinion.
Arnulf I, Thomas R, Roy A, Dauvilliers Y
Sleep Med Rev 2023 Jun;69:101766. Epub 2023 Feb 25 doi: 10.1016/j.smrv.2023.101766. PMID: 36921459
Nonpharmacologic and Pharmacologic Treatments of Adults in the Acute Phase of Major Depressive Disorder: A Living Clinical Guideline From the American College of Physicians.
Qaseem A, Owens DK, Etxeandia-Ikobaltzeta I, Tufte J, Cross JT Jr, Wilt TJ; Clinical Guidelines Committee of the American College of Physicians, Crandall CJ, Balk E, Cooney TG, Fitterman N, Hicks LA, Lin JS, Maroto M, Obley AJ, Tice JA, Yost J
Ann Intern Med 2023 Feb;176(2):239-252. Epub 2023 Jan 24 doi: 10.7326/M22-2056. PMID: 36689752
Narcolepsy: Diagnosis and management.
Golden EC, Lipford MC
Cleve Clin J Med 2018 Dec;85(12):959-969. doi: 10.3949/ccjm.85a.17086. PMID: 30526757

Recent clinical studies

Etiology

Understanding and approaching excessive daytime sleepiness.
Pérez-Carbonell L, Mignot E, Leschziner G, Dauvilliers Y
Lancet 2022 Sep 24;400(10357):1033-1046. Epub 2022 Sep 14 doi: 10.1016/S0140-6736(22)01018-2. PMID: 36115367
Histamine receptors, agonists, and antagonists in health and disease.
Panula P
Handb Clin Neurol 2021;180:377-387. doi: 10.1016/B978-0-12-820107-7.00023-9. PMID: 34225942
Excessive Daytime Sleepiness: A Clinical Review.
Gandhi KD, Mansukhani MP, Silber MH, Kolla BP
Mayo Clin Proc 2021 May;96(5):1288-1301. Epub 2021 Apr 9 doi: 10.1016/j.mayocp.2020.08.033. PMID: 33840518
A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
Johns MW
Sleep 1991 Dec;14(6):540-5. doi: 10.1093/sleep/14.6.540. PMID: 1798888
Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?
Ford DE, Kamerow DB
JAMA 1989 Sep 15;262(11):1479-84. doi: 10.1001/jama.262.11.1479. PMID: 2769898

Diagnosis

Narcolepsy and Idiopathic Hypersomnia.
Blattner M, Maski K
Sleep Med Clin 2023 Jun;18(2):183-199. Epub 2023 Mar 8 doi: 10.1016/j.jsmc.2023.01.003. PMID: 37120161
Understanding and approaching excessive daytime sleepiness.
Pérez-Carbonell L, Mignot E, Leschziner G, Dauvilliers Y
Lancet 2022 Sep 24;400(10357):1033-1046. Epub 2022 Sep 14 doi: 10.1016/S0140-6736(22)01018-2. PMID: 36115367
Idiopathic Hypersomnia and Other Hypersomnia Syndromes.
Trotti LM, Arnulf I
Neurotherapeutics 2021 Jan;18(1):20-31. doi: 10.1007/s13311-020-00919-1. PMID: 32901432Free PMC Article
Narcolepsy: Diagnosis and management.
Golden EC, Lipford MC
Cleve Clin J Med 2018 Dec;85(12):959-969. doi: 10.3949/ccjm.85a.17086. PMID: 30526757
Sleep Disturbances in Depression.
Murphy MJ, Peterson MJ
Sleep Med Clin 2015 Mar;10(1):17-23. Epub 2014 Dec 12 doi: 10.1016/j.jsmc.2014.11.009. PMID: 26055669Free PMC Article

Therapy

Update on the treatment of idiopathic hypersomnia: Progress, challenges, and expert opinion.
Arnulf I, Thomas R, Roy A, Dauvilliers Y
Sleep Med Rev 2023 Jun;69:101766. Epub 2023 Feb 25 doi: 10.1016/j.smrv.2023.101766. PMID: 36921459
Nonpharmacologic and Pharmacologic Treatments of Adults in the Acute Phase of Major Depressive Disorder: A Living Clinical Guideline From the American College of Physicians.
Qaseem A, Owens DK, Etxeandia-Ikobaltzeta I, Tufte J, Cross JT Jr, Wilt TJ; Clinical Guidelines Committee of the American College of Physicians, Crandall CJ, Balk E, Cooney TG, Fitterman N, Hicks LA, Lin JS, Maroto M, Obley AJ, Tice JA, Yost J
Ann Intern Med 2023 Feb;176(2):239-252. Epub 2023 Jan 24 doi: 10.7326/M22-2056. PMID: 36689752
European guideline and expert statements on the management of narcolepsy in adults and children.
Bassetti CLA, Kallweit U, Vignatelli L, Plazzi G, Lecendreux M, Baldin E, Dolenc-Groselj L, Jennum P, Khatami R, Manconi M, Mayer G, Partinen M, Pollmächer T, Reading P, Santamaria J, Sonka K, Dauvilliers Y, Lammers GJ
J Sleep Res 2021 Dec;30(6):e13387. Epub 2021 Jun 25 doi: 10.1111/jsr.13387. PMID: 34173288
Idiopathic Hypersomnia and Other Hypersomnia Syndromes.
Trotti LM, Arnulf I
Neurotherapeutics 2021 Jan;18(1):20-31. doi: 10.1007/s13311-020-00919-1. PMID: 32901432Free PMC Article
Sleep Disorders.
K Pavlova M, Latreille V
Am J Med 2019 Mar;132(3):292-299. Epub 2018 Oct 4 doi: 10.1016/j.amjmed.2018.09.021. PMID: 30292731

