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Childhood Primary Cutaneous Anaplastic Large Cell Lymphoma

MedGen UID:
232069
•Concept ID:
C1332999
•
Neoplastic Process
Synonyms: Childhood Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma; Childhood Primary Cutaneous CD30-Positive Anaplastic Large Cell Lymphoma; Childhood Primary Cutaneous Ki-1 Positive Anaplastic Large Cell Lymphoma; Childhood Primary Cutaneous Ki-1+ Anaplastic Large Cell Lymphoma; Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma; Pediatric Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma; Pediatric Primary Cutaneous K-1+ Anaplastic Large Cell Lymphoma

Definition

An anaplastic large cell lymphoma that occurs during childhood and is limited to the skin at the time of diagnosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Primary Cutaneous Anaplastic Large Cell Lymphoma

Recent clinical studies

Etiology

Cutaneous lymphoma: Kids are not just little people.
Ferenczi K, Makkar HS
Clin Dermatol 2016 Nov-Dec;34(6):749-759. Epub 2016 Jul 10 doi: 10.1016/j.clindermatol.2016.07.010. PMID: 27968935
Isolated cutaneous involvement in a child with nodal anaplastic large cell lymphoma.
Mendiratta V, Gandhi N, Rana S, Shukla S; Ramchander
Indian J Dermatol Venereol Leprol 2016 Jan-Feb;82(1):53-6. doi: 10.4103/0378-6323.164215. PMID: 26728811
Anaplastic large cell lymphoma: an unusual presentation in a 7-year-old girl.
Ju E, Adigun C, Dunphy C, Gold S, Morrell DS
Pediatr Dermatol 2012 Jul-Aug;29(4):498-503. Epub 2011 Oct 4 doi: 10.1111/j.1525-1470.2011.01465.x. PMID: 21967522
CD30(+) cutaneous lymphoma in association with atopic eczema.
Fletcher CL, Orchard GE, Hubbard V, Whittaker SJ, Edelson RL, Russell-Jones R
Arch Dermatol 2004 Apr;140(4):449-54. doi: 10.1001/archderm.140.4.449. PMID: 15096373

Diagnosis

A Case of ALK+ Anaplastic Large-Cell Lymphoma With Aberrant Myeloperoxidase Expression and Initial Cutaneous Presentation.
Gru AA, Voorhess PJ
Am J Dermatopathol 2018 Jul;40(7):519-522. doi: 10.1097/DAD.0000000000001061. PMID: 29905579
Cutaneous lymphoma: Kids are not just little people.
Ferenczi K, Makkar HS
Clin Dermatol 2016 Nov-Dec;34(6):749-759. Epub 2016 Jul 10 doi: 10.1016/j.clindermatol.2016.07.010. PMID: 27968935
Secondary ALK negative anaplastic large cell lymphoma in a patient with lymphomatoid papulosis of 40 years duration.
Marschalkó M, Eros N, Holló P, Hársing J, Bottlik G, Bátai A, Csukly Z, Masszi T, Szentirmai Z, Fodor J, Kárpáti S, Matolcsy A, Csomor J
Am J Dermatopathol 2010 Oct;32(7):708-12. doi: 10.1097/DAD.0b013e3181d46eba. PMID: 20644462
Primary cutaneous Ki-1(CD30) positive anaplastic large cell lymphoma in childhood.
Tomaszewski MM, Moad JC, Lupton GP
J Am Acad Dermatol 1999 May;40(5 Pt 2):857-61. doi: 10.1053/jd.1999.v40.a95960. PMID: 10321635

