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Colorectal Adenoma with Mild Dysplasia

MedGen UID:
232090
•Concept ID:
C1333106
•
Neoplastic Process

Definition

An adenoma that arises from the colon or rectum. It is characterized by the presence of mild epithelial dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Adenoma with Mild Dysplasia

Professional guidelines

PubMed

Correlation between protein kinase C activity and histopathological criteria in human colorectal adenoma.
Kusunoki M, Hatada T, Sakanoue Y, Yanagi H, Utsunomiya J
Br J Cancer 1992 May;65(5):673-6. doi: 10.1038/bjc.1992.143. PMID: 1586595Free PMC Article

Recent clinical studies

Etiology

Clinicopathological characterization of colonic polyps.
Qari YA
Niger J Clin Pract 2020 Aug;23(8):1048-1053. doi: 10.4103/njcp.njcp_490_19. PMID: 32788480
DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia.
Takiyama A, Tanaka T, Kazama S, Nagata H, Kawai K, Hata K, Otani K, Nishikawa T, Sasaki K, Kaneko M, Emoto S, Murono K, Takiyama H, Nozawa H
In Vivo 2018 Mar-Apr;32(2):365-371. doi: 10.21873/invivo.11247. PMID: 29475922Free PMC Article
Non-alcoholic fatty liver diseases and risk of colorectal neoplasia.
Ahn JS, Sinn DH, Min YW, Hong SN, Kim HS, Jung SH, Gu S, Rhee PL, Paik SW, Son HJ, Gwak GY
Aliment Pharmacol Ther 2017 Jan;45(2):345-353. Epub 2016 Nov 18 doi: 10.1111/apt.13866. PMID: 27859470
Expression of RUNX3 and β-catenin in the carcinogenesis of sporadic colorectal tubular adenoma.
Wang L, Li D, Liu Y, Wang Y, Cui J, Cui A, Wu W
Tumour Biol 2014 Jun;35(6):6039-46. Epub 2014 Mar 14 doi: 10.1007/s13277-014-1800-9. PMID: 24622886
Colorectal polyps and their relationship to cancer.
Kim EC, Lance P
Gastroenterol Clin North Am 1997 Mar;26(1):1-17. doi: 10.1016/s0889-8553(05)70280-6. PMID: 9119435

Diagnosis

DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia.
Takiyama A, Tanaka T, Kazama S, Nagata H, Kawai K, Hata K, Otani K, Nishikawa T, Sasaki K, Kaneko M, Emoto S, Murono K, Takiyama H, Nozawa H
In Vivo 2018 Mar-Apr;32(2):365-371. doi: 10.21873/invivo.11247. PMID: 29475922Free PMC Article
Non-alcoholic fatty liver diseases and risk of colorectal neoplasia.
Ahn JS, Sinn DH, Min YW, Hong SN, Kim HS, Jung SH, Gu S, Rhee PL, Paik SW, Son HJ, Gwak GY
Aliment Pharmacol Ther 2017 Jan;45(2):345-353. Epub 2016 Nov 18 doi: 10.1111/apt.13866. PMID: 27859470
The risk of colorectal cancer after an attack of uncomplicated diverticulitis.
Alexandersson BT, Hreinsson JP, Stefansson T, Jonasson JG, Bjornsson ES
Scand J Gastroenterol 2014 May;49(5):576-80. Epub 2014 Mar 13 doi: 10.3109/00365521.2014.886717. PMID: 24621325
Prevention of colorectal cancer by colonoscopic surveillance in families with hereditary colorectal cancer.
Stormorken AT, Clark N, Grindedal E, Maehle L, Møller P
Scand J Gastroenterol 2007 May;42(5):611-7. doi: 10.1080/00365520601010230. PMID: 17454882
Colorectal polyps and their relationship to cancer.
Kim EC, Lance P
Gastroenterol Clin North Am 1997 Mar;26(1):1-17. doi: 10.1016/s0889-8553(05)70280-6. PMID: 9119435

