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Bladder Papillary Urothelial Neoplasm of Low Malignant Potential

MedGen UID:
220407
•Concept ID:
C1266010
•
Neoplastic Process
Synonyms: Bladder Papillary Neoplasm of Low Malignant Potential; Bladder Papillary Transitional Cell Neoplasm of Low Malignant Potential; Bladder PUNLMP; Papillary transitional cell neoplasm of low malignant potential; Papillary urothelial neoplasm of low malignant potential
SNOMED CT: Papillary urothelial neoplasm of low malignant potential (128625004); Papillary transitional cell neoplasm of low malignant potential (128625004)

Definition

A papillary urothelial neoplasm that arises from the urinary bladder. The papillary structures exhibit minimal architectural distortion and minimal atypia. Mitoses are infrequent. Patients are at an increased risk of developing new papillary lesions. Occasionally, the new lesions are urothelial carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Papillary Urothelial Neoplasm of Low Malignant Potential

Professional guidelines

PubMed

2-micrometer continuous wave laser treatment for multiple non-muscle-invasive bladder cancer with intravesical instillation of epirubicin.
Liu H, Xue S, Ruan Y, Sun X, Han B, Xia S
Lasers Surg Med 2011 Jan;43(1):15-20. doi: 10.1002/lsm.21014. PMID: 21254138
Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients: a comprehensive review of literature with implications for patient management.
Paner GP, Zehnder P, Amin AM, Husain AN, Desai MM
Adv Anat Pathol 2011 Jan;18(1):79-89. doi: 10.1097/PAP.0b013e318204c0cf. PMID: 21169741
Diagnosis, evaluation and treatment of carcinoma in situ of the urinary bladder: the state of the art.
Williamson SR, Montironi R, Lopez-Beltran A, MacLennan GT, Davidson DD, Cheng L
Crit Rev Oncol Hematol 2010 Nov;76(2):112-26. Epub 2010 Jan 25 doi: 10.1016/j.critrevonc.2010.01.005. PMID: 20097572

Recent clinical studies

Etiology

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas.
Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
Young population bladder neoplasms.
Çivi Çetin K, Öner S, Erdoğan B, Simşek G, Sezer M
Eur Rev Med Pharmacol Sci 2023 Nov;27(21):10454-10461. doi: 10.26355/eurrev_202311_34320. PMID: 37975369
Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non-Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial.
Messing EM, Tangen CM, Lerner SP, Sahasrabudhe DM, Koppie TM, Wood DP Jr, Mack PC, Svatek RS, Evans CP, Hafez KS, Culkin DJ, Brand TC, Karsh LI, Holzbeierlein JM, Wilson SS, Wu G, Plets M, Vogelzang NJ, Thompson IM Jr
JAMA 2018 May 8;319(18):1880-1888. doi: 10.1001/jama.2018.4657. PMID: 29801011Free PMC Article

Diagnosis

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas.
Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
Young population bladder neoplasms.
Çivi Çetin K, Öner S, Erdoğan B, Simşek G, Sezer M
Eur Rev Med Pharmacol Sci 2023 Nov;27(21):10454-10461. doi: 10.26355/eurrev_202311_34320. PMID: 37975369
Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Tumour-like lesions of the urinary bladder.
Samaratunga H, Delahunt B, Yaxley J, Egevad L
Pathology 2021 Jan;53(1):44-55. Epub 2020 Oct 15 doi: 10.1016/j.pathol.2020.08.005. PMID: 33070959
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556