Therapy

Isolated cutaneous involvement in a child with nodal anaplastic large cell lymphoma.
Mendiratta V, Gandhi N, Rana S, Shukla S; Ramchander
Indian J Dermatol Venereol Leprol 2016 Jan-Feb;82(1):53-6. doi: 10.4103/0378-6323.164215. PMID: 26728811
Secondary ALK negative anaplastic large cell lymphoma in a patient with lymphomatoid papulosis of 40 years duration.
Marschalkó M, Eros N, Holló P, Hársing J, Bottlik G, Bátai A, Csukly Z, Masszi T, Szentirmai Z, Fodor J, Kárpáti S, Matolcsy A, Csomor J
Am J Dermatopathol 2010 Oct;32(7):708-12. doi: 10.1097/DAD.0b013e3181d46eba. PMID: 20644462
Primary cutaneous CD30-positive anaplastic large cell lymphoma in childhood: report of 4 cases and review of the literature.
Kumar S, Pittaluga S, Raffeld M, Guerrera M, Seibel NL, Jaffe ES
Pediatr Dev Pathol 2005 Jan-Feb;8(1):52-60. Epub 2005 Feb 23 doi: 10.1007/s10024-004-8087-6. PMID: 15719203
Lymphomatoid papulosis from childhood with anaplastic large-cell lymphoma of the small bowel.
Perna AG, Jones DM, Duvic M
Clin Lymphoma 2004 Dec;5(3):190-3. doi: 10.3816/clm.2004.n.025. PMID: 15636695
Primary cutaneous Ki-1(CD30) positive anaplastic large cell lymphoma in childhood.
Tomaszewski MM, Moad JC, Lupton GP
J Am Acad Dermatol 1999 May;40(5 Pt 2):857-61. doi: 10.1053/jd.1999.v40.a95960. PMID: 10321635

Prognosis

Cutaneous lymphoma: Kids are not just little people.
Ferenczi K, Makkar HS
Clin Dermatol 2016 Nov-Dec;34(6):749-759. Epub 2016 Jul 10 doi: 10.1016/j.clindermatol.2016.07.010. PMID: 27968935
Anaplastic large cell lymphoma: an unusual presentation in a 7-year-old girl.
Ju E, Adigun C, Dunphy C, Gold S, Morrell DS
Pediatr Dermatol 2012 Jul-Aug;29(4):498-503. Epub 2011 Oct 4 doi: 10.1111/j.1525-1470.2011.01465.x. PMID: 21967522
Primary cutaneous CD30-positive anaplastic large cell lymphoma in childhood: report of 4 cases and review of the literature.
Kumar S, Pittaluga S, Raffeld M, Guerrera M, Seibel NL, Jaffe ES
Pediatr Dev Pathol 2005 Jan-Feb;8(1):52-60. Epub 2005 Feb 23 doi: 10.1007/s10024-004-8087-6. PMID: 15719203
Primary cutaneous Ki-1(CD30) positive anaplastic large cell lymphoma in childhood.
Tomaszewski MM, Moad JC, Lupton GP
J Am Acad Dermatol 1999 May;40(5 Pt 2):857-61. doi: 10.1053/jd.1999.v40.a95960. PMID: 10321635
Primary and secondary cutaneous Ki-1+ (CD30+) anaplastic large cell lymphomas. Morphologic, immunohistologic, and clinical-characteristics.
Kaudewitz P, Stein H, Dallenbach F, Eckert F, Bieber K, Burg G, Braun-Falco O
Am J Pathol 1989 Aug;135(2):359-67. PMID: 2551170Free PMC Article

Clinical prediction guides

A case of primary cutaneous anaplastic large cell lymphoma with variant anaplastic lymphoma kinase translocation.
Sasaki K, Sugaya M, Fujita H, Takeuchi K, Torii H, Asahina A, Tamaki K
Br J Dermatol 2004 Jun;150(6):1202-7. doi: 10.1111/j.1365-2133.2004.05987.x. PMID: 15214912
CD30(+) cutaneous lymphoma in association with atopic eczema.
Fletcher CL, Orchard GE, Hubbard V, Whittaker SJ, Edelson RL, Russell-Jones R
Arch Dermatol 2004 Apr;140(4):449-54. doi: 10.1001/archderm.140.4.449. PMID: 15096373
Primary cutaneous Ki-1(CD30) positive anaplastic large cell lymphoma in childhood.
Tomaszewski MM, Moad JC, Lupton GP
J Am Acad Dermatol 1999 May;40(5 Pt 2):857-61. doi: 10.1053/jd.1999.v40.a95960. PMID: 10321635
Primary and secondary cutaneous Ki-1+ (CD30+) anaplastic large cell lymphomas. Morphologic, immunohistologic, and clinical-characteristics.
Kaudewitz P, Stein H, Dallenbach F, Eckert F, Bieber K, Burg G, Braun-Falco O
Am J Pathol 1989 Aug;135(2):359-67. PMID: 2551170Free PMC Article

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