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Metastatic Esophageal Adenocarcinoma

MedGen UID:
216043
•Concept ID:
C1142347
•
Neoplastic Process

Definition

An adenocarcinoma that arises from the esophagus and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Quality indicators for the management of Barrett's esophagus, dysplasia, and esophageal adenocarcinoma: international consensus recommendations from the American Gastroenterological Association Symposium.
Sharma P, Katzka DA, Gupta N, Ajani J, Buttar N, Chak A, Corley D, El-Serag H, Falk GW, Fitzgerald R, Goldblum J, Gress F, Ilson DH, Inadomi JM, Kuipers EJ, Lynch JP, McKeon F, Metz D, Pasricha PJ, Pech O, Peek R, Peters JH, Repici A, Seewald S, Shaheen NJ, Souza RF, Spechler SJ, Vennalaganti P, Wang K
Gastroenterology 2015 Nov;149(6):1599-606. Epub 2015 Aug 19 doi: 10.1053/j.gastro.2015.08.007. PMID: 26296479Free PMC Article

Recent clinical studies

Etiology

Cytopathological Heterogeneity of Circulating Tumor Cells in Non-metastatic Esophageal Adenocarcinoma.
Kuvendjiska J, Pitman MB, Martini V, Braun C, Grebe K, Timme S, Fichtner-Feigl S, Glatz T, Schmoor C, Guenzle J, Hoeppner J, Kulemann B
Anticancer Res 2020 Oct;40(10):5679-5685. doi: 10.21873/anticanres.14582. PMID: 32988893
Importance of investigating high-risk human papillomavirus in lymph node metastasis of esophageal adenocarcinoma.
Sharma P, Gautam SD, Rajendra S
World J Gastroenterol 2020 Jun 7;26(21):2729-2739. doi: 10.3748/wjg.v26.i21.2729. PMID: 32550750Free PMC Article
A 10-year review of survival among patients with metastatic gastrointestinal cancers: a population-based study.
Abdel-Rahman O
Int J Colorectal Dis 2020 May;35(5):911-920. Epub 2020 Mar 17 doi: 10.1007/s00384-020-03568-0. PMID: 32185469
Searching for metastases in ovarian tissue before autotransplantation: a tailor-made approach.
Hoekman EJ, Smit VT, Fleming TP, Louwe LA, Fleuren GJ, Hilders CG
Fertil Steril 2015 Feb;103(2):469-77. Epub 2014 Dec 10 doi: 10.1016/j.fertnstert.2014.11.001. PMID: 25497447
Cetuximab as second-line therapy in patients with metastatic esophageal adenocarcinoma: a phase II Southwest Oncology Group Study (S0415).
Gold PJ, Goldman B, Iqbal S, Leichman LP, Zhang W, Lenz HJ, Blanke CD
J Thorac Oncol 2010 Sep;5(9):1472-6. doi: 10.1097/JTO.0b013e3181e77a92. PMID: 20631636Free PMC Article

Diagnosis

Differential prognostic significance of sarcopenia in metastatic esophageal squamous and adenocarcinoma.
Zeuge U, Fares AF, Soriano J, Hueniken K, Bajwa J, Wang W, Schmid S, Rudolph-Naiberg S, Brown MC, Yeung J, Chen EX, Jang RW, Xu W, Elimova E, Liu G, Rozenberg D, McInnis MC
Esophagus 2023 Jul;20(3):557-566. Epub 2023 Jan 12 doi: 10.1007/s10388-022-00981-y. PMID: 36631713
Optimal First-Line Therapy for Metastatic Adenocarcinoma of the Esophagus.
Malla M, Fuqua J, Mukherjee S, Goldberg RM
Curr Treat Options Oncol 2022 Dec;23(12):1748-1760. Epub 2022 Oct 22 doi: 10.1007/s11864-022-01029-0. PMID: 36272049Free PMC Article
Importance of investigating high-risk human papillomavirus in lymph node metastasis of esophageal adenocarcinoma.
Sharma P, Gautam SD, Rajendra S
World J Gastroenterol 2020 Jun 7;26(21):2729-2739. doi: 10.3748/wjg.v26.i21.2729. PMID: 32550750Free PMC Article
A 10-year review of survival among patients with metastatic gastrointestinal cancers: a population-based study.
Abdel-Rahman O
Int J Colorectal Dis 2020 May;35(5):911-920. Epub 2020 Mar 17 doi: 10.1007/s00384-020-03568-0. PMID: 32185469
Orbital metastases.
Ng E, Ilsen PF
Optometry 2010 Dec;81(12):647-57. doi: 10.1016/j.optm.2010.07.026. PMID: 21111373

