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High Grade Corneal Squamous Intraepithelial Neoplasia

MedGen UID:
232288
•Concept ID:
C1334013
•
Neoplastic Process
Synonym: High Grade Corneal Intraepithelial Neoplasia

Definition

A precancerous neoplastic intraepithelial process with high-grade dysplastic features involving the corneal epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Corneal Squamous Intraepithelial Neoplasia

Recent clinical studies

Etiology

Corneal Microaneurysm-A Vascular Feature of Conjunctival Squamous Intraepithelial Neoplasia.
Stöckl V, Franchi A, Palme C, Steger B
Cornea 2024 Aug 1;43(8):1062-1064. Epub 2024 Apr 18 doi: 10.1097/ICO.0000000000003549. PMID: 38635480
Clinicopathologic correlation of ocular surface squamous neoplasia from a university hospital in North Taiwan 1994 to 2014.
Ma IH, Hu FR, Wang IJ, Chen WL, Hsu YJ, Chu HS, Yuan CT, Hou YC
J Formos Med Assoc 2019 Apr;118(4):776-782. Epub 2018 Sep 25 doi: 10.1016/j.jfma.2018.09.001. PMID: 30266199
Predictors of ocular surface squamous neoplasia recurrence after excisional surgery.
Galor A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W, Dubovy SR
Ophthalmology 2012 Oct;119(10):1974-81. Epub 2012 Jun 14 doi: 10.1016/j.ophtha.2012.04.022. PMID: 22704832Free PMC Article
Retrospective study of ocular surface squamous neoplasia.
Lee GA, Hirst LW
Aust N Z J Ophthalmol 1997 Nov;25(4):269-76. doi: 10.1111/j.1442-9071.1997.tb01514.x. PMID: 9395829

Diagnosis

Corneal Microaneurysm-A Vascular Feature of Conjunctival Squamous Intraepithelial Neoplasia.
Stöckl V, Franchi A, Palme C, Steger B
Cornea 2024 Aug 1;43(8):1062-1064. Epub 2024 Apr 18 doi: 10.1097/ICO.0000000000003549. PMID: 38635480
Predictors of ocular surface squamous neoplasia recurrence after excisional surgery.
Galor A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W, Dubovy SR
Ophthalmology 2012 Oct;119(10):1974-81. Epub 2012 Jun 14 doi: 10.1016/j.ophtha.2012.04.022. PMID: 22704832Free PMC Article
Retrospective study of ocular surface squamous neoplasia.
Lee GA, Hirst LW
Aust N Z J Ophthalmol 1997 Nov;25(4):269-76. doi: 10.1111/j.1442-9071.1997.tb01514.x. PMID: 9395829

Therapy

Corneal Microaneurysm-A Vascular Feature of Conjunctival Squamous Intraepithelial Neoplasia.
Stöckl V, Franchi A, Palme C, Steger B
Cornea 2024 Aug 1;43(8):1062-1064. Epub 2024 Apr 18 doi: 10.1097/ICO.0000000000003549. PMID: 38635480
Efficacy and safety of topical 5-fluorouracil in conjunctival intraepithelial neoplasia refractory to interferon alpha-2b.
Pérez-García P, Burgos-Blasco B, Gómez-Calleja V, Vidal-Villegas B, Méndez-Fernández R, Gegúndez-Fernández JA, Díaz-Valle D
J Oncol Pharm Pract 2023 Jun;29(4):975-979. Epub 2022 Sep 21 doi: 10.1177/10781552221125763. PMID: 36131486
Eye cancer in a young male with a vaping history.
Shields CL, Kim M, Lally SE, Chévez-Barrios P, Shields JA
Indian J Ophthalmol 2020 Aug;68(8):1699-1701. doi: 10.4103/ijo.IJO_27_20. PMID: 32709829Free PMC Article
Clinicopathologic correlation of ocular surface squamous neoplasia from a university hospital in North Taiwan 1994 to 2014.
Ma IH, Hu FR, Wang IJ, Chen WL, Hsu YJ, Chu HS, Yuan CT, Hou YC
J Formos Med Assoc 2019 Apr;118(4):776-782. Epub 2018 Sep 25 doi: 10.1016/j.jfma.2018.09.001. PMID: 30266199
Predictors of ocular surface squamous neoplasia recurrence after excisional surgery.
Galor A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W, Dubovy SR
Ophthalmology 2012 Oct;119(10):1974-81. Epub 2012 Jun 14 doi: 10.1016/j.ophtha.2012.04.022. PMID: 22704832Free PMC Article

Prognosis

Efficacy and safety of topical 5-fluorouracil in conjunctival intraepithelial neoplasia refractory to interferon alpha-2b.
Pérez-García P, Burgos-Blasco B, Gómez-Calleja V, Vidal-Villegas B, Méndez-Fernández R, Gegúndez-Fernández JA, Díaz-Valle D
J Oncol Pharm Pract 2023 Jun;29(4):975-979. Epub 2022 Sep 21 doi: 10.1177/10781552221125763. PMID: 36131486
Thyroid Carcinoma with NSD3::NUTM1 Fusion: a Case with Thyrocyte Differentiation and Colloid Production.
Allison DB, Rueckert J, Cornea V, Lee CY, Dueber J, Bocklage T
Endocr Pathol 2022 Jun;33(2):315-326. Epub 2022 Jan 8 doi: 10.1007/s12022-021-09700-2. PMID: 34997561Free PMC Article
Predictors of ocular surface squamous neoplasia recurrence after excisional surgery.
Galor A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W, Dubovy SR
Ophthalmology 2012 Oct;119(10):1974-81. Epub 2012 Jun 14 doi: 10.1016/j.ophtha.2012.04.022. PMID: 22704832Free PMC Article
Retrospective study of ocular surface squamous neoplasia.
Lee GA, Hirst LW
Aust N Z J Ophthalmol 1997 Nov;25(4):269-76. doi: 10.1111/j.1442-9071.1997.tb01514.x. PMID: 9395829

Clinical prediction guides

Corneal Microaneurysm-A Vascular Feature of Conjunctival Squamous Intraepithelial Neoplasia.
Stöckl V, Franchi A, Palme C, Steger B
Cornea 2024 Aug 1;43(8):1062-1064. Epub 2024 Apr 18 doi: 10.1097/ICO.0000000000003549. PMID: 38635480
Efficacy and safety of topical 5-fluorouracil in conjunctival intraepithelial neoplasia refractory to interferon alpha-2b.
Pérez-García P, Burgos-Blasco B, Gómez-Calleja V, Vidal-Villegas B, Méndez-Fernández R, Gegúndez-Fernández JA, Díaz-Valle D
J Oncol Pharm Pract 2023 Jun;29(4):975-979. Epub 2022 Sep 21 doi: 10.1177/10781552221125763. PMID: 36131486
Eye cancer in a young male with a vaping history.
Shields CL, Kim M, Lally SE, Chévez-Barrios P, Shields JA
Indian J Ophthalmol 2020 Aug;68(8):1699-1701. doi: 10.4103/ijo.IJO_27_20. PMID: 32709829Free PMC Article
Predictors of ocular surface squamous neoplasia recurrence after excisional surgery.
Galor A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W, Dubovy SR
Ophthalmology 2012 Oct;119(10):1974-81. Epub 2012 Jun 14 doi: 10.1016/j.ophtha.2012.04.022. PMID: 22704832Free PMC Article
Retrospective study of ocular surface squamous neoplasia.
Lee GA, Hirst LW
Aust N Z J Ophthalmol 1997 Nov;25(4):269-76. doi: 10.1111/j.1442-9071.1997.tb01514.x. PMID: 9395829

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