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Colorectal adenoma

MedGen UID:
224904
•Concept ID:
C1302401
•
Neoplastic Process
Synonym: Colorectal adenomas
SNOMED CT: Adenoma of large intestine (399432003)
 
Monarch Initiative: MONDO:0005484

Definition

An adenoma that arises from the colon or rectum. The group of colorectal adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas, sessile serrated adenomas/polyps, and familial adenomatous polyposis. [from NCI]

Professional guidelines

PubMed

Clinical utility of a serum glycome analysis in patients with colorectal cancer.
Takei D, Harada K, Nouso K, Miyahara K, Dohi C, Matsushita H, Kinugasa H, Hiraoka S, Nishimura SI, Okada H
J Gastroenterol Hepatol 2022 Apr;37(4):727-733. Epub 2022 Feb 16 doi: 10.1111/jgh.15781. PMID: 35064597
Colorectal Adenomas-Genetics and Searching for New Molecular Screening Biomarkers.
Siskova A, Cervena K, Kral J, Hucl T, Vodicka P, Vymetalkova V
Int J Mol Sci 2020 May 5;21(9) doi: 10.3390/ijms21093260. PMID: 32380676Free PMC Article
Helicobacter pylori: clinical management.
Malfertheiner P, Selgrad M, Bornschein J
Curr Opin Gastroenterol 2012 Nov;28(6):608-14. doi: 10.1097/MOG.0b013e32835918a7. PMID: 23010682

Recent clinical studies

Etiology

Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening.
Luo Z, Wang B, Luo F, Guo Y, Jiang N, Wei J, Wang X, Tseng Y, Chen J, Zhao B, Liu J
BMC Med 2023 Sep 4;21(1):336. doi: 10.1186/s12916-023-03034-y. PMID: 37667332Free PMC Article
Metabolic syndrome and colorectal adenoma risk: A systematic review and meta‑analysis.
Wu H, Zhang J, Zhou B
Clin Res Hepatol Gastroenterol 2021 Sep;45(5):101749. Epub 2021 Jun 29 doi: 10.1016/j.clinre.2021.101749. PMID: 34214702
Early detection and therapeutics.
Januszewicz W, Fitzgerald RC
Mol Oncol 2019 Mar;13(3):599-613. Epub 2019 Feb 20 doi: 10.1002/1878-0261.12458. PMID: 30677217Free PMC Article
Clinical evidence for the adenoma-carcinoma sequence.
Kronborg O, Fenger C
Eur J Cancer Prev 1999 Dec;8 Suppl 1:S73-86. PMID: 10772421
Colorectal adenoma progression and genetic change: is there a link?
Jass JR
Ann Med 1995 Jun;27(3):301-6. doi: 10.3109/07853899509002581. PMID: 7546618

Diagnosis

Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers.
Sun Y, Zhang X, Hang D, Lau HC, Du J, Liu C, Xie M, Pan Y, Wang L, Liang C, Zhou X, Chen D, Rong J, Zhao Z, Cheung AH, Wu Y, Gou H, Wong CC, Du L, Deng J, Hu Z, Shen H, Miao Y, Yu J
Cancer Cell 2024 Aug 12;42(8):1386-1400.e8. doi: 10.1016/j.ccell.2024.07.005. PMID: 39137727
Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma.
Chen F, Dai X, Zhou CC, Li KX, Zhang YJ, Lou XY, Zhu YM, Sun YL, Peng BX, Cui W
Gut 2022 Jul;71(7):1315-1325. Epub 2021 Aug 30 doi: 10.1136/gutjnl-2020-323476. PMID: 34462336Free PMC Article
Gut microbiome development along the colorectal adenoma-carcinoma sequence.
Feng Q, Liang S, Jia H, Stadlmayr A, Tang L, Lan Z, Zhang D, Xia H, Xu X, Jie Z, Su L, Li X, Li X, Li J, Xiao L, Huber-Schönauer U, Niederseer D, Xu X, Al-Aama JY, Yang H, Wang J, Kristiansen K, Arumugam M, Tilg H, Datz C, Wang J
Nat Commun 2015 Mar 11;6:6528. doi: 10.1038/ncomms7528. PMID: 25758642
Nutritional supplements and cancer: potential benefits and proven harms.
Harvie M
Am Soc Clin Oncol Educ Book 2014:e478-86. doi: 10.14694/EdBook_AM.2014.34.e478. PMID: 24857143
Obesity and colorectal cancer.
Bardou M, Barkun AN, Martel M
Gut 2013 Jun;62(6):933-47. Epub 2013 Mar 12 doi: 10.1136/gutjnl-2013-304701. PMID: 23481261

