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Non-invasive bladder papillary urothelial neoplasm

MedGen UID:
309424
•Concept ID:
C1518358
•
Neoplastic Process
Synonyms: Bladder Non-Invasive Papillary Urothelial Neoplasm; bladder papillary neoplasm of low malignant potential; bladder PUNLMP; Non-Invasive Bladder Papillary Urothelial Neoplasm; non-invasive bladder papillary urothelial neoplasm; papillary urothelial neoplasm of low malignant potential
 
Monarch Initiative: MONDO:0003822

Definition

A non-invasive papillary neoplasm of the bladder urothelium. [from NCI]

Recent clinical studies

Etiology

Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
Heterogenous NECTIN4 expression in urothelial high-risk non-muscle-invasive bladder cancer.
Garczyk S, Degener S, Bischoff F, Schnitzler T, Salz A, Golz R, Buchner A, Schulz GB, Schneider U, Gaisa NT, Knüchel R
Virchows Arch 2022 Jul;481(1):83-92. Epub 2022 Apr 28 doi: 10.1007/s00428-022-03328-1. PMID: 35484425Free PMC Article
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
Recent advances in pediatric bladder malignancies.
Lopes RI, Mello MF, Lorenzo AJ
F1000Res 2020;9 Epub 2020 Feb 25 doi: 10.12688/f1000research.19396.1. PMID: 32148770Free PMC Article
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.
Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI
Pathol Int 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. PMID: 20055945

Diagnosis

URINE CYTOLOGY AND AXILLARY TESTING FOR INTERPRETATION AND FOLLOW-UP OF URINARY TUMORS.
Kalogeraki AM, Tamiolakis DI, Mamoulakis CK
Acta Clin Croat 2022 Nov;61(3):505-510. doi: 10.20471/acc.2022.61.03.16. PMID: 37492363Free PMC Article
Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis.
Colling R, Colling H, Browning L, Verrill C
BMC Cancer 2021 Sep 6;21(1):995. doi: 10.1186/s12885-021-08698-4. PMID: 34488682Free PMC Article
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
Pathology of upper tract urothelial carcinoma with emphasis on staging.
Mazzucchelli R, Scarpelli M, Galosi AB, Di Primio R, Lopez-Beltran A, Cheng L, Montironi R
Int J Immunopathol Pharmacol 2014 Oct-Dec;27(4):509-16. doi: 10.1177/039463201402700406. PMID: 25572730

Therapy

Poncet's disease after the intravesical instillation of Bacillus Calmette-Guérin (BCG): a case report.
Sampaio PCM, Lira YG, Ribeiro HYU, de Paula Moreira F, Gadelha MSM, da Cruz SFS
BMC Res Notes 2017 Aug 18;10(1):416. doi: 10.1186/s13104-017-2606-9. PMID: 28821265Free PMC Article
Significance of a minor high-grade component in a low-grade noninvasive papillary urothelial carcinoma of bladder.
Reis LO, Taheri D, Chaux A, Guner G, Mendoza Rodriguez MA, Bivalacqua TJ, Schoenberg MP, Epstein JI, Netto GJ
Hum Pathol 2016 Jan;47(1):20-5. Epub 2015 Sep 25 doi: 10.1016/j.humpath.2015.09.007. PMID: 26520419
Pathology of carcinoma in situ of the urinary bladder and related lesions.
Farrow GM
J Cell Biochem Suppl 1992;16I:39-43. doi: 10.1002/jcb.240501308. PMID: 1305686

Prognosis

Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
Evolution of Urothelial Bladder Cancer in the Context of Molecular Classifications.
Minoli M, Kiener M, Thalmann GN, Kruithof-de Julio M, Seiler R
Int J Mol Sci 2020 Aug 7;21(16) doi: 10.3390/ijms21165670. PMID: 32784716Free PMC Article
Recent advances in pediatric bladder malignancies.
Lopes RI, Mello MF, Lorenzo AJ
F1000Res 2020;9 Epub 2020 Feb 25 doi: 10.12688/f1000research.19396.1. PMID: 32148770Free PMC Article
Pathology of upper tract urothelial carcinoma with emphasis on staging.
Mazzucchelli R, Scarpelli M, Galosi AB, Di Primio R, Lopez-Beltran A, Cheng L, Montironi R
Int J Immunopathol Pharmacol 2014 Oct-Dec;27(4):509-16. doi: 10.1177/039463201402700406. PMID: 25572730
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.
Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI
Pathol Int 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. PMID: 20055945

Clinical prediction guides

Heterogenous NECTIN4 expression in urothelial high-risk non-muscle-invasive bladder cancer.
Garczyk S, Degener S, Bischoff F, Schnitzler T, Salz A, Golz R, Buchner A, Schulz GB, Schneider U, Gaisa NT, Knüchel R
Virchows Arch 2022 Jul;481(1):83-92. Epub 2022 Apr 28 doi: 10.1007/s00428-022-03328-1. PMID: 35484425Free PMC Article
Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis.
Colling R, Colling H, Browning L, Verrill C
BMC Cancer 2021 Sep 6;21(1):995. doi: 10.1186/s12885-021-08698-4. PMID: 34488682Free PMC Article
Evolution of Urothelial Bladder Cancer in the Context of Molecular Classifications.
Minoli M, Kiener M, Thalmann GN, Kruithof-de Julio M, Seiler R
Int J Mol Sci 2020 Aug 7;21(16) doi: 10.3390/ijms21165670. PMID: 32784716Free PMC Article
Pure high-grade papillary urothelial bladder cancer: a luminal-like subgroup with potential for targeted therapy.
Schnitzler T, Ortiz-Brüchle N, Schneider U, Lurje I, Guricova K, Buchner A, Schulz GB, Heidenreich A, Gaisa NT, Knüchel R, Garczyk S
Cell Oncol (Dordr) 2020 Oct;43(5):807-819. Epub 2020 May 22 doi: 10.1007/s13402-020-00524-6. PMID: 32445084Free PMC Article
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.
Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI
Pathol Int 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. PMID: 20055945

Recent systematic reviews

Diagnostic and prognostic roles of CK20 in the pathology of urothelial lesions. A systematic review.
Sanguedolce F, Russo D, Calò B, Cindolo L, Carrieri G, Cormio L
Pathol Res Pract 2019 Jun;215(6):152413. Epub 2019 Apr 6 doi: 10.1016/j.prp.2019.04.005. PMID: 30987832

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