Therapy

Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis.
Groves CJ, Beveridge lG, Swain DJ, Saunders BP, Talbot IC, Nicholls RJ, Phillips RK
Dis Colon Rectum 2005 Apr;48(4):816-23. doi: 10.1007/s10350-004-0835-1. PMID: 15747076
Baseline findings of the Italian multicenter randomized controlled trial of "once-only sigmoidoscopy"--SCORE.
Segnan N, Senore C, Andreoni B, Aste H, Bonelli L, Crosta C, Ferraris R, Gasperoni S, Penna A, Risio M, Rossini FP, Sciallero S, Zappa M, Atkin WS; SCORE Working Group--Italy
J Natl Cancer Inst 2002 Dec 4;94(23):1763-72. doi: 10.1093/jnci/94.23.1763. PMID: 12464648
Risk factors for advanced colorectal adenomas: a pooled analysis.
Terry MB, Neugut AI, Bostick RM, Sandler RS, Haile RW, Jacobson JS, Fenoglio-Preiser CM, Potter JD
Cancer Epidemiol Biomarkers Prev 2002 Jul;11(7):622-9. PMID: 12101109
Detection rate of immunochemical fecal occult blood test for colorectal adenomatous polyps with severe dysplasia.
Nakama H, Abdul Fattah AS, Zhang B, Kamijo N, Fujimori K, Miyata K
J Gastroenterol 1997 Aug;32(4):492-5. doi: 10.1007/BF02934088. PMID: 9250896
p53 protein expression in colorectal adenomas: an immunohistochemical study using an antigen retrieval system.
Karamitopoulou E, Perentes E, Diamantis I, Vogt U, Wegmann W
Histopathology 1995 Dec;27(6):517-23. doi: 10.1111/j.1365-2559.1995.tb00322.x. PMID: 8838331

Prognosis

The risk of colorectal cancer after an attack of uncomplicated diverticulitis.
Alexandersson BT, Hreinsson JP, Stefansson T, Jonasson JG, Bjornsson ES
Scand J Gastroenterol 2014 May;49(5):576-80. Epub 2014 Mar 13 doi: 10.3109/00365521.2014.886717. PMID: 24621325
Prevention of colorectal cancer by colonoscopic surveillance in families with hereditary colorectal cancer.
Stormorken AT, Clark N, Grindedal E, Maehle L, Møller P
Scand J Gastroenterol 2007 May;42(5):611-7. doi: 10.1080/00365520601010230. PMID: 17454882
Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors.
Li JQ, Wu F, Masaki T, Kubo A, Fujita J, Dixon DA, Beauchamp RD, Ishida T, Kuriyama S, Imaida K
Int J Oncol 2004 Jul;25(1):87-95. PMID: 15201993
Prognostic and therapeutic score for colorectal adenomas and the role of serum and tissue carcinoembryonic antigen.
Rosandić M, Paar V
Eur J Gastroenterol Hepatol 1998 May;10(5):405-9. doi: 10.1097/00042737-199805000-00009. PMID: 9619387
Colorectal adenomas: morphologic features and the risk of developing metachronous adenomas and carcinomas in the colorectum.
Kellokumpu I, Husa A
Scand J Gastroenterol 1987 Sep;22(7):833-41. doi: 10.3109/00365528708991923. PMID: 3672041

Clinical prediction guides

DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia.
Takiyama A, Tanaka T, Kazama S, Nagata H, Kawai K, Hata K, Otani K, Nishikawa T, Sasaki K, Kaneko M, Emoto S, Murono K, Takiyama H, Nozawa H
In Vivo 2018 Mar-Apr;32(2):365-371. doi: 10.21873/invivo.11247. PMID: 29475922Free PMC Article
Expression of RUNX3 and β-catenin in the carcinogenesis of sporadic colorectal tubular adenoma.
Wang L, Li D, Liu Y, Wang Y, Cui J, Cui A, Wu W
Tumour Biol 2014 Jun;35(6):6039-46. Epub 2014 Mar 14 doi: 10.1007/s13277-014-1800-9. PMID: 24622886
Prevention of colorectal cancer by colonoscopic surveillance in families with hereditary colorectal cancer.
Stormorken AT, Clark N, Grindedal E, Maehle L, Møller P
Scand J Gastroenterol 2007 May;42(5):611-7. doi: 10.1080/00365520601010230. PMID: 17454882
Overexpression of p53 protein and histologic grades of dysplasia in colorectal adenomas.
Sameshima S, Kubota Y, Sawada T, Watanabe T, Kuroda T, Tsuno N, Higuchi Y, Shinozaki M, Sunouchi K, Masaki T, Saito Y, Muto T
Dis Colon Rectum 1996 May;39(5):562-7. doi: 10.1007/BF02058712. PMID: 8620809
Assessment of dysplasia in colorectal adenomas: an observer variation and morphometric study.
Brown LJ, Smeeton NC, Dixon MF
J Clin Pathol 1985 Feb;38(2):174-9. doi: 10.1136/jcp.38.2.174. PMID: 3968216Free PMC Article

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