Therapy

Total, red and processed meat consumption and human health: an umbrella review of observational studies.
Grosso G, La Vignera S, Condorelli RA, Godos J, Marventano S, Tieri M, Ghelfi F, Titta L, Lafranconi A, Gambera A, Alonzo E, Sciacca S, Buscemi S, Ray S, Del Rio D, Galvano F
Int J Food Sci Nutr 2022 Sep;73(6):726-737. Epub 2022 Mar 15 doi: 10.1080/09637486.2022.2050996. PMID: 35291893
Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study.
Chen YX, Gao QY, Zou TH, Wang BM, Liu SD, Sheng JQ, Ren JL, Zou XP, Liu ZJ, Song YY, Xiao B, Sun XM, Dou XT, Cao HL, Yang XN, Li N, Kang Q, Zhu W, Xu HZ, Chen HM, Cao XC, Fang JY
Lancet Gastroenterol Hepatol 2020 Mar;5(3):267-275. Epub 2020 Jan 8 doi: 10.1016/S2468-1253(19)30409-1. PMID: 31926918
Endoscopic full-thickness resection: Current status.
Schmidt A, Meier B, Caca K
World J Gastroenterol 2015 Aug 21;21(31):9273-85. doi: 10.3748/wjg.v21.i31.9273. PMID: 26309354Free PMC Article
Gut microbiome development along the colorectal adenoma-carcinoma sequence.
Feng Q, Liang S, Jia H, Stadlmayr A, Tang L, Lan Z, Zhang D, Xia H, Xu X, Jie Z, Su L, Li X, Li X, Li J, Xiao L, Huber-Schönauer U, Niederseer D, Xu X, Al-Aama JY, Yang H, Wang J, Kristiansen K, Arumugam M, Tilg H, Datz C, Wang J
Nat Commun 2015 Mar 11;6:6528. doi: 10.1038/ncomms7528. PMID: 25758642
Nutritional supplements and cancer: potential benefits and proven harms.
Harvie M
Am Soc Clin Oncol Educ Book 2014:e478-86. doi: 10.14694/EdBook_AM.2014.34.e478. PMID: 24857143

Prognosis

Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma.
Chen F, Dai X, Zhou CC, Li KX, Zhang YJ, Lou XY, Zhu YM, Sun YL, Peng BX, Cui W
Gut 2022 Jul;71(7):1315-1325. Epub 2021 Aug 30 doi: 10.1136/gutjnl-2020-323476. PMID: 34462336Free PMC Article
CX3CR1 Acts as a Protective Biomarker in the Tumor Microenvironment of Colorectal Cancer.
Yue Y, Zhang Q, Sun Z
Front Immunol 2021;12:758040. Epub 2022 Jan 24 doi: 10.3389/fimmu.2021.758040. PMID: 35140706Free PMC Article
Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome.
Wang X, Jia Y, Wen L, Mu W, Wu X, Liu T, Liu X, Fang J, Luan Y, Chen P, Gao J, Nguyen KA, Cui J, Zeng G, Lan P, Chen Q, Cheng B, Wang Z
Cancer Res 2021 May 15;81(10):2745-2759. Epub 2021 Mar 18 doi: 10.1158/0008-5472.CAN-20-3827. PMID: 34003774
Endoscopic full-thickness resection: Current status.
Schmidt A, Meier B, Caca K
World J Gastroenterol 2015 Aug 21;21(31):9273-85. doi: 10.3748/wjg.v21.i31.9273. PMID: 26309354Free PMC Article
Obesity and colorectal cancer.
Bardou M, Barkun AN, Martel M
Gut 2013 Jun;62(6):933-47. Epub 2013 Mar 12 doi: 10.1136/gutjnl-2013-304701. PMID: 23481261