Therapy

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
FGFR3 Mutational Activation Can Induce Luminal-like Papillary Bladder Tumor Formation and Favors a Male Sex Bias.
Shi MJ, Fontugne J, Moreno-Vega A, Meng XY, Groeneveld C, Dufour F, Kamoun A, Viborg Lindskrog S, Cabel L, Krucker C, Rapinat A, Dunois-Larde C, Lepage ML, Chapeaublanc E, Levrel O, Dixon V, Lebret T, Almeida A, De Reynies A, Rochel N, Dyrskjøt L, Allory Y, Radvanyi F, Bernard-Pierrot I
Eur Urol 2023 Jan;83(1):70-81. Epub 2022 Oct 21 doi: 10.1016/j.eururo.2022.09.030. PMID: 36273937
Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non-Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial.
Messing EM, Tangen CM, Lerner SP, Sahasrabudhe DM, Koppie TM, Wood DP Jr, Mack PC, Svatek RS, Evans CP, Hafez KS, Culkin DJ, Brand TC, Karsh LI, Holzbeierlein JM, Wilson SS, Wu G, Plets M, Vogelzang NJ, Thompson IM Jr
JAMA 2018 May 8;319(18):1880-1888. doi: 10.1001/jama.2018.4657. PMID: 29801011Free PMC Article
Cyclosporine A and tacrolimus inhibit urothelial tumorigenesis.
Kawahara T, Kashiwagi E, Li Y, Zheng Y, Miyamoto Y, Netto GJ, Ishiguro H, Miyamoto H
Mol Carcinog 2016 Feb;55(2):161-9. Epub 2015 Jan 15 doi: 10.1002/mc.22265. PMID: 25594762
Transurethral Resection of the Bladder Tumour as a Treatment Method in Children with Transitional Cell Carcinoma of the Bladder--Analysis of Our Material and Literature Review.
Apoznański W, Rysiakiewicz J, Polok M, Rysiakiewicz K, Siekanowicz P, Hilger T, Zagierski J, Hilger M, Nowak I, Kolęda P, Szydełko T
Adv Clin Exp Med 2015 May-Jun;24(3):505-9. doi: 10.17219/acem/36600. PMID: 26467141

Prognosis

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas.
Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
Young population bladder neoplasms.
Çivi Çetin K, Öner S, Erdoğan B, Simşek G, Sezer M
Eur Rev Med Pharmacol Sci 2023 Nov;27(21):10454-10461. doi: 10.26355/eurrev_202311_34320. PMID: 37975369
Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Mutational landscape of non-muscle-invasive bladder cancer.
Hurst CD, Knowles MA
Urol Oncol 2022 Jul;40(7):295-303. Epub 2018 Nov 13 doi: 10.1016/j.urolonc.2018.10.015. PMID: 30446444
Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non-Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial.
Messing EM, Tangen CM, Lerner SP, Sahasrabudhe DM, Koppie TM, Wood DP Jr, Mack PC, Svatek RS, Evans CP, Hafez KS, Culkin DJ, Brand TC, Karsh LI, Holzbeierlein JM, Wilson SS, Wu G, Plets M, Vogelzang NJ, Thompson IM Jr
JAMA 2018 May 8;319(18):1880-1888. doi: 10.1001/jama.2018.4657. PMID: 29801011Free PMC Article

Clinical prediction guides

Young population bladder neoplasms.
Çivi Çetin K, Öner S, Erdoğan B, Simşek G, Sezer M
Eur Rev Med Pharmacol Sci 2023 Nov;27(21):10454-10461. doi: 10.26355/eurrev_202311_34320. PMID: 37975369
Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
T1 bladder carcinoma with variant histology: pathological features and clinical significance.
Lopez-Beltran A, Blanca A, Cimadamore A, Montironi R, Luque RJ, Volavšek M, Cheng L
Virchows Arch 2022 May;480(5):989-998. Epub 2022 Feb 4 doi: 10.1007/s00428-021-03264-6. PMID: 35122124Free PMC Article
Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.
Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G
Int Braz J Urol 2016 Mar-Apr;42(2):242-6. doi: 10.1590/S1677-5538.IBJU.2015.0200. PMID: 27256177Free PMC Article
Bladder papillary urothelial neoplasm of low malignant potential in Chinese: a clinical and pathological analysis.
Zhang XK, Wang YY, Chen JW, Qin T
Int J Clin Exp Pathol 2015;8(5):5549-55. Epub 2015 May 1 PMID: 26191263Free PMC Article

Recent systematic reviews

Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients.
Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B, Pace G, Carmignani L
Urol Oncol 2013 Nov;31(8):1584-90. Epub 2012 Apr 19 doi: 10.1016/j.urolonc.2012.03.009. PMID: 22520573

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