Therapy

Immune Checkpoint Inhibitor-Associated Kelch-Like Protein-11 IgG Brainstem Encephalitis.
Aboseif A, Vorasoot N, Pinto MV, Guo Y, Hasan S, Zekeridou A, Chen JJ, Dubey D
Neurol Neuroimmunol Neuroinflamm 2024 May;11(3):e200218. Epub 2024 Mar 14 doi: 10.1212/NXI.0000000000200218. PMID: 38484218
Pembrolizumab-induced Toxic Epidermal Necrolysis in a Patient with Metastatic Esophageal Adenocarcinoma.
Gallo Marin B, Oliva R, Kahn B, Borgovan T, Brooks BE, Massoud CM
R I Med J (2013) 2022 Apr 1;105(3):34-36. PMID: 35349618Free PMC Article
Severe de novo pustular psoriasiform immune-related adverse event associated with nivolumab treatment for metastatic esophageal adenocarcinoma.
Seervai RNH, Heberton M, Cho WC, Gill P, Murphy MB, Aung PP, Nagarajan P, Torres-Cabala CA, Patel AB, Ruiz-Bañobre J, Om A, Yamamoto T, Nikolaou V, Curry JL
J Cutan Pathol 2022 May;49(5):472-481. Epub 2021 Dec 22 doi: 10.1111/cup.14185. PMID: 34888886
Interleukin-10 and -12 predict chemotherapy-associated toxicity in esophageal adenocarcinoma.
Schauer MC, Holzmann B, Peiper M, Friess H, Knoefel WT, Theisen J
J Thorac Oncol 2010 Nov;5(11):1849-54. doi: 10.1097/JTO.0b013e3181f19028. PMID: 20881642
Cetuximab as second-line therapy in patients with metastatic esophageal adenocarcinoma: a phase II Southwest Oncology Group Study (S0415).
Gold PJ, Goldman B, Iqbal S, Leichman LP, Zhang W, Lenz HJ, Blanke CD
J Thorac Oncol 2010 Sep;5(9):1472-6. doi: 10.1097/JTO.0b013e3181e77a92. PMID: 20631636Free PMC Article

Prognosis

Differential prognostic significance of sarcopenia in metastatic esophageal squamous and adenocarcinoma.
Zeuge U, Fares AF, Soriano J, Hueniken K, Bajwa J, Wang W, Schmid S, Rudolph-Naiberg S, Brown MC, Yeung J, Chen EX, Jang RW, Xu W, Elimova E, Liu G, Rozenberg D, McInnis MC
Esophagus 2023 Jul;20(3):557-566. Epub 2023 Jan 12 doi: 10.1007/s10388-022-00981-y. PMID: 36631713
Cytopathological Heterogeneity of Circulating Tumor Cells in Non-metastatic Esophageal Adenocarcinoma.
Kuvendjiska J, Pitman MB, Martini V, Braun C, Grebe K, Timme S, Fichtner-Feigl S, Glatz T, Schmoor C, Guenzle J, Hoeppner J, Kulemann B
Anticancer Res 2020 Oct;40(10):5679-5685. doi: 10.21873/anticanres.14582. PMID: 32988893
Importance of investigating high-risk human papillomavirus in lymph node metastasis of esophageal adenocarcinoma.
Sharma P, Gautam SD, Rajendra S
World J Gastroenterol 2020 Jun 7;26(21):2729-2739. doi: 10.3748/wjg.v26.i21.2729. PMID: 32550750Free PMC Article
A 10-year review of survival among patients with metastatic gastrointestinal cancers: a population-based study.
Abdel-Rahman O
Int J Colorectal Dis 2020 May;35(5):911-920. Epub 2020 Mar 17 doi: 10.1007/s00384-020-03568-0. PMID: 32185469
Orbital metastases.
Ng E, Ilsen PF
Optometry 2010 Dec;81(12):647-57. doi: 10.1016/j.optm.2010.07.026. PMID: 21111373

Clinical prediction guides

Cytopathological Heterogeneity of Circulating Tumor Cells in Non-metastatic Esophageal Adenocarcinoma.
Kuvendjiska J, Pitman MB, Martini V, Braun C, Grebe K, Timme S, Fichtner-Feigl S, Glatz T, Schmoor C, Guenzle J, Hoeppner J, Kulemann B
Anticancer Res 2020 Oct;40(10):5679-5685. doi: 10.21873/anticanres.14582. PMID: 32988893
Importance of investigating high-risk human papillomavirus in lymph node metastasis of esophageal adenocarcinoma.
Sharma P, Gautam SD, Rajendra S
World J Gastroenterol 2020 Jun 7;26(21):2729-2739. doi: 10.3748/wjg.v26.i21.2729. PMID: 32550750Free PMC Article
A 10-year review of survival among patients with metastatic gastrointestinal cancers: a population-based study.
Abdel-Rahman O
Int J Colorectal Dis 2020 May;35(5):911-920. Epub 2020 Mar 17 doi: 10.1007/s00384-020-03568-0. PMID: 32185469
Novel metastatic models of esophageal adenocarcinoma derived from FLO-1 cells highlight the importance of E-cadherin in cancer metastasis.
Liu DS, Hoefnagel SJ, Fisher OM, Krishnadath KK, Montgomery KG, Busuttil RA, Colebatch AJ, Read M, Duong CP, Phillips WA, Clemons NJ
Oncotarget 2016 Dec 13;7(50):83342-83358. doi: 10.18632/oncotarget.13391. PMID: 27863424Free PMC Article
Interleukin-10 and -12 predict chemotherapy-associated toxicity in esophageal adenocarcinoma.
Schauer MC, Holzmann B, Peiper M, Friess H, Knoefel WT, Theisen J
J Thorac Oncol 2010 Nov;5(11):1849-54. doi: 10.1097/JTO.0b013e3181f19028. PMID: 20881642

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