Prognosis

Narcolepsies, update in 2023.
Barateau L, Pizza F, Chenini S, Peter-Derex L, Dauvilliers Y
Rev Neurol (Paris) 2023 Oct;179(7):727-740. Epub 2023 Aug 25 doi: 10.1016/j.neurol.2023.08.001. PMID: 37634997
Treatment of central disorders of hypersomnolence: an American Academy of Sleep Medicine clinical practice guideline.
Maski K, Trotti LM, Kotagal S, Robert Auger R, Rowley JA, Hashmi SD, Watson NF
J Clin Sleep Med 2021 Sep 1;17(9):1881-1893. doi: 10.5664/jcsm.9328. PMID: 34743789Free PMC Article
Kleine-Levin Syndrome.
Afolabi-Brown O, Mason TBA 2nd
Paediatr Respir Rev 2018 Jan;25:9-13. Epub 2016 Dec 23 doi: 10.1016/j.prrv.2016.12.004. PMID: 28216256
Kleine-Levin syndrome; An update and mini-review.
Gadoth N, Oksenberg A
Brain Dev 2017 Sep;39(8):665-671. Epub 2017 Apr 20 doi: 10.1016/j.braindev.2017.04.003. PMID: 28434769
Kleine-Levin Syndrome.
Miglis MG, Guilleminault C
Curr Neurol Neurosci Rep 2016 Jun;16(6):60. doi: 10.1007/s11910-016-0653-6. PMID: 27137943

Clinical prediction guides

The relationship between sleep disturbance and cognitive impairment in mood disorders: A systematic review.
Pearson O, Uglik-Marucha N, Miskowiak KW, Cairney SA, Rosenzweig I, Young AH, Stokes PRA
J Affect Disord 2023 Apr 14;327:207-216. Epub 2023 Feb 3 doi: 10.1016/j.jad.2023.01.114. PMID: 36739007
Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study.
Kappelmann N, Arloth J, Georgakis MK, Czamara D, Rost N, Ligthart S, Khandaker GM, Binder EB
JAMA Psychiatry 2021 Feb 1;78(2):161-170. doi: 10.1001/jamapsychiatry.2020.3436. PMID: 33079133Free PMC Article
Diaphragmatic dysfunction.
Ricoy J, Rodríguez-Núñez N, Álvarez-Dobaño JM, Toubes ME, Riveiro V, Valdés L
Pulmonology 2019 Jul-Aug;25(4):223-235. Epub 2018 Dec 1 doi: 10.1016/j.pulmoe.2018.10.008. PMID: 30509855
The Sleep Disturbance Scale for Children (SDSC). Construction and validation of an instrument to evaluate sleep disturbances in childhood and adolescence.
Bruni O, Ottaviano S, Guidetti V, Romoli M, Innocenzi M, Cortesi F, Giannotti F
J Sleep Res 1996 Dec;5(4):251-61. doi: 10.1111/j.1365-2869.1996.00251.x. PMID: 9065877
A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
Johns MW
Sleep 1991 Dec;14(6):540-5. doi: 10.1093/sleep/14.6.540. PMID: 1798888

Recent systematic reviews

The relationship between sleep disturbance and cognitive impairment in mood disorders: A systematic review.
Pearson O, Uglik-Marucha N, Miskowiak KW, Cairney SA, Rosenzweig I, Young AH, Stokes PRA
J Affect Disord 2023 Apr 14;327:207-216. Epub 2023 Feb 3 doi: 10.1016/j.jad.2023.01.114. PMID: 36739007
Oral antihistamine-decongestant-analgesic combinations for the common cold.
De Sutter AI, Eriksson L, van Driel ML
Cochrane Database Syst Rev 2022 Jan 21;1(1):CD004976. doi: 10.1002/14651858.CD004976.pub4. PMID: 35060618Free PMC Article
European guideline and expert statements on the management of narcolepsy in adults and children.
Bassetti CLA, Kallweit U, Vignatelli L, Plazzi G, Lecendreux M, Baldin E, Dolenc-Groselj L, Jennum P, Khatami R, Manconi M, Mayer G, Partinen M, Pollmächer T, Reading P, Santamaria J, Sonka K, Dauvilliers Y, Lammers GJ
J Sleep Res 2021 Dec;30(6):e13387. Epub 2021 Jun 25 doi: 10.1111/jsr.13387. PMID: 34173288
Narcolepsy and psychosis: A systematic review.
Hanin C, Arnulf I, Maranci JB, Lecendreux M, Levinson DF, Cohen D, Laurent-Levinson C
Acta Psychiatr Scand 2021 Jul;144(1):28-41. Epub 2021 May 5 doi: 10.1111/acps.13300. PMID: 33779983Free PMC Article
Pharmacotherapies for sleep disturbances in dementia.
McCleery J, Sharpley AL
Cochrane Database Syst Rev 2020 Nov 15;11(11):CD009178. doi: 10.1002/14651858.CD009178.pub4. PMID: 33189083Free PMC Article

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