Clinical prediction guides

The basis and implications of diverging approaches to colorectal adenoma surveillance in the West.
Ow TW, Tse E, Iyngkaran G, Macrae F
Intern Med J 2023 Apr;53(4):635-639. Epub 2023 Apr 2 doi: 10.1111/imj.16029. PMID: 37005714
Total, red and processed meat consumption and human health: an umbrella review of observational studies.
Grosso G, La Vignera S, Condorelli RA, Godos J, Marventano S, Tieri M, Ghelfi F, Titta L, Lafranconi A, Gambera A, Alonzo E, Sciacca S, Buscemi S, Ray S, Del Rio D, Galvano F
Int J Food Sci Nutr 2022 Sep;73(6):726-737. Epub 2022 Mar 15 doi: 10.1080/09637486.2022.2050996. PMID: 35291893
Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma.
Chen F, Dai X, Zhou CC, Li KX, Zhang YJ, Lou XY, Zhu YM, Sun YL, Peng BX, Cui W
Gut 2022 Jul;71(7):1315-1325. Epub 2021 Aug 30 doi: 10.1136/gutjnl-2020-323476. PMID: 34462336Free PMC Article
CX3CR1 Acts as a Protective Biomarker in the Tumor Microenvironment of Colorectal Cancer.
Yue Y, Zhang Q, Sun Z
Front Immunol 2021;12:758040. Epub 2022 Jan 24 doi: 10.3389/fimmu.2021.758040. PMID: 35140706Free PMC Article
Endoscopic full-thickness resection: Current status.
Schmidt A, Meier B, Caca K
World J Gastroenterol 2015 Aug 21;21(31):9273-85. doi: 10.3748/wjg.v21.i31.9273. PMID: 26309354Free PMC Article

Recent systematic reviews

Total, red and processed meat consumption and human health: an umbrella review of observational studies.
Grosso G, La Vignera S, Condorelli RA, Godos J, Marventano S, Tieri M, Ghelfi F, Titta L, Lafranconi A, Gambera A, Alonzo E, Sciacca S, Buscemi S, Ray S, Del Rio D, Galvano F
Int J Food Sci Nutr 2022 Sep;73(6):726-737. Epub 2022 Mar 15 doi: 10.1080/09637486.2022.2050996. PMID: 35291893
Systematic review and meta-analysis: Associations between metabolic syndrome and colorectal neoplasia outcomes.
Lu L, Koo S, McPherson S, Hull MA, Rees CJ, Sharp L
Colorectal Dis 2022 Jun;24(6):681-694. Epub 2022 Mar 24 doi: 10.1111/codi.16092. PMID: 35156283
Metabolic syndrome and colorectal adenoma risk: A systematic review and meta‑analysis.
Wu H, Zhang J, Zhou B
Clin Res Hepatol Gastroenterol 2021 Sep;45(5):101749. Epub 2021 Jun 29 doi: 10.1016/j.clinre.2021.101749. PMID: 34214702
Metformin and colorectal cancer: a systematic review, meta-analysis and meta-regression.
Ng CW, Jiang AA, Toh EMS, Ng CH, Ong ZH, Peng S, Tham HY, Sundar R, Chong CS, Khoo CM
Int J Colorectal Dis 2020 Aug;35(8):1501-1512. Epub 2020 Jun 26 doi: 10.1007/s00384-020-03676-x. PMID: 32592092
Adult weight gain and colorectal adenomas-a systematic review and meta-analysis.
Schlesinger S, Aleksandrova K, Abar L, Vieria AR, Vingeliene S, Polemiti E, Stevens CAT, Greenwood DC, Chan DSM, Aune D, Norat T
Ann Oncol 2017 Jun 1;28(6):1217-1229. doi: 10.1093/annonc/mdx080. PMID: 28327995

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